Endografts, Pressure, and the Abdominal Aortic Aneurysm

Abdominal aortic aneurysms (AAA) are an expansion in diameter of the abdominal aorta and their rupture is a leading cause of mortality. One of the treatments for AAA is the implantation of an endograft (also called a stent graft), a combination of fabric and metal stents, to provide a new conduit for blood and shield the aneurysm sac from direct pressurization. After implantation of the stent graft, the aneurysm may shrink, grow, or stabilize in diameter ? even in the absence of apparent flow into the sac ? in some cases resulting in graft failure through component separation, kinking, or loss of seal at its ends. Greater understanding of AAA and treated AAA could provide insight on how treatment might be modified to improve treatment methods and/or design devices to be more effective in a wider range of patients. Computational models provide a means to investigate the biomechanics of endografts treating AAA through analysis of the endografts, the AAA, and the combination of them. Axisymmetric models of endograft-treated AAA showed that peak von Mises stress within the wall varied between 533 kPa and 1200 kPa when different material properties for the endograft were used. The patient-specific models, built from time series of patient CT scans with similar patient history but different outcomes, show that wall shrinkage and stability can be related to the level of stresses within the vessel wall, with the shrinking AAA showing a greater reduction by endograft treatment and a lower final value of average von Mises stress. The reduction in pressure felt by the wall is local to the central sac region. The inclusion of thrombus is also essential to accurate stress estimation. The combination of axisymmetric and patient-specific computational models explains in further detail the biomechanics of endograft treatment. The patient-specific reconstruction models show that when effectively deployed and reducing the pressure felt in the AAA wall, the graft is under tension in the sac region and compression at its ends

Switching dynamics of surface stabilized ferroelectric liquid crystal cells: effects of anchoring energy asymmetry

We study both theoretically and experimentally switching dynamics in surface stabilized ferroelectric liquid crystal cells with asymmetric boundary conditions. In these cells the bounding surfaces are treated differently to produce asymmetry in their anchoring properties. Our electro-optic measurements of the switching voltage thresholds that are determined by the peaks of the reversal polarization current reveal the frequency dependent shift of the hysteresis loop. We examine the predictions of the uniform dynamical model with the anchoring energy taken into account. It is found that the asymmetry effects are dominated by the polar contribution to the anchoring energy. Frequency dependence of the voltage thresholds is studied by analyzing the properties of time-periodic solutions to the dynamical equation (cycles). For this purpose, we apply the method that uses the parameterized half-period mappings for the approximate model and relate the cycles to the fixed points of the composition of two half-period mappings. The cycles are found to be unstable and can only be formed when the driving frequency is lower than its critical value. The polar anchoring parameter is estimated by making a comparison between the results of modelling and the experimental data for the shift vs frequency curve. For a double-well potential considered as a deformation of the Rapini-Papoular potential, the branch of stable cycles emerges in the low frequency region separated by the gap from the high frequency interval for unstable cycles.Comment: 35 pages, 15 figure

Liquid Crystal-Solid Interface Structure at the Antiferroelectric-Ferroelectric Phase Transition

Total Internal Reflection (TIR) is used to probe the molecular organization at the surface of a tilted chiral smectic liquid crystal at temperatures in the vicinity of the bulk antiferroelectric-ferroelectric phase transition. Data are interpreted using an exact analytical solution of a real model for ferroelectric order at the surface. In the mixture T3, ferroelectric surface order is expelled with the bulk ferroelectric-antiferroelectric transition. The conditions for ferroelectric order at the surface of an antiferroelectric bulk are presented

Dirac eigenvalues for a softcore Coulomb potential in d dimensions

A single fermion is bound by a softcore central Coulomb potential V(r) = -v/(r^q + b^q)^(1/q), v>0, b>0, q \ge 1, in d>1 spatial dimensions. Envelope theory is used to construct analytic lower bounds for the discrete Dirac energy spectrum. The results are compared to accurate eigenvalues obtained numerically.Comment: 8 pages 1 figur

Discovery of a young and massive stellar cluster: Spectrophotometric near-infrared study of Masgomas-1

Context: Recent near-infrared data have contributed to the discovery of new (obscured) massive stellar clusters and massive stellar populations in previously known clusters in our Galaxy. These discoveries lead us to view the Milky Way as an active star-forming machine. Aims: The main purpose of this work is to determine physically the main parameters (distance, size, total mass and age) of Masgomas-1, the first massive cluster discovered by our systematic search programme. Methods: Using near-infrared (J, H, and Ks) photometry we selected 23 OB-type and five red supergiant candidates for multi-object H- and K-spectroscopy and spectral classification. Results: Of the 28 spectroscopically observed stars, 17 were classified as OB-type, four as supergiants, one as an A-type dwarf star, and six as late-type giant stars. The presence of a supergiant population implies a massive nature of Masgomas-1, supported by our estimate of the cluster initial total mass of (1.94\pm0.28)\cdot10^4 M_{sun}, obtained after integrating of the cluster mass function. The distance estimate of 3.53 kpc locates the cluster closer than the Scutum--Centaurus base but still within that Galactic arm. The presence of an O9V star and red supergiants in the same population indicates that the cluster age is in the range of 8 to 10 Myr.Comment: 11 pages, 6 figures, 2 tables, A&A accepte

Extended longevity of DNA preservation in Levantine Paleolithic sediments, Sefunim Cave, Israel

Paleogenomic research can elucidate the evolutionary history of human and faunal populations. Although the Levant is a key land-bridge between Africa and Eurasia, thus far, relatively little ancient DNA data has been generated from this region, since DNA degrades faster in warm climates. As sediments can be a source of ancient DNA, we analyzed 33 sediment samples from different sedimentological contexts in the Paleolithic layers of Sefunim Cave (Israel). Four contained traces of ancient Cervidae and Hyaenidae mitochondrial DNA. Dating by optical luminescence and radiocarbon indicates that the DNA comes from layers between 30,000 and 70,000 years old, surpassing theoretical expectations regarding the longevity of DNA deposited in such a warm environment. Both identified taxa are present in the zooarchaeological record of the site but have since gone extinct from the region, and a geoarchaeological study suggests little movement of the sediments after their deposition, lending further support to our findings. We provide details on the local conditions in the cave, which we hypothesize were particularly conducive to the long-term preservation of DNA—information that will be pertinent for future endeavors aimed at recovering ancient DNA from the Levant and other similarly challenging contexts

Role of heavy-meson exchange in pion production near threshold

Recent calculations of $s$-wave pion production have severely underestimated the accurately known $pp\rightarrow pp\pi^0$\ total cross section near threshold. In these calculations, only the single-nucleon axial-charge operator is considered. We have calculated, in addition to the one-body term, the two-body contributions to this reaction that arise from the exchange of mesons. We find that the inclusion of the scalar $\sigma$-meson exchange current (and lesser contributions from other mesons) increases the cross section by about a factor of five, and leads to excellent agreement with the data. The results are neither very sensitive to changes in the distorting potential that generates the $NN$ wave function, nor to different choices for the meson-nucleon form factors. We argue that $pp\rightarrow pp\pi^0$\ data provide direct experimental evidence for meson-exchange contributions to the axial current.Comment: 28 Pages, IU-NTC #93-0

Near-infrared spectroscopy in NGC 7538

The characterisation of the stellar population toward young high-mass star-forming regions allows to constrain fundamental cluster properties like distance and age. These are essential when using high-mass clusters as probes to conduct Galactic studies. NGC 7538 is a star-forming region with an embedded stellar population only unearthed in the near-infrared. We present the first near-infrared spectro-photometric study of the candidate high-mass stellar content in NGC 7538. We obtained H and K spectra of 21 sources with both the multi-object and long-slit modes of LIRIS at the WHT, and complement these data with sub-arcsecond JHKs photometry of the region using the imaging mode of the same instrument. We find a wide variety of objects within the studied stellar population of NGC 7538. Our results discriminate between a stellar population associated to the HII region, but not contained within its extent, and several pockets of more recent star formation. We report the detection of CO bandhead emission toward several sources as well as other features indicative of a young stellar nature. We infer a spectro-photometric distance of 2.7+-0.5 kpc, an age spread in the range 0.5-2.2 Myr and a total mass ~1.7x10^3 Msun for the older population.Comment: 11 pages, 8 figures, 1 table, accepted by A&

Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [11C]-harmine positron emission tomography study

Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa–levodopa administration (P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels

A multi-wavelength census of star formation activity in the young embedded cluster around Serpens/G3-G6

Aims. The aim of this paper is to characterise the star formation activity in the poorly studied embedded cluster Serpens/G3-G6, located ~ 45' (3 pc) to the south of the Serpens Cloud Core, and to determine the luminosity and mass functions of its population of Young Stellar Objects (YSOs). Methods. Multi-wavelength broadband photometry was obtained to sample the near and mid-IR spectral energy distributions to separate YSOs from field stars and classify the YSO evolutionary stage. ISOCAM mapping in the two filters LW2 (5-8.5 um) and LW3 (12-18 um) of a 19' x 16' field was combined with JHKs data from 2MASS, Ks data from Arnica/NOT, and L' data from SIRCA/NOT. Continuum emission at 1.3 mm (IRAM) and 3.6 cm (VLA) was mapped to study the cloud structure and the coldest/youngest sources. Deep narrow band imaging at the 2.12 um S(1) line of H2 from NOTCam/NOT was obtained to search for signs of bipolar outflows. Results. We have strong evidence for a stellar population of 31 Class II sources, 5 flat-spectrum sources, 5 Class I sources, and two Class 0 sources. Our method does not sample the Class III sources. The cloud is composed of two main dense clumps aligned along a ridge over ~ 0.5 pc plus a starless core coinciding with absorption features seen in the ISOCAM maps. We find two S-shaped bipolar collimated flows embedded in the NE clump, and propose the two driving sources to be a Class 0 candidate (MMS3) and a double Class I (MMS2). For the Class II population we find a best age of ~ 2 Myr and compatibility with recent Initial Mass Functions (IMFs) by comparing the observed Class II luminosity function (LF), which is complete to 0.08 L_sun, to various model LFs with different star formation scenarios and input IMFs.Comment: 18 pages, 16 figures, 3 online tables, accepted by A&