Citrus Consumption and Risk of Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin

Animal experiments have demonstrated the photocarcinogenic properties of furocoumarins, a group of naturally occurring chemicals that are rich in citrus products. We conducted a prospective study for citrus consumption and risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin based on data from 41530 men in the Health Professionals Follow-up Study (1986–2010) and 63759 women in the Nurses’ Health Study (1984–2010) who were free of cancers at baseline. Over 24–26 years of follow-up, we documented 20840 incident BCCs and 3544 incident SCCs. Compared to those who consumed citrus products less than twice per week, the pooled multivariable-adjusted hazard ratios were 1.03 [95% confidence interval (95% CI): 0.99–1.08] for BCC and 1.14 (95% CI: 1.00–1.30) for SCC for those who consumed two to four times per week, 1.06 (95% CI: 1.01–1.11) for BCC and 1.15 (95% CI: 1.02–1.28) for SCC for five to six times per week, 1.11 (95% CI: 1.06–1.16) for BCC and 1.22 (95% CI: 1.08–1.37) for SCC for once to 1.4 times per day and 1.16 (95% CI: 1.09–1.23) for BCC and 1.21 (95% Cl: 1.06–1.38) for SCC for 1.5 times per day or more (P trend = 0.001 for BCC and 0.04 for SCC). In contrast, consumption of non-citrus fruit and juice appeared to be inversely associated with risk of BCC and SCC. Our findings support positive associations between citrus consumption and risk of cutaneous BCC and SCC in two cohorts of men and women, and call for further investigations to better understand the potential photocarcinogenesis associated with dietary intakes

Too many X′sX's, Y′sY's and Z′sZ's?

A large number of new states have been reported during the last few years in charmonium spectroscopy above the charmed meson production threshold. They have been called $X's$, $Y's$, and $Z's$. We reflect on the influence of thresholds on heavy meson spectroscopy comparing different flavor sectors and quantum numbers. The validity of a quark-model picture above open-flavor thresholds would severely restrict the number of channels that may lodge meson-meson molecules.Comment: 8 pages, 5 figure

A Blow-Up Criterion for Classical Solutions to the Compressible Navier-Stokes Equations

In this paper, we obtain a blow up criterion for classical solutions to the 3-D compressible Naiver-Stokes equations just in terms of the gradient of the velocity, similar to the Beal-Kato-Majda criterion for the ideal incompressible flow. In addition, initial vacuum is allowed in our case.Comment: 25 page

Upper critical magnetic field in Ba_0.68K_0.32Fe_2As_2 and Ba(Fe_0.93Co_0.07)_2As_2

We report measurements of the temperature dependence of the radio-frequency magnetic penetration depth in Ba_0.68K_0.32Fe_2As_2 and Ba(Fe_0.93Co_0.07)_2As_2 single crystals in pulsed magnetic fields up to 60 T. From our data, we construct an H-T phase diagram for the inter-plane (H || c) and in-plane (H || ab) directions for both compounds. For both field orientations in Ba_0.68K_0.32Fe_2As_2, we find a concave curvature of the Hc2(T) lines with decreasing anisotropy and saturation towards lower temperature. Taking into account Pauli spin paramagnetism we can describe Hc2(T) and its anisotropy. In contrast, we find that Pauli paramagnetic pair breaking is not essential for Ba(Fe_0.93Co_0.07)_2As_2. For this electron-doped compound, the data support a Hc2(T) dependence that can be described by the Werthamer Helfand Hohenberg model for H || ab and a two-gap behavior for H || c.Comment: 7 pages, 8 figure

Numerical Renormalization Group Approach to a Quantum Dot Coupled to Normal and Superconducting Leads

We study transport through a quantum dot coupled to normal and superconducting leads using the numerical renormalization group method. We show that the low-energy properties of the system are described by the local Fermi liquid theory despite of the superconducting correlations penetrated into the dot due to a proximity effect. We calculate the linear conductance due to the Andreev reflection in the presence of the Coulomb interaction. It is demonstrated that the maximum structure appearing in the conductance clearly characterizes a crossover between two distinct spin-singlet ground states, i.e. the superconducting singlet state and the Kondo singlet state. It is further elucidated that the gate-voltage dependence of the conductance shows different behavior in the superconducting singlet region from that in the Kondo singlet region.Comment: 10 pages, 6 figures; a typo in eq. (B.5) corrected, which does not affect any other results of the pape

Unitarizable Representations of the Deformed Para-Bose Superalgebra Uq[osp(1/2)] at Roots of 1

The unitarizable irreps of the deformed para-Bose superalgebra $pB_q$, which is isomorphic to $U_q[osp(1/2)]$, are classified at $q$ being root of 1. New finite-dimensional irreps of $U_q[osp(1/2)]$ are found. Explicit expressions for the matrix elements are written down.Comment: 19 pages, PlainTe

Dental students’ learning attitudes and perceptions of YouTube as a lecture video hosting platform in a flipped classroom in Korea

Purpose The aim of this study was to confirm the applicability of YouTube as a delivery platform of lecture videos for dental students and to assess their learning attitudes towards the flipped classroom model. Methods Learning experiences after using the YouTube platform to deliver preliminary video lectures in a flipped classroom were assessed by 69 second-year students (52 males, 17 females) at Dankook University College of Dentistry, Korea, who attended periodontology lectures during 2 consecutive semesters of the 2016 academic year. The instructor uploaded the lecture videos to YouTube before each class. At the end of the second semester, the students were surveyed using a questionnaire devised by the authors. Results Of the students, 53 (76.8%) always watched the lecture before the class, 48 (69.6%) used their smartphones, and 66 (95.7%) stated that they watched the lectures at home. The majority of the students replied that the video lectures were easier to understand than face to face lectures (82.6%) and that they would like to view the videos again after graduation (73.9%). Conclusion Our results indicate that YouTube is an applicable platform to deliver video lectures and to expose students to increased learning opportunities

The effect of voluntary IFRS adoption by unlisted fi rms on earnings quality and the cost of debt: empirical evidence from Korea

The present study empirically examines how voluntary International Financial Reporting Standards (IFRS) adoption influences the earnings quality and the cost of debt of unlisted firms in Korea. Since 2011, when the adoption of IFRS by listed firms became mandatory, more unlisted firms have adopted IFRS voluntarily, improving the transparency and reliability of their accounting information. Using the sample of unlisted firms with 3year study period of preand post-IFRS adoption, we examine whether IFRS voluntary adopters show both lower discretionary accruals and the cost of debt than those of non adopters, and whether both discretionary accruals and the cost of debt of voluntary adopters decrease after IFRS adoption. We employ the Heckman's two stage approach in order to avoid sample selection bias and cross sectional pooled OLS regression with or without clustering test. We complimentary report the results from firm-fixed effect panel model to generalise the results. The results show that firms which adopt IFRS have a higher earnings quality and a lower cost of debt that those which do not. These findings suggest that when unlisted firms issue bonds and borrow money, IFRS adoption contributes to decreasing the cost of debt

Role of Amphipathic Helix of a Herpesviral Protein in Membrane Deformation and T Cell Receptor Downregulation

Lipid rafts are membrane microdomains that function as platforms for signal transduction and membrane trafficking. Tyrosine kinase interacting protein (Tip) of T lymphotropic Herpesvirus saimiri (HVS) is targeted to lipid rafts in T cells and downregulates TCR and CD4 surface expression. Here, we report that the membrane-proximal amphipathic helix preceding Tip's transmembrane (TM) domain mediates lipid raft localization and membrane deformation. In turn, this motif directs Tip's lysosomal trafficking and selective TCR downregulation. The amphipathic helix binds to the negatively charged lipids and induces liposome tubulation, the TM domain mediates oligomerization, and cooperation of the membrane-proximal helix with the TM domain is sufficient for localization to lipid rafts and lysosomal compartments, especially the mutivesicular bodies. These findings suggest that the membrane-proximal amphipathic helix and TM domain provide HVS Tip with the unique ability to deform the cellular membranes in lipid rafts and to downregulate TCRs potentially through MVB formation