Perioperative statin therapy reduces mortality in normolipidemic patients undergoing cardiac surgery

ObjectiveStatins might have pleiotropic effects, independent of their ability to reduce lipid levels. Recent data have suggested that statins improve early survival and cardiovascular outcomes after coronary artery bypass graft surgery. The effectiveness of statin therapy in normolipidemic cardiac surgery patients is as yet unclear.MethodsWe evaluated 3056 consecutive patients who had undergone cardiac surgery between April 2004 and April 2009. Perioperative statin therapy was defined as continued treatment both before (≥ 6 months) and after the index surgery (included as a discharge medication). Hyperlipidemia (HL) was defined as a total cholesterol level greater than 200 mg/dL within 6 months before surgery. Four groups were analyzed: (1) statin-untreated normolipidemic (NL−, n = 1052); (2) statin-treated normolipidemic (NL+, n = 206); (3) statin-untreated hyperlipidemic (HL−, n = 638); and (4) statin-treated hyperlipidemic (HL+, n = 1160) patients. Adjusted hazard ratios accounted for the known preoperative cardiac risk factors. Mortality was ascertained by retrospective database review and the Social Security Death Index.ResultsThe mean follow-up was 2.2 years. The crude rate of 30-day mortality was 3.0% (32/1052), 0% (0/206), 8.0% (51/638), and 0.7% (8/1160) for the NL−, NL+, HL−, and HL+ groups, respectively. The overall all-cause crude mortality rate was 9.6% (101/1052), 3.9% (8/206), 17.2% (110/638), and 6.5% (75/1160) for the NL−, NL+, HL−, and HL+ groups, respectively. Statin therapy for NL patients undergoing cardiac surgery independently reduced the overall all-cause mortality (adjusted hazard ratio, 0.34; 95% confidence interval, 0.16–0.71; P = .004).ConclusionsPerioperative statin therapy was associated with reduced mid-term mortality for patients undergoing cardiac surgery, irrespective of their baseline lipid status. This clinical evidence suggests that the beneficial effects of statins might extend beyond their lipid-lowering ability

Intracluster supernovae in the Multi-epoch Nearby Cluster Survey

The Multi-Epoch Nearby Cluster Survey (MENeaCS) has discovered twenty-three cluster Type Ia supernovae (SNe) in the 58 X-ray selected galaxy clusters (0.05 < z < 0.15) surveyed. Four of our SN Ia events have no host galaxy on close inspection, and are likely intracluster SNe. Deep image stacks at the location of the candidate intracluster SNe put upper limits on the luminosities of faint hosts, with M_{r} > -13.0 mag and M_{g} > -12.5 mag in all cases. For such limits, the fraction of the cluster luminosity in faint dwarfs below our detection limit is <0.1%, assuming a standard cluster luminosity function. All four events occurred within ~600 kpc of the cluster center (projected), as defined by the position of the brightest cluster galaxy, and are more centrally concentrated than the cluster SN Ia population as a whole. After accounting for several observational biases that make intracluster SNe easier to discover and spectroscopically confirm, we calculate an intracluster stellar mass fraction of 0.16^{+0.13}_{-0.09} (68% CL) for all objects within R_{200}. If we assume that the intracluster stellar population is exclusively old, and the cluster galaxies themselves have a mix of stellar ages, we derive an upper limit on the intracluster stellar mass fraction of <0.47 (84% one-sided CL). When combined with the intragroup SNe results of McGee & Balogh, we confirm the declining intracluster stellar mass fraction as a function of halo mass reported by Gonzalez and collaborators. (Abridged)Comment: 24 pages, 8 figures, ApJ publishe

The Australia Telescope 20 GHz Survey: The Source Catalogue

We present the full source catalogue from the Australia Telescope 20 GHz (AT20G) Survey. The AT20G is a blind radio survey carried out at 20 GHz with the Australia Telescope Compact Array (ATCA) from 2004 to 2008, and covers the whole sky south of declination 0 deg. The AT20G source catalogue presented here is an order of magnitude larger than any previous catalogue of high-frequency radio sources, and includes 5890 sources above a 20 GHz flux-density limit of 40 mJy. All AT20G sources have total intensity and polarisation measured at 20 GHz, and most sources south of declination -15 deg also have near-simultaneous flux-density measurements at 5 and 8 GHz. A total of 1559 sources were detected in polarised total intensity at one or more of the three frequencies. We detect a small but significant population of non-thermal sources that are either undetected or have only weak detections in low-frequency catalogues. We introduce the term Ultra-Inverted Spectrum (UIS) to describe these radio sources, which have a spectral index alpha(5, 20) > +0.7 and which constitute roughly 1.2 per cent of the AT20G sample. The 20 GHz flux densities measured for the strongest AT20G sources are in excellent agreement with the WMAP 5-year source catalogue of Wright et al. (2009), and we find that the WMAP source catalogue is close to complete for sources stronger than 1.5 Jy at 23 GHz.Comment: 21 pages, accepted for publication in MNRA

Insight from the Consideration of REM dreams, Non-REM Dreams and Daydreams

Throughout history there have been reports and claims that consideration of dreams can produce personal realizations and insight. We assessed Exploration-Insight scores associated with discussing Rapid Eye Movement (REM) and non-REM (NREM) dreams in connection with recent waking life experiences. Thirty-one participants were cued in the sleep laboratory for a daydream report and then awakened from REM and N2 sleep for dream reports. Participants subsequently discussed each of their dream and daydream reports for 30-40 minutes with two experimenters, following the structured Ullman (1996) dream group discussion procedure. Participants assessed the benefit of discussing the reports by completing the Gains from (Day)Dream Interpretation (G(D)DI) questionnaire. We found no difference in G(D)DI scores between discussing REM and N2 dream reports, and no difference between dream and daydream discussions in engagement and thoroughness of exploring the reports. However, discussing dream reports produced higher scores on the G(D)DI Exploration-Insight subscale compared with discussing daydream reports. Significant differences were evident in items reflecting the learning of what the report means in terms of waking life issues. Frontal theta prior to waking from N2 was significantly associated with Exploration-Insight score obtained after N2 dream discussion, but this relationship was not found for REM dreams. The findings of high ratings of Exploration-Insight after discussing dreams were evident even though participants did not select the dream, unlike what can occur for home recorded dreams, and even though discussion was brief. We suggest that insight might be produced by embodied and metaphorical thinking in dreams

Evaluation of mobile learning: Students' experiences in a new rural-based medical school

<p>Abstract</p> <p>Background</p> <p>Mobile learning (ML) is an emerging educational method with success dependent on many factors including the ML device, physical infrastructure and user characteristics. At Gippsland Medical School (GMS), students are given a laptop at the commencement of their four-year degree. We evaluated the educational impact of the ML program from students' perspectives.</p> <p>Methods</p> <p>Questionnaires and individual interviews explored students' experiences of ML. All students were invited to complete questionnaires. Convenience sampling was used for interviews. Quantitative data was entered to SPSS 17.0 and descriptive statistics computed. Free text comments from questionnaires and transcriptions of interviews were thematically analysed.</p> <p>Results</p> <p>Fifty students completed the questionnaire (response rate 88%). Six students participated in interviews. More than half the students owned a laptop prior to commencing studies, would recommend the laptop and took the laptop to GMS daily. Modal daily use of laptops was four hours. Most frequent use was for access to the internet and email while the most frequently used applications were Microsoft Word and PowerPoint. Students appreciated the laptops for several reasons. The reduced financial burden was valued. Students were largely satisfied with the laptop specifications. Design elements of teaching spaces limited functionality. Although students valued aspects of the virtual learning environment (VLE), they also made many suggestions for improvement.</p> <p>Conclusions</p> <p>Students reported many educational benefits from school provision of laptops. In particular, the quick and easy access to electronic educational resources as and when they were needed. Improved design of physical facilities would enhance laptop use together with a more logical layout of the VLE, new computer-based resources and activities promoting interaction.</p

The GOGREEN Survey: Evidence of an excess of quiescent disks in clusters at 1.0<z<1.41.0<z<1.4

We present results on the measured shapes of 832 galaxies in 11 galaxy clusters at 1.0 < z <1.4 from the GOGREEN survey. We measure the axis ratio ($q$), the ratio of the minor to the major axis, of the cluster galaxies from near-infrared Hubble Space Telescope imaging using S\'ersic profile fitting and compare them with a field sample. We find that the median $q$ of both star-forming and quiescent galaxies in clusters increases with stellar mass, similar to the field. Comparing the axis ratio distributions between clusters and the field in four mass bins, the distributions for star-forming galaxies in clusters are consistent with those in the field. Conversely, the distributions for quiescent galaxies in the two environments are distinct, most remarkably in $10.1\leq\log(M/{\rm M}_{\odot})<10.5$ where clusters show a flatter distribution, with an excess at low $q$. Modelling the distribution with oblate and triaxial components, we find that the cluster and field sample difference is consistent with an excess of flattened oblate quiescent galaxies in clusters. The oblate population contribution drops at high masses, resulting in a narrower $q$ distribution in the massive population than at lower masses. Using a simple accretion model, we show that the observed $q$ distributions and quenched fractions are consistent with a scenario where no morphological transformation occurs for the environmentally quenched population in the two intermediate mass bins. Our results suggest that environmental quenching mechanism(s) likely produce a population that has a different morphological mix than those resulting from the dominant quenching mechanism in the field.Comment: Accepted for publication in ApJ. 25 pages, 15 figure