6 research outputs found
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
- Author
- Amin N. (Najaf)
- Arepalli S. (Sampath)
- Barker R.A. (Roger)
- Ben-Shlomo Y.
- Berendse H.W. (Henk W.)
- Berg D. (Daniela)
- Bettella F. (Francesco)
- Bhatia K.P. (Kailash)
- Bie R.M.A. (Rob) de
- Biffi A. (Alessandro)
- Blauwendraat C. (Cornelis)
- Bloem B.R. (Bastiaan)
- Bochdanovits Z. (Zoltan)
- Bonin M. (Malte) von
- Botia J.A. (Juan A.)
- Brice A. (Alexis)
- Brockmann K.
- Brooks J. (Janet)
- Burn D.J. (David)
- Caroline H Williams-Gray
- Castillo-Lizardo M. (Melissa)
- Charlesworth K. (Kate)
- Chen H. (Honglei)
- Chinnery P.F. (Patrick F.)
- Chong S. (Sean)
- Chouhan A.K. (Amit K.)
- Clarke C.E. (Carl E.)
- Cookson M.R. (Mark)
- Cooper J.M. (J Mark)
- Corvol J.C. (Jean-Christophe)
- Counsell C. (Carl)
- Damier P. (Philippe)
- Dartigues J.-F.
- David D.C. (Della C.)
- Deloukas P. (Panagiotis)
- Deuschl G. (Günther)
- Dexter D.T. (David)
- Dijk K.D. (Karin) van
- Dillman A. (Allissa)
- Dong J. (Jing)
- Drouet V. (Valérie)
- Duijn C.M. (Cornelia) van
- Durif F. (Frank)
- Dürr A. (Alexandra)
- Edkins T. (Ted)
- Escott-Price V. (Valentina)
- Evans J. (Jonathan Mark)
- Foltynie T. (Thomas)
- Gardner M. (Mac)
- Gasser T. (Thomas)
- Gibbs J.R. (J.Raphael)
- Goate A.M. (Alison)
- Gray E. (Emma)
- Guerreiro R. (Rita)
- Hardy J. (John)
- Harris C. (Clare)
- Heetveld S. (Sasja)
- Hernandez D.G. (Dena)
- Heutink P. (Peter)
- Hilten J.J. (Jacobus) van
- Hofman A. (Albert)
- Hollenbeck J.R. (John R.)
- Holton J.L. (Janice)
- Hu M. (Michele)
- Huang X. (Xiaohong)
- Hudson G. (Gavin)
- Hunt S.E. (Sarah E.)
- Illig T. (Thomas)
- Jain A. (Ashok)
- Jansen I. (Iris)
- Javier Simón-Sánchez
- Jose M Bras
- Jónsson P.V. (Pálmi)
- Lambert J.-C.
- Langford C. (Cordelia)
- Lechler M.C. (Marie C.)
- Lees A.J. (Andrew)
- Lesage S. (Suzanne)
- Li Y. (Yarong)
- Lichtner P. (Peter)
- Limousin P. (Patricia)
- Lopez G.
- Lorenz D. (Delia)
- Lubbe S. (Steven)
- Lubbe S.J. (Steven J.)
- Lungu C. (Codrin)
- Majounie E. (Elisa)
- Martinez M. (Maria)
- McNeill N.H. (Nathan)
- Michels H. (Helen)
- Moorby C. (Catriona)
- Moore M. (Matt)
- Morris H.R. (Huw R.)
- Mudanohwo E. (Ese)
- Mätzler W. (Walter)
- Nalls M.A. (Michael)
- Nicholas W Wood
- Nicolas A. (Aude)
- Nollen E.A. (Ellen A.)
- O'Sullivan S.S. (Sean)
- Pearson J. (Justin)
- Perlmutter J.S. (Joel)
- Plagnol V. (Vincent)
- Pollak P. (Pierre)
- Post B. (Bart)
- Potter S.C. (Simon)
- Price R. (Ryan)
- Pétursson H. (Hjörvar)
- Revesz T. (Tamas)
- Riess O. (Olaf)
- Rivadeneira Ramirez F. (Fernando)
- Rizzu P. (Patrizia)
- Ryten M. (Mina)
- Saad M. (Mohamad)
- Sawcer S.J. (Stephen)
- Schapira A. (Anthony)
- Scheffer H. (Hans)
- Schulte C. (Claudia)
- Seinstra R.I. (Renée I.)
- Sharma M.
- Shaw K. (Karen)
- Sheerin U.-M. (Una-Marie)
- Shoulson I. (Ira)
- Shulman J.M.
- Shulman L. (Lee)
- Simón-Sánchez J. (Javier)
- Singleton A. (Andrew)
- Singleton A. (Andrew)
- Smith C. (Colin)
- Spencer C.C.A. (Chris C.)
- Stefansson H. (Hreinn)
- Stockton J.D. (Joanna D.)
- Strange A. (Amy)
- Sveinbjörnsdóttir S. (Sigurlaug)
- Talbot D.
- Tanner C.M. (Carlie)
- Tashakkori-Ghanbaria A. (Avazeh)
- Tison F. (François)
- Trabzuni D. (Danyah)
- Traynor B.J. (Bryan)
- Uitterlinden A.G. (André)
- Vandrovcova J. (Jana)
- Velseboer D. (Daan)
- Vidailhet M. (M.)
- Walker R. (Robert)
- Warrenburg B. (Bart) van de
- Wickremaratchi M. (Mirdhu)
- Williams N. (Nigel)
- Winder-Rhodes S. (Sophie)
- Wurster K.D. (Kathrin)
- Ye H. (Hui)
- Yogi P. (Puja)
- Zwart J-A. (John-Anker)
- Publication venue
- Genome Biol
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson's disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated participants. To discover rare PD susceptibility variants, we performed WES in 1148 unrelated cases and 503 control participants. Candidate genes were subsequently validated for functions relevant to PD based on parallel RNA-interference (RNAi) screens in human cell culture and Drosophila and C. elegans models. RESULTS: Assuming autosomal recessive inheritance, we identify 27 genes that have homozygous or compound heterozygous loss-of-function variants in PD cases. Definitive replication and confirmation of these findings were hindered by potential heterogeneity and by the rarity of the implicated alleles. We therefore looked for potential genetic interactions with established PD mechanisms. Following RNAi-mediated knockdown, 15 of the genes modulated mitochondrial dynamics in human neuronal cultures and four candidates enhanced α-synuclein-induced neurodegeneration in Drosophila. Based on complementary analyses in independent human datasets, five functionally validated genes-GPATCH2L, UHRF1BP1L, PTPRH, ARSB, and VPS13C-also showed evidence consistent with genetic replication. CONCLUSIONS: By integrating human genetic and functional evidence, we identify several PD susceptibility gene candidates for further investigation. Our approach highlights a powerful experimental strategy with broad applicability for future studies of disorders with complex genetic etiologies
A Comprehensive Review Of The Tourism Forecasting Literature
- Author
- Ansari H.
- Archer Brian
- Armstrong J. Scott
- Artus J.E.
- Bar On Raymond R. V.
- Beaman J.
- Bechdolt B.V.
- Bell Michael
- Brandon C.H.
- C.Anthony Di Benedetto
- Canadian Government Office of Tourism
- Cesario F.J.
- Cheung H.K.
- Christensen J.E.
- Cicchetti C.J.
- Clarke Carl Denzil
- David Bojanic
- Doering T.R.
- Duke Keith E.
- Durden G.C.
- Edgell D.
- Freund J.R.
- Gearing C.E.
- Hendee J.C.
- Hof J.G.
- Jeske J.W.
- Kimboko Andre
- Lee Francis S. M.
- Makridakis S.
- Makridakis Spyros
- Malamud B.
- McAllister D.M.
- McCuen R.H.
- Mednick H.
- Oliveira R.A.
- Peterson G.L.
- Peterson G.L.
- Roger J. Calantone
- Rugg Donald
- Seely Richard L.
- Smith V. Kerry
- Stynes D.J.
- Swart W.W.
- Talhelm D.R.
- Tan Choon Thye
- Van de
- Wandner A.S.
- Wennergren E.B.
- Wolfe R.I.
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/01/1987
- Field of study
Major Reports of Tourism Forecasting Studies Are Classified by Forecasting Method Employed, Reviewed, Compared, and Critiqued. a Partial Meta-Analysis is Used to Attempt to Gauge Relative Accuracy of the Various Approaches Used in Differing Situations. Summary Statements on the Relative Usefulness of the Different Methods in Specific Forecasting Situations Are Provided. Some Conclusions Are Drawn to Aid Future Conduct and Reporting of Tourism Forecasting Reports. -Author
Does Academic Research Help or Hurt MBA Programs?
- Author
- AMA Task Force on the Development of Marketing Thought
- Anderson Eugene W
- Anderson T.W.
- Arrow Kenneth J
- Banker Rajiv D
- Bartelsman Eric J
- Bennis Warren G
- Boulding William
- Brown Stephen J
- Clarke D.G.
- Conover W.J.
- Cowan J.
- D'Aveni Richard A
- Debanjan Mitra
- Dekimpe Marnik G
- Epley D.R.
- Fairweather J.S.
- Fama Eugene F
- Fee C.E. C.J.
- Feldman K.
- Gallagher Katherine B
- Geers A.L.
- Golder Peter N
- Granger C.W.J.
- Griliches Zvi
- Hall Robert E
- Hanushek E.
- Hattie J.
- Hettmansperger T.P.
- Hoch Stephen J
- Iman R.L.
- Jacobson Robert
- Kerin Roger A
- Lord C. M.R.
- Lutkepohl H.
- McLaren K.R.
- Mela Carl F
- Mitra Debanjan
- Newman William H
- Nickell S.
- Nijs Vincent R
- Peter N Golder
- Pfeffer Jeffrey
- Russell G.
- Schoar Antoinette
- Siemens J.C. S.
- Steenkamp Jan Benedict E.M.
- Tellis Gerard J
- Tracy J.
- Trieschmann J.S. A.R.
- Van Heerde Herald
- Voss Glenn B
- Walther B.R.
- Wilson T.D. D.J.
- Publication venue
- 'American Marketing Association (AMA)'
- Publication date
- Field of study
Literatur
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- Saxer Victor
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- Schultz Hermann
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- Schwarte Karl-Heinz
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- Schöllgen Georg
- Schöllgen Georg
- Schöllgen Georg
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- Scourfield John H.D.
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- Sebastian J. Jayakiran
- Seeberg Reinhold
- Seigfried A.
- Selinger Reinhard
- Sellew Philipp
- Septuaginta
- Serra Zanetti Paolo
- Sherwin-White Adrian N
- Simone
- Simone
- Simone
- Simone
- Simone
- Simone
- Simone
- Simone
- Simonetti Manlio
- Simonetti Manlio
- Simonetti Manlio
- Snell Bruno
- Soden Hans
- Soden Hans
- Sohm Rudolph
- Sorabji Richard
- Spanneut Michel
- Spanneut Michel
- Spanneut Michel
- Spanneut Michel
- Spanneut Michel
- Spanneut Michel
- Spanneut Michel
- Speigl Jakob
- Starr James
- Steiner Martin
- Steinmetz Peter
- Stelzenberger Johannes
- Straaten Panétius
- Straw Carole E
- Stritzky Decischen
- Studer Basil
- Stuiber Alfred
- Swann William S
- Szarmach Marian
- Szarmach Marian
- Tampwo Maleya Chrysostome
- Taylor John H
- Teeuwen St.W.J.
- Thiering Barbara E
- Thraede Klaus
- Tibiletti
- Tibiletti
- Tibiletti
- Tibiletti
- Tornatora Alberto
- Trilling Wolfgang
- Trillitzsch Winfried
- Trisoglio P. S
- Turner C.H.
- Turner C.H.
- Turner C.H.
- Turner C.H.
- Turner C.H.
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- Watson Edward W
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- Wischmeyer Wolfgang
- Wlosok Antonie
- Wohleb Leo
- Wohleb Leo
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- Ysebaert Joseph
- Zerafa P.
- Zimbrich Ulrike
- Zimmermann Ruben
- Zwisa Carl
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
“Sphere to Cylinder”: Pseudo-Cylindrical Projections
- Author
- A. Cauchy
- A. Cauchy
- A. Cauchy
- A. Cauchy
- A. Cauchy
- A. Cauchy
- A. Cayley
- A. Cazenave
- A. Crumeyrolle
- A. Davies
- A. Dermanis
- A. Dermanis
- A. Dermanis
- A. Dermanis
- A. Edelman
- A. Fialkow
- A. Finzi
- A. Fotiou
- A. Friedmann
- A. Germain
- A. Germain
- A. Heppes
- A. Illert
- A. J. M. Spencer
- A. J. M. Spencer
- A. Kaya
- A. Kleinberg
- A. Klingatsch
- A. Kneser
- A. Korn
- A. Korn
- A. Korn
- A. Lomnicki
- A. Maltman
- A. Niermann
- A. Reithofer
- A. Ruas
- A. Saalfeld
- A. Schett
- A. Schoedlbauer
- A. Schoedlbauer
- A. Schoedlbauer
- A. Schoedlbauer
- A. Schoedlbauer
- A. Spilhaus
- A. Spilhaus
- A. Spilhaus
- A. Spilhaus
- A. Spilhaus
- A. Tarczy-Hornsch
- A. Voss
- A. Waalewijn
- A. Waalewijn
- A. Wangerin
- A. Wintner
- A.A. Izotov
- A.B. Peters
- A.C. Eringen
- A.C. King
- A.E. Nordenskioeld
- A.E. Young
- A.E. Young
- A.H. Robinson
- A.H. Robinson
- A.H. Robinson
- A.H. Robinson
- A.H. Robinson
- A.H. Robinson
- A.H. Robinson
- A.H. Robinson
- A.H. Robinson
- A.H.J. Christensen
- A.I. Markuschewitsch
- A.I. Miller
- A.I. Yanushaushas
- A.J. Kimerling
- A.J. Kimerling
- A.J. Spencer
- A.J. Vander Grinten
- A.J. Vander Grinten
- A.K. Saleh
- A.M. Nell
- A.N. Marchenko
- A.O. Barut
- A.P. Colvocoresses
- A.R. Bruss
- A.R. Forsyth
- A.R. Forsyth
- A.R. Hinks
- A.R. Hinks
- A.R. Hinks
- A.V. Skorokhod
- B. C. Carlson
- B. Chovitz
- B. Chovitz
- B. Chovitz
- B. Chovitz
- B. Chovitzm
- B. Eckmann
- B. Eitschberger
- B. Felsager
- B. Goussinsky
- B. Heck
- B. Moor De
- B. Mueller
- B. Opozda
- B. R. Seth
- B. Riemann
- B. Riemann
- B. Riemann
- B. Sturmfels
- B.C. Carlson
- B.C. Carlson
- B.C. Carlson
- B.C. Carlson
- B.C. Carlson
- B.C. Carlson
- B.C. Carlson
- B.C. Carlson
- B.H. Brown
- B.K.P. Horn
- B.K.P. Horn
- B.R. Seth
- B.Y. Chen
- B.Y. Chen
- Bertil Matérn
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- W.K. Hristow
- W.K. Hristow
- W.K. Hristow
- W.L. Sjogren
- W.O. Vogel
- W.O. Vogel
- W.R. Fuchs
- W.R. Tobler
- W.R. Tobler
- W.R. Tobler
- W.R. Tobler
- W.R. Tobler
- W.R. Tobler
- W.R. Tobler
- W.R. Tobler
- W.R. Tobler
- W.S. Massey
- Wilhelm Klingenberg
- World Geodetic System Committee
- Y. Huryen
- Y. Kaminske
- Y. Saad
- Y.-C. Wong
- Y.H. Yang
- Y.L. Luke
- Y.L. Luke
- Y.M. Chan
- Y.M. Yuzefovich
- Y.S. Frolov
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study