Parallel execution of the Simplex algorithm

This project is concerned with the optimal distribution of the computation and the data in parallelized Simplex algorithms. Test cases were implemented on a 16-processor Transputer system from INMOS Corporation. By careful consideration of distribution of computations and data, a nearly linear speedup pattern was obtained. The most interesting thing in this study was that 1) the execution time is not dependant on communication delay, 2) overhead due to parallelization does not significantly increase as the number of processors increase and 3) the Simplex algorithm communication delay is not so significant if the problem size is big enough.Keywords and phrases : message-passing, two-phase Simplex, linear programming, distributed memory, multiprocessor syste

User interface system based on active objects

An active-object user interface system (AOUIS) is a user interface system implemented as an active object system (AOS). An AOS is a transition-based object-oriented system suitable for the design of various concurrent systems. In an AOUIS, user interface objects, which are sometimes called "widgets", are represented as active user interface objects (AUIOs). The behavior of an AUIO is defined by the transition rules, the equational assignment statements, and the event routines provided in its class definition. Furthermore, an AUIO can be constructed from its component AUIOs through structural composition as ifit were a hardware object. Thus, AUIOs are better encapsulated and provide more flexible communication protocols than ordinary user interface objects. In addition, declarative descriptions of multiple views can be provided for each AUIO.Key Words and Phrases : user interface management system, active object system, production system, structural composition, software IC, subject/view

A General Multivariate Exponentially Weighted Moving Average Control Chart

1 online resource (PDF, 30 pages

Actionbase system for manufacturing control

A modern computerized manufacturing control system must manage production data, coordinate control actions, and provide user-friendly interfaces. An actionbase management system (ABMS) is a general software system that facilitates implementations of actionbase systems that provide these capabilities for different applications. Besides an ordinary data management facility, our ABMS includes action control and user interface subsystems implemented as active object systems (AOSs). An AOS is a transition-based object-oriented system suitable for the design of various concurrent systems. The behavior of each active object is defined by the transition rules, the equational assignment statements, and the event routines provided in its class definition. An active object can be constructed from its component active objects through structural composition as if it were a hardware object. The user interface management subsystem of the ABMS allows us to provide declarative descriptions of views for active objects. These views provide user interfaces for an actionbase system.Key Words and Phrases: manufacturing control, flexible manufacturing system, actionbase system, active-object system, software IC, object-oriented concurrent system, graphical user interface, active-object user interface

A Program for Design and Performance Evaluation of Multivariate Exponentially Weighted Moving Average Control Charts

1 online resource (PDF, 19 pages

Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability

Necroptosis is a regulated caspase-independent cell death pathway with morphological features resembling passive non-regulated necrosis. Several diverse structure classes of necroptosis inhibitors have been reported to date, including a series of 3,3a,4,5-tetrahydro-2H-benz[g]indazoles (referred to as the Nec-3 series) displaying potent activity in cellular assays. However, evaluation of the tricyclic necroptosis inhibitor’s stability in mouse liver microsomes indicated that they were rapidly degraded. A structure–activity relationship (SAR) study of this compound series revealed that increased liver microsomal stability could be accomplished by modification of the pendent phenyl ring and by introduction of a hydrophilic substituent (i.e., ?-hydroxyl) to the acetamide at the 2-position of the tricyclic ring without significantly compromising necroptosis inhibitory activity. Further increases in microsomal stability could be achieved by utilizing the 5,5-dioxo-3-phenyl-2,3,3a,4-tetrahydro-[1]benzothiopyrano[4,3-c]pyrazoles. However, in this case necroptosis inhibitory activity was not maintained. Overall, these results provide a strategy for generating potent and metabolically stable tricyclic necrostatin analogs (e.g., 33, LDN-193191) potentially suitable for in vivo studies

Parallel programming and designing in object oriented environment SS/1

Parallel software development requires the flexibility to describe algorithms regardless of hardware specification, the ability to accommodate existing applications. and maintainability throughout the software life cycle. We propose the following model to address these issues. Our model incorporates aspects of the object-oriented and large grain data flow programming paradigms, and introduces a concept called a "Server". "Servers" are objects as well as self-contained processes which communicate with each other by sending messages. The server paradigm considers all components of a program as servers. This concept helps in designing flexible and dynamically reconfigurable software. The major goals of the server model are reusability, maintainability, and productivity. These are realized through encapsulation, instantiation, and inheritance features of the server model, as well as a graphical design environment with the capability of tracing and debugging the user's design based on the data flow information

Improving Binding Specificity of Pharmacological Chaperones That Target Mutant Superoxide Dismutase-1 Linked to Familial Amyotrophic Lateral Sclerosis Using Computational Methods

We recently described a set of drug-like molecules obtained from an in silico screen that stabilize mutant superoxide dismutase-1 (SOD-1) linked to familial amyotrophic lateral sclerosis (ALS) against unfolding and aggregation but exhibited poor binding specificity toward SOD-1 in presence of blood plasma. A reasonable but not a conclusive model for the binding of these molecules was proposed on the basis of restricted docking calculations and site-directed mutagenesis of key residues at the dimer interface. A set of hydrogen bonding constraints obtained from these experiments were used to guide docking calculations with compound library around the dimer interface. A series of chemically unrelated hits were predicted, which were experimentally tested for their ability to block aggregation. At least six of the new molecules exhibited high specificity of binding toward SOD-1 in the presence of blood plasma. These molecules represent a new class of molecules for further development into clinical candidates