United States Asylum Law: The Failure Of the United States To Accommodate Women\u27s Gender-Based Asylum Claims

Give me your tired, your poor, Your huddled masses yearning to breathe free, The wretched refuse of your teeming shore. Send these, the homeless, tempest tossed to me: I lift my lamp beside the golden door. Those are the words of Emma Lazarus, inscribed on the Statute of Liberty

Advanced Satellite Technique for Volcanic Activity Monitoring and Early Warning.

Nowadays, satellite remote sensing is an important tool for volcanic activity monitoring, thanks to several operational satellite platforms providing data everywhere with high observational frequencies and generally at low cost. Among different techniques available, an advanced satellite method, named RST (Robust Satellite Technique). based on the multitemporal analysis of satellite data, has shown a high capability in volcanic activity monitoring. This approach has proved capable of identifyimg and tracking volcanic ash Cloud and of correctly detecting and monitoring volcanic thermal anomalies. This paper analyzes some recent results, obtained applying this approach to the last eruptive events of Mt. Etna using both polar and geostationary satellites. In particular, for the first time, this approach is implemented on the present geostationary platform MSG-SEVIRI, with 15 min of temporal resolution. Preliminary results, together with a future potential of this implementation, are shown and discussed. Moreover, a differential RST index in time domain is also proposed for near real-time application, as a possible contribution to the development of an efficient early warning satellite system for volcanic hazard mitigation

Advanced satellite technique for volcanic activity monitoring and early warning

Nowadays, satellite remote sensing is an important tool for volcanic activity monitoring, thanks to several operational satellite platforms providing data everywhere with high observational frequencies and generally at low cost. Among different techniques available, an advanced satellite method, named RST (Robust Satellite Technique), based on the multitemporal analysis of satellite data, has shown a high capability in volcanic activity monitoring. This approach has proved capable of identifying and tracking volcanic ash cloud and of correctly detecting and monitoring volcanic thermal anomalies. This paper analyzes some recent results, obtained applying this approach to the last eruptive events of Mt. Etna using both polar and geostationary satellites. In particular, for the first time, this approach is implemented on the present geostationary platform MSG-SEVIRI, with 15 min of temporal resolution. Preliminary results, together with a future potential of this implementation, are shown and discussed. Moreover, a differential RST index in time domain is also proposed for near real-time application, as a possible contribution to the development of an efficient early warning satellite system for volcanic hazard mitigation

ASSESSMENT OF NEW TECHNOLOGIES IN A MULTI-DISCIPLINARY DESIGN ANALYSIS AND OPTIMIZATION ENVIRONMENT INCLUDING RAMS AND COST DISCIPLINES

The aim of the present paper is to assess the effect of new technologies on the whole aircraft product including its costs, reliability and maintainability characteristics. Several studies have been conducted dealing with the preliminary evaluation of Reliability, Availability, Maintainability and Safety (RAMS) of conventional aircraft. They provide a very effective method to preliminary estimate RAMS characteristics but their employment is not completely suitable for the analysis of unconventional configurations adopting new technologies. This paper aims at evaluating how the aircraft costs and RAMS characteristics are affected by new structures material, natural laminar flow wing technology and unconventional actuator system (electro-hydrostatic actuators), hence an update of the state of the art models is needed. This evaluation is performed by means of a setup and execution of a Multidisciplinary Design Analysis and Optimization (MDAO) workflow. The MDAO environment includes the aircraft conceptual design, aircraft performance, structure design, engine design, on-board systems design, RAMS and maintenance cost modules. The RAMS module is used to obtain the failure rates and maintenance effort (in terms of maintenance man hour per flight hour) at subsystem level. The cost module is based on a new maintenance cost model able to estimate the operating cost of the different aircraft variants. The selected new technologies are applied to a regional jet developed within the framework of AGILE research project. For each technology, a different variant of this aircraft is analyzed. Results show that some important saves are reached both in terms of maintenance and fuel cost when new technologies are applied

Environmental & flight control system architecture optimization from a family concept design perspective

One method an Original Equipment Manufacturer (OEM) can apply to reduce development and manufacturing costs is family concept design: each product family member is designed for a different design point, but a significant amount of components is shared among the family members. In this case, a trade-off exists between member performance and commonality. In the design of complex systems, often many different architectures are possible, and the design space is too large to explore exhaustively. In this work, we present an application of a new architecture optimization method to the design of a family of passenger transport jets, with a focus on the sizing of the Environmental Control System (ECS) and Flight Control System (FCS). The architecture design space is modeled using the Architecture Design Space Graph (ADSG), a novel method for constructing model-based system architecture optimization problems. Decisions are extracted and the multi-objective optimization problem is automatically formulated. Objectives used are commonality, representing acquisition costs, and fuel burn, representing a part of operation costs. These metrics are evaluated using a cross-organizational collaborative multidisciplinary analysis toolchain, and the resulting Multidisciplinary Design Optimization (MDO) problem is solved using a multi-objective evolutionary optimization algorithm. The results show that the trade-off between commonality and fuel burn is only present above a certain commonality level

Withaferin A activates TRIM16 for its anti‐cancer activity in melanoma

Although selective BRAF inhibitors and novel immunotherapies have improved short-term treatment responses in metastatic melanoma patients, acquired resistance to these therapeutics still represent a major challenge in clinical practice. In this study, we evaluated the efficacy of Withaferin A (WFA), derived from the medicinal plant Withania Somnifera, as a novel therapeutic agent for the treatment of melanoma. WFA showed selective toxicity to melanoma cells compared to non-malignant cells. WFA induced apoptosis, significantly reduced cell proliferation and inhibited migration of melanoma cells. We identified that repression of the tumour suppressor TRIM16 diminished WFA cytotoxicity, suggesting that TRIM16 was in part responsible for the cytotoxic effects of WFA in melanoma cells. Together our data indicates that WFA has potent cytopathic effects on melanoma cells through TRIM16, suggesting a potential therapeutic application of WFA in the disease

Collaborative Design of a Business Jet Family Using the AGILE 4.0 MBSE Environment

This paper presents the collaborative model-based design of a business jet family. In family design, a trade-off is made between aircraft performance, reducing fuel burn, and commonality, reducing manufacturing costs. The family is designed using Model-Based Systems Engineering (MBSE) methods developed in the AGILE 4.0 project. The EC-funded AGILE 4.0 project extends the scope of the preliminary aircraft design process to also include systems engineering phases and new design domains like manufacturing, maintenance, and certification. Stakeholders, needs, requirements, and architecture models of the business jet family are presented. Then, the collaborative Multidisciplinary Design Analysis and Optimization (MDAO) capabilities are used to integrate various aircraft design disciplines, including overall aircraft design, onboard systems design, wing structural sizing, tailplane sizing, mission analysis, and cost estimation. Decisions regarding the degree of commonality are implemented by optionally fixing the design of a shared component when sizing an aircraft

A first measurement of the interaction cross section of the tau neutrino

The DONuT experiment collected data in 1997 and published first results in 2000 based on four observed $\nu_\tau$ charged-current (CC) interactions. The final analysis of the data collected in the experiment is presented in this paper, based on $3.6 \times 10^{17}$ protons on target using the 800 GeV Tevatron beam at Fermilab. The number of observed $\nu_\tau$ CC interactions is 9, from a total of 578 observed neutrino interactions. We calculated the energy-independent part of the tau-neutrino CC cross section ($\nu + \bar \nu$), relative to the well-known $\nu_e$ and $\nu_\mu$ cross sections. The ratio $\sigma(\nu_\tau)$/$\sigma(\nu_{e,\mu})$ was found to be $1.37\pm0.35\pm0.77$. The $\nu_\tau$ CC cross section was found to be $0.72 \pm 0.24\pm0.36 \times 10^{-38}$ cm$^{2}\rm{GeV}^{-1}$. Both results are in agreement the Standard Model.Comment: 37 pages, 15 figure