Beneath the City: Unearthing Naples' Archaeological Underground for New Urban Continuity

This study explores the potential of connecting the visible cityscape with concealed subterranean spaces, aiming to reshape urban continuity. It departs from the traditional perception of underground areas as purely technical domains, seeking fresh perspectives on inhabiting these concealed environments. Using three Naples locations as case studies, we develop a methodology applicable to similar urban contexts, emphasizing the archaeological underground's ability to trigger socio-economic transformations. Accordingly, it advocates for deliberate design interventions to reintegrate the archaeological underground into contemporary urban dynamics, offering strategies to redefine the relationship between city dwellers and their urban environment. Through case studies and visual representations, the study presents design solutions that enhance the use of subterranean spaces, fostering accessibility, community engagement, and cultural preservation. These initiatives promote enduring economic sustainability, potentially benefiting other cities facing similar challenges, and creating a harmonious connection between archaeological underground layers and the modern urban fabric. In summary, this research underscores the vast potential of subterranean spaces for future urban development, requiring innovative methodologies and technological integration to shape a unified and adaptable cityscape

The Bell Jar di Sylvia Plath: tracce di una mitologia

L'obiettivo della suddetta tesi è quello di dimostrare, attraverso l'analisi del romanzo The Bell Jar, come l'arte di Sylvia Plath si snodi e si sviluppi attraverso l'uso ricorrente di immagini, simboli e isotopie che creano una vera e propria mitologia. In virtù di questo le poesie e le opere in prosa possono essere considerate come singole parti di un'unica grande opera mitologica, il cui fine è quello di narrare un processo simbolico di morte e rinascita

Vowel variability and contrast in Childhood Apraxia of Speech: acoustics and articulation

none5noPhoneme production may be affected by limited speech motor control in Childhood Apraxia of Speech (CAS), with a general instability of acoustic targets across multiple repetitions of speech stimuli. This acoustic and Ultrasound Tongue Imaging (UTI) study shows that increased variability and reduction of contrast in vowel production is found in native Italian speakers with CAS, particularly as far as the height dimension is concerned. The data suggest that vowel production should play a major role in CAS diagnosis and treatment. Moreover, this study shows that a combined acoustic and articulatory approach allows direct observation of lingual dynamics together with an estimation of changes in the acoustic dimension. The two dimensions are shown not to correspond in a straightforward way in the speech of children with CAS, and encourage consideration of articulatory compensation strategies aimed at saving the acoustic identity of vowels.openLenoci, Giovanna; Celata, Chiara; Ricci, Irene; Chilosi, Anna; Barone, VincenzoLenoci, Giovanna; Celata, Chiara; Ricci, Irene; Chilosi, Anna; Barone, Vincenz

Etude de l'efficacité d'un humain avec une canne

International audienceThis paper proposes a mathematical model of the walking with canes for an anthropomorphic biped with two identical legs with massless feet, two identical arms, and a torso. The walking is performed in the sagittal plane. The walking gait, which is cyclic, is composed of single support (SS) phases and impacts. The period of this cyclic walking is determined by the stride, because the motion of coupled arms is synchronized on this stride. The cane is considered massless. Thus in order to compare the walking with and without massless cane, the dynamic dynamic. Numerical tests show that the magnitude of the ground reaction in the stance foot is less with a massless-cane assistance than without one. Especially, the results prove that it is better to use canes with a handle

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain, prior and after the development of Alzheimer Disease (AD). The aberrant modulation of the mTOR signalling in DS and AD age-related cognitive decline affects crucial neuronal pathways, including insulin signaling and autophagy, involved in pathology onset and progression. Within this context, the therapeutic use of mTOR-inhibitors may prevent/attenuate the neurodegenerative phenomena. By our work we aimed to rescue mTOR signalling in DS mice by a novel rapamycin intranasal administration protocol (InRapa) that maximizes brain delivery and reduce systemic side effects. Methods: Ts65Dn mice were administered with InRapa for 12 weeks, starting at 6 months of age demonstrating, at the end of the treatment by radial arms maze and novel object recognition testing, rescued cognition. Results: The analysis of mTOR signalling, after InRapa, demonstrated in Ts65Dn mice hippocampus the inhibition of mTOR (reduced to physiological levels), which led, through the rescue of autophagy and insulin signalling, to reduced APP levels, APP processing and APP metabolites production, as well as, to reduced tau hyperphosphorylation. In addition, a reduction of oxidative stress markers was also observed. Discussion: These findings demonstrate that chronic InRapa administration is able to exert a neuroprotective effect on Ts65Dn hippocampus by reducing AD pathological hallmarks and by restoring protein homeostasis, thus ultimately resulting in improved cognition. Results are discussed in term of a potential novel targeted therapeutic approach to reduce cognitive decline and AD-like neuropathology in DS individuals

Derivative securities in risk management and asset pricing

The high informational content and the ease of accessibility are among the most attractive features which make derivative securities particularly useful in financial applications. With a special focus on risk management and asset pricing, I present several methodologies which involve the use of option and futures data in the estimation process. This doctoral thesis consists of three chapters. The first one, “Forward-looking VaR and CVaR: an application to the Natural gas Market”, presents, backtests and compares point risk forecasts for the natural gas market using a novel methodology which introduces derivative securities into a classical calibration setting. The second chapter, “A Bayesian Estimate of the Pricing Kernel”, is a joint work with G. Barone-Adesi and A. Mira. The article sets the pricing kernel estimation into a Bayesian framework, which enables to combine the use of derivative and historical data in the physical density calibration. Thanks to their higher accuracy and flexibility, the resulting pricing kernel estimates display a monotonic decreasing shape over a large range of returns, consistently with the classical theory. The third chapter, “S&P 500 Index, an Option-Implied Risk Analysis”, is a joint work with G. Barone-Adesi and C. Sala. Tested on the US equity market, the article presents a detailed analysis on the performance of the option-implied risk metrics both in absolute terms and relative to the existing historical-based risk metrics

Clinical presentation and treatment of Wilson's disease: a single-centreexperience

Thirty patients with Wilson's disease (WD) were observed at a movement disorder clinic between 1970 and 2000. Disease onset was at the mean age (SD) of 14.5 (+/-5.9) years. Presentation with hepatic disease occurred in 12 of 30 patients and with neurologic disease in 15. Three patients were asymptomatic at the time of diagnosis. The mean (SD) delay to diagnosis was 5.9 (+/-5.7) years. Five patients diagnosed in an advanced stage of disease died before initiating treatment. Eighteen patients were followed and treated with D-penicillamine alone or in combination with zinc sulphate. Treatment improved most of neurological symptoms. Dystonic postures, behavioural disturbances and dysarthria were the most resistant neurological signs. 'Pseudo-sclerotic' neurologic involvement predicted a good outcome, whereas hepatic onset and 'classic' neurologic involvement were associated with a poorer prognosis. Two of the 18 treated patients died of hepatic failure due to voluntary discontinuation of therapy. Both D-penicillamine and zinc sulphate were well tolerated. No teratogenic effect of D-penicillamine was observed throughout 5 pregnancies. Our results suggest that D-penicillamine or a combination of D-penicillamine and zinc sulphate is a safe and effective long-term treatment in patients with WD

XENOGENEIC DERMAL MATRIX VERSUS AUTOLOGOUS CONNECTIVE TISSUE GRAFT VERSUS NO GRAFT AT ABUTMENT CONNECTION FOR IMPROVING AESTHETICS: 6-MONTH OUTCOMES OF A RANDOMISED CONTROLLED TRIAL

OBJECTIVES. The aim of this multicentre randomised controlled trial was to evaluate the efficacy of a xenogeneic dermal matrix in widening keratinised peri-implant tissues du-ring second-stage surgery, and to compare it to both autologous connective tissue graft and a control group with no augmentation. MATERIAL AND METHODS. Patients requiring an increase in keratinised gingiva width were enrolled by four university/dental practices and randomised into three different groups for grafting procedures at the implant uncovering stage: either xenogeneic dermal matrix (Group X), autologous connective tissue graft (Group A) or no graft (control, Group C). The primary outcomes were width of keratinised tissue and facial soft tissue levels, evaluated at three different time points (T0, implant uncovering stage; T1 and T2, six weeks and six months after surgery, respectively). Secondary outcomes were: implant failure, complications, marginal bone loss, papilla index, facial soft tissue level, pink esthetic score, and aesthetic assessment by patients. RESULTS. Thirty-six patients, with one implant per patient, were enrolled at two centres (18 at each centre): 12 for control, 12 for xenogeneic dermal matrix and 12 for autologous tissue graft. Three patients dropped out and two patients from the autologous group had implant failures. No complications were recorded. After six months, the width of keratini-sed tissue increased by 0.16 ± 1.01 (P = 0.79), 1.05 ± 0.76 (P = 0.01) and 0.80 ± 1.73 mm (P = 0.28), and facial soft tissue level was-0.95 ± 0.85 (P = 0.04), 0.32 ± 0.57 (P = 0.15) and 0.35 ± 0.79 mm (P = 0.30) respectively in Groups C, X and A groups. Between-group analysis showed that, with respect to control, only facial soft tissue level (1.31 mm, P = 0.01) and width of keratinised mucosa (2.43 mm, P = 0.01) outcomes in the autologous graft group were statistically significant at T2. Mean marginal bone loss between T0-T2 was-0.4 ± 0.4mm, with no differences between groups. Pink aesthetic score showed no significant differences between groups, being 0.89 for A-C (P = 0.41), 0.88 for A–X (P = 0.63) and 0.72 for X-C (P = 0.88). Patient’s aesthetic satisfaction (Visual Analogue Scale) was 92.2 ± 8.4, 93.8 ± 7.7, 97.2 ± 3.0, for Groups C, X and A, respectively. Between the two dental centres, only facial soft tissue level at T0–T2 was significantly different, by 0.67 ± 0.62 mm (P = 0.03). CONCLUSIONS. After six months, autologous connective tissue graft yielded a significant gain in facial soft tissue levels and width of keratinised mucosa, as compared to the control group (no graft)