Study of optical, thermal and radio frequency properties of low emissivity coatings with frequency selective surfaces

The use of frequency selective surfaces (FSSs) defined on railcar windows with a metallic low-e coating to improve the reception of mobile communications signals is becoming ever more common. The proximity of the glass to the passenger in this scenario has introduced a new parameter to consider, aesthetics. This paper presents a complete study of the development of a FSS defined by laser ablation, considering all current requirements. The fabricated samples will be characterized in the optical and radiofrequency ranges of the spectrum. Also, by means of an electron microscope, the chemical elements of each area of the samples will be quantified, in order to study the ablation process. New samples will be made using these parameters, and its performance according to specifications verified. These data will be correlated, using digital image processing, to the aesthetic impact of the engraved FSS, as confirmation of the optimal laser configuration

Proton pump inhibitors display antitumor effects in barrett's adenocarcinoma cells

Recent evidence has reported that proton pump inhibitors (PPIs) can exert antineoplastic effects through the disruption of pH homeostasis by inhibiting vacuolar ATPase (H+-VATPase), a proton pump overexpressed in several tumor cells, but this aspect has not been deeply investigated in EAC yet. In the present study, the expression of H+-VATPase was assessed through the metaplasia-dysplasia-adenocarcinoma sequence in Barrett''s esophagus (BE) and the antineoplastic effects of PPIs and cellular mechanisms involved were evaluated in vitro. H+-VATPase expression was assessed by immunohistochemistry in paraffined-embedded samples or by immunofluorescence in cultured BE and EAC cell lines. Cells were treated with different concentrations of PPIs and parameters of citotoxicity, oxidative stress, and autophagy were evaluated. H+-VATPase expression was found in all biopsies and cell lines evaluated, showing differences in the location of the pump between the cell lines. Esomeprazole inhibited proliferation and cell invasion and induced apoptosis of EAC cells. Production of reactive oxygen species (ROS) seemed to be involved in the cytotoxic effects observed since the addition of N-acetylcysteine significantly reduced esomeprazole-induced apoptosis in EAC cells. Esomeprazole also reduced intracellular pH of tumor cells, whereas only disturbed the mitochondrial membrane potential in OE33 cells. Esomeprazole induced autophagy in both EAC cells, but also triggered a blockade in autophagic flux in the metastatic cell line. These data provide in vitro evidence supporting the potential use of PPIs as novel antineoplastic drugs for EAC and also shed some light on the mechanisms that trigger PPIs cytotoxic effects, which differ upon the cell line evaluated

Listeria monocytogenes Inhibits Serotonin Transporter in Human Intestinal Caco-2 Ce

Listeria monocytogenes is a Gram-positive bacterium that can cause a serious infection. Intestinal microorganisms have been demonstrated to contribute to intestinal physiology not only through immunological responses but also by modulating the intestinal serotonergic system. Serotonin (5- HT) is a neuromodulator that is synthesized in the intestinal epithelium and regulates the whole intestinal physiology. The serotonin transporter (SERT), located in enterocytes, controls intestinal 5-HT availability and therefore serotonin’s effects. Infections caused by L. monocytogenes are well described as being due to the invasion of intestinal epithelial cells; however, the effect of L. monocytogenes on the intestinal epithelium remains unknown. The main aim of this work, therefore, was to study the effect of L. monocytogenes on SERT. Caco2/TC7 cell line was used as an enterocyte-like in vitro model, and SERT functional and molecular expression assays were performed. Our results demonstrate that living L. monocytogenes inhibits serotonin uptake by reducing SERT expression at the brush border membrane. However, neither inactivated L. monocytogenes nor soluble metabolites were able to affect SERT. The results also demonstrate that L. monocytogenes yields TLR2 and TLR10 transcriptional changes in intestinal epithelial cells and suggest that TLR10 is potentially involved in the inhibitory effect observed on SERT. Therefore, L. monocytogenes, through TLR10-mediated SERT inhibition, may induce increased intestinal serotonin availability and potentially contributing to intestinal physiological changes and the initiation of the inflammatory response.This work was funded by grants from the Spanish Ministry of Science and Innovation and the European Regional Development Fund (ERDF/FEDER) (BFU2010-18971), Zaragoza University (UZ2014- BIO-03), European Social Found (ESF), and the Aragon Regional Government (B61) and the Foundation for the Study of Inflammatory Bowel Diseases in Aragón (ARAINF 2012/0567). E. Latorre and E. Layunta are PhD student fellows from Aragon Regional Government (B105/11 and B022/13)

Astronomical Site Ranking Based on Tropospheric Wind Statistics

We present comprehensive and reliable statistics of high altitude wind speeds and the tropospheric flows at the location of five important astronomical observatories. Statistical analysis exclusively of high altitude winds point to La Palma as the most suitable site for adaptive optics, with a mean value of 22.13 m/s at the 200 mbar pressure level. La Silla is at the bottom of the ranking, with the largest average value 200 mbar wind speed(33.35 m/s). We have found a clear annual periodicity of high altitude winds for the five sites in study. We have also explored the connection of high to low altitude atmospheric winds as a first approach of the linear relationship between the average velocity of the turbulence and high altitude winds (Sarazin & Tokovinin 2001). We may conclude that high and low altitude winds show good linear relationships at the five selected sites. The highest correlation coefficients correspond to Paranal and San Pedro Martir, while La Palma and La Silla show similar high to low altitude wind connection. Mauna Kea shows the smallest degree of correlation, which suggests a weaker linear relationship. Our results support the idea of high altitude winds as a parameter for rank astronomical sites in terms of their suitability for adaptive optics, although we have no evidence for adopting the same linear coefficient at different sites. The final value of this linear coefficient at a particular site could drastically change the interpretation of high altitude wind speeds as a direct parameter for site characterization.Comment: 18 pages, 5 figures. Accepted in MNRA

Efficacy of standard and low drift nozzles for insecticide applications against Aonidiella aurantii (Maskell) in citrus

Drift is especially critical when spraying fruit, vine and citrus orchards where pesticides are intensively used. In this context, cone low drift nozzles (LDN) intended for spraying tree crops, have been evaluated relating to cone standard nozzles (STN) in laboratory and deciduous fruit orchards (Van de Zande et al. 2012); (Planas et al., 2013)

A patient self-made point-of-care fecal test improves diagnostic accuracy compared with fecal calprotectin alone in inflammatory bowel disease patients

Background: Monitoring inflammatory bowel disease patients may be challenging. Fecal calprotectin is one of the most performed tests. Other fecal biomarkers are less used in clinical practice. Rapid fecal tests that could be performed by patients may be a useful strategy to closely monitor disease activity. Methods: We performed a prospective observational study including consecutive inflammatory bowel disease patients referred for colonoscopy in a single center. Certest FOB + Transferrin + Calprotectin + Lactoferrin® (Certest Biotec S.L, Zaragoza, Spain), a one-step point-of-care test which simultaneously detects these four biomarkers was performed. Endoscopic inflammatory activity was defined using the Mayo score (=1) in ulcerative colitis, SES-CD (>3) and Rutgeerts scores (=1) for Crohn’s disease. Results: Out of a total of 106 patients (56.5% female, mean age 51 years), 54 (50.9%) were diagnosed with ulcerative colitis and 52 (49.1%) with Crohn’s disease. Endoscopic activity was detected in 42 patients (39.0%). Fecal calprotectin provided the best sensitivity (97.6%), with limited specificity (34.4%). Compared to calprotectin, the other 3 fecal biomarkers showed better specificity (87.5–92.1%) and lower sensitivity (45.2–59.5%). Patients with a negative result in all biomarkers (19/106—17.9%) had 100% (CI 95% 97.4–100) negative predictive value, while patients with the 4 biomarkers positive (13/106—12.3%) had 100% (CI 95% 96.1–100) positive predictive value of endoscopic inflammatory activity. AUROC of this 4 biomarker point-of-care test was 0.845 (95% CI 0.771–0.920), significantly higher than the AUROCs of any of the 4 biomarkers. Conclusions: This test may be a useful strategy to monitor inflammatory activity in clinical practice by excluding or prioritizing patients in need of a colonoscopy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Thinning of the Monte Perdido Glacier in the Spanish Pyrenees since 1981

This paper analyzes the evolution of the Monte Perdido Glacier, the third largest glacier in the Pyrenees, from 1981 to the present. We assessed the evolution of the glacier''s surface area by analysis of aerial photographs from 1981, 1999, and 2006, and changes in ice volume by geodetic methods with digital elevation models (DEMs) generated from topographic maps (1981 and 1999), airborne lidar (2010) and terrestrial laser scanning (TLS, 2011, 2012, 2013, and 2014) data. We interpreted the changes in the glacier based on climate data from nearby meteorological stations. The results indicate that the degradation of this glacier accelerated after 1999. The rate of ice surface loss was almost three times greater during 1999-2006 than during earlier periods. Moreover, the rate of glacier thinning was 1.85 times faster during 1999-2010 (rate of surface elevation change = -8.98 ± 1.80 m, glacier-wide mass balance = -0.73 ± 0.14 m w.e. yr-1) than during 1981-1999 (rate of surface elevation change = -8.35 ± 2.12 m, glacier-wide mass balance = -0.42 ± 0.10 m w.e. yr-1). From 2011 to 2014, ice thinning continued at a slower rate (rate of surface elevation change = -1.93 ± 0.4 m yr-1, glacier-wide mass balance = -0.58 ± 0.36 m w.e. yr-1). This deceleration in ice thinning compared to the previous 17 years can be attributed, at least in part, to two consecutive anomalously wet winters and cool summers (2012-2013 and 2013-2014), counteracted to some degree by the intense thinning that occurred during the dry and warm 2011-2012 period. However, local climatic changes observed during the study period do not seem sufficient to explain the acceleration of ice thinning of this glacier, because precipitation and air temperature did not exhibit statistically significant trends during the study period. Rather, the accelerated degradation of this glacier in recent years can be explained by a strong disequilibrium between the glacier and the current climate, and likely by other factors affecting the energy balance (e.g., increased albedo in spring) and feedback mechanisms (e.g., heat emitted from recently exposed bedrock and debris covered areas)