The %age of GS-expressing tumors with nuclear (N), cytosolic (C) and normal membranous (M) β-catenin expression is indicated

Numbers on top indicate the total amount of HCCs in each group.<p><b>Copyright information:</b></p><p>Taken from "Correlation between β-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma"</p><p>http://www.molecular-cancer.com/content/7/1/21</p><p>Molecular Cancer 2008;7():21-21.</p><p>Published online 18 Feb 2008</p><p>PMCID:PMC2287186.</p><p></p

Clinical characteristics of patients with viral resistance.

<p>Clinical characteristics of patients with viral resistance.</p

Minimal residual viremia in HBeAg positive individuals treated with nucleos(t)ide analogues.

<p>Minimal residual viremia in HBeAg positive individuals treated with nucleos(t)ide analogues.</p

Minimal residual viremia according to treatment regimen.

<p>Minimal residual viremia according to treatment regimen.</p

Minimal residual viremia in HBeAg negative individuals treated with nucleos(t)ide analogues.

<p>Minimal residual viremia in HBeAg negative individuals treated with nucleos(t)ide analogues.</p

Baseline characteristics of the study cohort.

<p>Baseline characteristics of the study cohort.</p

Minimal residual viremia in untreated HBsAg carriers.

<p>Minimal residual viremia in untreated HBsAg carriers.</p

Evaluation of Transient Elastography, Acoustic Radiation Force Impulse Imaging (ARFI), and Enhanced Liver Function (ELF) Score for Detection of Fibrosis in Morbidly Obese Patients

<div><p>Background</p><p>Liver fibrosis induced by non-alcoholic fatty liver disease causes peri-interventional complications in morbidly obese patients. We determined the performance of transient elastography (TE), acoustic radiation force impulse (ARFI) imaging, and enhanced liver fibrosis (ELF) score for fibrosis detection in bariatric patients.</p><p>Patients and Methods</p><p>41 patients (median BMI 47 kg/m²) underwent 14-day low-energy diets to improve conditions prior to bariatric surgery (day 0). TE (M and XL probe), ARFI, and ELF score were performed on days -15 and -1 and compared with intraoperative liver biopsies (NAS staging).</p><p>Results</p><p>Valid TE and ARFI results at day -15 and -1 were obtained in 49%/88% and 51%/90% of cases, respectively. High skin-to-liver-capsule distances correlated with invalid TE measurements. Fibrosis of liver biopsies was staged as F1 and F3 in n = 40 and n = 1 individuals. However, variations (median/range at d-15/-1) of TE (4.6/2.6–75 and 6.7/2.9–21.3 kPa) and ARFI (2.1/0.7–3.7 and 2.0/0.7–3.8 m/s) were high and associated with overestimation of fibrosis. The ELF score correctly classified 87.5% of patients.</p><p>Conclusion</p><p>In bariatric patients, performance of TE and ARFI was poor and did not improve after weight loss. The ELF score correctly classified the majority of cases and should be further evaluated.</p></div

Performance of ELF score.

<p>The diagnostic accuracy of the ELF score for detection of advanced liver fibrosis (≥F2) was evaluated in a cohort of non-bariatric NAFLD patients [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0141649#pone.0141649.ref017" target="_blank">17</a>]. The calculated cut-off was applied to the bariatric cohort and correctly classified the majority of patients. Grey boxes below each bar indicate the median value.</p

Applicability and diagnostic value of non-invasive methods for fibrosis detection prior to bariatric surgery.

<p>The category “correctly classified” indicates the proportion of F0-1 cases with liver stiffness measurement results below the respective cut-off values for significant fibrosis (≥F2).</p><p>TE—transient elastography; ARFI–Acoustic Radiation Force Impulse Imaging</p><p>^a According to the manufacturer’s recommendation, the use of XL probe was indicated in all cases with valid measurements (skin-to-liver-capsule distance > 25 mm).</p><p>^b ELF score could be calculated from all analyzed serum specimens. However, serum samples for ELF score were not available in one (before diet) and two (after diet) cases, respectively.</p><p>Applicability and diagnostic value of non-invasive methods for fibrosis detection prior to bariatric surgery.</p