Tracking Brownian motion in three dimensions and characterization of individual nanoparticles using a fiber-based high-finesse microcavity

The dynamics of nanosystems in solution contain a wealth of information with relevance for diverse fields ranging from materials science to biology and biomedical applications. When nanosystems are marked with fluorophores or strong scatterers, it is possible to track their position and reveal internal motion with high spatial and temporal resolution. However, markers can be toxic, expensive, or change the object's intrinsic properties. Here, we simultaneously measure dispersive frequency shifts of three transverse modes of a high-finesse microcavity to obtain the three-dimensional path of unlabeled SiO$_2$ nanospheres with $300$$\mathrm{\mu}$s temporal and down to $8$nm spatial resolution. This allows us to quantitatively determine properties such as the polarizability, hydrodynamic radius, and effective refractive index. The fiber-based cavity is integrated in a direct-laser-written microfluidic device that enables the precise control of the fluid with ultra-small sample volumes. Our approach enables quantitative nanomaterial characterization and the analysis of biomolecular motion at high bandwidth.Comment: 7 pages, 3 figure

UnRectDepthNet: Self-Supervised Monocular Depth Estimation using a Generic Framework for Handling Common Camera Distortion Models

In classical computer vision, rectification is an integral part of multi-view depth estimation. It typically includes epipolar rectification and lens distortion correction. This process simplifies the depth estimation significantly, and thus it has been adopted in CNN approaches. However, rectification has several side effects, including a reduced field of view (FOV), resampling distortion, and sensitivity to calibration errors. The effects are particularly pronounced in case of significant distortion (e.g., wide-angle fisheye cameras). In this paper, we propose a generic scale-aware self-supervised pipeline for estimating depth, euclidean distance, and visual odometry from unrectified monocular videos. We demonstrate a similar level of precision on the unrectified KITTI dataset with barrel distortion comparable to the rectified KITTI dataset. The intuition being that the rectification step can be implicitly absorbed within the CNN model, which learns the distortion model without increasing complexity. Our approach does not suffer from a reduced field of view and avoids computational costs for rectification at inference time. To further illustrate the general applicability of the proposed framework, we apply it to wide-angle fisheye cameras with 190$^\circ$ horizontal field of view. The training framework UnRectDepthNet takes in the camera distortion model as an argument and adapts projection and unprojection functions accordingly. The proposed algorithm is evaluated further on the KITTI rectified dataset, and we achieve state-of-the-art results that improve upon our previous work FisheyeDistanceNet. Qualitative results on a distorted test scene video sequence indicate excellent performance https://youtu.be/K6pbx3bU4Ss.Comment: Minor fixes added after IROS 2020 Camera ready submission. IROS 2020 presentation video - https://www.youtube.com/watch?v=3Br2KSWZRr

Replicative manufacturing of metal moulds for low surface roughness polymer replication

Tool based manufacturing processes like injection moulding allow fast and high-quality mass-market production, but for optical polymer components the production of the necessary tools is time-consuming and expensive. In this paper a process to fabricate metal-inserts for tool based manufacturing with smooth surfaces via a casting and replication process from fused silica templates is presented. Bronze, brass and cobalt-chromium could be successfully replicated from shaped fused silica replications achieving a surface roughnesses of Rq 8 nm and microstructures in the range of 5 µm. Injection moulding was successfully performed, using a commercially available injection moulding system, with thousands of replicas generated from the same tool. In addition, three-dimensional bodies in metal could be realised with 3D-Printing of fused silica casting moulds. This work thus represents an approach to high-quality moulding tools via a scalable facile and cost-effective route surpassing the currently employed cost-, labour- and equipment-intensive machining techniques

Exposition von Bio-Milchvieh gegenüber dem Labmagenwurm Ostertagia ostertagi durch Messung von Antikörpertitern in Tankmilch: vorläufige Ergebnisse in Österreich

Wir untersuchten die Exposition von Bio-Milchvieh gegenüber O. ostertagi in Österreich durch Messung von parasitenspezifischer Antikörper in Tankmilch. Es wurde eine hohe Parasiten-Exposition bestätigt, was ein Monitoring und die Einführung nachhaltiger, lokal relevanten Kontrolle rechtfertigt

Head and neck paragangliomas: clinical and molecular genetic classification

Head and neck paragangliomas are tumors arising from specialized neural crest cells. Prominent locations are the carotid body along with the vagal, jugular, and tympanic glomus. Head and neck paragangliomas are slowly growing tumors, with some carotid body tumors being reported to exist for many years as a painless lateral mass on the neck. Symptoms depend on the specific locations. In contrast to paraganglial tumors of the adrenals, abdomen and thorax, head and neck paragangliomas seldom release catecholamines and are hence rarely vasoactive. Petrous bone, jugular, and tympanic head and neck paragangliomas may cause hearing loss. The internationally accepted clinical classifications for carotid body tumors are based on the Shamblin Class I–III stages, which correspond to postoperative permanent side effects. For petrous-bone paragangliomas in the head and neck, the Fisch classification is used. Regarding the molecular genetics, head and neck paragangliomas have been associated with nine susceptibility genes: NF1, RET, VHL, SDHA, SDHB, SDHC, SDHD, SDHAF2 (SDH5), and TMEM127. Hereditary HNPs are mostly caused by mutations of the SDHD gene, but SDHB and SDHC mutations are not uncommon in such patients. Head and neck paragangliomas are rarely associated with mutations of VHL, RET, or NF1. The research on SDHA, SDHAF2 and TMEM127 is ongoing. Multiple head and neck paragangliomas are common in patients with SDHD mutations, while malignant head and neck paraganglioma is mostly seen in patients with SDHB mutations. The treatment of choice is surgical resection. Good postoperative results can be expected in carotid body tumors of Shamblin Class I and II, whereas operations on other carotid body tumors and other head and neck paragangliomas frequently result in deficits of the cranial nerves adjacent to the tumors. Slow growth and the tendency of hereditary head and neck paragangliomas to be multifocal may justify less aggressive treatment strategies

Geochemical studies of impact breccias and country rocks from the El'gygytgyn impact structure, Russia

The complex impact structure El'gygytgyn (age 3.6 Ma, diameter 18 km) in northeastern Russia was formed in ~88 Ma old volcanic target rocks of the Ochotsk-Chukotsky Volcanic Belt (OCVB). In 2009, El'gygytgyn was the target of a drilling project of the International Continental Scientific Drilling Program (ICDP), and in summer 2011 it was investigated further by a Russian–German expedition. Drill core material and surface samples, including volcanic target rocks and impactites, have been investigated by various geochemical techniques in order to improve the record of trace element characteristics for these lithologies and to attempt to detect and constrain a possible meteoritic component. The bedrock units of the ICDP drill core reflect the felsic volcanics that are predominant in the crater vicinity. The overlying suevites comprise a mixture of all currently known target lithologies, dominated by felsic rocks but lacking a discernable meteoritic component based on platinum group element abundances. The reworked suevite, directly overlain by lake sediments, is not only comparatively enriched in shocked minerals and impact glass spherules, but also contains the highest concentrations of Os, Ir, Ru, and Rh compared to other El'gygytgyn impactites. This is—to a lesser extent—the result of admixture of a mafic component, but more likely the signature of a chondritic meteoritic component. However, the highly siderophile element contribution from target material akin to the mafic blocks of the ICDP drill core to the impactites remains poorly constrained