Development of a coded 16-ary CPFSK coherent demodulator

Theory and hardware are described for a proof-of-concept 16-ary continuous phase frequency shift keying (16-CPFSK) digital modem. The 16 frequencies are spaced every 1/16th baud rate for 2 bits/sec/Hz operation. Overall rate 3/4 convolutional coding is incorporated. The demodulator differs significantly from typical quadrature phase detector approaches in that phase is coherently measured by processing the baseband output of a frequency discriminator. Baud rate phase samples from the baseband processor are decoded to yield the original data stream. The method of encoding onto the 16-ary phase nodes, together with convolutional coding gain, results in near quad PSK (QPSK) performance. The modulated signal is of constant envelope; thus the power amplifier can be saturated for peak performance. The spectrum is inherently bandlimited and requires no RF filter

Interview: Ken Clarke on Western democracy, the press, and the longevity of our political leaders

In advance of a talk to the LSE Alumni Society, the former Chancellor of the Exchequer and current Minister without Portfolio Ken Clarke spoke to Democratic Audit’s Sean Kippin about where democracy, the press, and our public discourse have gone wrong

Naked singularity resolution in cylindrical collapse

In this paper, we study the gravitational collapse of null dust in the cylindrically symmetric spacetime. The naked singularity necessarily forms at the symmetry axis. We consider the situation in which null dust is emitted again from the naked singularity formed by the collapsed null dust and investigate the back-reaction by this emission for the naked singularity. We show a very peculiar but physically important case in which the same amount of null dust as that of the collapsed one is emitted from the naked singularity as soon as the ingoing null dust hits the symmetry axis and forms the naked singularity. In this case, although this naked singularity satisfies the strong curvature condition by Kr\'{o}lak (limiting focusing condition), geodesics which hit the singularity can be extended uniquely across the singularity. Therefore we may say that the collapsing null dust passes through the singularity formed by itself and then leaves for infinity. Finally the singularity completely disappears and the flat spacetime remains.Comment: 17 pages, no figur

Effect of Primordial Magnetic Field on Seeds for Large Scale Structure

Magnetic field plays a very important role in many astronomical phenomena at various scales of the universe. It is no exception in the early universe. Since the energy density, pressure, and tension of the primordial magnetic field affect gravitational collapses of plasma, the formation of seeds for large scale structures should be influenced by them. Here we numerically investigate the effects of stochastic primordial magnetic field on the seeds of large scale structures in the universe in detail. We found that the amplitude ratio between the density spectra with and without PMF ($|P(k)/P_0(k)|$ at $k>0.2$ Mpc$^{-1}$) lies between 75% and 130% at present for the range of PMF strengths 0.5 nG $< B_\lambda < 1.0$ nG, depending on the spectral index of PMF and the correlation between the matter density and the PMF distributions.Comment: 20 pages, 5 figures, submitted to PRD 23 Jan 2006, Revised 02 Oct 2006, accepted for publication in PR

Stellar Encounters: A Stimulus for Disc Fragmentation?

An interaction between a star-disc system and another star will perturb the disc, possibly resulting in a significant modification of the disc structure and its properties. It is still unclear if such an encounter can trigger fragmentation of the disc to form brown dwarfs or gas giant planets. This paper details high resolution Smoothed Particle Hydrodynamics (SPH) simulations investigating the influence of stellar encounters on disc dynamics. Star-star encounters (where the primary has a self-gravitating, marginally stable protostellar disc, and the secondary has no disc) were simulated with various orbital parameters to investigate the resulting disc structure and dynamics. This work is the first of its kind to incorporate realistic radiative transfer techniques to realistically model the resulting thermodynamics. The results suggest that the effect of stellar encounters is to prohibit fragmentation - compressive and shock heating stabilises the disc, and the radiative cooling is insufficient to trigger gravitational instability. The encounter strips the outer regions of the disc (either through tidal tails or by capture of matter to form a disc around the secondary), which triggers a readjustment of the primary disc to a steeper surface density profile (and a flatter Toomre Q profile). The disc around the secondary plays a role in the potential capture of the secondary to form a binary. However, this applies only to orbits that are parabolic - hyperbolic encounters do not form a secondary disc, and are not captured.Comment: 16 figures, 2 tables, accepted for publication in MNRA

Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy

Despite advancements in cancer therapeutics, acute myeloid leukemia patients over 60 years old have a 5-year survival rate of less than 8%. In an attempt to improve this, epigenetic modifying agents have been combined as therapies in clinical studies. In particular combinations with Decitabine and Vorinostat have had varying degrees of efficacy. This study therefore aimed to understand the underlying molecular mechanisms of these agents to identify potential rational epi-sensitized combinations. Combined Decitabine-Vorinostat treatment synergistically decreased cell proliferation, induced apoptosis, enhanced acetylation of histones and further decreased DNMT1 protein with HL-60 cells showing a greater sensitivity to the combined treatment than OCI-AML3. Combination therapy led to reprogramming of unique target genes including AXL, a receptor tyrosine kinase associated with cell survival and a poor prognosis in AML, which was significantly upregulated following treatment. Therefore targeting AXL following epi-sensitization with Decitabine and Vorinostat may be a suitable triple combination. To test this, cells were treated with a novel triple combination therapy including BGB324, an AXL specific inhibitor. Triple combination increased the sensitivity of OCI-AML3 cells to Decitabine and Vorinostat as shown through viability assays and significantly extended the survival of mice transplanted with pretreated OCI-AML3 cells, while bioluminescence imaging showed the decrease in disease burden following triple combination treatment. Further investigation is required to optimize this triple combination, however, these results suggest that AXL is a potential marker of response to Decitabine-Vorinostat combination treatment and offers a new avenue of epigenetic combination therapies for acute myeloid leukemia

Characterization of zebrafish polymerase iii promoters for the expression of short hairpin RNA interference molecules

RNA interference (RNAi) is a powerful, sequence specific, and long-lasting method of gene knockdown, and can be elicited by the expression of short-hairpin RNA (shRNA) molecules driven via polymerase III type 3 promoters from a DNA vector or transgene. To further develop RNAi as a tool in zebrafish, we have characterized the zebrafish U6 and H1 snRNA promoters and compared the efficiency of each of the promoters to express an shRNA and silence a reporter gene, relative to previously characterized U6 promoters from pufferfish, chicken, and mouse. Our results show that the zebrafish polymerase III promoters were capable of effective gene silencing in the zebrafish ZF4 cell line, but were ineffective in mammalian Vero cells. In contrast, mouse and chicken promoters were active in Vero but not ZF4 cells, highlighting the importance of homologous promoters to achieve effective silencing

‘Not clinically effective but cost-effective’ - paradoxical conclusions in randomised controlled trials with ‘doubly null’ results: a cross-sectional study

Objectives Randomised controlled trials in healthcare increasingly include economic evaluations. Some show small differences which are not statistically significant. Yet these sometimes come to paradoxical conclusions such as: 'the intervention is not clinically effective' but 'is probably cost-effective'. This study aims to quantify the extent of non-significant results and the types of conclusions drawn from them. Design Cross-sectional retrospective analysis of randomised trials published by the UK's National Institute for Health Research (NIHR) Health Technology Assessment programme. We defined as 'doubly null' those trials that found non-statistically significant differences in both primary outcome and cost per patient. Paradoxical was defined as concluding in favour of an intervention, usually compared with placebo or usual care. No human participants were involved. Our sample was 226 randomised trial projects published by the Health Technology Assessment programme 2004 to 2017. All are available free online. Results The 226 projects contained 193 trials with a full economic evaluation. Of these 76 (39%) had at least one 'doubly null' comparison. These 76 trials contained 94 comparisons. In these 30 (32%) drew economic conclusions in favour of an intervention. Overall report conclusions split roughly equally between those favouring the intervention (14), and those favouring either the control (7) or uncertainty (9). Discussion Trials with 'doubly null' results and paradoxical conclusions are not uncommon. The differences observed in cost and quality-adjustedlife year were small and non-statistically significant. Almost all these trials were also published in leading peer-reviewed journals. Although some guidelines for reporting economic results require cost-effectiveness estimates regardless of statistical significance, the interpretability of paradoxical results has nowhere been addressed. Conclusions Reconsideration is required of the interpretation of cost-effectiveness analyses in randomised controlled trials with 'doubly null' results, particularly when economics favours a novel intervention.</p

Teleconsultation/telediagnosis using teledentistry technology: a pilot feasibility study

Abstract—This study assessed the feasibility of a teledentistry model for teleconsultation and telediagnosis in Residential Aged Care Facilities. Study feasibility was defined by the ability to develop remote treatment plans. Reliability of the remote assessments was assessed by comparing with those performed by traditional face-to-face oral examinations. An intraoral camera was operated by trained teledentistry assistants with the aim of screening residents for oral diseases and pathological conditions. The model was supported by traning and an instructional kit for the introral camera operators. The structure, content and delivery of the program, was evaluated. Residents ’ views about the structure, content and delivery of the program were also evaluated. A total of 50 residents participated in this assessment. Results indicated that the proposed teledentistry approach for oral health screening is feasible and reliable as an alternative to traditional oral health examination. Residents expressed high levels of satisfaction with the teledentistry service. This study provides an innovative solution towards closing the service delivery gap in the provision of sustainable oral health care services to underserviced populations (e.g., nursing homes, rural areas)