Dynamic reorganization of the middle fusiform gyrus: long-term bird expertise predicts decreased face selectivity

What is the functional relationship between face-selective and expertise-predicated object-selective regions in the human middle fusiform gyrus? In two separate fMRI experiments, superior behaviorally-measured bird expertise predicts both higher middle fusiform gyrus selectivity for birds and, concomitantly, lower selectivity for faces. This finding suggests a long-term dynamic reorganization of the neural mechanisms underlying the visual recognition of faces and non-face

Mathematical modeling supports substantial mouse neural progenitor cell death

<p>Abstract</p> <p>Background</p> <p>Existing quantitative models of mouse cerebral cortical development are not fully constrained by experimental data.</p> <p>Results</p> <p>Here, we use simple difference equations to model neural progenitor cell fate decisions, incorporating intermediate progenitor cells and initially low rates of neural progenitor cell death. Also, we conduct a sensitivity analysis to investigate possible uncertainty in the fraction of cells that divide, differentiate, and die at each cell cycle.</p> <p>Conclusion</p> <p>We demonstrate that uniformly low-level neural progenitor cell death, as concluded in previous models, is incompatible with normal mouse cortical development. Levels of neural progenitor cell death up to and exceeding 50% are compatible with normal cortical development and may operate to prevent forebrain overgrowth as observed following cell death attenuation, as occurs in caspase 3-null mutant mice.</p

Pathognomonic and epistatic genetic alterations in B-cell non-Hodgkin lymphoma [preprint]

B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B-NHL such as diffuse large B-cell lymphoma (DLBCL) have been comprehensively interrogated at the genomic level, but other less common subtypes such as mantle cell lymphoma (MCL) remain sparsely characterized. Furthermore, multiple B-NHL subtypes have thus far not been comprehensively compared to identify conserved or subtype-specific patterns of genomic alterations. Here, we employed a large targeted hybrid-capture sequencing approach encompassing 380 genes to interrogate the genomic landscapes of 755 B-NHL tumors at high depth; primarily including DLBCL, MCL, follicular lymphoma (FL), and Burkitt lymphoma (BL). We identified conserved hallmarks of B-NHL that were deregulated across major subtypes, such as the frequent genetic deregulation of the ubiquitin proteasome system (UPS). In addition, we identified subtype-specific patterns of genetic alterations, including clusters of co-occurring mutations that are pathognomonic. The cumulative burden of mutations within a single cluster were more significantly discriminatory of B-NHL subtypes than individual mutations, implicating likely patterns of genetic epistasis that contribute to disease etiology. We therefore provide a framework of co-occurring mutations that deregulate genetic hallmarks and likely cooperate in lymphomagenesis of B-NHL subtypes

To Fee or Not to Fee? Satisfaction, Service Quality, and Support of an Entrance Fee of a State Park System

In the past decade, state government appropriation reductions have forced park agencies to seek other sources of revenue to support park operations. To overcome shrinking budgets, many public park agencies embrace private sector business models and investigate customer satisfaction, service quality, and user fee structures. The purpose of this study was to obtain public input regarding service quality, general satisfaction, and experience use history of state park visitation. A total of 382 Oklahoma state park users completed an online survey and were sorted into Pro-Fee (n = 200, 52%) and No-Fee (n = 182, 48%) groups for one-way multivariate analysis of variance (MANOVA) tests. The researchers found a significant difference between the two groups on service quality, but not on overall satisfaction or behavioral intention (e.g., revisit, recommending the park). When comparing Pro-Fee and No-Fee groups, researchers found no statistically significant variance in visitors’ demographics, such as gender, education level, and income, whereas the number of years that had passed since the visitors’ first visit showed a significant difference between the groups. The findings of this study provide valuable insight for discussions related to entrance fees and service fees in state park systems

SmartMocap: Joint Estimation of Human and Camera Motion using Uncalibrated RGB Cameras

Markerless human motion capture (mocap) from multiple RGB cameras is a widely studied problem. Existing methods either need calibrated cameras or calibrate them relative to a static camera, which acts as the reference frame for the mocap system. The calibration step has to be done a priori for every capture session, which is a tedious process, and re-calibration is required whenever cameras are intentionally or accidentally moved. In this paper, we propose a mocap method which uses multiple static and moving extrinsically uncalibrated RGB cameras. The key components of our method are as follows. First, since the cameras and the subject can move freely, we select the ground plane as a common reference to represent both the body and the camera motions unlike existing methods which represent bodies in the camera coordinate. Second, we learn a probability distribution of short human motion sequences ($\sim$1sec) relative to the ground plane and leverage it to disambiguate between the camera and human motion. Third, we use this distribution as a motion prior in a novel multi-stage optimization approach to fit the SMPL human body model and the camera poses to the human body keypoints on the images. Finally, we show that our method can work on a variety of datasets ranging from aerial cameras to smartphones. It also gives more accurate results compared to the state-of-the-art on the task of monocular human mocap with a static camera. Our code is available for research purposes on https://github.com/robot-perception-group/SmartMocap

Aerothermodynamic Design of the Mars Science Laboratory Heatshield

Aerothermodynamic design environments are presented for the Mars Science Laboratory entry capsule heatshield. The design conditions are based on Navier-Stokes flowfield simulations on shallow (maximum total heat load) and steep (maximum heat flux, shear stress, and pressure) entry trajectories from a 2009 launch. Boundary layer transition is expected prior to peak heat flux, a first for Mars entry, and the heatshield environments were defined for a fully-turbulent heat pulse. The effects of distributed surface roughness on turbulent heat flux and shear stress peaks are included using empirical correlations. Additional biases and uncertainties are based on computational model comparisons with experimental data and sensitivity studies. The peak design conditions are 197 W/sq cm for heat flux, 471 Pa for shear stress, 0.371 Earth atm for pressure, and 5477 J/sq cm for total heat load. Time-varying conditions at fixed heatshield locations were generated for thermal protection system analysis and flight instrumentation development. Finally, the aerothermodynamic effects of delaying launch until 2011 are previewed

Demonstration of a Posterior Atrial Input to the Atrioventricular Node During Sustained Anterograde Slow Pathway Conduction

AbstractObjectives. This study sought to demonstrate electrophysiologic evidence for the existence of different anatomic atrial input sites of fast and slow conduction pathways in patients with dual atrioventricular (AV) node physiology.Background. Although a separate posterior exit site exists for a retrograde slow AV node pathway, it remains unresolved whether a separate atrial input site into the AV node actually exists in patients with dual anterograde AV node pathway physiology.Methods. In 10 patients with dual AV node pathway physiology, atrial pacing at three chosen drive cycle lengths (DCL1, DCL2 and DCL3) was performed at an anterior site (A) just above the His bundle recording site and at a posterior atrial site (P) just below the coronary sinus ostium. DCL3 was chosen as the one cycle length that resulted in a long AH interval consistent with slow pathway conduction. The stimulus to His bundle conduction times (SH) at both sites (SHPand SHA, respectively) and their differences (ΔSH = SHP− SHA) at each of the three drive cycle lengths were analyzed.Results. The mean ± SD ΔSH values for DCL1 and DCL2 measured 9 ± 16 and 8 ± 18 ms, respectively, and the mean ΔSH value at DCL3 measured −34 ± 24 ms, which was significantly different from the mean ΔSH values at DCL1 and DCL2 (both p < 0.05).Conclusions. The significant change in the ΔSH (SHP− SHA) value during slow pathway conduction could be accounted for by a corresponding shift of anterograde input from an anterior to a posterior entry site to the AV node. These findings support the notion that a separate anterograde entry site of the slow pathway does exist in patients with dual AV node pathway physiology

Implementing Welfare-to-Work Services: A Study of Staff Decision-Making

Copyright 2006 Alliance for Children and FamiliesIn the post-welfare reform era, increased discretion has been given to frontline staff for day-today welfare policy implementation. To determine how frontline staff address the complex needs of welfare program participants in this new policy environment, the decision-making processes of welfare staff (N = 52) in 11 San Francisco Bay Area county social service agencies were assessed through a case vignette using a Web-based survey design. We examined staff decision making in four areas: problem recognition, goal formulation, information search processes, and evaluation. The results suggest that the high level o f staff discretion apparent in the day-to-day implementation of welfare policy may have important implications for participants. Several recommendations for policy, practice, and future research are presented

Resonant spin Hall conductance in quantum Hall systems lacking bulk and structural inversion symmetry

Following a previous work [Shen, Ma, Xie and Zhang, Phys. Rev. Lett. 92, 256603 (2004)] on the resonant spin Hall effect, we present detailed calculations of the spin Hall conductance in two-dimensional quantum wells in a strong perpendicular magnetic field. The Rashba coupling, generated by spin-orbit interaction in wells lacking bulk inversion symmetry, introduces a degeneracy of Zeeman-split Landau levels at certain magnetic fields. This degeneracy, if occuring at the Fermi energy, will induce a resonance in the spin Hall conductance below a characteristic temperature of order of the Zeeman energy. At very low temperatures, the spin Hall current is highly non-ohmic. The Dresselhaus coupling due to the lack of structure inversion symmetry partially or completely suppresses the spin Hall resonance. The condition for the resonant spin Hall conductance in the presence of both Rashba and Dresselhaus couplings is derived using a perturbation method. In the presence of disorder, we argue that the resonant spin Hall conductance occurs when the two Zeeman split extended states near the Fermi level becomes degenerate due to the Rashba coupling and that the the quantized charge Hall conductance changes by 2e^2/h instead of e^2/h as the magnetic field changes through the resonant field.Comment: 9 pages, 7 figures. This is a sequel to Physical Review Letters 90, 256603 (2004