The associations between callous-unemotional traits and symptoms of conduct problems, hyperactivity and anxiety : a twin study

Les traits d’insensibilité émotionnelle, tels le manque d’empathie, le manque de remords et l’affect superficiel, sont corrélés avec les troubles de comportement chez les jeunes. La recherche suggère que les traits d’insensibilité émotionnelle et les troubles de comportement sont influencés par des facteurs génétiques communs, et pourraient aussi être influencés, du moins en partie, par des facteurs environnementaux communs. Bien que travaux antérieurs suggèrent que les traits d’insensibilité émotionnelle soient positivement (p. ex., hyperactivité) ou négativement (p. ex., anxiété) associés à d’autres symptômes de psychopathologie, les études portant sur les facteurs étiologiques communs aux traits d’insensibilité émotionnelle et ces autres symptômes de psychopathologie sont plus limitées. Objectifs. Nous proposons d’examiner les associations étiologiques entre les traits d’insensibilité émotionnelle et 1) les troubles de comportement, 2) l’hyperactivité, et 3) l’anxiété, à l’aide d’un échantillon de jumeaux. Méthode. Les participants sont 204 paires complètes et 18 paires incomplètes de jumeaux de même sexe (n = 426; 42% filles; 43% MZ; âge = 15 ans) issus du Child and Adolescents Twin Study in Sweden, une étude longitudinale composée de jumeaux suédois. Des mesures auto-révélées ont été utilisées pour évaluer les traits d’insensibilité émotionnelle, les troubles de comportement, l’hyperactivité et l’anxiété. Des modèles d’équations structurelles ont été estimés afin d’évaluer les contributions génétiques et environnementales des traits d’insensibilité émotionnelle ainsi que leur chevauchement étiologique avec les troubles de comportement, l’hyperactivité et l’anxiété. Résultats. Nous avons trouvé une corrélation génétique forte et positive entre les traits d’insensibilité émotionnelle et les troubles de comportement, mais aucune corrélation significative sur le plan des facteurs environnementaux. Nous avons trouvé une corrélation génétique modérée entre les traits d’insensibilité émotionnelle et l’hyperactivité. Nous avons également trouvé une corrélation génétique modeste et négative entre les traits d’insensibilité émotionnelle et l’anxiété. Conclusion. Ces résultats suggèrent l’existence de facteurs génétiques communs expliquant les traits d’insensibilité émotionnelle et les troubles de comportement, plus particulièrement, et dans une moindre mesure les traits d’insensibilité émotionnelle et l’hyperactivité. En outre, les résultats suggèrent que des facteurs génétiques contribuant à la présence de traits d’insensibilité émotionnelle contribueraient aussi à la diminution des symptômes d’anxiété.Callous-unemotional (CU) traits, such as lack of empathy, lack of guilt and shallow affect, are associated with conduct problems in youth. Research suggests that CU traits and conduct problems share common genetic factors and, possibly environmental factors. Despite evidence for a behavioural association between CU traits and hyperactivity and between CU traits and low anxiety, the etiological associations between these pairs have been considerably less explored. Objectives. Using a twin model-fitting approach, we investigated the etiological associations between CU traits and 1) conduct problems, 2) hyperactivity and 3) anxiety. Method. Participants were 204 complete pairs and 18 incomplete pairs of same-sex twins (n = 426; 42% female; 43% MZ; age = 15) drawn from the Child and Adolescents Twin Study in Sweden, a longitudinal study of twins born in Sweden. CU traits, conduct problems, hyperactivity and anxiety were assessed through self-reports. Structural equation modeling was used to conduct model-fitting analyses. Results. We found a strong positive genetic correlation between CU traits and conduct problems but no significant environmental correlations. We found a moderate genetic correlation between CU traits and hyperactivity. We also found a modest but significant negative genetic correlation between CU traits and anxiety. Conclusion. These findings suggest that common genetic factors explain CU traits and conduct problems, more particularly, and to a lesser extent CU traits and hyperactivity. In addition, these findings suggest that some of the genetic factors contributing to CU traits may also contribute to decreasing levels of anxiety

The National Singing Programme for primary schools in England: an initial baseline study

The ‘Sing Up’ National Singing Programme for Primary schools in England was launched in November 2007 under the UK Government’s ‘Music Manifesto’. ‘Sing Up’ is a four-year programme whose overall aim is to raise the status of singing and increase opportunities for children throughout the country to enjoy singing as part of their everyday lives, in and out of school. As part of the Programme’s research evaluation, a key focus has been to build an initial picture of singing in Primary schools across England. This information could then be used as a ‘baseline’ by which the programme’s subsequent impact could be judged, including ‘before’ and ‘after’ measures of schools that receive particular ‘Sing Up’ input. This paper reports an overview of key outcomes of first five months of baseline profiling (October, 2007 to February 2008), embracing analyses of the singing behaviours of 3,472 children in 76 Primary schools. These findings are complimented by additional analyses of children’s views on singing in and out of school; and the self-efficacy of their class teachers’ (n=90), both as singers and as teachers of singing

Confirmatory Factor Analysis of the Patient Health Questionnaire‐9: A Study of the Participants From the Spinal Cord Injury Model Systems

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146986/1/pmr2533.pd

The views of doctors in their first year of medical practice on the lasting impact of a preparation for house officer course they undertook as final year medical students

<p>Abstract</p> <p>Background</p> <p>The UK General Medical Council recommends that medical students have the opportunity of shadowing the outgoing new doctor whose post they will soon undertake. At the University of Nottingham the two-week shadowing period was preceded by two weeks of lectures/seminars wherein students followed sessions on topics such as common medical/surgical emergencies, contracts, time management, surviving the first two years of clinical practice, careers advice and so on.</p> <p>The present study aimed to gain a better knowledge and understanding of the lasting impact of a four-week preparation course for new Foundation Year 1 doctors [F1 s - interns]. The objectives chosen to achieve this aim were:</p> <p>1/ to determine the extent to which the lecture/seminar course and shadowing period achieved their stated aim of smoothing the transition from life as a medical student to work as a new doctor;</p> <p>2/ to evaluate perceptions of the importance of various forms of knowledge in easing the transition between medical student and new doctor</p> <p>Method</p> <p>In the spring of 2007, 90 graduates from Nottingham were randomly selected and then emailed a link to a short, online survey of quantitative and qualitative questions. Of these 76 responded. Analysis of quantitative data was carried out using SPSS 16.0 and employed McNemar's test. Analysis of the qualitative data was carried out using the constant comparative method.</p> <p>Results</p> <p>Only 31% of respondents strongly agreed or agreed that the lecture/seminar part of the course prepared them well for their first FY1 post; 14% agreed that during their first job they drew on the knowledge gained during the lecture/seminar course; 94% strongly agreed or agreed that the shadowing part of the course was more useful than the lecture/seminar part.</p> <p>Experiential knowledge gained in the shadowing was the most highly valued, followed by procedural knowledge with propositional knowledge coming far behind.</p> <p>Conclusions</p> <p>Our study shows that new doctors retrospectively value most the knowledge they are able to transfer to the workplace and value least material which seems to repeat what they had learned for their final exams.</p

A Systematic Multidisciplinary Process for User Engagement and Sensor Evaluation: Development of a Digital Toolkit for Assessment of Movement in Children with Cerebral Palsy

Objectives: To describe and critique a systematic multidisciplinary approach to user engagement, and selection and evaluation of sensor technologies for development of a sensor-based Digital Toolkit for assessment of movement in children with cerebral palsy (CP).Methods: A sequential process was employed comprising three steps: Step 1: define user requirements, by identifying domains of interest; Step 2: map domains of interest to potential sensor technologies; and Step 3: evaluate and select appropriate sensors to be incorporated into the Digital Toolkit. The process employed a combination of principles from frameworks based in either healthcare or technology design.Results: A broad range of domains were ranked as important by clinicians, patients and families, and industry users. These directly informed the device selection and evaluation process that resulted in three sensor-based technologies being agreed for inclusion in the Digital Toolkit, for use in a future research study.Conclusion: This report demonstrates a systematic approach to user engagement and device selection and evaluation during the development of a sensor-based solution to a healthcare problem. It also provides a narrative on the benefits of employing a multidisciplinary approach throughout the process. This work uses previous frameworks for evaluating sensor technologies and expands on the methods used for user engagement

The genome sequence and effector complement of the flax rust pathogen Melampsora lini

Rust fungi cause serious yield reductions on crops, including wheat, barley, soybean, coffee, and represent real threats to global food security. Of these fungi, the flax rust pathogen Melampsora lini has been developed most extensively over the past 80 years as a model to understand the molecular mechanisms that underpin pathogenesis. During infection, M. lini secretes virulence effectors to promote disease. The number of these effectors, their function and their degree of conservation across rust fungal species is unknown. To assess this, we sequenced and assembled de novo the genome of M. lini isolate CH5 into 21,130 scaffolds spanning 189 Mbp (scaffold N50 of 31 kbp). Global analysis of the DNA sequence revealed that repetitive elements, primarily retrotransposons, make up at least 45% of the genome. Using ab initio predictions, transcriptome data and homology searches, we identified 16,271 putative protein-coding genes. An analysis pipeline was then implemented to predict the effector complement of M. lini and compare it to that of the poplar rust, wheat stem rust and wheat stripe rust pathogens to identify conserved and species-specific effector candidates. Previous knowledge of four cloned M. lini avirulence effector proteins and two basidiomycete effectors was used to optimize parameters of the effector prediction pipeline. Markov clustering based on sequence similarity was performed to group effector candidates from all four rust pathogens. Clusters containing at least one member from M. lini were further analyzed and prioritized based on features including expression in isolated haustoria and infected leaf tissue and conservation across rust species. Herein, we describe 200 of 940 clusters that ranked highest on our priority list, representing 725 flax rust candidate effectors. Our findings on this important model rust species provide insight into how effectors of rust fungi are conserved across species and how they may act to promote infection on their hosts.This work was funded by a grant from the CSIRO Transformational Biology Capability Platform to Adnane Nemri. Claire Anderson was supported by an ARC Discovery Grant (DP120104044) awarded to David A. Jones and Peter N. Dodds

What works to reduce sedentary behavior in the office, and could these intervention components transfer to the home working environment?:A rapid review and transferability appraisal

BackgroundWorking patterns have changed dramatically due to COVID-19, with many workers now spending at least a portion of their working week at home. The office environment was already associated with high levels of sedentary behavior, and there is emerging evidence that working at home further elevates these levels. The aim of this rapid review (PROSPERO CRD42021278539) was to build on existing evidence to identify what works to reduce sedentary behavior in an office environment, and consider whether these could be transferable to support those working at home.MethodsThe results of a systematic search of databases CENTRAL, MEDLINE, Embase, PsycInfo, CINHAL, and SportDiscus from 10 August 2017 to 6 September 2021 were added to the references included in a 2018 Cochrane review of office based sedentary interventions. These references were screened and controlled peer-reviewed English language studies demonstrating a beneficial direction of effect for office-based interventions on sedentary behavior outcomes in healthy adults were included. For each study, two of five authors screened the title and abstract, the full-texts, undertook data extraction, and assessed risk of bias on the included studies. Informed by the Behavior Change Wheel, the most commonly used intervention functions and behavior change techniques were identified from the extracted data. Finally, a sample of common intervention strategies were evaluated by the researchers and stakeholders for potential transferability to the working at home environment.ResultsTwenty-two studies including 29 interventions showing a beneficial direction of effect on sedentary outcomes were included. The most commonly used intervention functions were training (n = 21), environmental restructuring (n = 21), education (n = 15), and enablement (n = 15). Within these the commonly used behavior change techniques were instructions on how to perform the behavior (n = 21), adding objects to the environment (n = 20), and restructuring the physical environment (n = 19). Those strategies with the most promise for transferring to the home environment included education materials, use of role models, incentives, and prompts.ConclusionsThis review has characterized interventions that show a beneficial direction of effect to reduce office sedentary behavior, and identified promising strategies to support workers in the home environment as the world adapts to a new working landscape.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278539, identifier CRD42021278539

The utility of MAS5 expression summary and detection call algorithms

<p>Abstract</p> <p>Background</p> <p>Used alone, the MAS5.0 algorithm for generating expression summaries has been criticized for high False Positive rates resulting from exaggerated variance at low intensities.</p> <p>Results</p> <p>Here we show, with replicated cell line data, that, when used alongside detection calls, MAS5 can be both selective and sensitive. A set of differentially expressed transcripts were identified that were found to be changing by MAS5, but unchanging by RMA and GCRMA. Subsequent analysis by real time PCR confirmed these changes. In addition, with the Latin square datasets often used to assess expression summary algorithms, filtered MAS5.0 was found to have performance approaching that of its peers.</p> <p>Conclusion</p> <p>When used alongside detection calls, MAS5 is a sensitive and selective algorithm for identifying differentially expressed genes.</p