519 research outputs found
Strategies for Wildlife Disease Surveillance
Epidemiologic surveillance is defined by the Centers for Disease Control and Prevention (CDC) as the ongoing systematic and continuous collection, analysis, and interpretation of health data\u27: The objective of surveillance is to generate data for rapid response to the detection of a disease of concern to apply prevention, control, or eradication measures as well as to evaluate such interventions. This is distinct from disease monitoring, which usually does not involve a particular response to disease detection.
Surveillance for wildlife diseases has increased in importance due to the emergence and re-emergence of wildlife diseases that are threats to human, animal, and ecosystem health, or could potentially have a negative economic impact. It has been estimated that 75% of emerging human diseases are zoonotic in origin, of which the majority originate from wildlife (Taylor et al. 2001). However, there are unique challenges concerning wildlife disease surveillance such that disease and pathogens can be very difficult to detect and measure in wild animals. These challenges have been described previously (Wobeser 2006), but one of the primary issues is that disease in wildlife often goes unrecognized, especially in remote locations. Furthermore, sick and dead animals are very difficult to detect, as animals will disguise the signs of illness or hide when diseased. Carcasses from diseased animals are also rapidly removed by scavengers or will rapidly decompose, rendering them suboptimal for diagnostic purposes. There is also a lack of validated diagnostic tests for most wildlife disease agents as well as baseline data. The paucity of laboratory capacity with expertise in wildlife disease diagnostic investigation is also an impediment. Finally, surveillance networks for wildlife diseases that perform field investigations and report disease events are under-developed in most regions of the world.
Despite these challenges, a number of very important epidemiological surveillance projects have been ongoing or recently developed, and some examples are described in this chapter. The examples are mostly drawn from the experiences of the U.S. Geological Survey National Wildlife Health Center (NWHC) and are provided to illustrate the different surveillance strategies and sampling techniques that can be used and have proven successful. Some future directions for wildlife disease surveillance are also suggested
Feedback and coaching
If used thoughtfully and with intent, feedback and coaching will promote learning and growth as well as personal and professional development in our learners. Feedback is an educational tool as well as a social interaction between learner and supervisor, in the context of a respectful and trusting relationship. It challenges the learner’s thinking and supports the learner’s growth. Coaching is an educational philosophy dedicated to supporting learners’ personal and professional development and growth and supporting them to reach their potential. In clinical education, feedback is most effective when it is explicitly distinguished from summative assessment. Importantly, feedback should be about firsthand observed behaviors (which can be direct or indirect) and not about information which comes from a third party. Learners are more receptive to feedback if it comes from a source that they perceive as credible, and with whom they have developed rapport. The coaching relationship between learner and supervisor should also be built on mutual trust and respect. Coaching can be provided in the moment (feedback on everyday clinical activities that leads to performance improvement, even with short interaction with a supervisor) and over time (a longer term relationship with a supervisor in which there is reflection on the learner’s development and co-creation of new learning goals). Feedback and coaching are most valuable when the learner and teacher exhibit a growth mindset. At the organizational level, it is important that both the structures and training are in place to ensure a culture of effective feedback and coaching in the clinical workplace. Conclusions: Having a thoughtful and intentional approach to feedback and coaching with learners, as well as applying evidence-based principles, will not only contribute in a significant way to their developmental progression, but will also provide them with the tools they need to have the best chance of achieving competence throughout their training
The Supernova Remnant CTB104A : Magnetic Field Structure and Interaction with the Environment
We present new, high resolution 1420 and 408 MHz continuum images and HI and
12CO (J=1-0) spectral line maps of the diffuse supernova remnant CTB104A
(G93.7-0.3). Analysis of the complex continuum emission reveals no significant
spectral index variations across the remnant. Three prominences around CTB104A
are found to be related to the SNR, while one extension to the east is
identified as an HII region associated with a background molecular shell. Small
scale polarization and rotation measure (RM) structures are turbulent in
nature, but we find a well-ordered RM gradient across the remnant, extending
from southeast to northwest. This gradient does not agree with the direction of
the global Galactic magnetic field, but does agree with a large-scale RM
anomaly inferred from rotation measure data by Cleg et al. (1992). We show that
the observed morphology of CTB104A is consistent with expansion in a uniform
magnetic field, and this is supported by the observed RM distribution. By
modeling the RM gradient with a simple compression model we have determined the
magnetic field strength within the remnant as Bo ~ 2.3 micro G. We have
identified signatures of the interaction of CTB104A with the surrounding
neutral material, and determined its distance, from the kinematics of the HI
structure encompassing the radio emission, as 1.5 kpc. We also observed clear
breaks in the HI shell that correspond well to the positions of two of the
prominences, indicating regions where hot gas is escaping from the interior of
the SNR.Comment: 7 pages, Latex with aastex and emulateapj5, 12 figures, ApJ accepte
Complex roles of myoglianin in regulating adult performance and lifespan
Myoglianin, the Drosophila homolog of the secreted vertebrate proteins Myostatin and GDF-11, is an important regulator of neuronal modelling, and synapse function and morphology. While Myoglianin suppression during development elicits positive effects on the neuromuscular system, genetic manipulations of myoglianin expression levels have a varied effect on the outcome of performance tests in aging flies. Specifically, Myoglianin preserves jumping ability, has no effect on negative geotaxis, and negatively regulates flight performance in aging flies. In addition, Myoglianin exhibits a tissue-specific effect on longevity, with myoglianin upregulation in glial cells increasing the median lifespan. These findings indicate complex role for this TGF-β-like protein in governing neuromuscular signalling and consequent behavioural outputs and lifespan in adult flies
The homeobox transcription factor Even-skipped regulates acquisition of electrical properties in Drosophila neurons.
BACKGROUND: While developmental processes such as axon pathfinding and synapse formation have been characterized in detail, comparatively less is known of the intrinsic developmental mechanisms that regulate transcription of ion channel genes in embryonic neurons. Early decisions, including motoneuron axon targeting, are orchestrated by a cohort of transcription factors that act together in a combinatorial manner. These transcription factors include Even-skipped (Eve), islet and Lim3. The perdurance of these factors in late embryonic neurons is, however, indicative that they might also regulate additional aspects of neuron development, including the acquisition of electrical properties. RESULTS: To test the hypothesis that a combinatorial code transcription factor is also able to influence the acquisition of electrical properties in embryonic neurons we utilized the molecular genetics of Drosophila to manipulate the expression of Eve in identified motoneurons. We show that increasing expression of this transcription factor, in two Eve-positive motoneurons (aCC and RP2), is indeed sufficient to affect the electrical properties of these neurons in early first instar larvae. Specifically, we observed a decrease in both the fast K+ conductance (IKfast) and amplitude of quantal cholinergic synaptic input. We used charybdotoxin to pharmacologically separate the individual components of IKfast to show that increased Eve specifically down regulates the Slowpoke (a BK Ca2+-gated potassium channel), but not Shal, component of this current. Identification of target genes for Eve, using DNA adenine methyltransferase identification, revealed strong binding sites in slowpoke and nAcRalpha-96Aa (a nicotinic acetylcholine receptor subunit). Verification using real-time PCR shows that pan-neuronal expression of eve is sufficient to repress transcripts for both slo and nAcRalpha-96Aa. CONCLUSION: Taken together, our findings demonstrate, for the first time, that Eve is sufficient to regulate both voltage- and ligand-gated currents in motoneurons, extending its known repertoire of action beyond its already characterized role in axon guidance. Our data are also consistent with a common developmental program that utilizes a defined set of transcription factors to determine both morphological and functional neuronal properties
The Origin of the 24-micron Excess in Red Galaxies
Observations with the Spitzer Space Telescope have revealed a population of
red-sequence galaxies with a significant excess in their 24-micron emission
compared to what is expected from an old stellar population. We identify 900
red galaxies with 0.15<z<0.3 from the AGN and Galaxy Evolution Survey (AGES)
selected from the NOAO Deep Wide-Field Survey Bootes field. Using Spitzer/MIPS,
we classify 89 (~10%) with 24-micron infrared excess (f24>0.3 mJy). We
determine the prevalence of AGN and star-formation activity in all the AGES
galaxies using optical line diagnostics and mid-IR color-color criteria. Using
the IRAC color-color diagram from the IRAC Shallow Survey, we find that 64% of
the 24-micron excess red galaxies are likely to have strong PAH emission
features in the 8-micron IRAC band. This fraction is significantly larger than
the 5% of red galaxies with f24<0.3 mJy that are estimated to have strong PAH
emission, suggesting that the infrared emission is largely due to
star-formation processes. Only 15% of the 24-micron excess red galaxies have
optical line diagnostics characteristic of star-formation (64% are classified
as AGN and 21% are unclassifiable). The difference between the optical and
infrared results suggest that both AGN and star-formation activity is occurring
simultaneously in many of the 24-micron excess red galaxies. These results
should serve as a warning to studies that exclusively use optical line
diagnostics to determine the dominant emission mechanism in the infrared and
other bands. We find that ~40% of the 24-micron excess red galaxies are edge-on
spiral galaxies with high optical extinctions. The remaining sources are likely
to be red galaxies whose 24-micron emission comes from a combination of
obscured AGN and star-formation activity.Comment: ApJ, accepted; 11 pages, 7 figures; corrected reference to IRAC
Shallow Survey in abstrac
XBootes: An X-Ray Survey of the NDWFS Bootes Field - Paper I Overview and Initial Results
We obtained a 5 ksec deep Chandra X-ray Observatory ACIS-I map of the 9.3
square degree Bootes field of the NOAO Deep Wide-Field Survey. Here we describe
the data acquisition and analysis strategies leading to a catalog of 4642
(3293) point sources with 2 or more (4 or more) counts, corresponding to a
limiting flux of roughly 4(8)x10^{-15} erg cm^{-2}s^{-1} in the 0.5-7 keV band.
These Chandra XBootes data are unique in that they consitute the widest
contiguous X-ray field yet observed to such a faint flux limit. Because of the
extraordinarily low background of the ACIS, we expect only 14% (0.7%) of the
sources to be spurious. We also detected 43 extended sources in this survey.
The distribution of the point sources among the 126 pointings (ACIS-I has a 16
x 16 arcminute field of view) is consistent with Poisson fluctuations about the
mean of 36.8 sources per pointing. While a smoothed image of the point source
distribution is clumpy, there is no statistically significant evidence of large
scale filamentary structure. We do find however, that for theta>1 arcminute,
the angular correlation function of these sources is consistent with previous
measurements, following a power law in angle with slope -0.7. In a 1.4 deg^{2}
sample of the survey, approximately 87% of the sources with 4 or more counts
have an optical counterpart to R ~26 mag. As part of a larger program of
optical spectroscopy of the NDWFS Bootes area, spectra have been obtained for
\~900 of the X-ray sources, most of which are QSOs or AGN.Comment: 18 Pages, 10 figures (AASTex Preprint format
The 1<z<5 Infrared Luminosity Function of Type I Quasars
We determine the rest-frame 8 micron luminosity function of type I quasars
over the redshift range 1<z<5. Our sample consists of 292 24 micron sources
brighter than 1 mJy selected from 7.17 square degrees of the Spitzer Space
Telescope MIPS survey of the NOAO Deep Wide-Field Survey Bootes field. The AGN
and Galaxy Evolution Survey (AGES) has measured redshifts for 270 of the R<21.7
sources and we estimate that the contamination of the remaining 22 sources by
stars and galaxies is low. We are able to select quasars missed by ultra-violet
excess quasar surveys, including reddened type I quasars and 2.2<z<3.0 quasars
with optical colors similar to main sequence stars. We find reddened type I
quasars comprise 20% of the type I quasar population. Nonetheless, the shape,
normalization, and evolution of the rest-frame 8 micron luminosity function is
comparable to that of quasars selected from optical surveys. The 8 micron
luminosity function of type I quasars is well approximated by a power-law with
index -2.75(+/-0.14). We directly measure the peak of the quasar space density
to be at z=2.6(+/-0.3).Comment: Accepted for publication in the ApJ, 19 pages, 12 figure
Spitzer observations of the Massive star forming complex S254-S258: structure and evolution
We present Spitzer-IRAC, NOAO 2.1meter-Flamingos, Keck-NIRC, and
FCRAO-SEQUOIA observations of the massive star forming complex S254-S258,
covering an area of 25x20 arc-minutes. Using a combination of the IRAC and NIR
data, we identify and classify the young stellar objects (YSO) in the complex.
We detect 510 sources with near or mid IR-excess, and we classify 87 Class I,
and 165 Class II sources. The YSO are found in clusters surrounded by isolated
YSO in a low-density distributed population. The ratio of clustered to total
YSO is 0.8. We identify six new clusters in the complex. One of them,
G192.63-00, is located around the ionizing star of the HII region S255. We
hypothesize that the ionizing star of S255 was formed in this cluster. We also
detect a southern component of the cluster in HII region S256. The cluster
G192.54-0.15, located inside HII region S254 has a VLSR of 17 km/s with respect
to the main cloud, and we conclude that it is located in the background of the
complex. The structure of the molecular cloud is examined using 12CO and 13CO,
as well as a near-IR extinction map. The main body of the molecular cloud has
VLSR between 5 and 9 km/s. The arc-shaped structure of the molecular cloud,
following the border of the HII regions, and the high column density in the
border of the HII regions support the idea that the material has been swept up
by the expansion of the HII regions.Comment: Accepted for publication in The Astrophysical Journa
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