Water depth and slush drag instrumentation

Water depth and slush drag instrumentatio

Survey of psychosocial support provided by UK paediatric oncology centres

Aim: To obtain a comprehensive overview of current patterns of psychosocial support provided by National Health Service ( NHS) paediatric oncology treatment centres across the UK. Methods: A postal questionnaire was sent to co-ordinators in the UK Children's Cancer Study Group ( a professional body that is responsible for the organisation of treatment and management of childhood cancer in the UK) in 21 treatment centres and three separate Teenage Cancer Trus units. A range of psychosocial topics were explored, including ratio of staff providing support to patients; facilities provided for children and families; psychosocial support services such as support groups; information provision; and transition support. Results: There were many good areas of support provided by centres, but there was also a lack of standard practices and procedures. All centres employed social workers, play specialists, and paediatric oncology outreach nurses, but patient to staff ratios varied across centres. The poorest staff provision was among psychologists, where patient to staff ratios ranged from 132:1 to 1100:1. Written information was standard practice, while provision of other types of information (audiovisual, online) varied; none of the centres provided audio information specifically for children/young people. Conclusion: This variability in practices among centres frequently occurred, as centres rarely had procedures formally agreed or recorded in writing. British government policy currently seeks to develop standards and guidelines of care throughout the National Health Service. This study further demonstrates the importance of standards and the need to agree guidelines for the provision of psychosocial support for children/young people and their families throughout the course of the illness

Statistical expansions and locally uniform Fréchet differentiability

Estimators which have locally uniform expansions are shown in this paper to be asymptotically equivalent to M-estimators. The M-functionals corresponding to these M-estimators are seen to be locally uniformly Fréchet differentiable. Other conditions for M-functionals to be locally uniformly Fréchet differentiable are given. An example of a commonly used estimator which is robust against outliers is given to illustrate that the locally uniform expansion need not be valid

Health and the Transition from Employment to Retirement

The relationship between employment and retirement is changing dramatically. In contrast to an earlier pattern of relatively stable career employment leading to retirement around age 65, increasing numbers of men and women are leaving their major employment situation earlier. The process of retirement therefore takes on new meaning and duration. The segment of a person's life between stable career employment and permanent retirement at pensionable age can be quite disruptive, involving difficult job searches, employment at lower levels than before, lower wages and repeated job displacement. There is virtually no research about the effects of life course instability in mid- to late-life on health, but limited research on instability early in the working life shows that instability leads to increased mortality. The possibility that labour force instability later in life has adverse health consequences is great and merits further investigation.health; employment; retirement

The Effect of NAG–thiazoline on Morphology and Surface Hydrophobicity of Escherichia Coli

The β-hexosaminidase inhibitor and structural analog of the putative oxazolium reaction intermediate of lytic transglycosylases, N-acetylglucosamine thiazoline (NAG–thiazoline), was synthesized in 46% overall yield and tested as an inhibitor of Escherichia coli growth. NAG–thiazoline, at concentrations up to 1 mg/ml, was not found to affect the viability of E. coli DH5α

Autonomous Cars, Electric and Hybrid Cars, and Ridesharing: Perceptions vs. Reality

Autonomous Cars, Electric and Hybrid Cars, and Ridesharing are all important new technologies in today\u27s society that can have potentially large impacts on the environment in the future. This study was conducted to determine the differences in perceptions of Gettysburg College students regarding Autonomous Cars, Electric and Hybrid Cars, and Ridesharing and the reality of these topics in the real world. This paper also compares the perceptions of Environmental Studies majors/minors to the perceptions of other majors at Gettysburg College. The primary research was conducted by analyzing questions that were a part of a survey consisting of 16 questions which was administered to Gettysburg College students via Facebook class group pages and the Environmental Studies majors email alias. The study group consisted of 110 students with 31 of them being Environmental Studies majors/minors and 79 of them being non-Environmental Studies majors/minors. It was determined that there were no statistically significant differences between the Environmental Studies majors/minors and students that are other majors/minors at Gettysburg College. From our survey, we found that there is a distinct gap in knowledge on the current and future impacts on the environment from Autonomous Cars, Electric and Hybrid Cars, and Ridesharing. The questions that ask which power method produces more greenhouse gas emissions as well as the questions about the miles per gallon of participants’ personal vehicles were the most accurately answered. Overall, Gettysburg College students regardless of major or minor were found to have mostly inaccurate perceptions on the topics of Autonomous Cars, Electric and Hybrid Cars, and Ridesharing

Forces and Structures of the Herpes Simplex Virus (HSV) Entry Mechanism.

This paper discusses physical and structural aspects of the mechanisms herpes simplex virus (HSV) uses for membrane fusion. Calculations show that herpes simplex virus glycoprotein D has such avidity for its receptors that it can hold the virion against the plasma membrane of a neuron strongly enough for glycoprotein B (gB) to disrupt both leaflets of the bilayer. The strong electric field generated by the cell potential across perforations at this disruption would break the hydrogen bonds securing the gB fusion loops, leading to fusion of the plasma and viral membranes. This mechanism agrees with the high stability of the tall trimeric spike structure of gB and is consistent with the probable existence of a more compact initial conformation that would allow it to closely approach the plasma membrane. The release of the fusion domains by disruption of hydrogen bonds is shared with the endocytotic entry pathway where, for some cell types not punctured by gB, the virus is able to induce inward forces that cause endocytosis and the fusion loops are released by acidification. The puncture-fusion mechanism requires low critical strain or high tissue strain, matching primary tropism of neural processes at the vermillion border. In support of this mechanism, this paper proposes a functional superstructure of the antigens essential to entry and reviews its consistency with experimental evidence

De-cloaking Torture: Boumediene and the Military Commissions Act

The Military Commissions Act of 2006 (MCA) marked the high tide and endgame for hiding torture. It\u27s unraveling did more to uncover the Bush administration\u27s secret interrogation practices than did the political change in Washington. International and domestic backlash against the government\u27s embrace of harsh interrogation techniques, frequently rising to the level of torture, also played a role. However, the Supreme Court\u27s decisions ending in Boumediene v. Bush played the decisive role. Boumediene, and the Supreme Court decisions that led up to it, made inevitable that which politics had left contingent and reversible. It also provided legal and political cover

Virginia\u27s Capital Murder Sentencing Proceeding: A Defense Perspective

Capital murder trials present a unique challenge to defense counsel. Many capital defendants are demonstrably guilty of heinous crimes, and a single-minded defense concentrating solely on acquittal in the face of overwhelming evidence of guilt will often alienate the jury. The lawyer who focuses entirely on the guilt stage without attending to the sentencing stage may be consigning his client to the electric chair. This article deals with the sentencing phase of a capital murder trial, where life imprisonment, the jury\u27s only alternative to the death penalty, represents a victory for the defense