cis-Dichloridobis(triphenyl­phosphine-κP)platinum(II) chloro­form solvate

In the title compound, [PtCl2(C18H15P)2]·CHCl3, each PtII centre adopts a nearly square-planar coordination geometry formed by two P atoms [Pt—P = 2.2481 (17) and 2.2658 (19) Å] and two Cl anions [Pt—Cl = 2.3244 (19) and 2.3548 (17) Å]. The Cl atoms of the chloro­form solvent mol­ecule are disordered over two orientations in a 0.778 (11):0.222 (11) ratio. The crystal packing is stabilized by weak inter­molecular C—H⋯Cl hydrogen bonds, exhib­iting voids with a volume of 215 Å3

1,3-Bis(carboxy­meth­yl)imidazolium triiodide 1-carboxyl­atomethyl-3-carboxy­methyl­imidazolium

In the title compound, C7H9N2O4 +·I3 −·C7H8N2O4, the two imidazolium units are hydrogen bonded through the carboxyl groups. The units are further linked via inter­molecular O—H⋯O hydrogen bonding, resulting in a one-dimensional ladder-type structure. As a result, the two carb­oxy groups of each imidazolium unit adopt a cis configuration with respect to the imidazolium ring

Evaluation of precipitable water vapor from five reanalysis products with ground-based GNSS observations

At present, the global reliability and accuracy of Precipitable Water Vapor (PWV) from different reanalysis products have not been comprehensively evaluated. In this study, PWV values derived by 268 Global Navigation Satellite Systems (GNSS) stations around the world covering the period from 2016 to 2018 are used to evaluate the accuracies of PWV values from five reanalysis products. The temporal and spatial evolution is not taken into account in this analysis, although the temporal and spatial evolution of atmospheric flows is one of the most important information elements available in numerical weather prediction products. The evaluation results present that five reanalysis products with PWV accuracy from high to low are in the order of the fifth generation of European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis (ERA5), ERA-Interim, Japanese 55-year Reanalysis (JRA-55), National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR), and NCEP/DOE (Department of Energy) according to root mean square error (RMSE), bias and correlation coefficient. The ERA5 has the smallest RMSE value of 1.84 mm, while NCEP/NCAR and NCEP/DOE have bigger RMSE values of 3.34 mm and 3.51 mm, respectively. The findings demonstrate that ERA5 and two NCEP reanalysis products have the best and worst performance, respectively, among five reanalysis products. The differences in the accuracy of the five reanalysis products are mainly attributed to the differences in the spatial resolution of reanalysis products. There are some large absolute biases greater than 4 mm between GNSS PWV values and the PWV values of five reanalysis products in the southwest of South America and western China due to the limit of terrains and fewer observations. The accuracies of five reanalysis products are compared in different climatic zones. The results indicate that the absolute accuracies of five reanalysis products are highest in the polar regions and lowest in the tropics. Furthermore, the effects of different seasons on the accuracies of five reanalysis products are also analyzed, which indicates that RMSE values of five reanalysis products in summer and in winter are the largest and the smallest in the temperate regions. Evaluation results from five reanalysis products can help us to learn more about the advantages and disadvantages of the five released water vapor products and promote their applications.Peer ReviewedPostprint (published version

2-Oxo-2,3-dihydro-1H-imidazo[1,2-a]pyridinium iodide

In the title compound, C7H7N2O+·I−, the carbonyl C and O atoms of the cation and the iodide ion are situated on mirror planes. The mean plane of the imidazo[1,2-d]pyridinium cation is perpendicular to the mirror plane as a consequence of the disorder of the cation over two opposite orientations of equal occupancy. In the crystal, N—H⋯I interactions are present

Exponential multistability of memristive Cohen-Grossberg neural networks with stochastic parameter perturbations

© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/.Due to instability being induced easily by parameter disturbances of network systems, this paper investigates the multistability of memristive Cohen-Grossberg neural networks (MCGNNs) under stochastic parameter perturbations. It is demonstrated that stable equilibrium points of MCGNNs can be flexibly located in the odd-sequence or even-sequence regions. Some sufficient conditions are derived to ensure the exponential multistability of MCGNNs under parameter perturbations. It is found that there exist at least (w+2) l (or (w+1) l) exponentially stable equilibrium points in the odd-sequence (or the even-sequence) regions. In the paper, two numerical examples are given to verify the correctness and effectiveness of the obtained results.Peer reviewe

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Glucomannan promotes Bacteroides ovatus to improve intestinal barrier function and ameliorate insulin resistance

Abstract Bioactive dietary fiber has been proven to confer numerous health benefits against metabolic diseases based on the modification of gut microbiota. The metabolic protective effects of glucomannan have been previously reported in animal experiments and clinical trials. However, critical microbial signaling metabolites and the host targets associated with the metabolic benefits of glucomannan remain elusive. The results of this study revealed that glucomannan supplementation alleviated high‐fat diet (HFD)‐induced insulin resistance in mice and that its beneficial effects were dependent on the gut microbiota. Administration of glucomannan to mice promoted the growth of Bacteroides ovatus. Moreover, colonization with B. ovatus in HFD‐fed mice resulted in a decrease in insulin resistance, accompanied by improved intestinal barrier integrity and reduced systemic inflammation. Furthermore, B. ovatus‐derived indoleacetic acid (IAA) was established as a key bioactive metabolite that fortifies intestinal barrier function via activation of intestinal aryl hydrocarbon receptor (AhR), leading to an amelioration in insulin resistance. Thus, we conclude that glucomannan acts through the B. ovatus‐IAA‐intestinal AhR axis to relieve insulin resistance