BOND: Bayesian Oxygen and Nitrogen abundance Determinations in giant H II regions using strong and semi-strong lines

We present BOND, a Bayesian code to simultaneously derive oxygen and nitrogen abundances in giant H II regions. It compares observed emission lines to a grid of photoionization models without assuming any relation between O/H and N/O. Our grid spans a wide range in O/H, N/O and ionization parameter U, and covers different starburst ages and nebular geometries. Varying starburst ages accounts for variations in the ionizing radiation field hardness, which arise due to the ageing of H II regions or the stochastic sampling of the initial mass function. All previous approaches assume a strict relation between the ionizing field and metallicity. The other novelty is extracting information on the nebular physics from semi-strong emission lines. While strong lines ratios alone ([O III]/Hbeta, [O II]/Hbeta and [N II]/Hbeta) lead to multiple O/H solutions, the simultaneous use of [Ar III]/[Ne III] allows one to decide whether an H II region is of high or low metallicity. Adding He I/Hbeta pins down the hardness of the radiation field. We apply our method to H II regions and blue compact dwarf galaxies, and find that the resulting N/O vs O/H relation is as scattered as the one obtained from the temperature-based method. As in previous strong-line methods calibrated on photoionization models, the BOND O/H values are generally higher than temperature-based ones, which might indicate the presence of temperature fluctuations or kappa distributions in real nebulae, or a too soft ionizing radiation field in the models.Comment: MNRAS in press; 21 pages, 22 figures, 2 tables; code, data and results available at http://bond.ufsc.b

Transition (LINER/HII) nuclei as evolved Composite (Seyfert 2/Starburst) nuclei

We compare the circumnuclear stellar population and environmental properies of Seyfert and Composite (Seyfert + Starburst) nuclei with those of LINERs and LINER/HII transition galaxies (TOs), and discuss evidences for evolution from Seyfert/Composite to LINER/TO nuclei.Comment: 2 pages, 1 figure; to appear in the Proceedings of IAU Symp. No. 222: The Interplay among Black Holes, Stars and ISM in Galactic Nuclei, CUP, eds. T. Storchi-Bergmann, L. Ho and H. R. Schmit

Stellar population gradients in Seyfert 2 galaxies. Northern sample

We use high signal-to-noise ratio long-slit spectra in the 3600-4700A range of the twenty brightest northern Seyfert 2 galaxies to study the variation of the stellar population properties as a function of distance from the nucleus. In order to characterize the stellar population and other continuum sources (e.g. featureless continuum FC) we have measured equivalent widths Ws of six absorption features, four continuum colours and their radial variations, and performed spectral population synthesis as a function of distance from the nucleus. About half the sample has CaIIK and G-band W values smaller at the nucleus than at 1 kpc from it, due to a younger population and/or FC. The stellar population synthesis shows that, while at the nucleus, 75% of the galaxies present contribution > 20% of ages younger or equal than 100Myr and/or of a FC, this proportion decreases to 45% at 3 kpc. In particular, 55% of the galaxies have contribution > 10% of the 3 Myr/FC component (a degenerate component in which one cannot separate what is due to a FC or to a 3 Myr stellar population) at the nucleus, but only 25% of them have this contribution at 3 kpc. As reference, the stellar population of 10 non-Seyfert galaxies, spanning the Hubble types of the Seyfert (from S0 to Sc) was also studied. A comparison between the stellar population of the Seyferts and that of the non-Seyferts shows systematic differences: the contribution of ages younger than 1 Gyr is in most cases larger in the Seyfert galaxies than in non-Seyferts, not only at the nucleus but up to 1 kpc from it.Comment: 23 pages, 18 figures, MNRAS in pres

The Nature of the Optical Light in Seyfert 2 Galaxies with Polarized Continuum

We investigate the nature of the optical continuum and stellar population in the central kpc of the Seyfert 2s Mrk 348, Mrk 573, NGC 1358 and Mrk 1210 using long-slit spectra obtained along the radio or extended emission axis. These galaxies are known to have polarized continuum-including polarized broad lines in Mrk 348 and Mrk 1210--and previous studies indicate featureless continuum (FC) contributions in the 20-50% range at 5500 A. Nevertheless, our measurements of the equivalent widths of absorption lines and continuum ratios as a function of distance from the nuclei show no dilution of the lines nor bluening of the spectrum, as expected if a blue FC was present at the nucleus in the above proportions. We investigate one possibility to account for this effect: that the stellar population at the nucleus is the same as that from the surrounding bulge and dominates the nuclear light. A spectral analysis confirms that this hypothesis works for Mrk 348, NGC 1358 and Mrk 1210, for which we find stellar contributions at the nucleus larger than 90% at all wavelengths. We find that a larger stellar population contribution to the nuclear spectra can play the role of the ``second FC'' source inferred from previous studies. Stellar population synthesis shows that the nuclear regions of Mrk 348 and Mrk 1210 have important contributions of young to intermediate age stars (0--100 Myr), not present in templates of elliptical galaxies. In the case of Mrk 1210, this is further confirmed by the detection of a ``Wolf-Rayet feature'' in the nuclear emission-line spectrum.Comment: ApJ, accepted. Uses aaspp4.sty. [22 pages

Obscuring Active Galactic Nuclei with Nuclear Starburst Disks

We assess the potential of nuclear starburst disks to obscure the Seyfert-like AGN that dominate the hard X-ray background at z~1. Over 1200 starburst disk models, based on the theory developed by Thompson et al., are calculated for five input parameters: the black hole mass, the radial size of the starburst disk, the dust-to-gas ratio, the efficiency of angular momentum transport in the disk, and the gas fraction at the outer disk radius. We find that a large dust-to-gas ratio, a relatively small starburst disk, a significant gas mass fraction, and efficient angular momentum transport are all important to produce a starburst disk that can potentially obscure an AGN. The typical maximum star-formation rate in the disks is ~10 solar masses per year. Assuming no mass-loss due to outflows, the starburst disks feed gas onto the black hole at rates sufficient to produce hard X-ray luminosities of 10^{43}-10^{44} erg s^{-1}. The starburst disks themselves should be detectable at mid-infrared and radio wavelengths; at z=0.8, the predicted fluxes are ~1 mJy at 24microns and ~10-30 microJy at 1.4GHz. Thus, we predict a large fraction of radio/X-ray matches in future deep radio surveys. The starburst disks should be easily distinguished from AGN in future 100microns surveys by Herschel with expected fluxes of ~5 mJy. Any AGN-obscuring starbursts will be associated with hot dust, independent of AGN heating, resulting in observable signatures for separating galactic and nuclear star-formation. Finally, because of the competition between gas and star-formation, nuclear starbursts will be associated with lower-luminosity AGN. Thus, this phenomenon is a natural explanation for the observed decrease in the fraction of obscured AGN with luminosity.Comment: 13 pages, 12 figures, 3 in color; accepted by Ap

Cyclosporin A and doxorubicin-ifosfamide in resistant solid tumours: a phase I and an immunological study.

In order to test whether circumvention of clinical resistance can be obtained in common solid tumours by targeting different drug resistance mechanisms, a phase I clinical and immunological study was designed. The purpose of the study was to determine the dose of cyclosporin A (CsA), in combination with doxorubicin (DOX) and ifosfamide (IFX), needed to achieve steady-state whole-blood levels of 2000 ng ml-1 and the associated toxicity of this combination. Treatment consisted of CsA 5 mg kg-1 as a 2 h loading infusion, followed by a CsA 3 day continuous infusion (c.i.) (days 1-3) at doses that were escalated from 10 to 18 mg kg-1 day-1. Chemotherapy consisted of DOX 55 mg m-2 by i.v. 24 h c.i. (day 2) and IFX 2 g m-2 i.v. over 1 h on days 1 and 3. Treatments were repeated every 4 weeks. Eighteen patients with previously treated resistant solid tumours received 39 cycles. Mean steady-state CsA levels > or = 2000 ng ml-1 were reached at 5 mg kg-1 loading dose followed by a 3 day c.i. of 16 mg kg-1 day-1 or greater. Haematological toxicity was greater than expected for the same chemotherapy alone. One patient died of intracranial haemorrhage due to severe thrombopenia. Other observed toxicities were: asymptomatic hyperbilirubinaemia (46% cycles), mild nephrotoxicity (20% cycles), hypomagnesaemia (72% cycles), mild increase in body weight (100% cycles), hypertension (15% cycles) and headache (15% cycles). Overall the toxicity was acceptable and manageable. No alterations in absolute lymphocyte number, the lymphocyte subsets studied (CD3, CD4, CD8, CD19) or CD4/CD8 ratio were observed in patients receiving more than one treatment cycle, although there were significant and non-uniform variations in the values of the different lymphocyte subsets studied when pre- and post-treatment values were compared. There was also a significant increase in the CD4/CD8 ratio. Tumour regressions were observed in two patients (epidermoid carcinoma of the cervix and Ewing's sarcoma). The CsA dose recommended for phase II trials is a 5 mg kg-1 loading dose followed by a 3-day c.i. of 16 mg kg-1 day-1 simultaneously with DOX and IFX at the doses administered in this study

The Electron Scattering Region in Seyfert Nuclei

The electron scattering region (ESR) is one of important ingredients in Seyfert nuclei because it makes possible to observe the hidden broad line region (hereafter HBLR) in some type 2 Seyfert nuclei (hereafter S2s). However, little is known about its physical and geometrical properties. Using the number ratio of S2s with and without HBLR, we investigate statistically where the ESR is in Seyfert nuclei. Our analysis suggests that the ESR is located at radius between $\sim$ 0.01 pc and $\sim$ 0.1 pc from the central engine. We also discuss a possible origin of the ESR briefly.Comment: 5 pages and 1 figure. The Astrophysical Journal (Letters), in pres

The cosmic evolution of the spatially-resolved star formation rate and stellar mass of the CALIFA survey

We investigate the cosmic evolution of the absolute and specific star formation rate (SFR, sSFR) of galaxies as derived from a spatially-resolved study of the stellar populations in a set of 366 nearby galaxies from the CALIFA survey. The analysis combines GALEX and SDSS images with the 4000 break, H_beta, and [MgFe] indices measured from the datacubes, to constrain parametric models for the SFH, which are then used to study the cosmic evolution of the star formation rate density (SFRD), the sSFR, the main sequence of star formation (MSSF), and the stellar mass density (SMD). A delayed-tau model, provides the best results, in good agreement with those obtained from cosmological surveys. Our main results from this model are: a) The time since the onset of the star formation is larger in the inner regions than in the outer ones, while tau is similar or smaller in the inner than in the outer regions. b) The sSFR declines rapidly as the Universe evolves, and faster for early than for late type galaxies, and for the inner than for the outer regions of galaxies. c) SFRD and SMD agree well with results from cosmological surveys. At z< 0.5, most star formation takes place in the outer regions of late spiral galaxies, while at z>2 the inner regions of the progenitors of the current E and S0 are the major contributors to SFRD. d) The inner regions of galaxies are the major contributor to SMD at z> 0.5, growing their mass faster than the outer regions, with a lookback time at 50% SMD of 9 and 6 Gyr for the inner and outer regions. e) The MSSF follows a power-law at high redshift, with the slope evolving with time, but always being sub-linear. f) In agreement with galaxy surveys at different redshifts, the average SFH of CALIFA galaxies indicates that galaxies grow their mass mainly in a mode that is well represented by a delayed-tau model, with the peak at z~2 and an e-folding time of 3.9 Gyr.Comment: 23 pages, 16 figures, 6 tables, accepted for publication in Astronomy & Astrophysics. *Abridged abstract