Who Are Opposed to Free Trade in the Philippines?

In a democratic country, economic policies succeed or fail depending on the political support they receive. Open trade policies that were initiated and accepted years ago can be reversed in accordance with the government's free trade conviction and popular pressure. However, popular pressure for or against open trade is affected by other factors. This paper attempts to link these factors with individual preferences toward either more protectionism or greater trade liberalization. Using ordered logit estimation of thousands of survey data, the paper finds that gender, economic class, and urban population negatively correlate with pro-trade attitudes in the Philippines. It also notes that the effect of some of the demographic variables on protectionist sentiment is markedly different from their effects among more developed Western nations.free trade, trade policies, policy preferences, political economy

Who Are Opposed to Free Trade in the Philippines?

In a democratic country, economic policies succeed or fail depending on the political support they receive. Open trade policies that were initiated and accepted years ago can be reversed in accordance with the government's free trade conviction and popular pressure. However, popular pressure for or against open trade is affected by other factors. This paper attempts to link these factors with individual preferences toward either more protectionism or greater trade liberalization. Using ordered logit estimation of thousands of survey data, the paper finds that gender, economic class, and urban population negatively correlate with pro-trade attitudes in the Philippines. It also notes that the effect of some of the demographic variables on protectionist sentiment is markedly different from their effects among more developed Western nations.free trade, trade policies, policy preferences, political economy

Induction of Stress-Induced Renal Cellular Senescence In Vitro: Impact of Mouse Strain Genetic Diversity.

Cellular senescence, a stress-induced state of irreversible cell cycle arrest, is associated with organ dysfunction and age-related disease. While immortalized cell lines bypass key pathways of senescence, important mechanisms of cellular senescence can be studied in primary cells. Primary tubular epithelial cells (PTEC) derived from mouse kidney are highly susceptible to develop cellular senescence, providing a valuable tool for studying such mechanisms. Here, we tested whether genetic differences between mouse inbred strains have an impact on the development of stress-induced cellular senescence in cultured PTEC. Kidneys from 129S1, B6, NOD, NZO, CAST, and WSB mice were used to isolate PTEC. Cells were monitored for expression of typical senescence markers (SA-β-galactosidase, γ-H2AX+/Ki67-, expression levels of CDKN2A, lamin B1, IL-1a/b, IL-6, G/M-CSF, IFN-g, and KC) at 3 and 10 days after pro-senescent gamma irradiation. Clear differences were found between PTEC from different strains with the highest senescence values for PTEC from WSB mice and the lowest for PTEC from 129S1 mice. PTEC from B6 mice, the most commonly used inbred strain in senescence research, had a senescence score lower than PTEC from WSB and CAST mice but higher than PTEC from NZO and 129S1 mice. These data provide new information regarding the influence of genetic diversity and help explain heterogeneity in existing data. The observed differences should be considered when designing new experiments and will be the basis for further investigation with the goal of identifying candidate loci driving pro- or anti-senescent pathways

Bridging educational communities to creatively explore social justice topics through film and dance

This school-university partnership collaborative project was student-centered andfocused on supporting learning goals for three different groups of students through knowledgesharing and translating theory into practice. Students from three levels of education (high school, undergraduate, and graduate students) engaged in a multi-semester, integrated arts project that culminated in the performance of film and dance representations of social justice topics in education. The project engaged the community through the public performance and connected school, university and the community to advocate for social justice and the arts. We share the student learning outcomes from this project to demonstrate that the school-university partnership can provide valid pedagogical support for the collaborators. The mutual non-hierarchicalrelationship between the partners was the key to the success of the collaboration

Damage Assessment of a Sixteen Story Building Following the 2017 Central Mexico Earthquake

The 2017 M7.1 Central Mexico Earthquake caused significant infrastructural damage in the Mexico City area. The earthquake contained a significant pulse in the long period, resulting in numerous buildings severely damaged or collapsed. This paper discusses a reinforced concrete building which was still partially occupied post-earthquake. The building’s interior walls were examined to have substantial damage, including some extensive cracking. In January 2018, the authors visited the structure and collected detailed assessment data. The data collection included ground-based lidar scans and recorded ambient vibrations of the damaged structure using accelerometers. Eleven scans were collected from the four exterior facades to create a three-dimensional point cloud of the building. The collected point cloud data were used to measure and quantify the permanent deformation of the structure at three corners as well as to generate depth maps of two parallel exterior walls. The measurements based on the lidar point cloud data are accurate with an error of 2 mm at 10 meters, enabling high resolute and accurate assessments. As for the accelerometers, one setup with sixty minutes of ambient vibrations data collection was performed. Twenty unidirectional accelerometers were installed on the basement, ground, second, fourth, eighth, tenth and roof floors at southwest and northeast corners to capture the torsional and translational acceleration structural response. The collected data can be used to perform system identification throughout operational modal analysis to demonstrate the dynamic and modal properties of the structures. Both the lidar and system identification sensing techniques provide essential input to establish and calibrate a detailed finite element model. The outputs are used to validate through the comparison of modal frequencies obtained in operational modal analysis method. Besides, the finite element model also provides a detailed response and insight to understand performance under future earthquakes

Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial.

Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2 (PGE-M), prostacyclin (PGI-M), and thromboxane B2 (TxB2) in HIV-infected women switching to RAL-containing antiretroviral therapy (ART). Thirty-seven women (RAL = 17; PI/NNRTI = 20) with a median age of 43 years and BMI 32 kg/m(2) completed week 24. TxB2 increased in the RAL versus PI/NNRTI arm (+0.09 versus -0.02; P = 0.06). Baseline PGI-M was lower in the RAL arm (P = 0.005); no other between-arm cross-sectional differences were observed. In the PI/NNRTI arm, 24-week visceral adipose tissue change correlated with PGI-M (rho = 0.45; P = 0.04) and TxB2 (rho = 0.44; P = 0.005) changes, with a trend seen for PGE-M (rho = 0.41; P = 0.07). In an adjusted model, age ≥ 50 years (N = 8) was associated with increased PGE-M (P = 0.04). In this randomized trial, a switch to RAL did not significantly affect urinary eicosanoids over 24 weeks. In women continuing PI/NNRTI, increased visceral adipose tissue correlated with increased PGI-M and PGE-M. Older age (≥ 50) was associated with increased PGE-M. Relationships between aging, adiposity, ART, and eicosanoids during HIV-infection require further study

Functional piezocrystal characterisation under varying conditions

Piezocrystals, especially the relaxor-based ferroelectric crystals, have been subject to intense investigation and development within the past three decades, motivated by the performance advantages offered by their ultrahigh piezoelectric coefficients and higher electromechanical coupling coefficients than piezoceramics. Structural anisotropy of piezocrystals also provides opportunities for devices to operate in novel vibration modes, such as the d36 face shear mode, with domain engineering and special crystal cuts. These piezocrystal characteristics contribute to their potential usage in a wide range of low- and high-power ultrasound applications. In such applications, conventional piezoelectric materials are presently subject to varying mechanical stress/pressure, temperature and electric field conditions. However, as observed previously, piezocrystal properties are significantly affected by a single such condition or a combination of conditions. Laboratory characterisation of the piezocrystal properties under these conditions is therefore essential to fully understand these materials and to allow electroacoustic transducer design in realistic scenarios. This will help to establish the extent to which these high performance piezocrystals can replace conventional piezoceramics in demanding applications. However, such characterisation requires specific experimental arrangements, examples of which are reported here, along with relevant results. The measurements include high frequency-resolution impedance spectroscopy with the piezocrystal material under mechanical stress 0–60 MPa, temperature 20–200 °C, high electric AC drive and DC bias. A laser Doppler vibrometer and infrared thermal camera are also integrated into the measurement system for vibration mode shape scanning and thermal conditioning with high AC drive. Three generations of piezocrystal have been tested: (I) binary, PMN-PT; (II) ternary, PIN-PMN-PT; and (III) doped ternary, Mn:PIN-PMN-PT. Utilising resonant mode analysis, variations in elastic, dielectric and piezoelectric constants and coupling coefficients have been analysed, and tests with thermal conditioning have been carried out to assess the stability of the piezocrystals under high power conditions

Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim

AZD6244 (ARRY-142886) is an inhibitor of MEK1/2 and can inhibit cell proliferation or induce apoptosis in a cell-type dependent manner. The precise molecular mechanism of AZD6244-induced apoptosis is not clear. To investigate mechanisms of AZD6244 induced apoptosis in human lung cancer, we determined the molecular changes of two subgroups of human lung cancer cell lines that are either sensitive or resistant to AZD6244 treatment. We found that AZD6244 elicited a large increase of Bim proteins and a smaller increase of PUMA and NOXA proteins, and induced cell death in sensitive lung cancer cell lines, but had no effect on other Bcl-2 related proteins in those cell lines. Knockdown of Bim by siRNA greatly increased the IC50 and reduced apoptosis for AZD6244 treated cells. We also found that levels of endogenous p-Thr32-FOXO3a and p-Ser253-FOXO3a were lower in AZD6244-sensitive cells than in AZD6244-resistant cells. In the sensitive cells, AZD6244 induced FOXO3a nuclear translocation required for Bim activation. Moreover, the silencing of FOXO3a by siRNA abrogated AZD6244-induced cell apoptosis. In addition, we found that transfection of constitutively active AKT up-regulated p-Thr32-FOXO3a and p-Ser253-FOXO3a expression and inhibited AZD6244-induced Bim expression in sensitive cells. These results show that Bim plays an important role in AZD6244-induced apoptosis in lung cancer cells and that the PI3K/AKT/FOXO3a pathway is involved in Bim regulation and susceptibility of lung cancer cells to AZD6244. These results have implications in the development of strategies to overcome resistance to MEK inhibitors