Excited nucleons with chirally improved fermions

We study positive and negative parity nucleons on the lattice using the chirally improved lattice Dirac operator. Our analysis is based on a set of three operators chi_i with the nucleon quantum numbers but in different representations of the chiral group and with different diquark content. We use a variational method to separate ground state and excited states and determine the mixing coefficients for the optimal nucleon operators in terms of the chi_i. We clearly identify the negative parity resonances N(1535) and N(1650) and their masses agree well with experimental data. The mass of the observed excited positive parity state is too high to be interpreted as the Roper state. Our results for the mixing coefficients indicate that chiral symmetry is important for N(1535) and N(1650) states. We confront our data for the mixing coefficients with quark models and provide insights into the physics of the nucleon system and the nature of strong decays.Comment: Tables added, small modifications in the tex

Melting and freezing of argon in a granular packing of linear mesopore arrays

Freezing and melting of Ar condensed in a granular packing of template-grown arrays of linear mesopores (SBA-15, mean pore diameter 8 nanometer) has been studied by specific heat measurements C as a function of fractional filling of the pores. While interfacial melting leads to a single melting peak in C, homogeneous and heterogeneous freezing along with a delayering transition for partial fillings of the pores result in a complex freezing mechanism explainable only by a consideration of regular adsorption sites (in the cylindrical mesopores) and irregular adsorption sites (in niches of the rough external surfaces of the grains, and at points of mutual contact of the powder grains). The tensile pressure release upon reaching bulk liquid/vapor coexistence quantitatively accounts for an upward shift of the melting/freeezing temperature observed while overfilling the mesopores.Comment: 4 pages, 4 figures, to appear as a Letter in Physical Review Letter

Baryon spectroscopy with spatially improved quark sources

We study baryons on the lattice with a special focus on excited states. For that purpose we construct several interpolators which differ in their Dirac structure. These interpolators are built from Jacobi smeared quarks with different widths in order to allow for operators with improved spatial wavefunctions. We compute all cross correlations and use the variational method to determine which combinations of operators have best overlap with ground and excited states. Our approach yields promising results for the spin-1/2 baryons: nucleon, sigma, xi and lambda. For the spin-3/2 baryons, delta and omega, we obtain results which are consistent with results of other groups.Comment: LaTeX [PoS], 6 pages, 4 figures, talk presented at Lattice 2005 (Hadron spectrum and quark masses

Ivabradine use in pregnant women—treatment indications and pregnancy outcome: an evaluation of the German Embryotox database

Purpose: Ivabradine has been approved for the treatment of chronic heart failure and chronic stable angina pectoris in Europe. Based on adverse outcomes of reproductive animal studies and the lack of human data, ivabradine is considered contraindicated during pregnancy. The aim of this observational study is to analyse ivabradine use before and during pregnancy. Methods: We evaluated all ivabradine-related requests to the German Embryotox Institute from 2007 to 2019. Exposed pregnancies were analysed as to their outcome. Results: Off-label use for supraventricular tachycardia was frequent in women of childbearing age. Of 38 prospectively ascertained pregnancies with ivabradine exposure and completed follow-up, 32 resulted in live births, 3 in spontaneous abortions, and 3 were electively terminated. One neonate presented with major birth defects (atrial septal defect and cleft palate). In 33/38 patients, ivabradine was discontinued after confirmation of pregnancy without cardiac deterioration and 5/38 women continued ivabradine throughout pregnancy. In addition, there were 3 retrospectively reported pregnancies including one major birth defect (tracheal atresia). Conclusion: This case series represents the largest cohort of ivabradine-exposed pregnancies, published so far. According to our findings, ivabradine appears not to be a major teratogen. However, established drugs of choice with strong evidence of low risk for the unborn should be preferred in women planning pregnancy. After inadvertent exposure during pregnancy or lack of treatment alternatives, fetal ultrasound for structural anomalies and growth restriction is recommended. In addition, close monitoring is necessary in pregnant women with supraventricular arrhythmias or cardiac disease

Fetal adverse effects following NSAID or metamizole exposure in the 2nd and 3rd trimester: an evaluation of the German Embryotox cohort

Background: Non-steroidal anti-inflammatory drugs (NSAID) are frequently used to treat pain, fever and inflammatory conditions. Due to evidenced fetotoxicity, treatment with NSAID and metamizole should be avoided in the 3rd trimester of pregnancy. There is an ongoing debate on fetotoxic risk of 2nd trimester use which is why we have conducted this study. Methods: In this observational cohort study outcome of pregnancies with NSAID and/or metamizole exposure in the 2nd and/or 3rd trimester (study cohort n = 1092) was compared with pregnancies exposed to NSAID and/or metamizole in the 1st trimester only (comparison cohort, n = 1154). The WHO-UMC system was used to assess causality between study medication and study endpoints. Prenatal study endpoints were constriction of ductus arteriosus Botalli, oligohydramnios, late spontaneous abortion (SAB) or stillbirth. Postnatal study endpoints were patent ductus arteriosus (PDA), anomalies of the right heart ventricle, primary pulmonary hypertension (PPHT), and neonatal impairment of kidney function. Results: Ductus arteriosus constriction was diagnosed in 5/1092 (0.5%) in the study cohort versus 0/1154 pregnancies in the comparison cohort. In one fetus, ductus arteriosus constriction and oligohydramnios occurred already in the late 2nd trimester after long-term NSAID exposure. Oligohydramnios was diagnosed in 41/1092 (3.8%) in the study cohort versus 29/1154 (2.5%) cases in the comparison cohort [RR, 1.5 (95% CI 0.9-2.4)]. Limited to 2nd trimester, oligohydramnios occurred in 8/904 (0.9%) versus 2/1154 (0.2%) pregnancies [RR, 5.1 (95% CI 1.1-24.0)]. At least in four of the 2nd trimester exposed pregnancies NSAID exposure lasted several weeks. Late SAB or stillbirth occurred in 14/1092 (1.3%) versus 17/1154 (1.5%). Postnatal cardiovascular or renal pathology did not differ between the cohorts. Conclusions: NSAID use in the 2nd trimester limited to a few days does not appear to pose a relevant risk. Use for longer periods in the advanced 2nd trimester, however, may cause oligohydramnios and ductus arteriosus constriction similar to effects observed after 3rd trimester use

First Order Chiral Phase Transition from a Six-fermion ''Instanton''-Interaction

We compute the first order chiral phase transition for an instanton motivated quark model with a local six-quark interaction. In order to compare different solutions of the gap equation we compute the bosonic effective action -- a two particle irreducible free energy functional. We find that the first order transition ends for a critical current quark mass, with continuous crossover for larger quark masses. Furthermore, we investigate different possible order parameters, including a color octet condensate. We also compare our formalism with mean field theory.Comment: 10 pages, 3 figures, uses revtex

Instantons and color symmetry breaking in the vacuum

The instanton interaction in QCD generates an effective potential for scalar quark-antiquark condensates in the color singlet and octet channels. For three light quark flavors the cubic term in this potential induces an octet condensate and ``spontaneous breaking'' of color in the vacuum. Realistic masses of the rho- and eta'-mesons are compatible with renormalization-group-improved instanton perturbation theory.Comment: 8 pages,LaTex,modified instanton vertex,improved mass of eta

Searching for KvBLL calorons in SU(3) lattice gauge field ensembles

We discuss Kraan - van Baal - Lee - Lu (KvBLL) solutions of the classical Yang-Mills equations with temperature in the context of SU(3) lattice gauge theory. We present discretized lattice versions of KvBLL solutions and other dyonic structures, obtained by cooling in order to understand their variety and signature. An analysis of the zero modes of the lattice Dirac operator for different fermionic boundary conditions gives clear evidence for a KvBLL-like background of finite T lattice subensembles with Q = +/-1. Using APE-smearing we are able to study the topological charge density q(x) of the configurations and to corroborate this interpretation.Comment: Presented at LATTICE 2003 (topology) by C. Gattringer and E.M. Ilgenfritz, 6 page

The topological susceptibility of SU(3) gauge theory near T_c

We compute the topological susceptibility chi_t in SU(3) lattice gauge theory using fermionic methods based on the Atiyah-Singer index theorem. Near the phase transition we find a smooth crossover behavior for chi_t with values decreasing from (191(5) MeV)^4 to (100(5) MeV)^4 as we increase the temperature from 0.88 T_c to 1.31 T_c, showing that topological excitations exist far above T_c. Our study is the first large scale analysis of the topological susceptibility at high temperature based on the index theorem and the results agree well with field theoretical methods.Comment: Concluding statement reworded. To appear in Physics Letters