COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Nos groupes locaux

Cholley André. Nos groupes locaux. In: L'information géographique, volume 1, n°4, 1936. pp. 195-196

Remarques sur quelques points de vue géographiques (suite)

Cholley André. Remarques sur quelques points de vue géographiques (suite). In: L'information géographique, volume 12, n°4, 1948. pp. 127-135

« L'Information Géographique »

Cholley André. « L'Information Géographique ». In: L'information géographique, volume 3, n°1, 1938. pp. 1-6

La Revue « Inter-Nord »

Cholley André. La Revue « Inter-Nord ». In: Annales de Géographie, t. 76, n°417, 1967. p. 598

Lucien Goron (1886-1954)

Cholley André. Lucien Goron (1886-1954). In: Annales de Géographie, t. 63, n°337, 1954. p. 236

le climat du bassin parisien d'après M. P. Pédelaborde

Cholley André. le climat du bassin parisien d'après M. P. Pédelaborde. In: Annales de Géographie, t. 68, n°369, 1959. pp. 450-455

Groupes d'études pour l'enseignement de la géographie

Cholley André. Groupes d'études pour l'enseignement de la géographie . In: L'information géographique, volume 3, n°5, 1939. p. 238

Notes de géographie Beaujolaise

Cholley André. Notes de géographie Beaujolaise. In: Annales de Géographie, t. 38, n°211, 1929. pp. 26-46

Atlas de l'Est et Atlas du Nord de la France

Cholley André. Atlas de l'Est et Atlas du Nord de la France. In: Annales de Géographie, t. 73, n°400, 1964. pp. 641-659