459 research outputs found
Stone Quarries and Sourcing in the Carolina Slate Belt
Research Report No. 25, Research Laboratories of Archaeology, University of North Carolina at Chapel Hill. Reports in this series discuss the findings of archaeological excavations and research projects undertaken by the RLA between 1984 and present
Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring.
The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously intractable diseases. These exciting times in biomedical innovation require the development of novel technologies to facilitate the sophisticated, multifaceted, high-paced workflows necessary to support modern large molecule drug discovery. A high-level aspiration is a true integration of "lab-on-a-chip" methods that vastly miniaturize cellulmical experiments could transform the speed, cost, and success of multiple workstreams in biologics development. Several microscale bioprocess technologies have been established that incrementally address these needs, yet each is inflexibly designed for a very specific process thus limiting an integrated holistic application. A more fully integrated nanoscale approach that incorporates manipulation, culture, analytics, and traceable digital record keeping of thousands of single cells in a relevant nanoenvironment would be a transformative technology capable of keeping pace with today's rapid and complex drug discovery demands. The recent advent of optical manipulation of cells using light-induced electrokinetics with micro- and nanoscale cell culture is poised to revolutionize both fundamental and applied biological research. In this review, we summarize the current state of the art for optical manipulation techniques and discuss emerging biological applications of this technology. In particular, we focus on promising prospects for drug discovery workflows, including antibody discovery, bioassay development, antibody engineering, and cell line development, which are enabled by the automation and industrialization of an integrated optoelectronic single-cell manipulation and culture platform. Continued development of such platforms will be well positioned to overcome many of the challenges currently associated with fragmented, low-throughput bioprocess workflows in biopharma and life science research
A Sample of Very Young Field L Dwarfs and Implications for the Brown Dwarf "Lithium Test" at Early Ages
Using a large sample of optical spectra of late-type dwarfs, we identify a
subset of late-M through L field dwarfs that, because of the presence of
low-gravity features in their spectra, are believed to be unusually young. From
a combined sample of 303 field L dwarfs, we find observationally that
7.6+/-1.6% are younger than 100 Myr. This percentage is in agreement with
theoretical predictions once observing biases are taken into account. We find
that these young L dwarfs tend to fall in the southern hemisphere (Dec < 0 deg)
and may be previously unrecognized, low-mass members of nearby, young
associations like Tucana-Horologium, TW Hydrae, beta Pictoris, and AB Doradus.
We use a homogeneously observed sample of roughly one hundred and fifty
6300-10000 Angstrom spectra of L and T dwarfs taken with the Low-Resolution
Imaging Spectrometer at the W. M. Keck Observatory to examine the strength of
the 6708-A Li I line as a function of spectral type and further corroborate the
trends noted by Kirkpatrick et al. (2000). We use our low-gravity spectra to
investigate the strength of the Li I line as a function of age. The data weakly
suggest that for early- to mid-L dwarfs the line strength reaches a maximum for
a few 100 Myr, whereas for much older (few Gyr) and much younger (<100 Myr) L
dwarfs the line is weaker or undetectable. We show that a weakening of lithium
at lower gravities is predicted by model atmosphere calculations, an effect
partially corroborated by existing observational data. Larger samples
containing L dwarfs of well determined ages are needed to further test this
empirically. If verified, this result would reinforce the caveat first cited in
Kirkpatrick et al. (2006) that the lithium test should be used with caution
when attempting to confirm the substellar nature of the youngest brown dwarfs.Comment: 73 pages with 22 figures; to appear in ApJ (Dec 20, 2008, v689n2
issue
The Arecibo Legacy Fast ALFA Survey: X. The HI Mass Function and Omega_HI From the 40% ALFALFA Survey
The Arecibo Legacy Fast ALFA (ALFALFA) survey has completed source extraction
for 40% of its total sky area, resulting in the largest sample of HI-selected
galaxies to date. We measure the HI mass function from a sample of 10,119
galaxies with 6.2 < log (M_HI/M_Sun) < 11.0 and with well-described mass errors
that accurately reflect our knowledge of low-mass systems. We characterize the
survey sensitivity and its dependence on profile velocity width, the effect of
large-scale structure, and the impact of radio frequency interference in order
to calculate the HIMF with both the 1/Vmax and 2DSWML methods. We also assess a
flux-limited sample to test the robustness of the methods applied to the full
sample. These measurements are in excellent agreement with one another; the
derived Schechter function parameters are phi* = 4.8 (+/- 0.3) * 10^-3, log
(M*/M_Sun) + 2 log(h_70) = 9.96 (+/- 0.2), and alpha = -1.33 (+/- 0.02). We
find Omega_HI = 4.3 (+/- 0.3) * 10^-4, 16% larger than the 2005 HIPASS result,
and our Schechter function fit extrapolated to log (M_HI/M_Sun) = 11.0 predicts
an order of magnitude more galaxies than HIPASS. The larger values of Omega_HI
and of M* imply an upward adjustment for estimates of the detection rate of
future large-scale HI line surveys with, e.g., the Square Kilometer Array. A
comparison with simulated galaxies from the Millennium Run and a treatment of
photoheating as a method of baryon removal from HI-selected halos indicates
that the disagreement between dark matter mass functions and baryonic mass
functions may soon be resolved.Comment: 21 pages, 13 figures, submitted to Ap
Instrumental performance and results from testing of the BLAST-TNG receiver, submillimeter optics, and MKID arrays
Polarized thermal emission from interstellar dust grains can be used to map
magnetic fields in star forming molecular clouds and the diffuse interstellar
medium (ISM). The Balloon-borne Large Aperture Submillimeter Telescope for
Polarimetry (BLASTPol) flew from Antarctica in 2010 and 2012 and produced
degree-scale polarization maps of several nearby molecular clouds with
arcminute resolution. The success of BLASTPol has motivated a next-generation
instrument, BLAST-TNG, which will use more than 3000 linear polarization
sensitive microwave kinetic inductance detectors (MKIDs) combined with a 2.5m
diameter carbon fiber primary mirror to make diffraction-limited observations
at 250, 350, and 500 m. With 16 times the mapping speed of BLASTPol,
sub-arcminute resolution, and a longer flight time, BLAST-TNG will be able to
examine nearby molecular clouds and the diffuse galactic dust polarization
spectrum in unprecedented detail. The 250 m detector array has been
integrated into the new cryogenic receiver, and is undergoing testing to
establish the optical and polarization characteristics of the instrument.
BLAST-TNG will demonstrate the effectiveness of kilo-pixel MKID arrays for
applications in submillimeter astronomy. BLAST-TNG is scheduled to fly from
Antarctica in December 2017 for 28 days and will be the first balloon-borne
telescope to offer a quarter of the flight for "shared risk" observing by the
community.Comment: Presented at SPIE Millimeter, Submillimeter, and Far-Infrared
Detectors and Instrumentation for Astronomy VIII, June 29th, 201
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Use of temperature to improve West Nile virus forecasts
Ecological and laboratory studies have demonstrated that temperature modulates West Nile virus (WNV) transmission dynamics and spillover infection to humans. Here we explore whether inclusion of temperature forcing in a model depicting WNV transmission improves WNV forecast accuracy relative to a baseline model depicting WNV transmission without temperature forcing. Both models are optimized using a data assimilation method and two observed data streams: mosquito infection rates and reported human WNV cases. Each coupled model-inference framework is then used to generate retrospective ensemble forecasts of WNV for 110 outbreak years from among 12 geographically diverse United States counties. The temperature-forced model improves forecast accuracy for much of the outbreak season. From the end of July until the beginning of October, a timespan during which 70% of human cases are reported, the temperature-forced model generated forecasts of the total number of human cases over the next 3 weeks, total number of human cases over the season, the week with the highest percentage of infectious mosquitoes, and the peak percentage of infectious mosquitoes that on average increased absolute forecast accuracy 5%, 10%, 12%, and 6%, respectively, over the non-temperature forced baseline model. These results indicate that use of temperature forcing improves WNV forecast accuracy and provide further evidence that temperature influences rates of WNV transmission. The findings provide a foundation for implementation of a statistically rigorous system for real-time forecast of seasonal WNV outbreaks and their use as a quantitative decision support tool for public health officials and mosquito control programs
L-Edge Spectroscopy of Dilute, Radiation-Sensitive Systems Using a Transition-Edge-Sensor Array
We present X-ray absorption spectroscopy and resonant inelastic X-ray
scattering (RIXS) measurements on the iron L-edge of 0.5 mM aqueous
ferricyanide. These measurements demonstrate the ability of high-throughput
transition-edge-sensor (TES) spectrometers to access the rich soft X-ray
(100-2000eV) spectroscopy regime for dilute and radiation-sensitive samples.
Our low-concentration data are in agreement with high-concentration
measurements recorded by conventional grating-based spectrometers. These
results show that soft X-ray RIXS spectroscopy acquired by high-throughput TES
spectrometers can be used to study the local electronic structure of dilute
metal-centered complexes relevant to biology, chemistry and catalysis. In
particular, TES spectrometers have a unique ability to characterize frozen
solutions of radiation- and temperature-sensitive samples.Comment: 19 pages, 4 figure
Three red suns in the sky: A transiting, terrestrial planet in a triple M-dwarf system at 6.9 pc
We present the discovery from Transiting Exoplanet Survey Satellite (TESS) data of LTT 1445Ab. At a distance of 6.9 pc, it is the second nearest transiting exoplanet system found to date, and the closest one known for which the primary is an M dwarf. The host stellar system consists of three mid-to-late M dwarfs in a hierarchical configuration, which are blended in one TESS pixel. We use MEarth data and results from the Science Processing Operations Center data validation report to determine that the planet transits the primary star in the system. The planet has a radius of , an orbital period of days, and an equilibrium temperature of K. With radial velocities from the High Accuracy Radial Velocity Planet Searcher, we place a 3σ upper mass limit of 8.4 on the planet. LTT 1445Ab provides one of the best opportunities to date for the spectroscopic study of the atmosphere of a terrestrial world. We also present a detailed characterization of the host stellar system. We use high-resolution spectroscopy and imaging to rule out the presence of any other close stellar or brown dwarf companions. Nineteen years of photometric monitoring of A and BC indicate a moderate amount of variability, in agreement with that observed in the TESS light-curve data. We derive a preliminary astrometric orbit for the BC pair that reveals an edge-on and eccentric configuration. The presence of a transiting planet in this system hints that the entire system may be co-planar, implying that the system may have formed from the early fragmentation of an individual protostellar core.Accepted manuscrip
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