Formation, Manipulation, and Elasticity Measurement of a Nanometric Column of Water Molecules

Nanometer-sized columns of condensed water molecules are created by an atomic-resolution force microscope operated in ambient conditions. Unusual stepwise decrease of the force gradient associated with the thin water bridge in the tip-substrate gap is observed during its stretch, exhibiting regularity in step heights (~0.5 N/m) and plateau lengths (~1 nm). Such "quantized" elasticity is indicative of the atomic-scale stick-slip at the tip-water interface. A thermodynamic-instability-induced rupture of the water meniscus (5-nm long and 2.6-nm wide) is also found. This work opens a high-resolution study of the structure and the interface dynamics of a nanometric aqueous column.Comment: 4 pages, 3 figure

Polarization Switching Dynamics Governed by Thermodynamic Nucleation Process in Ultrathin Ferroelectric Films

A long standing problem of domain switching process - how domains nucleate - is examined in ultrathin ferroelectric films. We demonstrate that the large depolarization fields in ultrathin films could significantly lower the nucleation energy barrier (U*) to a level comparable to thermal energy (kBT), resulting in power-law like polarization decay behaviors. The "Landauer's paradox": U* is thermally insurmountable is not a critical issue in the polarization switching of ultrathin ferroelectric films. We empirically find a universal relation between the polarization decay behavior and U*/kBT.Comment: 5 pages, 4 figure

Strange meson-nucleon states in the quark potential model

The quark potential model and resonating group method are used to investigate the $\bar{K}N$ bound states and/or resonances. The model potential consists of the t-channel and s-channel one-gluon exchange potentials and the confining potential with incorporating the QCD renormalization correction and the spin-orbital suppression effect in it. It was shown in our previous work that by considering the color octet contribution, use of this model to investigate the $KN$ low energy elastic scattering leads to the results which are in pretty good agreement with the experimental data. In this paper, the same model and method are employed to calculate the masses of the $\bar{K}N$ bound systems. For this purpose, the resonating group equation is transformed into a standard Schr\"odinger equation in which a nonlocal effective $\bar{K}N$ interaction potential is included. Solving the Schr\"odinger equation by the variational method, we are able to reproduce the masses of some currently concerned $\bar{K}N$ states and get a view that these states possibly exist as $\bar{K}N$ molecular states. For the $KN$ system, the same calculation gives no support to the existence of the resonance $\Theta ^{+}(1540)$ which was announced recently.Comment: 15 pages, 4 figure

Test of the Kolmogorov-Johnson-Mehl-Avrami picture of metastable decay in a model with microscopic dynamics

The Kolmogorov-Johnson-Mehl-Avrami (KJMA) theory for the time evolution of the order parameter in systems undergoing first-order phase transformations has been extended by Sekimoto to the level of two-point correlation functions. Here, this extended KJMA theory is applied to a kinetic Ising lattice-gas model, in which the elementary kinetic processes act on microscopic length and time scales. The theoretical framework is used to analyze data from extensive Monte Carlo simulations. The theory is inherently a mesoscopic continuum picture, and in principle it requires a large separation between the microscopic scales and the mesoscopic scales characteristic of the evolving two-phase structure. Nevertheless, we find excellent quantitative agreement with the simulations in a large parameter regime, extending remarkably far towards strong fields (large supersaturations) and correspondingly small nucleation barriers. The original KJMA theory permits direct measurement of the order parameter in the metastable phase, and using the extension to correlation functions one can also perform separate measurements of the nucleation rate and the average velocity of the convoluted interface between the metastable and stable phase regions. The values obtained for all three quantities are verified by other theoretical and computational methods. As these quantities are often difficult to measure directly during a process of phase transformation, data analysis using the extended KJMA theory may provide a useful experimental alternative.Comment: RevTex, 21 pages including 14 ps figures. Submitted to Phys. Rev. B. One misprint corrected in Eq.(C1

Magnetic Vortex Core Reversal by Excitation of Spin Waves

Micron-sized magnetic platelets in the flux closed vortex state are characterized by an in-plane curling magnetization and a nanometer-sized perpendicularly magnetized vortex core. Having the simplest non-trivial configuration, these objects are of general interest to micromagnetics and may offer new routes for spintronics applications. Essential progress in the understanding of nonlinear vortex dynamics was achieved when low-field core toggling by excitation of the gyrotropic eigenmode at sub-GHz frequencies was established. At frequencies more than an order of magnitude higher vortex state structures possess spin wave eigenmodes arising from the magneto-static interaction. Here we demonstrate experimentally that the unidirectional vortex core reversal process also occurs when such azimuthal modes are excited. These results are confirmed by micromagnetic simulations which clearly show the selection rules for this novel reversal mechanism. Our analysis reveals that for spin wave excitation the concept of a critical velocity as the switching condition has to be modified.Comment: Minor corrections and polishing of previous versio

Essential nonlinearities in hearing

Our hearing organ, the cochlea, evidently poises itself at a Hopf bifurcation to maximize tuning and amplification. We show that in this condition several effects are expected to be generic: compression of the dynamic range, infinitely shrap tuning at zero input, and generation of combination tones. These effects are "essentially" nonlinear in that they become more marked the smaller the forcing: there is no audible sound soft enough not to evoke them. All the well-documented nonlinear aspects of hearing therefore appear to be consequences of the same underlying mechanism.Comment: 4 pages, 3 figure

The cis/trans interconversion of the calcium regulating hormone calcitonin is catalyzed by cyclophilin

AbstractThe cytosolic peptidyl-prolyl cis/trans isomerase cyclophilin from pig kidney can accelerate catalytically the cis/trans isomerization of prolyl peptide bonds. One- and two-dimensional 1H NMR spectroscopy was used to prove that the polypeptide hormone calcitonin is a substrate for cyclophilin. Isomerization of only one of the two prolyl peptide bonds is catalyzed significantly. The efficiency of catalysis was calculated by lineshape analysis and NOESY spectroscopy. Cyclosporin A completely blocks the effect of the enzyme on the conformational dynamics of the polypeptide

Plasmoid-Induced-Reconnection and Fractal Reconnection

As a key to undertanding the basic mechanism for fast reconnection in solar flares, plasmoid-induced-reconnection and fractal reconnection are proposed and examined. We first briefly summarize recent solar observations that give us hints on the role of plasmoid (flux rope) ejections in flare energy release. We then discuss the plasmoid-induced-reconnection model, which is an extention of the classical two-ribbon-flare model which we refer to as the CSHKP model. An essential ingredient of the new model is the formation and ejection of a plasmoid which play an essential role in the storage of magnetic energy (by inhibiting reconnection) and the induction of a strong inflow into reconnection region. Using a simple analytical model, we show that the plasmoid ejection and acceleration are closely coupled with the reconnection process, leading to a nonlinear instability for the whole dynamics that determines the macroscopic reconnection rate uniquely. Next we show that the current sheet tends to have a fractal structure via the following process path: tearing, sheet thinning, Sweet- Parker sheet, secondary tearing, further sheet thinning... These processes occur repeatedly at smaller scales until a microscopic plasma scale (either the ion Larmor radius or the ion inertial length) is reached where anomalous resistivity or collisionless reconnection can occur. The current sheet eventually has a fractal structure with many plasmoids (magnetic islands) of different sizes. When these plasmoids are ejected out of the current sheets, fast reconnection occurs at various different scales in a highly time dependent manner. Finally, a scenario is presented for fast reconnection in the solar corona on the basis of above plasmoid-induced-reconnection in a fractal current sheet.Comment: 9 pages, 11 figures, with using eps.sty; Earth, Planets and Space in press; ps-file is also available at http://stesun8.stelab.nagoya-u.ac.jp/~tanuma/study/shibata2001

Biomarker analysis in stage III–IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival

The aim of this study was to analyse the impact of epidermal growth factor receptor (EGFR), thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), aurora kinase (ARK) A/B, and excision repair cross-complementing gene 1 (ERCC1) on the efficacy of adjuvant chemotherapy with 5-fluorouracil and cisplatin (FP) after curative gastric resection. Normal and cancer tissue were separately obtained from gastrectomy samples of 153 patients with AJCC stage III–IV (M0) who subsequently treated with adjuvant FP chemotherapy. TS, DPD, TP, ERCC1, and ARK proteins were measured by immunohistochemistry (IHC). EGFR expression was investigated using a standardized IHC with the EGFR PharmDx assay. Amplification of EGFR gene was analysed using fluorescent in situ hybridisation (FISH). In multivariate analysis, stage, ratio of positive to removed lymph nodes, and EGFR expression were significant prognostic factors for overall survival. Patients with higher EGFR expression had better overall survival than those with lower expression (relative risk: 0.475 (95% confidence interval, 0.282–0.791, P=0.005). Low EGFR expression might be a predictive marker for relapse in curative resected stage III–IV (M0) gastric cancer patients who received adjuvant FP chemotherapy