It's hard to be a saint in the city: notions of city in the Rebus novels of Ian Rankin

This thesis contends that within the Rebus series of detective novels by Ian Rankin, we find a unique depiction of Edinburgh: one that is equally indebted to American crime fiction and to previous fictional portrayals of the city in Scottish literature. The first chapter takes as a case study Raymond Chandler's "The Big Sleep", and uses it to draw comparisons between Rankin's Edinburgh and similar methods of writing about city in American crime fiction, particularly the 'hard-boiled' strain that emerged in the 1930s. The second chapter draws upon similarities between the Edinburgh of the Rebus novels and that of Rankin's primary Scottish influences - namely, Muriel Spark's "The Prime Of Miss Jean Brodie" and Robert Louis Stevenson's "The Strange Case Of Dr Jekyll And Mr Hyde" - to establish some kind of continuity in how the city is portrayed across centuries. The third and final chapter focuses specifically upon Rankin's combination of these seemingly disparate elements to create his own idiosyncratic take on Edinburgh, with close readings of the Rebus novels "Hide & Seek", "Set In Darkness" and "Exit Music"

The Effect of Plant Water Storage on Water Fluxes within the Coupled Soil–Plant System

In addition to buffering plants from water stress during severe droughts, plant water storage (PWS) alters many features of the spatio-temporal dynamics of water movement in the soil–plant system. How PWS impacts water dynamics and drought resilience is explored using a multi-layer porous media model

A Review of Biomimetic Air Vehicle Research: 1984-2014

Biomimetic air vehicles (BAV) are a class of unmanned aircraft that mimic the flapping wing kinematics of flying organisms (e.g. birds, bats, and insects). Research into BAV has rapidly expanded over the last 30 years. In this paper, we present a comprehensive bibliometric review of engineering and biology journal articles that were published on this subject between 1984 and 2014. These articles are organized into five topical categories: aerodynamics, guidance and control, mechanisms, structures and materials, and system design. All of the articles are compartmented into one of these categories based on their primary focus. Several aspects of these articles are examined: publication year, number of citations, journal, authoring organization and country, non-academic funding sources, and the flying organism focused upon for bio-mimicry. This review provides useful information on the state of the art of BAV research and insight on potential future directions. Our intention is that this will serve as a resource for those already engaged in BAV research and enable insight that promotes further research interest

Crystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Sulfolobus solfataricus.

Journal ArticleResearch Support, Non-U.S. Gov'tThe three-dimensional structure of the Sulfolobus solfataricus serine:pyruvate aminotransferase has been determined to 1.8 Å resolution. The structure of the protein is a homodimer that adopts the type I fold of pyridoxal 5'-phosphate (PLP)-dependent aminotransferases. The structure revealed the PLP cofactor covalently bound in the active site to the active-site lysine in the internal aldimine form. The structure of the S. solfataricus enzyme was also determined with an amino form of the cofactor pyridoxamine 5'-phosphate bound in the active site and in complex with gabaculine, an aminotransferase inhibitor. These structures showed the changes in the enzyme active site during the course of the catalytic reaction. A comparison of the structure of the S. solfataricus enzyme with that of the closely related alanine:glyoxylate aminotransferase has identified structural features that are proposed to be responsible for the differences in substrate specificity between the two enzymes. These results have been complemented by biochemical studies of the substrate specificity and thermostability of the S. solfataricus enzyme.University of ExeterBBSRCEPSRCWellcome Trus

A Concept for Extending the Applicability of Constraint-Induced Movement Therapy through Motor Cortex Activity Feedback Using a Neural Prosthesis

This paper describes a concept for the extension of constraint-induced movement therapy (CIMT) through the use of feedback of primary motor cortex activity. CIMT requires residual movement to act as a source of feedback to the patient, thus preventing its application to those with no perceptible movement. It is proposed in this paper that it is possible to provide feedback of the motor cortex effort to the patient by measurement with near infrared spectroscopy (NIRS). Significant changes in such effort may be used to drive rehabilitative robotic actuators, for example. This may provide a possible avenue for extending CIMT to patients hitherto excluded as a result of severity of condition. In support of such a paradigm, this paper details the current status of CIMT and related attempts to extend rehabilitation therapy through the application of technology. An introduction to the relevant haemodynamics is given including a description of the basic technology behind a suitable NIRS system. An illustration of the proposed therapy is described using a simple NIRS system driving a robotic arm during simple upper-limb unilateral isometric contraction exercises with healthy subjects

Interactions among chronic and acute impacts on coral recruits: the importance of size-escape thresholds

Newly settled recruits typically suffer high mortality from disturbances, but rapid growth reduces their mortality once size-escape thresholds are attained. Ocean acidification (OA) reduces the growth of recruiting benthic invertebrates, yet no direct effects on survivorship have been demonstrated. We tested whether the reduced growth of coral recruits caused by OA would increase their mortality by prolonging their vulnerability to an acute disturbance: fish herbivory on surrounding algal turf. After two months' growth in ambient or elevated CO levels, the linear extension and calcification of coral (Acropora millepora) recruits decreased as CO partial pressure (pCO) increased. When recruits were subjected to incidental fish grazing, their mortality was inversely size dependent. However, we also found an additive effect of pCO such that recruit mortality was higher under elevated pCO irrespective of size. Compared to ambient conditions, coral recruits needed to double their size at the highest pCOto escape incidental grazing mortality. This general trend was observed with three groups of predators (blenny, surgeonfish, and parrotfish), although the magnitude of the fish treatment varied among species. Our study demonstrates the importance of size-escape thresholds in early recruit survival and how OA can shift these thresholds, potentially intensifying population bottlenecks in benthic invertebrate recruitment

A single system account of enhanced recognition memory in synaesthesia

Researchers often adjudicate between models of memory according to the models’ ability to explain impaired patterns of performance (e.g. in amnesia). In contrast, evidence from special groups with enhanced memory is very rarely considered. Here, we explored how people with unusual perceptual experiences (synaesthesia) perform on various measures of memory and test how computational models of memory may account for their enhanced performance. We contrasted direct and indirect measures of memory (i.e. recognition memory, repetition priming, and fluency) in grapheme-colour synaesthetes and controls using a Continuous Identification with Recognition (CID-R) paradigm. Synaesthetes outperformed controls on recognition memory and showed a different reaction time pattern for identification. The data were most parsimoniously accounted for by a single-system computational model of the relationship between recognition and identification. Overall, the findings speak in favour of enhanced processing as an explanation for the memory advantage in synaesthesia. In general, our results show how synaesthesia can be used as an effective tool to study how individual differences in perception affect cognitive functions

Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells

AbstractIn this report, we demonstrate a direct correlation between protein kinase C (PKC) activity and adriamycin (ADR) resistance in mouse fibrosarcoma cells. PKC activity was measured in four murine UV-2237M fibrosarcoma cell lines that differed in the degrees to which they expressed resistance to ADR, which is an inhibitor of PKC. A comparison of the four cell lines revealed a positive correlation between the level of PKC activity and resistance to ADR. Incubation of the cells with the PKC inhibitor H-7 produced a partial reversal of ADR resistance. Taken together, these results suggest a role for PKC in the mechanism of ADR resistance

Pkd1 transgenic mice: Adult model of polycystic kidney disease with extrarenal and renal phenotypes

While high levels of Pkd1 expression are detected in tissues of patients with autosomal dominant polycystic kidney disease (ADPKD), it is unclear whether enhanced expression could be a pathogenetic mechanism for this systemic disorder. Three transgenic mouse lines were generated from a Pkd1-BAC modified by introducing a silent tag via homologous recombination to target a sustained wild type genomic Pkd1 expression within the native tissue and temporal regulation. These mice specifically overexpressed the Pkd1 transgene in extrarenal and renal tissues from approximately 2- to 15-fold over Pkd1 endogenous levels in a copy-dependent manner. All transgenic mice reproducibly developed tubular and glomerular cysts leading to renal insufficiency. Interestingly, Pkd1(TAG) mice also exhibited renal fibrosis and calcium deposits in papilla reminiscent of nephrolithiasis as frequently observed in ADPKD. Similar to human ADPKD, these mice consistently displayed hepatic fibrosis and approximately 15% intrahepatic cysts of the bile ducts affecting females preferentially. Moreover, a significant proportion of mice developed cardiac anomalies with severe left ventricular hypertrophy, marked aortic arch distention and/or valvular stenosis and calcification that had profound functional impact. Of significance, Pkd1(TAG) mice displayed occasional cerebral lesions with evidence of ruptured and unruptured cerebral aneurysms. This Pkd1(TAG) mouse model demonstrates that overexpression of wildtype Pkd1 can trigger the typical adult renal and extrarenal phenotypes resembling human ADPKD.This work was supported by the Canadian Institutes of Health Research (CIHR) [MOP-81325 to MT] and a CIHR Frederick Banting and Charles Best studentship to AK and a Fonds de la Recherche en Santé du Québec (FRSQ) studentship to MC