On Definite Plural NP's and the Meaning of "all"

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Subcellular localization of 14-3-3 proteins in Toxoplasma gondii tachyzoites and evidence for a lipid raft-associated form. in « Fems

Abstract A polyclonal antibody was raised against a Toxoplasma gondii 14-3-3^gluthatione S-transferase fusion protein obtained by cloning a 14-3-3 cDNA sequence determined from the T. gondii database. This antibody specifically recognized T. gondii 14-3-3 without any crossreaction with mammalian proteins. Immunofluorescence microscopy studies of the tachyzoites or the T. gondii-infected cells suggested cytosolic and membranous localizations of 14-3-3 protein. Different subcellular fractions were prepared for electrophoresis analysis and immunodetection. 14-3-3 proteins were found in the cytosol, the membrane fraction and Triton X-100-resistant membranes. Two 14-3-3 isoforms were detected. The major one was mainly cytoplasmic and to a lesser extent membrane-associated, whereas the minor isoform was associated with the detergent-resistant lipid rafts.

Characterization of the LIGO detectors during their sixth science run

31 pages, 13 figures - See paper for full list of authorsInternational audienceIn 2009-2010, the Laser Interferometer Gravitational-wave Observatory (LIGO) operated together with international partners Virgo and GEO600 as a network to search for gravitational waves of astrophysical origin. The sensitiv- ity of these detectors was limited by a combination of noise sources inherent to the instrumental design and its environment, often localized in time or frequency, that couple into the gravitational-wave readout. Here we review the performance of the LIGO instruments during this epoch, the work done to characterize the de- tectors and their data, and the effect that transient and continuous noise artefacts have on the sensitivity of LIGO to a variety of astrophysical sources

Searching for stochastic gravitational waves using data from the two co-located LIGO Hanford detectors

21 pages, 10 figures, 5 tables, see paper for full list of authorsInternational audienceSearches for a stochastic gravitational-wave background (SGWB) using terrestrial detectors typically involve cross-correlating data from pairs of detectors. The sensitivity of such cross-correlation analyses depends, among other things, on the separation between the two detectors: the smaller the separation, the better the sensitivity. Hence, a co-located detector pair is more sensitive to a gravitational-wave background than a non-co-located detector pair. However, co-located detectors are also expected to suffer from correlated noise from instrumental and environmental effects that could contaminate the measurement of the background. Hence, methods to identify and mitigate the effects of correlated noise are necessary to achieve the potential increase in sensitivity of co-located detectors. Here we report on the first SGWB analysis using the two LIGO Hanford detectors and address the complications arising from correlated environmental noise. We apply correlated noise identification and mitigation techniques to data taken by the two LIGO Hanford detectors, H1 and H2, during LIGO's fifth science run. At low frequencies, 40 - 460 Hz, we are unable to sufficiently mitigate the correlated noise to a level where we may confidently measure or bound the stochastic gravitational-wave signal. However, at high frequencies, 460-1000 Hz, these techniques are sufficient to set a 95% confidence level (C.L.) upper limit on the gravitational-wave energy density of \Omega(f)<7.7 x 10^{-4} (f/ 900 Hz)^3, which improves on the previous upper limit by a factor of ∼180. In doing so, we demonstrate techniques that will be useful for future searches using advanced detectors, where correlated noise (e.g., from global magnetic fields) may affect even widely separated detectors

Predicative Possessives Relational Nouns and Floating Quantifiers

Green (1971) notes the apparent unacceptability of certain quantificational expressions as possessors of singular head nouns. We provide data from a range of English dialects to show that such constructions are not straightforwardly unacceptable, but there are a number of restrictions on their use. We build on Kayne’s (1993; 1994) analysis of English possessives in conjunction with considerations on floating quantifiers to explain both the types of possessive that are permitted in the relevant dialects and their distribution, which is restricted to predicative position

A collaborative model to implement flexible, accessible and efficient oncogenetic services for hereditary breast and ovarian cancer : the C-MOnGene study

Medical genetic services are facing an unprecedented demand for counseling and testing for hereditary breast and ovarian cancer (HBOC) in a context of limited resources. To help resolve this issue, a collaborative oncogenetic model was recently developed and implemented at the CHU de Québec-Université Laval; Quebec; Canada. Here, we present the protocol of the C-MOnGene (Collaborative Model in OncoGenetics) study, funded to examine the context in which the model was implemented and document the lessons that can be learned to optimize the delivery of oncogenetic services. Within three years of implementation, the model allowed researchers to double the annual number of patients seen in genetic counseling. The average number of days between genetic counseling and disclosure of test results significantly decreased. Group counseling sessions improved participants' understanding of breast cancer risk and increased knowledge of breast cancer and genetics and a large majority of them reported to be overwhelmingly satisfied with the process. These quality and performance indicators suggest this oncogenetic model offers a flexible, patient-centered and efficient genetic counseling and testing for HBOC. By identifying the critical facilitating factors and barriers, our study will provide an evidence base for organizations interested in transitioning to an oncogenetic model integrated into oncology care; including teams that are not specialized but are trained in genetics

Sensitivity Achieved by the LIGO and Virgo Gravitational Wave Detectors during LIGO's Sixth and Virgo's Second and Third Science Runs

See paper for full list of authors - Associated data products are publicly accessible here https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=63432We summarize the sensitivity achieved by the LIGO and Virgo gravitational wave detectors for low-mass compact binary coalescence (CBC) searches during LIGO's sixth science run and Virgo's second and third science runs. We present strain noise power spectral densities (PSDs) which are representative of the typical performance achieved by the detectors in these science runs. The data presented here and in the accompanying web-accessible data files are intended to be released to the public as a summary of detector performance for low-mass CBC searches during S6 and VSR2-3

The gravitational wave detector VIRGO

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The Virgo data acquisition system

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