A Critical Assessment of Occluded Fronts

The aim of this work was the assessment about the structure and use of the conceptual model of occlusion in operational weather forecasting. In the beginning a survey has been made about the conceptual model of occlusion as introduced to operational forecasters in the Finnish Meteorological Institute (FMI). In the same context an overview has been performed about the use of the conceptual model in modern operational weather forecasting, especially in connection with the widespread use of numerical forecasts. In order to evaluate the features of the occlusions in operational weather forecasting, all the occlusion processes occurring during year 2003 over Europe and Northern Atlantic area have been investigated using the conceptual model of occlusion and the methods suggested in the FMI. The investigation has yielded a classification of the occluded cyclones on the basis of the extent the conceptual model has fitted the description of the observed thermal structure. The seasonal and geographical distribution of the classes has been inspected. Some relevant cases belonging to different classes have been collected and analyzed in detail: in this deeper investigation tools and techniques, which are not routinely used in operational weather forecasting, have been adopted. Both the statistical investigation of the occluded cyclones during year 2003 and the case studies have revealed that the traditional classification of the types of the occlusion on the basis of the thermal structure doesn’t take into account the bigger variety of occlusion structures which can be observed. Moreover the conceptual model of occlusion has turned out to be often inadequate in describing well developed cyclones. A deep and constructive revision of the conceptual model of occlusion is therefore suggested in light of the result obtained in this work. The revision should take into account both the progresses which are being made in building a theoretical footing for the occlusion process and the recent tools and meteorological quantities which are nowadays available

Numerical Drop Test of a Full Composite Fuselage Section Having Two Components of Velocity

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Error Field and Correction Coils in DTT: a preliminary analysis

The Divertor Tokamak Test (DTT) facility, construction starting at Frascati, Italy, is designed to test different solutions for divertor in view of DEMO. A preliminary analysis of the error fields (EFs) assumed a simplified model of rigid and independent displacements and rotations. A methodology based on the first order truncated Taylor expansion has been applied, linking the displacement parameters and the EFs within the required accuracies. A system of in-vessel copper coils has been designed to counteract EFs and the ampere-turns necessary to force them back within the request limits has been calculated. Here, the details of the analysis have been provided

MINOCA Associated with a Myocardial Bridge: Pathogenesis, Diagnosis and Treatment

Myocardial bridging (MB) is the most frequent congenital coronary anomaly characterized by a segment of an epicardial coronary artery that passes through the myocardium. MB is an important cause of myocardial ischemia and is also emerging as a possible cause of myocardial infarction with non-obstructed coronary arteries (MINOCA). There are multiple mechanisms underlying MINOCA in patients with MB (i.e., MB-mediated increased risk of epicardial or microvascular coronary spasm, atherosclerotic plaque disruption and spontaneous coronary artery dissection). The identification of the exact pathogenetic mechanism is crucial in order to establish a patient-tailored therapy. This review provides the most up-to-date evidence regarding the pathophysiology of MINOCA in patients with MB. Moreover, it focuses on the available diagnostic tools that could be implemented at the time of coronary angiography to achieve a pathophysiologic diagnosis. Finally, it focuses on the therapeutic implications associated with the different pathogenetic mechanisms of MINOCA in patients with MB

The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males

The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNFα production was demonstrated in HEK293 cells transfected with TLR3L412F-encoding plasmid and stimulated with specific agonist poly(I:C). A statistically significant reduced survival at 28 days was shown in L412F COVID-19 patients treated with the autophagy-inhibitor hydroxychloroquine (p = 0.038). An increased frequency of autoimmune disorders such as co-morbidity was found in L412F COVID-19 males with specific class II HLA haplotypes prone to autoantigen presentation. Our analyses indicate that L412F polymorphism makes males at risk of severe COVID-19 and provides a rationale for reinterpreting clinical trials considering autophagy pathways. Abbreviations: AP: autophagosome; AUC: area under the curve; BafA1: bafilomycin A1; COVID-19: coronavirus disease-2019; HCQ: hydroxychloroquine; RAP: rapamycin; ROC: receiver operating characteristic; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; TLR: toll like receptor; TNF/TNF-α: tumor necrosis factor

A method to compute the impact of iron parts and external fields on the low frequency magnetic sensors in smart devices

Many devices for the smart mobility make use of low frequency magnetic sensors to determine the alignment of the device with respect to the earth field. In highly manned areas, the presence of meaningful disturbance fields must be expected and as much as possible counteracted. Typical sources of disturbances are metallic parts or AC power lines, possibly carrying spurious current harmonics induced by rectifiers. Numerical analysis is hard also when the environment is known since the numerical computation requires meshing of complex 3D structures and non-linear problems resolution. In this paper, a numerical model able to treat, in a fast but accurate way, such complex 3D nonlinear problems is applied to estimate the impact of disturbing fields on the magnetic measurement of the device alignment

A Design Approach for 3D Shimming

Active magnetic shielding of finite domains benefits of a direct effective solution based on the concept of stream function on the domain boundary. In linear systems the solution is flexible and effective when the geometry admits decomposition in eigenfunctions. The paper extends the approach to more complex geometries, by introducing an intermediation domain where the eigenfunctions are available in analytical form