Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.

UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis. SIGNIFICANCE: We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. Cancer Discov; 6(9); 1052-67. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 932.The Breast Cancer Association Consortium (BCAC), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL), and the Ovarian Cancer Association Consortium (OCAC) that contributed breast, prostate, and ovarian cancer data analyzed in this study were in part funded by Cancer Research UK [C1287/A10118 and C1287/A12014 for BCAC; C5047/A7357, C1287/A10118, C5047/A3354, C5047/A10692, and C16913/A6135 for PRACTICAL; and C490/A6187, C490/A10119, C490/A10124, C536/A13086, and C536/A6689 for OCAC]. Funding for the Collaborative Oncological Gene-environment Study (COGS) infrastructure came from: the European Community's Seventh Framework Programme under grant agreement number 223175 (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, and C8197/A16565), the US National Institutes of Health (CA128978) and the Post-Cancer GWAS Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative (1U19 CA148537, 1U19 CA148065, and 1U19 CA148112), the US Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund [with donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07)]. Additional financial support for contributing studies is documented under Supplementary Financial Support.This is the author accepted manuscript. The final version is available from the American Association for Cancer Research via http://dx.doi.org/10.1158/2159-8290.CD-15-122

Hanseníase borderline virchowiana Borderline lepromatous leprosy

É apresentado caso de hanseníase borderline virchowiana com quatro anos de evolução e lesões cutâneas de difícil diagnóstico na rede de saúde. O exame histopatológico mostrando estruturas granulomatosas desorganizadas e múltiplos bacilos álcool-ácido resistentes foi essencial para o diagnóstico. Casos como o descrito possibilitam a contaminação dos conviventes e o surgimento de novos casos de hanseníase no futuro.<br>It is presented a case of borderline lepromatous leprosy with 4 years of evolution and cutaneous lesions of difficult diagnosis in the National Health System. The histopathological evaluation, which was essential for the diagnosis, showed disorganized granulomatous structures and multiple alcohol -acid resistant bacilli. Cases like the one described here are responsible for the contamination of cohabitants and the appearance of new cases of leprosy

VizieR Online Data Catalog Optical and IR photometry of OGLE-2017-BLG-0406 (Hirao+, 2020)

The microlensing event OGLE-2017-BLG-0406 was first discovered on March 27 (HJD'=HJD-2450000=7839) by the Optical Gravitational Lensing Experiment (OGLE) collaboration. The event lies in the OGLE-IV field BLG506, and the observations were conducted at the cadence of once per hour by using the 1.3m Warsaw telescope located at Las Campanas Observatory in Chile. The Microlensing Observations in Astrophysics (MOA) group independently discovered this event on May 5 (HJD'=7879) by using the MOA alert system. MOA observed this event with 15 minutes cadence by using MOA-II telescope at Mt. John University Observatory in New Zealand. The event was also independently discovered by the Korean Microlensing Network (KMTNet) survey using its post-season event finder. KMTNet observes toward the Galactic bulge by using three 1.6m telescopes at the Cerro Tololo Inter-American Observatory in Chile (CTIO: KMT-C), and the South African Astronomical Observatory in South Africa (SAAO: KMT-S). Because this event was in an overlapping region between two fields (KMTNet BLG02 and BLG42), the observations were conducted at a 15minute cadence. On June 2 (HJD'=7907), the Microlensing Follow-up Network (μFUN) collaboration, the Microlensing Network for the Detection of Small Terrestrial Exoplanet (MiNDSTEp) collaboration and Las Cumbres Observatory (LCO) global network of telescope collaboration started high-cadence follow-up observations. μFUN used the following telescopes: the 1.3m CTIO telescope in Chile, the 0.41m Auckland telescope and the 0.36m Farm Cove telescope in New Zealand, and the 0.30m Perth Exoplanet Survey Telescope (PEST), and the 0.25m Craigie telescope in Australia. MiNDSTEp used the 1.54m Danish Telescope at La Silla Observatory in Chile. LCO used the 1.0m telescopes at CTIO in Chile and at SSO in Australia. We also obtained three near-infrared images taken at different epochs (HJD'~7911, 7918 and 7942). The observations were made with SIRIUS, a simultaneous imager in J, H, and KS bands, covering an area 7.7x.7 arcmin2 with a pixel scale of 0.45" on the 1.4m InfraRed Survey Facility (IRSF) telescope at SAAO. OGLE-2017-BLG-0406 was observed by the Spitzer space telescope with the 3.6μm (L-band) channel of the IRAC camera. Spitzer started to observe this event on June 26 (HJD'=7931). (17 data files)...