Questioning mobility ideals – the value of proximity for residents in socially deprived urban areas in Sweden

Despite discourses of contemporary high-mobility, a life characterised by high mobility is in sharp contrast to many people's experiences and personal preferences. Previous research has shown that mobility and transport opportunities are unevenly distributed in society. The paper explores how young unemployed people and low-skilled care workers in two Swedish urban municipalities prefer to travel less and stay local rather than undergoing time-consuming and expensive public transport trips. The results show that various temporal and spatial restrictions are significant regarding the extent to which public transport can cater for mobility needs, and that transport opportunities are part of an individual's opportunity to be socially included. The results indicate that other policy areas, such as the labour market policy and the public health policy, are equally important for social inclusion

Urban greenspace for social integration: Which types of greenspace do new-Swedes prefer and why?

Urban greenspace (UGS) is a key public resource offering a broad range of nature -based solutions and is increasingly looked to as a potential arena to promote social integration in Europe 's increasingly multicultural urban and peri-urban areas. However, relatively little research has explored the preferences and perceptions of immigrants in relation to UGS, especially in European contexts. Without such knowledge, planners risk entrenching planning structures that inadvertently result in segregation and environmental injustice. Using survey and participatory mapping methods with 261 immigrants in eight sampled settlements across Sweden, this study explores which types of UGS foreign -born immigrants in Sweden (i.e., new -Swedes) prefer and why. We found that new -Swedes are frequent users of a wide spectrum of UGS types, with the most preferred types including forests, large parks and lakes. The majority of respondents were satisfied with the quality (73%), availability (68%) and accessibility (76%) of UGS in their hometowns. Our regression analysis identified 51 key factors that had a meaningful effect on preferences for different types of UGS. Key factors were distributed relatively evenly across blocks of predictor variables concerning characteristics of UGS, socio-demographic factors, activity preferences, and perceptions. Our results indicate that new -Swedes ' UGS preferences are broadly comparable with those of the general population in Sweden. We found little evidence to suggest that ethnocultural factors played a major role in the preferences of our respondents. Furthermore, our results suggest that nature -connectedness might be an important determinant of new -Swedes ' UGS preferences. Based on these findings, we highlight several opportunities to further develop UGS strategies to support different dimensions of social integration, e.g., using popular UGS as interactive spaces for cultural learning, as a platform for intercultural contacts and for maintaining cultural traditions, and to contribute towards a greater sense of social membership in their new country. A crucial implication of our study is that the use of UGS to support social integration may further contribute to the increasing complexity of the UGS planning and management challenge. This implies the need for a systems perspective in UGS research, policy -making, planning and management to consider UGS as part of an integrated urban social -ecological system and to coordinate measures across sectors

Mars Aquarius Mission and Titan Explorer

The Mars Aquarius Mission is designed to carry out several scientific studies of the surface and subsurface of Mars with an emphasis on locating subterranean water. This mission is a precursor to a manned mission to Mars. A manned mission will require an extended stay on the planet's surface, and an accessible source of water will greatly simplify life support requirements. Using data from previous Mars observations, four sites were selected as possible locations of subsurface water. The Aquarius spacecraft carries one penetrator for each of these sites

Barcoding a partir de posos de café - Explorando la biodiversidad de gasterópodos pterópodos a partir de posos de frascos de colección

Despite their cosmopolitan occurrence and massive plankton sampling during expeditions, the genetic diversity within Pteropoda Cuvier, 1804 is still largely unexplored. In this study we present a next-generation environmental barcoding approach to zooplankton bulk samples, which were collected during the circumglobal 2010 Malaspina expedition to evaluate pteropod diversity. We introduce a technique that avoids destructive procedures and leaves material intact for further morphological investigations. We extracted DNA out of the dregs (organic material such as mucus or body parts) of 27 sample containers for molecular barcoding (average 100-260 bp of COI). We were able to identify 7128 operational taxonomic units corresponding to the species composition contained in the examined samples. Among them were three species of thecosome pteropods, Creseis acicula, Creseis virgula and Cavolinia inflexa, which are discussed with respect to their taxonomy and their geographic distribution. Unidentified gymnosomes were also present in our samples from warmer regions in oceanic waters of the southern Indian Ocean. To facilitate identification of species, it is beneficial to create a better database of pteropod COI barcodes. Furthermore, gathering environmental barcoding data on a broad global scale will help to better understand species abundance and distribution of pteropods in the world’s oceans, and potentially those of other planktonic organisms.A pesar de su presencia cosmopolita y las actividades de muestreo masivo de plancton durante las expediciones, la diversidad genética dentro de los Pteropoda Cuvier, 1804 está todavía inexplorada en gran medida. En este estudio se presenta una aproximación desde el barcoding ambiental aplicada a muestras generales de zooplancton recogidas durante la expedición circumglobal “Malaspina 2010”, con el fin de evaluar la diversidad de pterópodos. Se introduce una técnica que evita procedimientos destructivos de tal modo que el material permanece intacto para futuras investigaciones morfológicas. Extrajimos ADN de los posos (material orgánico como moco o partes del cuerpo) de 27 recipientes de muestras para el barcoding (promedio de 100- 260 bp de COI). Se pudieron identificar 7128 “OTUs” correspondientes a la composición de las especies contenidas en las muestras examinadas. Entre ellas se encontraron tres especies de pterópodos tecosomados, Creseis acicula, Creseis virgula y Cavolinia inflexa, cuya taxonomía y distribución geográfica son discutidas. Gimnosomados no identificados procedentes de regiones más templadas de aguas oceánicas del sur del Océnao Indico también estaban presentes. Para facilitar la identificación de especies, es beneficioso crear una base de datos ampliada de códigos de barras COI de pterópodos. Además, la recopilación de datos de barcoding ambiental a una escala mundial amplia ayudará a comprender mejor la abundancia y distribución de especies de pterópodos en los océanos del mundo y de otros posibles organismos planctónicos

Nowhere to Go: Maternity Care Deserts Across the U.S.

Consistent, high-quality maternity care is essential to protect the health of all moms and babies. Maternity care encompasses health care services for women during pregnancy, delivery and postpartum. With over 3.5 million births in the U.S. annually, and rising rates of maternal mortality and morbidity, there is ample opportunity to improve maternal and birth outcomes in our country. The 2022 Nowhere to Go: Maternity Care Deserts Across the U.S. report is an update of the 2020 report and aims to increase education and raise awareness about maternity care deserts. Along with data and maternity care deserts classification updates, new topics touching on the postpartum period, the importance of telehealth and the intersection of chronic disease and pregnancy are included

Optimal loading dose of meropenem before continuous infusion in critically ill patients: a simulation study

The aim of this study was to investigate optimal loading doses prior to continuous infusion of meropenem in critically ill patients. A previously published and successfully evaluated pharmacokinetic model of critically ill patients was used for stochastic simulations of virtual patients. Maintenance doses administered as continuous infusion of 1.5-6~g/24~h with preceding loading doses (administered as 30~min infusion) of 0.15-2~g were investigated. In addition to the examination of the influence of individual covariates, a best-case and worst-case scenario were simulated. Dosing regimens were considered adequate if the 5th percentile of the concentration-time profile did not drop at any time below four times the S/I breakpoint (= 2~mg/L) of Pseudomonas aeruginosa according to the EUCAST definition. Low albumin concentrations, high body weight and high creatinine clearances increased the required loading dose. A maximum loading dose of 0.33~g resulted in sufficient plasma concentrations when only one covariate showed extreme values. If all three covariates showed extreme values (= worst-case scenario), a loading dose of 0.5~g was necessary. Higher loading doses did not lead to further improvements of target attainment. We recommend the administration of a loading dose of 0.5~g meropenem over 30~min immediately followed by continuous infusion

Family Voices on Parental School Choice in Milwaukee: What can we learn from low-income families?

This report, designed as one component of the comprehensive evaluation of the Milwaukee school system being conducted by the School Choice Demonstration Project (SCDP), is based on focus group conversations with low-income families whose children attend Milwaukee public and private schools. The report seeks to elucidate the demand side of school choice from the perspective of the end users. More specifically, it describes the experiences of low-income families and uses their insights to better understand the strengths and limitations of their attempts to exercise parental school choice. Among its distinguishing characteristics, Milwaukee has the first publicly funded means-tested voucher program in the United States. Coupled with traditional public schools and a robust charter school community, Milwaukee provides an unprecedented set of school options to its residents. Equally as important, Milwaukee provides those interested in urban education reform with a unique opportunity to learn from a city at a relatively advanced phase of school reform

Five Fractions versus Seven Fractions SBRT for Intermediate- and High-Risk Prostate Cancer: A Propensity Score Matched Pair Analysis.

PURPOSE To compare two stereotactic body radiotherapy (SBRT) regimens in patients with intermediate- or high-risk prostate cancer with regards toxicity and efficacy. METHODS/MATERIAL We retrospectively collected data from 198 patients treated with SBRT for prostate cancer at two different institutions. Patients received either 35-36.25 Gy in five fractions (group A) using Cyberknife robotic platform or 42.7 Gy in seven fractions (group B) using a C-arm LINAC (image-guided). Propensity score matching was done (2:1 nearest neighbor matching without replacement), resulting in 120 patients (80 patients for group A, 40 patients for group B). Toxicity, PSA nadir, biochemical failure and disease-free survival (DFS) were analyzed. RESULTS Median follow up of all patients was 13 months (range 1-91 months). Overall, 23.3% of patients had ≥G2 acute GU toxicity (21.1% group A versus 30% group B (p = 0.222)) and 6.6% of patients ≥G2 GI toxicity (2.5% versus 15% (p = 0.010)). There was one acute G3 GU toxicity in arm A and one acute G4 rectal bleeding in group B (anticoagulated patient). Regarding late toxicity, 14.1% of patients had ≥G2 late GU toxicity (17.4% versus 6.6% (p = 0.159)) and 5.0% of patients had ≥G2 late GI toxicity (1.4% versus 13.3% (p = 0.013)). There was one G3 late GU toxicity in arm B and two G3 late GI toxicities, one in each arm. Relative median PSA reduction was 92.4% (-53.9-99.9%) from baseline PSA (93.7% (-53.9-99.9%) in group A versus 87.7% (39.8-99.9%) in group B (p = 0.043). In total, 4.2% of patients had biochemical relapse, 5.0% in group A and 2.5% in group B (p = 0.518). One-year DFS in the overall cohort was 97.3%, 98.8% in group A and 94.3% in group B (p = 0.318). CONCLUSION Both SBRT regimens have acceptable acute and late toxicity and good efficacy. There are significantly more GI toxicities in the seven-fraction regimen. Longer follow-up is warranted for better comparison of long-term efficacy