Geophysical Survey in Sub-Saharan Africa: magnetic and Electromagnetic Investigation of the UNESCO World Heritage Site of Songo Mnara, Tanzania

Magnetometry and Slingram electromagnetic surveys were conducted at the UNESCO World Heritage Site of Songo Mnara, Tanzania, as part of a multi-national programme of investigation to examine the uses of space within and outside of this stonetown. The town was a major Islamic trading port during the 14th and 15th centuries.The surveys detected significant evidence for the containment of activities within the town walls, and previously unknown anthropogenic activity was revealed between the existing coral rag buildings, as well as within the open areas inside the town. Over 40 areas of magnetic disturbance were identified that corresponded directly with areas of high magnetic susceptibility in the Slingram electromagnetic in-phase responses.On excavation many of these anomalies were found to correlate with wattle and daub structures, indicating a hitherto unidentified population, and the location of the anomalies also suggests a potentially deliberate delineation of space within the open areas of the stonetown. The combined results of the three geophysical data sets indicate that there are clear delineations in the use of space within Songo Mnara. This coupled with the presence of industrial activities and evidence of more ephemeral occupation, neither of which had previously been recorded at the site, indicates that the pre-existing town plan is in need of significant reappraisal. The current plan, based upon the remains of extant and collapsed coral buildings, can now be updated to incorporate the more ephemeral aspects of Swahili sites including activity areas, and notably, the homes of the ‘hidden majority’of the population.The results establish the benefit of a combined approach at these sites, and demonstrate that further invasive and non-invasive exploration is required in order to fully exploit the significance of the role of geophysical techniques in understanding Swahili towns

How universal is the fractional-quantum-Hall edge Luttinger liquid?

This article reports on our microscopic investigations of the edge of the fractional quantum Hall state at filling factor $\nu=1/3$. We show that the interaction dependence of the wave function is well described in an approximation that includes mixing with higher composite-fermion Landau levels in the lowest order. We then proceed to calculate the equal time edge Green function, which provides evidence that the Luttinger exponent characterizing the decay of the Green function at long distances is interaction dependent. The relevance of this result to tunneling experiments is discussed.Comment: 5 page

The 'four principles of bioethics' as found in 13(th) century Muslim scholar Mawlana's teachings

BACKGROUND: There have been different ethical approaches to the issues in the history of philosophy. Two American philosophers Beachump and Childress formulated some ethical principles namely 'respect to autonomy', 'justice', 'beneficence' and 'non-maleficence'. These 'Four Principles' were presented by the authors as universal and applicable to any culture and society. Mawlana, a great figure in Sufi tradition, had written many books which not only guide people how to worship God to be close to Him, but also advise people how to lead a good life to enrich their personality, as well as to create a harmonious society and a peaceful world. METHODS: In this study we examined the major works of Mawlana to find out which of these 'Four Principles of Bioethics' exist in Mawlana's ethical understanding. RESULTS: We have found in our study that all these principles exist in Mawlana's writings and philosophy in one form or another. CONCLUSIONS: We have concluded that, further to Beachump and Childress' claim that these principles are universal and applicable to any culture and society, these principles have always existed in different moral traditions in different ways, of which Mawlana's teaching might be presented as a good example

Mapping the Archaeology of Somaliland: Religion, Art, Script, Time, Urbanism, Trade and Empire

FdA – Publicaties zonder aanstelling Universiteit LeidenHeritage of Indigenous People

The elusive archaeology of Kongo urbanism: the case of Kindoki, Mbanza Nsundi (Lower Congo, DRC)

We present here results, analyses and an in-depth historical contextualisation of the fieldwork undertaken in 2012 and 2013 at the Kindoki site in the Lower Congo (DRC). This site is linked with Mbanza Nsundi, one of the Kongo Kingdom's provincial capitals, which turns out to be archaeologically 'elusive'. Pinpointing its location proved to be particularly challenging. To this end, a historically-informed excavation methodology was developed that was never implemented in Central Africa before. We combined a strategy of systematic test pits with a large-scale 50 m grid approach. A cemetery was identified on Kindoki Hill with distinct but contemporaneous quarters of a 16th-17thcenturies settlement on both sides. The cemetery itself contains mainly 18th-century burials, in all likelihood of successive Nsundi rulers. The foreign, especially Portuguese, ceramics excavated on the hilltop and the hundreds of Venetian and likely Bavarian beads found in the graves are indicative of Mbanza Nsundi's connection to trade routes linking the Atlantic coast with the Pool region. The most striking discovery is that of a previously unknown type of comb-impressed pottery, from a pit with a calibrated radiocarbon date AD 1294-1393 (2 sigma). This suggests that a settlement had been developing at Kindoki since at least the 14th century, which allows us, for the very first time, to spatially bridge Kongo history and 'prehistory'. For the entire Lower Congo region only three 14C dates posterior to AD 1000 were available before the start of the KongoKing project, twelve have been added for just Kindoki

Humanized Mice Recapitulate Key Features of HIV-1 Infection: A Novel Concept Using Long-Acting Anti-Retroviral Drugs for Treating HIV-1

BACKGROUND: Humanized mice generate a lymphoid system of human origin subsequent to transplantation of human CD34+ cells and thus are highly susceptible to HIV infection. Here we examined the efficacy of antiretroviral treatment (ART) when added to food pellets, and of long-acting (LA) antiretroviral compounds, either as monotherapy or in combination. These studies shall be inspiring for establishing a gold standard of ART, which is easy to administer and well supported by the mice, and for subsequent studies such as latency. Furthermore, they should disclose whether viral breakthrough and emergence of resistance occurs similar as in HIV-infected patients when ART is insufficient. METHODS/PRINCIPAL FINDINGS: NOD/shi-scid/γ(c)null (NOG) mice were used in all experimentations. We first performed pharmacokinetic studies of the drugs used, either added to food pellets (AZT, TDF, 3TC, RTV) or in a LA formulation that permitted once weekly subcutaneous administration (TMC278: non-nucleoside reverse transcriptase inhibitor, TMC181: protease inhibitor). A combination of 3TC, TDF and TMC278-LA or 3TC, TDF, TMC278-LA and TMC181-LA suppressed the viral load to undetectable levels in 15/19 (79%) and 14/14 (100%) mice, respectively. In successfully treated mice, subsequent monotherapy with TMC278-LA resulted in viral breakthrough; in contrast, the two LA compounds together prevented viral breakthrough. Resistance mutations matched the mutations most commonly observed in HIV patients failing therapy. Importantly, viral rebound after interruption of ART, presence of HIV DNA in successfully treated mice and in vitro reactivation of early HIV transcripts point to an existing latent HIV reservoir. CONCLUSIONS/SIGNIFICANCE: This report is a unique description of multiple aspects of HIV infection in humanized mice that comprised efficacy testing of various treatment regimens, including LA compounds, resistance mutation analysis as well as viral rebound after treatment interruption. Humanized mice will be highly valuable for exploring the antiviral potency of new compounds or compounds targeting the latent HIV reservoir