Genetic determinants of pre-eclampsia: HLA-G and KIR2DL4 alleles/haplotypes and risk of pre-eclampsia in a malay population

Master'sMASTER OF SCIENC

Characterization of the Cellular response to Hypoxia

Ph.DDOCTOR OF PHILOSOPH

A Customized Reconfiguration Controller with Remote Direct ICAP Access for Dynamically Reconfigurable Platform

As FPGA dynamic partial reconfiguration getting into mainstream, design of reconfiguration controller becomes an active research. Most of the existing reconfiguration controllers support only the loading of partial bitstream into configuration memory without allowing user to access ICAP directly, which can provide user higher controllability over the reconfigurable device. This paper presents the architecture of a customized reconfiguration controller with remote direct ICAP access. Remote direct ICAP access allows user to configure or readback device internal registers, which offer user higher controllability over the reconfigurable device. Additionally, the proposed reconfiguration controller achieved at least 3.19 Gbps of reconfiguration throughput, which reduces the platform service downtime during dynamic partial reconfiguration. In order to reduce the latency and transmission overhead of remote functional update, partial bitstream is compressed with run-length encoding before transmission

An FPGA-based network system with service-uninterrupted remote functional update

The recent emergence of 5G network enables mass wireless sensors deployment for internet-of-things (IoT) applications. In many cases, IoT sensors in monitoring and data collection applications are required to operate continuously and active at all time (24/7) to ensure all data are sampled without loss. Field-programmable gate array (FPGA)-based systems exhibit a balanced processing throughput and datapath flexibility. Specifically, datapath flexibility is acquired from the FPGA-based system architecture that supports dynamic partial reconfiguration feature. However, device functional update can cause interruption to the application servicing, especially in an FPGA-based system. This paper presents a standalone FPGA-based system architecture that allows remote functional update without causing service interruption by adopting a redundancy mechanism in the application datapath. By utilizing dynamic partial reconfiguration, only the updating datapath is temporarily inactive while the rest of the circuitry, including the redundant datapath, remain active. Hence, there is no service interruption and downtime when a remote functional update takes place due to the existence of redundant application datapath, which is critical for network and communication systems. The proposed architecture has a significant impact for application in FPGA-based systems that have little or no tolerance in service interruption

Accelerating Extreme Learning Machine on FPGA by Hardware Implementation of Given Rotation - QRD

Currently, Extreme Learning Machine (ELM) is one of the research trends in the machine learning field due to its remarkable performances in terms of complexity and computational speed. However, the big data era and the limitations of general-purpose processor cause the increasing of interest in hardware implementation of ELM in order to reduce the computational time. Hence, this work presents the hardware-software co-design of ELM to improve the overall performances. In the co-design paradigm, one of the important components of ELM, namely Given Rotation-QRD (GR-QRD) is developed as a hardware core. Field Programmable Gate Array (FPGA) is chosen as the platform for ELM implementation due to its reconfigurable capability and high parallelism. Moreover, the learning accuracy and computational time would be used to evaluate the performances of the proposed ELM design. Our experiment has shown that GR-QRD accelerator helps to reduce the computational time of ELM training by 41.75% while maintaining the same training accuracy in comparison to pure software of ELM

Memory T Cell Responses Targeting the SARS Coronavirus Persist up to 11 Years Post-Infection

10.1016/j.vaccine.2016.02.063Vaccine34172008–201

Giant oyster mushroom, Pleurotus giganteus (Agaricomycetes): Current status of the cultivation methods, chemical composition, biological, and health-promoting properties

Pleurotus giganteus (Berk.) Karunarathna & Hyde is one of the largest edible mushrooms which can be found either in groups or solitary and in soil and buried woods, but seldom in grassland. It has been recorded in Southeast Asia, Australasia, and China by either its common names or local names. Previously known as Lentinus/Panus giganteus, its unique physical characteristics and the utilization of molecular tools have since anchored its taxonomical position in the Pleurotus genus. A sawdust-based substrate coupled with soil casing method is described as a standard cultivation procedure for P. giganteus. The basidiocarp of P. giganteus is found to be rich in carbohydrates, proteins, polyunsaturated fatty acids, and polysaccharides. Both ethanol and aqueous extracts of P. giganteus have been studied in vitro for its antioxidative, antifungal, anticancer, hepatoprotective, and neurite outgrowth capabilities. The review covers the optimum cultivation methods of P. giganteus, as well as its various biological activities and medicinal properties that have been studied by different approaches. Available data in regards to the chemical compounds present in P. giganteus are also compiled for future references. Overall, both in vitro and in vivo studies have shown significant bioactivity comparable to other recognized Pleurotoid mushrooms

Intrastrain Comparison of the Chemical Composition and Antioxidant Activity of an Edible Mushroom, Pleurotus giganteus

Two strains of Pleurotus giganteus (commercial and wild) were tested for their ability to induce neurite outgrowth in rat pheochromocytoma (PC12) and mouse neuroblastoma-2a (N2a) cells. Treatment with the mushroom extracts resulted in neuronal differentiation and neuronal elongation, but not nerve growth factor (NGF) production. Linoleic acid (4.5–5.0%, w/w) which is a major fatty acid present in the ethanol extract promoted NGF biosynthesis when augmented with low concentration of NGF (5 ng/mL). The two strains of mushroom were found to be high in protein (154–192 g kg−1), total polysaccharides, phenolics, and flavonoids as well as vitamins B1, B2, and B3. The total phenolics present in the mushroom extracts were positively correlated to the antioxidant activity (free radical scavenging, ferric reducing power, and lipid peroxidation inhibition). To conclude, P. giganteus could potentially be used in well-balanced diet and as a source of dietary antioxidant to promote neuronal health

Bibliometric Analysis of Mushroom Poisoning: From Diversity to Clinical Management

The earliest publication related to mushroom poisoning dates back to 1837. To date, bibliometric analysis related to the field of mushroom poisoning has not been published. This study aimed to assess the most significant publications in this field as well as the associated trends and important drivers in the research related to mushroom poisoning. The Scopus database was screened to identify relevant publications on mushroom poisoning. A total of 985 publications with a minimum of five citations were identified and analyzed. Pearson’s correlation demonstrated an insignificant weak negative correlation (Pearson’s correlation of −0.020, P > 0.01) between the number of years since publication and the number of citation counts of a paper. Bradford’s law of scattering revealed that one-third of publications were published in 31 core journals, with Clinical Toxicology topping the list (41 papers). VOSviewer was used to generate a network visualization based on country. The United States was the largest contributor of publications on mushroom poisoning, contributing 19.6% of 985. China is an emerging leader in publications on mushroom poisoning research since 2011, with the most recent average publication year of 2011.18. A term map was also created to visualize the co-occurrence of key terms, whereby Amanita phalloides–related research appeared to be the most frequently published topic in this field. In conclusion, the results of this bibliometric study shed light on the status of mushroom poisoning research and can guide investigators on current research trends for high-impact knowledge contribution in the field