Quantum phase slips in superconducting Nb nanowire networks deposited on self-assembled Si templates

Robust porous silicon substrates were employed for generating interconnected networks of superconducting ultrathin Nb nanowires. Scanning electron microscopy analysis was performed to investigate the morphology of the samples, which constitute of polycrystalline single wires with grain size of about 10 nm. The samples exhibit nonzero resistance over a broad temperature range below the critical temperature, fingerprint of phase slippage processes. The transport data are satisfactory reproduced by models describing both thermal and quantum fluctuations of the superconducting order parameter in thin homogeneous superconducting wires.Comment: accepted for publication on Applied Physics Letter

On numerical solution of Fredholm and Hammerstein integral equations via Nystr\"{o}m method and Gaussian quadrature rules for splines

Nystr\"{o}m method is a standard numerical technique to solve Fredholm integral equations of the second kind where the integration of the kernel is approximated using a quadrature formula. Traditionally, the quadrature rule used is the classical polynomial Gauss quadrature. Motivated by the observation that a given function can be better approximated by a spline function of a lower degree than a single polynomial piece of a higher degree, in this work, we investigate the use of Gaussian rules for splines in the Nystr\"{o}m method. We show that, for continuous kernels, the approximate solution of linear Fredholm integral equations computed using spline Gaussian quadrature rules converges to the exact solution for $m \rightarrow \infty$, $m$ being the number of quadrature points. Our numerical results also show that, when fixing the same number of quadrature points, the approximation is more accurate using spline Gaussian rules than using the classical polynomial Gauss rules. We also investigate the non-linear case, considering Hammerstein integral equations, and present some numerical tests.RYC-2017-2264

Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ

Nucleophosmin (NPM1) is a multifunctional nucleolar protein implicated in ribogenesis, centrosome duplication, cell cycle control, regulation of DNA repair and apoptotic response to stress stimuli. The majority of these functions are played through the interactions with a variety of protein partners. NPM1 is frequently overexpressed in solid tumors of different histological origin. Furthermore NPM1 is the most frequently mutated protein in acute myeloid leukemia (AML) patients. Mutations map to the C-terminal domain and lead to the aberrant and stable localization of the protein in the cytoplasm of leukemic blasts. Among NPM1 protein partners, a pivotal role is played by the tumor suppressor Fbw7γ, an E3-ubiquitin ligase that degrades oncoproteins like c-MYC, cyclin E, Notch and c-jun. In AML with NPM1 mutations, Fbw7γ is degraded following its abnormal cytosolic delocalization by mutated NPM1. This mechanism also applies to other tumor suppressors and it has been suggested that it may play a key role in leukemogenesis. Here we analyse the interaction between NPM1 and Fbw7γ, by identifying the protein surfaces implicated in recognition and key aminoacids involved. Based on the results of computational methods, we propose a structural model for the interaction, which is substantiated by experimental findings on several site-directed mutants. We also extend the analysis to two other NPM1 partners (HIV Tat and CENP-W) and conclude that NPM1 uses the same molecular surface as a platform for recognizing different protein partners. We suggest that this region of NPM1 may be targeted for cancer treatment

Quantum Field Theory of Forward Rates with Stochastic Volatility

In a recent formulation of a quantum field theory of forward rates, the volatility of the forward rates was taken to be deterministic. The field theory of the forward rates is generalized to the case of stochastic volatility. Two cases are analyzed, firstly when volatility is taken to be a function of the forward rates, and secondly when volatility is taken to be an independent quantum field. Since volatiltiy is a positive valued quantum field, the full theory turns out to be an interacting nonlinear quantum field theory in two dimensions. The state space and Hamiltonian for the interacting theory are obtained, and shown to have a nontrivial structure due to the manifold moving with a constant velocity. The no arbitrage condition is reformulated in terms of the Hamiltonian of the system, and then exactly solved for the nonlinear interacting case.Comment: 7 Figure

Wet Chemical Method for Making Graphene-like Films from Carbon Black

Reduction of strongly oxidized carbon black by hydrazine hydrate yields water-insoluble graphene-like sheets that undergo to self-assembling in thin film on surfaces after drying. The height of a drop-casted graphene-like film was determined by atomic force microscopy (AFM) to be around 20 nm, corresponding to approximately 25 graphene-like layers. The oxidized carbon black and the corresponding reduced form were carefully characterized

Modeling house price dynamics with heterogeneous speculators

This paper investigates the impact of speculative behavior on house price dynamics. Speculative demand for housing is modeled using a heterogeneous agent approach, whereas ‘real’ demand and housing supply are represented in a standard way. Together, real and speculative forces determine excess demand in each period and house price adjustments. Three alternative models are proposed, capturing in different ways the interplay between fundamental trading rules and extrapolative trading rules, resulting in a 2D, a 3D, and a 4D nonlinear discretetime dynamical system, respectively. While the destabilizing effect of speculative behavior on the model’s steady state is proven in general, the three specific cases illustrate a variety of situations that can bring about endogenous dynamics, with lasting and significant price swings around the ‘fundamental ’ price, as we have seen in many real markets

The impact of the method of consent on response rates in the ISAAC time trends study.

BACKGROUND: Centres in Phases I and III of the International Study of Asthma and Allergies in Childhood (ISAAC) programme used the method of consent (passive or active) required by local ethics committees. METHODS: Retrospectively, relationships between achieved response rates and method of consent for 13-14 and 6-7-year-olds (adolescents and children, respectively), were examined between phases and between English and non-English language centres. RESULTS: Information was obtained for 113 of 115 centres for adolescents and 72/72 centres for children. Both age groups: most centres using passive consent achieved high response rates (>80% adolescents and >70% children). English language centres using active consent showed a larger decrease in response rate. Adolescents: seven centres changed from passive consent in Phase I to active consent in Phase III (median decrease of 13%), with five centres showing lower response rates (as low as 34%). Children: no centre changed consent method between phases. Centres using active consent had lower median response rates (lowest response rate 45%). CONCLUSION: The requirement for active consent for population school-based questionnaire studies can impact negatively on response rates, particularly English language centres, thus adversely affecting the validity of the data. Ethics committees need to consider this issue carefully.Revisión por pare

The ATLAS discovery potential for MSSM neutral Higgs bosons decaying to a mu+mu- pair in the mass range up to 130 GeV

Results are presented on the discovery potential for MSSM neutral Higgs bosons in the Mh-{max}scenario. The region of large tan beta, between 15 and 50, and mass between ~ 95 and 130 GeV is considered in the framework of the ATLAS experiment at the Large Hadron Collider (LHC), for a centre-of-mass energy = 14 TeV. This parameter region is not fully covered by the present data either from LEP or from Tevatron. The h/A bosons, supposed to be very close in mass in that region, are studied in the channel h/A -> mu+mu- accompanied by two b-jets. The study includes a method to control the most copious background, Zo -> mu+mu- accompanied by two b-jets. A possible contribution of the H boson to the signal is also considered

Anatomy of a mixed bioclastic–siliciclastic regressive tidal sand ridge: Facies-based case study from the lower Pleistocene Siderno Strait, southern Italy

Sand ridges, a common feature of modern open shelves, reflect persistent currents and sediment availability under recent transgressive conditions. They represent the largest bedforms in the oceans and, as such, can yield information on long-term oceanographic processes. However, there is a limited number of tidal sand ridges documented from the rock record, examples of regressive tidal sand ridges are scarce and studies describing ridges in straits are even more rare. This study analyses a Gelasian succession within a structurally controlled, tide-dominated strait in the Siderno Basin, southern Italy. The strait connected two wider basins, and accumulated sediments reworked by amplified tidal (bi-directional) currents. A series of tidal sand ridges with superimposed dunes developed close to the south-eastern end of the strait, where bathymetry was deeper and flow expansion occurred. One of the best-exposed tidal sand ridges, 65 m thick, crops out along a ca 2 km long cliff. Large-scale, ESE-prograding, seaward-offlapping shingles contain sets of bioclastic–siliciclastic, coarse-grained, cross-stratified sandstones, erosionally overlying upper Pliocene shelf marls and fine-grained sandstones. Cross-strata show angular, tangential and sigmoidal foresets with compound architectures and a SSE migration, i.e. oblique to the main growth direction. Fossil content indicates open-marine conditions. The succession changes abruptly across an erosion surface to non-tidal, highly burrowed mixed siliciclastic–bioclastic fine-grained sandstones, less than 15 m thick. Documented features reflect stages of nucleation, active accretion and abandonment of an individual sand ridge, during a complete cycle of relative sea-level change. The ridge formed during a phase of normal regression, with accretion occurring during an initial highstand and the ensuing falling stage. During the lowstand the ridge was split into several minor bodies by enhanced tidal currents. The ensuing transgression draped the moribund ridge with tabular strata, whereas final highstand shelf sedimentation reworked the top of the underlying sand body with weak currents