Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study

Background Decreased muscle strength can lead to adverse health outcomes in the elderly. A potential association between phthalate exposure and muscle strength was suggested previously, but has not been investigated directly. We hypothesized that phthalate exposure is associated with lower handgrip strength and that the association is modified by the dietary omega-6 to omega-3 ratio. Methods We analyzed 1,228 participants (≥60 years of age) recruited in Seoul and Asan, Republic of Korea. The study participants were surveyed up to three times between 2012 and 2015. At every survey, we collected urine samples and measured handgrip strength twice for each hand. The associations between urine phthalate metabolite concentrations and handgrip strength were evaluated using linear mixed models. Based on dietary information from 391 individuals who participated in the first survey in Seoul, we evaluated the heterogeneity of the association for those with high and low omega-6 to omega-3 ratios, using 8.81 (the 75th quantile) as a cutoff value. Results Log-transformed creatinine-adjusted concentrations of mono-(2-ethyl-5-oxohexyl phthalate (MEOHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono-n-butyl phthalate (MnBP) were inversely associated with all measured handgrip strengths (β = −0.69 to −0.42, all p-values < 0.05). Associations between phthalate biomarkers and handgrip strength did not differ by sex. When the dietary subgroup was stratified by the omega-6 to omega-3 ratio, the associations were stronger among participants with high ratios. Conclusions We found inverse associations between phthalate biomarkers and handgrip strength in the elderly; this association was modified by the dietary omega-6 to omega-3 ratio

Case Study on the Changes in the Physical Environment in Forest Healing Spaces

This study was conducted to investigate changes in the physical environment in forest healing spaces by examining each of two tree species in a space within the Kasuya Research Forest, Kyushu University. At the study site, culmination and sunset showed high TNVOCs, low concentrations of particulate matter, and low PPD. Of the NVOCs, camphor was detected with the highest concentrations, 0.359 ng/m^3 and 0.142 ng/m^3, in C. camphora and M. thunbergii, respectively. Coniferous trees are generally used when creating an environment for healing purposes, as they are known to emit a large amount of NVOCs. However, according to our results, deciduous trees also emit NVOCs of sufficient concentrations. Therefore, if forest healing spaces are created with the appropriate components, it can have effective results

Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study

Background Decreased muscle strength can lead to adverse health outcomes in the elderly. A potential association between phthalate exposure and muscle strength was suggested previously, but has not been investigated directly. We hypothesized that phthalate exposure is associated with lower handgrip strength and that the association is modified by the dietary omega-6 to omega-3 ratio. Methods We analyzed 1,228 participants (≥60 years of age) recruited in Seoul and Asan, Republic of Korea. The study participants were surveyed up to three times between 2012 and 2015. At every survey, we collected urine samples and measured handgrip strength twice for each hand. The associations between urine phthalate metabolite concentrations and handgrip strength were evaluated using linear mixed models. Based on dietary information from 391 individuals who participated in the first survey in Seoul, we evaluated the heterogeneity of the association for those with high and low omega-6 to omega-3 ratios, using 8.81 (the 75th quantile) as a cutoff value. Results Log-transformed creatinine-adjusted concentrations of mono-(2-ethyl-5-oxohexyl phthalate (MEOHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono-n-butyl phthalate (MnBP) were inversely associated with all measured handgrip strengths (β = −0.69 to −0.42, all p-values < 0.05). Associations between phthalate biomarkers and handgrip strength did not differ by sex. When the dietary subgroup was stratified by the omega-6 to omega-3 ratio, the associations were stronger among participants with high ratios. Conclusions We found inverse associations between phthalate biomarkers and handgrip strength in the elderly; this association was modified by the dietary omega-6 to omega-3 ratio

Association of urinary 3-phenoxybenzoic acid levels with self-reported depression symptoms in a rural elderly population in Asan, South Korea

Objectives: This study aimed to evaluate the association between presence of depression symptoms and the exposure level to insecticides among aged population in rural area, determined via measured levels of urinary 3-phenoxybenzoic acid (3-PBA), after controlling for socioeconomic confounding factors. Methods: Using a cross-sectional study design, we randomly recruited participants for our study (161 male and 239 female) from rural areas of Asan, Chungnam, Korea. Environmental risk factor exposure was assessed using a questionnaire, and gas chromatography- mass spectrometry was used to analyze urinary 3-PBA levels. We used a logistic regression analysis to assess the association of urinary 3-PBA levels with the presence of self-reported depression symptoms. Results: After controlling for creatinine levels, the median (interquartile range) concentration of 3-PBA was approximately 1.5 times (p<0.05) higher among female (1.54 [0.90 to 2.35]) μg/g) than among male (1.06 [0.64 to 1.81] μg/g). Our study found that among female participants, the unit increase in 3-PBA levels exhibited a likely positive association (odds ratio, 1.12; 95% confidence interval, 1.00 to 1.25) with an increased risk of presence of self-reported depression symptoms, after adjusting for socioeconomic insurance type, daily physical condition, marital status, smoking status, and age. Conclusions: Given our finding of a potential association between the presence of selfreported depression symptoms and 3-PBA levels, precautions should be considered to minimize exposure to insecticides and thus protect the health of aged residents in rural areas

Pneumatic-type surgical robot end-effector for laparoscopic surgical-operation-by-wire

Background Although minimally invasive surgery (MIS) affords several advantages compared to conventional open surgery, robotic MIS systems still have many limitations. One of the limitations is the non-uniform gripping force due to mechanical strings of the existing systems. To overcome this limitation, a surgical instrument with a pneumatic gripping system consisting of a compressor, catheter balloon, micro motor, and other parts is developed. Method This study aims to implement a surgical instrument with a pneumatic gripping system and pitching/yawing joints using micro motors and without mechanical strings based on the surgical-operation-by-wire (SOBW) concept. A 6-axis external arm for increasing degrees of freedom (DOFs) is integrated with the surgical instrument using LabVIEW® for laparoscopic procedures. The gripping force is measured over a wide range of pressures and compared with the simulated ideal step function. Furthermore, a kinematic analysis is conducted. To validate and evaluate the systems clinical applicability, a simple peg task experiment and workspace identification experiment are performed with five novice volunteers using the fundamentals of laparoscopic surgery (FLS) board kit. The master interface of the proposed system employs the hands-on-throttle-and-stick (HOTAS) controller used in aerospace engineering. To develop an improved HOTAS (iHOTAS) controller, 6-axis force/torque sensor was integrated in the special housing. Results The mean gripping force (after 1,000 repetitions) at a pressure of 0.3 MPa was measured to be 5.8 N. The reaction time was found to be 0.4 s, which is almost real-time. All novice volunteers could complete the simple peg task within a mean time of 176 s, and none of them exceeded the 300 s cut-off time. The systems workspace was calculated to be 11,157.0 cm3. Conclusions The proposed pneumatic gripping system provides a force consistent with that of other robotic MIS systems. It provides near real-time control. It is more durable than the existing other surgical robot systems. Its workspace is sufficient for clinical surgery. Therefore, the proposed system is expected to be widely used for laparoscopic robotic surgery. This research using iHOTAS will be applied to the tactile force feedback system for surgeons safe operation

Additional file 1: of Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study

Phthalate exposure and lower handgrip strength in an elderly population: A repeated-measures study. Table S1. Correlations between handgrip strengths (kg) in the Korean Elderly Environmental Panel II Study (2012–2015). Table S2. Distribution of urinary phthalate metabolites (μg/L) in the Korean Elderly Environmental Panel II Study (2012–2015). Table S3. Correlations between Phthalate Metabolite Levels (μg/L) Measured at Three Surveys in the Korean Elderly Environmental Panel II Study (2012–2015). Table S4. Correlations between Levels of Each Phthalate Metabolites (μg/L) in the Korean Elderly Environmental Panel II Study (2012–2015). Table S5. Associations between Urinary Phthalate Metabolite Concentrations (Log-transformed, μg/g Creatinine) and Handgrip Strength in Multiple Pollutant Models (n = 892) in the Korean Elderly Environmental Panel II Study (2012–2015). Table S6. Associations between urinary phthalate metabolite concentrations (log transformed, μg/g creatinine) and handgrip strength, stratified by the median of the omega-6 to omega-3 ratio (n = 391) in the Korean Elderly Environmental Panel II Study (2012–2015). Table S7. Associations between urinary phthalate metabolite concentrations (log transformed, μg/g creatinine) and handgrip strength, stratified by the 90th quantile of the omega-6 to omega-3 ratio (n = 391) in the Korean Elderly Environmental Panel II Study (2012–2015).Table S8. Associations between Urinary Phthalate Metabolite Concentrations (Log-transformed, μg/g Creatinine) and Handgrip Strength after Excluding Those Who had been Diagnosed with Stroke (n = 1,181), Osteoporosis, or Osteoarthritis (n = 815). Table S9. Associations between urinary phthalate metabolite concentrations (log transformed, μg/g creatinine) and handgrip strength, after inverse probability weighting for follow-up (n = 1,228) in the Korean Elderly Environmental Panel II Study (2012–2015). Table S10. Associations between urinary phthalate metabolite concentrations (log transformed, μg/g creatinine) and handgrip strength stratified by the 75th quantile of the omega-6 to omega-3 ratio, after inverse probability weighting for follow-up (n = 391) in the Korean Elderly Environmental Panel II Study (2012–2015). (DOCX 41 kb

Association by Spatial Interpolation between Ozone Levels and Lung Function of Residents at an Industrial Complex in South Korea

Spatial interpolation is employed to improve exposure estimates and to assess adverse health effects associated with environmental risk factors. Since various studies have reported that high ozone (O3) concentrations can give rise to adverse effects on respiratory symptoms and lung function, we investigated the association between O3 levels and lung function using a variety of spatial interpolation techniques and evaluated how different methods for estimating exposure may influence health results for a cohort from an industrial complex (Gwangyang Bay) in South Korea in 2009. To estimate daily concentrations of O3 in each subject, four different methods were used, which include simple averaging, nearest neighbor, inverse distance weighting, and kriging. Also, to compare the association between O3 levels and lung function by age-groups, we explored ozone’s impacts on three age-related groups: children (9–14 years), adults (15–64 years), and the elderly (≥65 years). The overall change of effect size on lung function in each age group tended to show similar patterns for lag and methods for estimating exposure. A significant negative association was only observed between O3 levels and FVC and FEV1 for most of the lag and methods in children. The largest effect of O3 levels was found at the average for the lung function test day and last 2 days (0–2 days). In conclusions, the spatial interpolation methods may benefit in providing individual-level exposure with appropriate temporal resolution from ambient monitors. However, time-activity patterns of residents, monitoring site locations, methodological choices, and other factors should be considered to minimize exposure misclassification