Hygro-thermo-chemo-mechanical coupled discrete model for the self-healing in Ultra High Performance Concrete

Reliable durability predictions and design for advanced cement-based materials cannot disregard the modelling of their inherent self-healing capability. A discrete meso-scale model to simulate the recovery in water tightness, stiffness and strength induced by the (stimulated) autogenous healing of cracks for Ultra High Performance Concrete is presented. In this paper the model is implemented into the numerical framework of the Multiphysics-Lattice Discrete Particle Model (M-LDPM), resulting from the coupling of the Hygro-Thermo-Chemical (HTC) model and Lattice Discrete Particle Model (LDPM). Consistently with experimental evidence, the development of the self-repairing process is modelled as consisting of two independent stages: (a) the healing of matrix cracks, affecting both moisture permeability and fracture strength in the cracked state, and (b) the recovery in terms of fibre bridging action, relying on the adhesion between the healing products and the walls of the tunnel cracks which form during the fibre debonding process. This research activity is framed into the Horizon 2020 project ReSHEALience (GA 760824)

Numerical modelling via a coupled discrete approach of the autogenous healing for Fibre-Reinforced Cementitious Composites (FRCCs)

Aiming to predict long-term performance of advanced cement-based materials and design more durable structures, a reliable modelling of the autogenous healing of cementitious materials is crucial. A dis-crete model for the regain in terms of water tightness, stiffness and strength induced by the autogenous and/or “stimulate" autogenous healing was recently proposed for ordinary plain concrete. The modelling proposal stemmed from the coupling of two models, namely the Hygro-Thermo-Chemical (HTC) model, on one side,and the Lattice Discrete Particle Model (LDPM), on the other side, resulting in the Multiphysics-Lattice Discrete Particle Model (M-LDPM). Being this approach not customised only for ordinary concrete, but for the whole broad category of cementitious materials, in this paper, its application to Fibre-Reinforced Cementitious Composites is presented. To accurately simulate what has been experimentally observed so far, the mechanical model is updated to also include the self-healing of the tunnel cracks at the fibre-matrix interfaces. Therefore,the self-repairing process is modelled to develop on two independent stages: (a) matrix cracks healing, and(b) fibre bridging action restoring. This research activity is part of the modelling tasks framed into the project ReSHEALience, funded from the European Union’s Horizon 2020 Research and Innovation Programme

Prevalence of HBV genotypes in South American immigrants affected by HBV-related chronic active hepatitis

This study evaluated the prevalence of HBV infection in a population of South American immigrants in Italy and to determine in patients with detectable serum HBV-DNA the HBVgenotypes. Between April 2005 and April 2006 a total of 130 South American immigrants were tested for HBsAg. In HBsAg positive patients the biochemical and virological activity of infection and the possible presence of co-infections (HCV, HDV, HIV) were evaluated. In patients with detectable serum HBV DNA, the HBV genotype was determined by INNOLiPA. Among the 130 subjects tested, 14 (10.7%) resulted HBsAg positive. All were men, with a mean age of 22 years (range 19-37) and 12 (85.7 %) came from Brazil, while 2 (14.3%) came from Ecuador. All patients infected by HBV had elevated alanine-aminotransferase serum levels (mean level was 127 IU/L, range 74-312) and serum HBV DNA detectable by PCR-Real Time (mean level 1,037,652 copies/mL, range 19,876-1,377,648). Genotype distribution was as follow: genotype D, 9 (64.2%), genotype A, 5 (35.8%). All patients infected by genotype D came from Brazil, while among the patients infected by genotype A, three came from Brazil and two from Ecuador. Our study evidences a moderate prevalence of HBV-infection in South American immigrants with the identification of two genotypes, D and A. These genotypes are not the most prevalent in the South America and this is probably the expression of a possible geographical redistribution of HBV genotypes

Modelling of autogenous healing for regular concrete via a discrete model

In this paper a numerical model for autogenous healing of normal strength concrete is presented in detail, along with preliminary results of its validation, which is planned to be achieved by comparing the results of numerical analyses with those of a dedicated experimental campaign. Recently the SMM (Solidification-Microprestress-Microplane model M4) model for concrete, which makes use of a modified microplane model M4 and the solidification-microprestress theory, has been extended to incorporate the autogenous healing effects. The moisture and heat fields, as well as the hydration degree, are obtained from the solution of a hygro-thermo-chemical problem, which is coupled with the SMM model. The updated model can also simulate the effects of cracking on the permeability and the restoring effect of the self-healing on the mechanical constitutive laws, i.e. the microplane model. In this work, the same approach is introduced into a discrete model, namely the Lattice Discrete Particle Model (LDPM). A numerical example is presented to validate the proposed computational model employing experimental data from a recent test series undertaken at Politecnico di Milano

Prevalence of HBV-genotypes in immigrants affected by HBV-related chronic active hepatitis

BACKGROUND: The genetic heterogeneity of the HBV genome has been established and eight genotypes can be classified according to the criterion of >8% differences in the complete nucleotide sequence of the viral genome. AIMS: To evaluate the prevalence of HBV-infection in a population of immigrants and to determine in patients with detectable serum HBV-DNA the HBV-genotypes. METHODS: Between January 2005 and December 2005 a total of 556 immigrants were tested for HBsAg. In HBsAg positive patients the biochemical and virological activity of infection and the possible presence of co-infections (HCV, HDV, HIV) were evaluated. In patients with detectable serum HBV DNA, the HBV-genotype was determined by INNOLiPA. RESULTS: Among the 556 subjects tested, 60 (10.7%) resulted HBsAg positive. All were men, and 42 (70%) come from Africa, 10 (16.6%) from Asia and 9 (14.4%) from East-Europe. 28/60 (46.6%) patients presented normal ALT levels (<40 IU/L) and undetectable serum HBV DNA (<100 copies/mL in real-time PCR), while 32 (53.4%) patients had ALT levels above laboratory normal values and detectable serum HBV DNA. Genotype distribution was as follow: genotype E, 16 (50%), genotype D, 9 (28.1%), genotype A, 7 (21.9%). CONCLUSION: Our study evidences a moderate prevalence of HBV-infection in immigrants, particularly in sub-Saharan African people, and the potentiality of migratory flow in the introduction of genotype non-D hepatitis B virus, potentially characterized by a different natural history and, possibly, a different response to antiviral treatment

Effects of mixed of a ketogenic diet in overweight and obese women with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a commonly occurring endocrine disorder characterized by hirsutism, anovulation, and polycystic ovaries. Often comorbid with insulin resistance, dyslipidemia, and obesity, it also carries significant risk for the development of cardiovascular and metabolic sequelae, including diabetes and metabolic syndrome. The relationship between central obesity and the development of insulin resistance is widely verified. Adipose tissue excess and the coexistent dysregulation of adipocyte functions directly contribute to the pathogenesis of the metabolic complications observed in women with PCOS. In the light of these evidence, the most therapeutic option prescribed to obese women with PCOS, regardless of the phenotype e from the severity of clinical expression, is lifestyle correction by diet and physical activity. The aim of this study is to evaluate the beneficial effects of ketogenic diet in 17 obese women with PCOS. Our results showed that the ketogenic diet inducing therapeutic ketosis, improves the anthropometric and many biochemical parameters such as LH, FSH, SHBG, insulin sensitivity and HOMA index. In addition, it induces a reduction in androgenic production, whereas the contextual reduction of fat mass reduced the acyclic production of estrogens deriving from the aromatization in the adipose tissue of the androgenic excess, with an improvement of the LH/FSH ratio. This is the first study on the effects of the ketogenic diet on PCOS, however, further studies are needed to elucidate the mechanism underlying ketogenic diet effects

Heart rate variability reduction is related to a high amount of visceral adiposity in healthy young women

Several heart rate variability (HRV) studies show abnormalities in autonomic nervous control in obese and overweight subjects. However, some of the results appear to be controversial. Here we investigate the HRV profile in seventy adult normotensive women and its association with general and visceral adiposity. Specifically, we recorded the electrocardiographic (ECG) activity in subjects during a supine resting state for five minutes in a quiet room late in the morning. Total fat mass (TFM) and visceral adipose tissue (VAT) were instead estimated using dual-energy X-ray absorptiometry (DXA). Finally, we used simple a linear regression analysis of frequency and time-domain parameters to study the relationship between HRV and adiposity. Our data showed an overall reduction of the HRV related to an increase of TFM although this regression appeared significant only for high frequencies (HF). When the linear regression was applied between HRV variables and VAT, the slope of the line increases, thus unveiling a statistically significant relation (i.e. the more VAT, the lower HRV). Finally, a control analysis showed that age does not alter the relation between HRV and VAT when used as a confounding factor in multiple regression. To conclude, these findings point to abnormal activity of the autonomic nervous system (ANS) in subjects with an excess of VAT and represent a starting point to determine a non-invasive index of cardiac wellness for clinical and nutritional application

A brief review about anxiety and aggressive behavior in pediatric age

Anxiety can be considered a normal experience of the human being and as such also of the child. It manifests itself in different ways according to the level of development: in the smaller the child, the more anxiety is expressed with manifestations that involve the whole organism, becoming evident either with motor excitement or with physical discomfort. As the psychic apparatus is structured, anxiety is experienced as an inner phenomenon and is experienced as an unpleasant state. Fortunately, we are all a bit anxious, even if there are some people who are more, others less