6,744 research outputs found
Local Fire Department Emergency Management Planning Solutions
Geographic information systems (GIS) technology is a valuable tool when it comes to asset and emergency management response planning. This paper outlines the procedures involved in using GIS to effectively support the City of Montclair, California‟s incident response procedures by organizing their map resources into formats that are easy to use and easily accessible. GIS tools were be used to create a map book as well as a custom search tool that are user friendly, readily updated, more data rich, and more accurate than the City‟s existing system. This tool gives emergency managers a greater understanding of their surroundings and infrastructure with which to plan their responses
Bayesian Spatial Binary Regression for Label Fusion in Structural Neuroimaging
Many analyses of neuroimaging data involve studying one or more regions of
interest (ROIs) in a brain image. In order to do so, each ROI must first be
identified. Since every brain is unique, the location, size, and shape of each
ROI varies across subjects. Thus, each ROI in a brain image must either be
manually identified or (semi-) automatically delineated, a task referred to as
segmentation. Automatic segmentation often involves mapping a previously
manually segmented image to a new brain image and propagating the labels to
obtain an estimate of where each ROI is located in the new image. A more recent
approach to this problem is to propagate labels from multiple manually
segmented atlases and combine the results using a process known as label
fusion. To date, most label fusion algorithms either employ voting procedures
or impose prior structure and subsequently find the maximum a posteriori
estimator (i.e., the posterior mode) through optimization. We propose using a
fully Bayesian spatial regression model for label fusion that facilitates
direct incorporation of covariate information while making accessible the
entire posterior distribution. We discuss the implementation of our model via
Markov chain Monte Carlo and illustrate the procedure through both simulation
and application to segmentation of the hippocampus, an anatomical structure
known to be associated with Alzheimer's disease.Comment: 24 pages, 10 figure
Beyond Transactional Narratives of Agency: Peer Consultants’ Antiracist Professionalization
Social justice movements, especially Black Lives Matter, inspired many writing center administrators to reflect on their commitments to antiracism and engage with antiracist professional development with their staff. However, there is continued need to study the impact antiracist professional development has on writing center consultants’ ability to practice antiracism in sessions. This article presents a predominantly white institution (PWI) writing center’s attempt to do this work, with a particular emphasis on how antiracist professional development complicates portrayals of consultant agency within the writing center. The study analyzes qualitative data collected from consultants’ reflective writing, survey, and interview responses. Results illustrate that, in the context of enacting antiracism in and beyond the writing center, consultants showed messy, partial, and incomplete forms of agency with the professional development curriculum impacting consultants of color and white consultants differently. These findings suggest writing center studies must embrace an understanding of antiracist professional development that is reflective, fragmented, and iterative, and identify more concrete practices of antiracist consulting
Team strategic philosophy: requiem for the infinite game
Deliberate accountability has arrived in the medical arena, producing an age of reward for measured performance, and belief in publicizing metrics to ensure clarity, with winning defined as hitting targets, whereby staff are incentivised by arbitrary objectives. Finite game theory declares that players are known, rules are fixed, and the objective agreed, but infinite game theory asserts that players are both known and unknown, rules are changeable, and the objective is to perpetuate the game; these standards are clearly at odds and risk real world chaos in global universal medical education and clinical outcomes and functioning. Five principles are necessary to lead an infinite game: first, a fair basis, such that sacrifices for its advancement are promoted; second, a trusting blame-free team culture and environment; third, competitors viewed as worthy rivals, rather than adversaries, promoting healthy competition; fourth, existential flexibility when faced with credible evidence; and finally, transformational leadership; including infinite game theory into healthcare planning may be difficult, but the potential rewards are surely worth the existential fight
Combined analysis of microbial metagenomic and metatranscriptomic sequencing data to assess in situ physiological conditions in the premature infant gut.
Microbes alter their transcriptomic profiles in response to the environment. The physiological conditions experienced by a microbial community can thus be inferred using meta-transcriptomic sequencing by comparing transcription levels of specifically chosen genes. However, this analysis requires accurate reference genomes to identify the specific genes from which RNA reads originate. In addition, such an analysis should avoid biases in transcript counts related to differences in organism abundance. In this study we describe an approach to address these difficulties. Sample-specific meta-genomic assembled genomes (MAGs) were used as reference genomes to accurately identify the origin of RNA reads, and transcript ratios of genes with opposite transcription responses were compared to eliminate biases related to differences in organismal abundance, an approach hereafter named the "diametric ratio" method. We used this approach to probe the environmental conditions experienced by Escherichia spp. in the gut of 4 premature infants, 2 of whom developed necrotizing enterocolitis (NEC), a severe inflammatory intestinal disease. We analyzed twenty fecal samples taken from four premature infants (4-6 time points from each infant), and found significantly higher diametric ratios of genes associated with low oxygen levels in samples of infants later diagnosed with NEC than in samples without NEC. We also show this method can be used for examining other physiological conditions, such as exposure to nitric oxide and osmotic pressure. These study results should be treated with caution, due to the presence of confounding factors that might also distinguish between NEC and control infants. Nevertheless, together with benchmarking analyses, we show here that the diametric ratio approach can be applied for evaluating the physiological conditions experienced by microbes in situ. Results from similar studies can be further applied for designing diagnostic methods to detect NEC in its early developmental stages
A UV to Mid-IR Study of AGN Selection
We classify the spectral energy distributions (SEDs) of 431,038 sources in
the 9 sq. deg Bootes field of the NOAO Deep Wide-Field Survey (NDWFS). There
are up to 17 bands of data available per source, including ultraviolet (GALEX),
optical (NDWFS), near-IR (NEWFIRM), and mid-infrared (IRAC/MIPS) data, as well
as spectroscopic redshifts for ~20,000 objects, primarily from the AGN and
Galaxy Evolution Survey (AGES). We fit galaxy, AGN, stellar, and brown dwarf
templates to the observed SEDs, which yield spectral classes for the Galactic
sources and photometric redshifts and galaxy/AGN luminosities for the
extragalactic sources. The photometric redshift precision of the galaxy and AGN
samples are sigma/(1+z)=0.040 and sigma/(1+z)=0.169, respectively, with the
worst 5% outliers excluded. Based on the reduced chi-squared of the SED fit for
each SED model, we are able to distinguish between Galactic and extragalactic
sources for sources brighter than I=23.5. We compare the SED fits for a
galaxy-only model and a galaxy+AGN model. Using known X-ray and spectroscopic
AGN samples, we confirm that SED fitting can be successfully used as a method
to identify large populations of AGN, including spatially resolved AGN with
significant contributions from the host galaxy and objects with the emission
line ratios of "composite" spectra. We also use our results to compare to the
X-ray, mid-IR, optical color and emission line ratio selection techniques. For
an F-ratio threshold of F>10 we find 16,266 AGN candidates brighter than I=23.5
and a surface density of ~1900 AGN per deg^2.Comment: Submitted to ApJ, 35 pages, 17 figures, 2 table
Wideband Agile Digital Microwave Radiometer
The objectives of this work were to take the initial steps needed to develop a field programmable gate array (FPGA)- based wideband digital radiometer backend (>500 MHz bandwidth) that will enable passive microwave observations with minimal performance degradation in a radiofrequency-interference (RFI)-rich environment. As manmade RF emissions increase over time and fill more of the microwave spectrum, microwave radiometer science applications will be increasingly impacted in a negative way, and the current generation of spaceborne microwave radiometers that use broadband analog back ends will become severely compromised or unusable over an increasing fraction of time on orbit. There is a need to develop a digital radiometer back end that, for each observation period, uses digital signal processing (DSP) algorithms to identify the maximum amount of RFI-free spectrum across the radiometer band to preserve bandwidth to minimize radiometer noise (which is inversely related to the bandwidth). Ultimately, the objective is to incorporate all processing necessary in the back end to take contaminated input spectra and produce a single output value free of manmade signals to minimize data rates for spaceborne radiometer missions. But, to meet these objectives, several intermediate processing algorithms had to be developed, and their performance characterized relative to typical brightness temperature accuracy re quirements for current and future microwave radiometer missions, including those for measuring salinity, soil moisture, and snow pack
Distinct Patterns of Default Mode and Executive Control Network Circuitry Contribute to Present and Future Executive Function in Older Adults
Executive function (EF) performance in older adults has been linked with functional and structural profiles within the executive control network (ECN) and default mode network (DMN), white matter hyperintensities (WMH) burden and levels of Alzheimer\u27s disease (AD) pathology. Here, we simultaneously explored the unique contributions of these factors to baseline and longitudinal EF performance in older adults. Thirty-two cognitively normal (CN) older adults underwent neuropsychological testing at baseline and annually for three years. Neuroimaging and AD pathology measures were collected at baseline. Separate linear regression models were used to determine which of these variables predicted composite EF scores at baseline and/or average annual change in composite ΔEF scores over the three-year follow-up period. Results demonstrated that low DMN deactivation, high ECN activation and WMH burden were the main predictors of EF scores at baseline. In contrast, poor DMN and ECN WM microstructure and higher AD pathology predicted greater annual decline in EF scores. Subsequent mediation analysis demonstrated that DMN WM microstructure uniquely mediated the relationship between AD pathology and ΔEF. These results suggest that functional activation patterns within the DMN and ECN and WMHs contribute to baseline EF while structural connectivity within these networks impact longitudinal EF performance in older adults
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