Global Competition Versus Regional Interests: FDI and Pharmaceuticals in India

This essay explores the economic dynamics of global competition versus regional interests corresponding to the treatment of intellectual property rights (IPRs) in India and the relative effects of such policies on its domestic pharmaceutical industry. The scope of considerations are formally limited to variables implicative of the transnational flow of capital within the pharmaceuticals industry, most specifically those pertaining to foreign direct investment (FDI).   India, as the second most populated country in the world, has been the focus of much discussion regarding patent violations in its pharmaceutical industry. International pressures and membership covenants of the World Trade Organization (WTO) have succeeded in structuring policy such that process patents are now legitimized. This has brought dilemmas between global and regional conflicts of interest to open discussion, and has become a pressing political agenda among various industry stakeholders. This paper discusses the history of Indian internal protection in the pharmaceutical industry and suggests ways in which India may continue to benefit when regulatory barriers are reduced and global trade covenants are abided. The  essay  first examines trends in global FDI and Knowledge Process Outsourcing (KPO). It highlights changes to Indian policy, and subsequently discusses other matters associated with the protection of IPRs including parallel imports, price discrimination, and corruption. Lastly, suggestions are made for viable ways of enabling India to comply with WTO mandates for participation in the global marketplace, while concurrently attending to its domestic needs as well.

First record of Paraprionospio coora Wilson, 1990 (Polychaeta: Spionidae) from the Mediterranean Sea)

The spionid polychaete Paraprionospio pinnata (Ehlers, 1901) has been widely reported from the Mediterranean Sea. We examined some specimens belonging to the genera Paraprionospio that had been collected from the Aegean Sea, Sea of Marmara and the Spanish Mediterranean coast, and identified them as Paraprionospio coora Wilson, 1990, which is new to the Mediterranean fauna. This finding indicates that P. coora has a widespread geographical distribution in Australia, Far East and the Mediterranean, and suggests that the previous records of P. pinnata from the Mediterranean are questionable

Historical Perspectives on Trade and Risk on the Silk Road, Middle East and China

In this paper we examine historical trends in the Silk Road where we discuss historical trade risks, Chinese dynasties and trade. We examine trade risks along the land and sea routes through Central Asia and Middle East. We discuss Chinese balance of payments during different dynasties and the changes in the land and the sea routes. We examine how the trade patterns and routes shifted with the discovery of the New World and when the Dutch and the British formed pooled risk trade associations

Genomic Analysis of Immune Response against Vibrio Cholerae Hemolysin in Caenorhabditis elegans

Vibrio cholerae cytolysin (VCC) is among the accessory V. cholerae virulence factors that may contribute to disease pathogenesis in humans. VCC, encoded by hlyA gene, belongs to the most common class of bacterial toxins, known as poreforming toxins (PFTs). V. cholerae infects and kills Caenorhabditis elegans via cholerae toxin independent manner. VCC is required for the lethality, growth retardation and intestinal cell vacuolation during the infection. However, little is known about the host gene expression responses against VCC. To address this question we performed a microarray study in C. elegans exposed to V. cholerae strains with intact and deleted hlyA genes. Many of the VCC regulated genes identified, including C-type lectins, Prion-like (glutamine [Q]/asparagine [N]-rich)-domain containing genes, genes regulated by insulin/ IGF-1-mediated signaling (IIS) pathway, were previously reported as mediators of innate immune response against other bacteria in C. elegans. Protective function of the subset of the genes up-regulated by VCC was confirmed using RNAi. By means of a machine learning algorithm called FastMEDUSA, we identified several putative VCC induced immune regulatory transcriptional factors and transcription factor binding motifs. Our results suggest that VCC is a major virulence factor, which induces a wide variety of immune response- related genes during V. cholerae infection in C. elegans

New records of alien polychaete species for the coasts of Turkey

This paper reports two alien polychaete species (Phyllodoce longifrons and Exogone africana) new to the faunal inventory of Turkey as well as two species (Ceratonereis mirabilis and Onuphis eremita oculata) new to the entire Aegean Sea. It is the first time the phyllodocid species P. longifrons is being classified as an alien species. The re-descriptions of P. longifrons and E. africana are given, and their alien status and establishment success are discussed

The validity of eight neoclassical facial canons in the Turkish adults

The neoclassical canons were used to define the proportions between various areas of the head and face. Therefore, this study was done to establish the neoclassical canons of facial proportions in Turkish adults. A total of 200 healthy adults 20 to 35 years of age were examined. Using anthropometric landmarks, 5 horizontal and 9 vertical direct measurements were made on the faces with a sliding calliper. Results have been compared with 8 neoclassical facial canons. When comparing between sexes, a significant difference has been found in all measurements except the upper facial width, left eye-fissure width, forehead height I and II (p < 0.005). The nasofacial proportion has been found to include the most proportional subjects (33%) followed by the orbito-nasal (30%), the orbital proportion (25%) and the naso-oral proportion (17%) in the female. Considering the male, the orbital proportion has been found to include the most proportional subjects (23%) followed by the orbito-nasal proportion (21%), naso-facial proportion (19%) and the naso-oral proportion (17%). The neoclassical canons have been shown to rarely be applicable to Turkish adults and our results may contribute to determine the concepts of transcultural facial structures

Transfusion-transmitted virus prevalence in subjects at high risk of sexually transmitted infection in Turkey

ObjectiveTo assess the possible sexual transmission of virus and to identify the prevalence of TTV viremia in Turkey and its association with other hepatotropic viruses.MethodsSerum samples were collected from 81 subjects (74 prostitutes and seven homosexual men) at high risk of sexually transmitted infection and from 81 healthy controls (74 females and seven males). Sera of patients and controls were tested for TTV, hepatitis A virus, hepatitis B virus, hepatitis C virus, and human immunodeficiency virus. Also, serum alanine and aspartate aminotransferases were measured.ResultsThe prevalence rates of TTV viremia in the risk group and control group were 86.4% and 82.7%, respectively. There was a statistical difference in mean age between TTV-infected and uninfected subjects (38.6 ± 9.9 versus 32.2 ± 6.1 years, respectively, P < 0.001). Prevalence rates of TTV infection in subjects with positive anti-HAV and positive anti-HBc were high when compared with subjects who were negative for these.ConclusionWe suggest that TTV infection has a diverse route of transmission, and its prevalence increases with age; also, the prevalence rate of TTV is high in certain risk groups. The prevalence rates of TTV in the group at risk for sexual transmission (86.4%) and in the control group (82.7%) were among the highest ever reported in the world. Also, we suggest that TTV generally does not cause clinical disease, in spite of this high prevalence

A composite sandwich plate with a novel core design

© 2018 Elsevier Ltd In this study, a new core design is introduced for sandwich composite structures. Its strength and failure behavior are investigated via three-point bending tests. E-glass-fiber-reinforced epoxy resin is selected as the material for both the core and the face sheets. The core has an egg-crate shape. Acoustic emission (AE) method is used to detect the progression of damage. Signals due to elastic waves caused by activated damage mechanisms are investigated in order to identify the corresponding failure modes. A finite element model of the sandwich structure is developed to predict the failure behavior of the specimens under the loading conditions in the tests. A promising agreement between the results of the finite element model and the experiments is observed. The force-deflection-relation, the failure load as well as the region where damage initiates are accurately predicted

Amyloid Inspired Self-Assembled Peptide Nanofibers

Cataloged from PDF version of article.Amyloid peptides are important components in many degenerative diseases as well as in maintaining cellular metabolism. Their unique stable structure provides new insights in developing new materials. Designing bioinspired selfassembling peptides is essential to generate new forms of hierarchical nanostructures. Here we present oppositely charged amyloid inspired peptides (AIPs), which rapidly self-assemble into nanofibers at pH 7 upon mixing in water caused by noncovalent interactions. Mechanical properties of the gels formed by selfassembled AIP nanofibers were analyzed with oscillatory rheology. AIP gels exhibited strong mechanical characteristics superior to gels formed by self-assembly of previously reported synthetic short peptides. Rheological studies of gels composed of oppositely charged mixed AIP molecules (AIP-1 + 2) revealed superior mechanical stability compared to individual peptide networks (AIP-1 and AIP-2) formed by neutralization of net charges through pH change. Adhesion and elasticity properties of AIP mixed nanofibers and charge neutralized AIP-1, AIP-2 nanofibers were analyzed by high resolution force− distance mapping using atomic force microscopy (AFM). Nanomechanical characterization of self-assembled AIP-1 + 2, AIP-1, and AIP-2 nanofibers also confirmed macroscopic rheology results, and mechanical stability of AIP mixed nanofibers was higher compared to individual AIP-1 and AIP-2 nanofibers self-assembled at acidic and basic pH, respectively. Experimental results were supported with molecular dynamics simulations by considering potential noncovalent interactions between the amino acid residues and possible aggregate forms. In addition, HUVEC cells were cultured on AIP mixed nanofibers at pH 7 and biocompatibility and collagen mimetic scaffold properties of the nanofibrous system were observed. Encapsulation of a zwitterionic dye (rhodamine B) within AIP nanofiber network was accomplished at physiological conditions to demonstrate that this network can be utilized for inclusion of soluble factors as a scaffold for cell culture studies. Copyright © 2012 American Chemical Societ