Homeless Population Enumeration

There is currently very limited information on homeless population including, population size, demographic, geological location, and such; these are all vital information that are required to create resources and supports that helps to meet the needs of homeless population (Forchuk, 2021). Dr. Richard Booth’s ongoing research on homeless population enumeration aims to generate accurate quantitative representation of the homelessness incidence. It will be undertaking the form of a scoping review by reviewing relevant literatures to explore and synthesize various enumeration processes and conceptualization of construct of ‘homelessness’

Effects of moxibustion for constipation treatment: a systematic review of randomized controlled trials

Several studies reported that moxibustion was effective in treating constipation. This systematic review assesses the clinical evidence for or against moxibustion for treating constipation. Twelve databases were searched from their inception to March 2010. Only randomized clinical trials (RCTs) were included if they compared moxibustion with placebo, sham treatment, drug therapy or no treatment. The methodological quality of these RCTs was assessed with the Cochrane risk of bias analysis. All three RCTs included in the study had a high risk of bias. Two included studies found favorable effects of moxibustion. The third RCT showed significant effects in the moxibustion group. Given that the methodological quality of all RCTs was poor, the results from the present review are insufficient to suggest that moxibustion is an effective treatment for constipation. More rigorous studies are warranted

Cosimulation of MBD (Multi Body Dynamics) and DEM of many spheres using GPU technology

In this paper, dynamic simulation model which have many sphere particles and MBD (Multi Body Dynamics) entities, i.e. bodies, joints, forces, is built and simulated. Many sphere particles are solved with DEM (Discrete Element Method) and simulated with GPU technology. Fast algorithm is applied to calculate hertzian contact forces between many sphere particles (from 100,000 to 1,000,000) and NVIDIA’s CUDA is used to accelerate the calculation. Explicit integration method is applied to solve the many spheres. MBD (Multi Body Dynamics) entities are simulated with recursive formulation. Constraints are reduced by recursive formulation and implicit generalized alpha method is applied to solve dynamic model. Many sphere particles and MBD (Multi Body Dynamics) entities are co-simulated within commercial software RecurDyn. The interaction forces between many sphere particles and rigid body mesh are calculated and applied to each body to simulate two parts simultaneously. These models are built and simulated; fork lifter with sand model, oil in oil tank model, oil filled engine system and water filled washing machine model. All models are simulated with NVIDIA’s GPU and the result is shown

Intelligent CCTV Surveillance Based on Sound Recognition and Sound Localization

CCTV is used for many purposes, especially for surveillance and fortraffic condition monitoring. This paper proposesan intelligent CCTV system that tracks sound events based on sound recognition and sound localization. From the experimental results, it is evident that the proposed method can be successfully used for the intelligent CCTV system of CCTV

Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death through Nox1-Regenerated Oxidative Stress

In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death. We found that MMP3 activation causes the induction of Nox1 via mitochondrial reactive oxygen species (ROS) production and subsequently Rac1 activation, eventually leading to Nox1-derived superoxide generation in a rat DA neuronal N27 cells exposed to 6-OHDA. While a MMP3 inhibitor, NNGH, largely attenuated mitochondrial ROS and subsequent Nox1 induction, both apocynin, a putative Nox inhibitor and GKT137831, a Nox1 selective inhibitor failed to reduce 6-OHDA-induced mitochondrial ROS. However, both inhibitors for MMP3 and Nox1 similarly attenuated 6-OHDA-induced N27 cell death. RNAi-mediated selective inhibition of MMP3 or Nox1 showed that knockdown of either MMP3 or Nox1 significantly reduced 6-OHDA-induced ROS generation in N27 cells. While 6-OHDA-induced Nox1 was abolished by MMP3 knockdown, Nox1 knockdown did not alter MMP3 expression. Direct overexpression of autoactivated MMP3 (actMMP3) in N27 cells or in rat substantia nigra (SN) increased expression of Nox1. Selective knockdown of Nox1 in the SN achieved by adeno-associated virus-mediated overexpression of Nox1-specific shRNA largely attenuated the actMMP3-mediated dopaminergic neuronal loss. Furthermore, Nox1 expression was significantly attenuated in Mmp3 null mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Together we established novel molecular mechanisms underlying oxidative stress-mediated dopaminergic neuronal death in which MMP3 activation is a key upstream event that leads to mitochondrial ROS, Nox1 induction and eventual dopaminergic neuronal death. Our findings may lead to the development of novel therapeutic approach

Acupuncture and Moxibustion for Cancer-Related Fatigue: An Overview of Systematic Reviews and Meta-Analysis

Although acupuncture (AT) is used in the treatment of CRF, the evidence from different systematic reviews (SRs) of AT has not yet been comprehensively evaluated. Moxibustion, which is a treatment method that is well established within Traditional East Asian Medicine, applies the heat of burning herbs towards or onto special points on the skin. Commonly, the herb Artemisia vulgaris, is used. It has been used for palliative cancer care, as well as for CRF. The aim of this overview was to evaluate the efficacy of AT and moxibustion in the management of CRF. Eleven databases were searched through for studies that were published from their dates of inception to February 2022. The study selection, the data extraction, and the assessment were performed independently by two researchers. The methodological and report quality were assessed by using the Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) tool. The evidence quality was evaluated by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Fifteen SRs on AT (n = 10) and moxibustion (n = 5) treatments for CRF were included, and they include 169 randomized controlled trials and 14,392 participants. All of the SRs that were evaluated by the AMASTAR-2 had more than one deficiency, and so all of the SRs were rated as either low or critically low. For the GRADE, 18 outcomes were rated as very-low-quality evidence, 13 as low-quality evidence, 3 as moderate-quality evidence, and 0 as high-quality evidence. Most of the SRs reached the potential benefits of AT for CRF. No serious adverse effects were identified. In conclusion, the evidence suggests that, despite the advantages of AT in terms of the improvement in and the safety of the treatment of CRF, the methodological quality of most of these studies is low, which limits our ability to draw definitive meanings. Further research of high quality is needed in order to confirm these findings.T.Y. Choi, L.A., J.H.J. and M.S.L. were supported by the Korea Institute of Oriental Medicine, Korea (KSN2021210). T.A. is the PI of an ongoing study that is funded by a grant from Pink Ribbon, which is a collaboration between The Norwegian Cancer Association and the Breast Cancer Society (Contract no.: 207697-2019). The funder had no role in the study design, the data collection and analysis, the decision to publish, or the preparation of the manuscript.publishedVersio

Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death through Nox1-Regenerated Oxidative Stress

In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death. We found that MMP3 activation causes the induction of Nox1 via mitochondrial reactive oxygen species (ROS) production and subsequently Rac1 activation, eventually leading to Nox1-derived superoxide generation in a rat DA neuronal N27 cells exposed to 6-OHDA. While a MMP3 inhibitor, NNGH, largely attenuated mitochondrial ROS and subsequent Nox1 induction, both apocynin, a putative Nox inhibitor and GKT137831, a Nox1 selective inhibitor failed to reduce 6-OHDA-induced mitochondrial ROS. However, both inhibitors for MMP3 and Nox1 similarly attenuated 6-OHDA-induced N27 cell death. RNAi-mediated selective inhibition of MMP3 or Nox1 showed that knockdown of either MMP3 or Nox1 significantly reduced 6-OHDA-induced ROS generation in N27 cells. While 6-OHDA-induced Nox1 was abolished by MMP3 knockdown, Nox1 knockdown did not alter MMP3 expression. Direct overexpression of autoactivated MMP3 (actMMP3) in N27 cells or in rat substantia nigra (SN) increased expression of Nox1. Selective knockdown of Nox1 in the SN achieved by adeno-associated virus-mediated overexpression of Nox1-specific shRNA largely attenuated the actMMP3-mediated dopaminergic neuronal loss. Furthermore, Nox1 expression was significantly attenuated in Mmp3 null mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Together we established novel molecular mechanisms underlying oxidative stress-mediated dopaminergic neuronal death in which MMP3 activation is a key upstream event that leads to mitochondrial ROS, Nox1 induction and eventual dopaminergic neuronal death. Our findings may lead to the development of novel therapeutic approach

Prediction of the Chemical Composition and Fermentation Parameters of Fresh Coarse Italian Ryegrass Haylage Using Near Infrared Spectroscopy

Italian ryegrass (Lolium multiflorum) is an annual forage grass species which is widely cultivated in South Korea. It grows extensively in the southern part of the country and is an important component of winter forage for livestock. Each year, in Korea, over one million hectares of Italian ryegrass is converted to round bale haylage. Quality control is an important field in forage utilization research and marketing, and involves the estimation of forage nutrient content. Wet chemistry is the traditional method used to analyze the nutrient content of forage. However, this technique is often destructive, expensive, and time consuming, and it is not suitable for real-time feedstuff analysis. Near infrared spectroscopy (NIRS), on the other hand, is an alternative technique that has several major advantages over traditional methods. The analysis of silage nutrient content, using NIR, conventionally includes the drying and milling of samples. However, these processes can lead to reduction of volatile acids, which are important components of silage. NIRS can be affected by spectral regions, drying and grinding methods, particle size, packing density and the temperature of samples (Reeves and Blosser, 1991). In order to obtain accurate NIRS results, sample preparation, and the measurement conditions of the calibration set and predicted samples, need to match. The objectives of this study were to (1) assess the usefulness of NIRS in determining the nutritional composition and fermentative parameters of fresh coarse samples of Italian ryegrass haylage, (2) assess the predictive value of various NIRS calibration models, and (3) explore cost-effective and time saving methods for forage quality estimation, in field populations

Old drug, new findings: colistin resistance and dependence of

Colistin is an old drug, and its use has recently resurged because of increasing antibiotic resistance in gram-negative bacteria such as Acinetobacter baumannii. Although the colistin resistance rates in gram-negative bacteria are currently not high, many colistin-resistant isolates are being identified and the possibility of horizontal transmission of colistin resistance has increased because of the plasmid-borne colistin resistance gene mcr-1 (mobilized colistin resistance). In this review, we have discussed colistin resistance in A. baumannii. In addition, we have reviewed an abnormal phenomenon called colistin dependence in A. baumannii