4,144 research outputs found
VI-Band Follow-Up Observations of Ultra-Long-Period Cepheid Candidates in M31
The ultra-long period Cepheids (ULPCs) are classical Cepheids with pulsation
periods exceeding days. The intrinsic brightness of ULPCs are ~1
to ~3 mag brighter than their shorter period counterparts. This makes them
attractive in future distance scale work to derive distances beyond the limit
set by the shorter period Cepheids. We have initiated a program to search for
ULPCs in M31, using the single-band data taken from the Palomar Transient
Factory, and identified eight possible candidates. In this work, we presented
the VI-band follow-up observations of these eight candidates. Based on our
VI-band light curves of these candidates and their locations in the
color-magnitude diagram and the Period-Wesenheit diagram, we verify two
candidates as being truly ULPCs. The six other candidates are most likely other
kinds of long-period variables. With the two confirmed M31 ULPCs, we tested the
applicability of ULPCs in distance scale work by deriving the distance modulus
of M31. It was found to be mag. The large error
in the derived distance modulus, together with the large intrinsic dispersion
of the Period-Wesenheit (PW) relation and the small number of ULPCs in a given
host galaxy, means that the question of the suitability of ULPCs as standard
candles is still open. Further work is needed to enlarge the sample of
calibrating ULPCs and reduce the intrinsic dispersion of the PW relation before
re-considering ULPCs as suitable distance indicators.Comment: 13 pages, with 14 Figures and 4 Tables (one online table). AJ
accepte
Comparative study of visible light polymerized gelatin hydrogels for 3D culture of hepatic progenitor cells
Photopolymerization techniques have been widely used to create hydrogels for biomedical applications. Visible light-based photopolymerizations are commonly initiated by type II (i.e., noncleavage-type) photoinitiator in conjunction with a coinitiator. On the other hand, type I photoinitiators (i.e., cleavage type) are rarely compatible with visible light-based initiation due to their limited molar absorbability in the visible light wavelengths. Here, we report visible light initiated orthogonal photoclick crosslinking to fabricate gelatin-norbornene and poly(ethylene glycol)-tetra-thiol hydrogels using either cleavage-type (i.e., lithium acylphosphinate, LAP) or noncleavage-type photoinitiator (i.e., eosin-Y, EY) without the use of a coinitiator. Regardless of the initiator type, the step-growth gelatin-PEG hybrid hydrogels crosslinked and degraded similarly. While both systems exhibited similar cytocompatibility for hepatic progenitor HepaRG cells, gelation initiated by noncleavage-type initiator EY afforded slightly higher degree of hepatic gene expression
First-principles method of propagation of tightly bound excitons: exciton band structure of LiF and verification with inelastic x-ray scattering
We propose a simple first-principles method to describe propagation of
tightly bound excitons. By viewing the exciton as a composite object (an
effective Frenkel exciton in Wannier orbitals), we define an exciton kinetic
kernel to encapsulate the exciton propagation and decay for all binding energy.
Applied to prototypical LiF, our approach produces three exciton bands, which
we verified quantitatively via inelastic x-ray scattering. The proposed
real-space picture is computationally inexpensive and thus enables study of the
full exciton dynamics, even in the presence of surfaces and impurity
scattering. It also provides intuitive understanding to facilitate practical
exciton engineering in semiconductors, strongly correlated oxides, and their
nanostructures.Comment: 5 pages, 4 figures. Accepted by PR
Is ambient noise tomography across ocean basins possible?
International audienceBased on year-long cross-correlations of broad-band seismic records obtained at sixty-six stations within or adjacent to the Pacific Basin, we show that broad-band ambient noise is observed to propagate coherently between island stations and between island and continent stations. For many station pairs, high signal-to-noise ratio (SNR) fundamental mode Rayleigh wave Green functions are observed, which establishes the physical basis for ambient noise tomography across the Pacific. Similar trends for continental and oceanic stations are observed in the relationship between the ambient noise level at a station and the ''noise coherence distance'' – the longest distance at which a high SNR cross-correlation signal is observed for a station. Because locally generated noise obscures long distance coherent noise, situating stations at quiet locations on islands is necessary for the success of ambient noise tomography. Local noise poses a particular challenge at atoll sites and, on the basis of analysis of data from station H2O, at ocean bottom sites at periods above $25 sec
Dynamic control of hydrogel crosslinking via sortase-mediated reversible transpeptidation
Cell-laden hydrogels whose crosslinking density can be dynamically and reversibly tuned are highly sought-after for studying pathophysiological cellular fate processes, including embryogenesis, fibrosis, and tumorigenesis. Special efforts have focused on controlling network crosslinking in poly(ethylene glycol) (PEG) based hydrogels to evaluate the impact of matrix mechanics on cell proliferation, morphogenesis, and differentiation. In this study, we sought to design dynamic PEG-peptide hydrogels that permit cyclic/reversible stiffening and softening. This was achieved by utilizing reversible enzymatic reactions that afford specificity, biorthogonality, and predictable reaction kinetics. To that end, we prepared PEG-peptide conjugates to enable sortase A (SrtA) induced tunable hydrogel crosslinking independent of macromer contents. Uniquely, these hydrogels can be completely degraded by the same enzymatic reactions and the degradation rate can be tuned from hours to days. We further synthesized SrtA-sensitive peptide linker (i.e., KCLPRTGCK) for crosslinking with 8-arm PEG-norbornene (PEG8NB) via thiol-norbornene photocrosslinking. These hydrogels afford diverse softening paradigms through control of network structures during crosslinking or by adjusting enzymatic parameters during on-demand softening. Importantly, user-controlled hydrogel softening promoted spreading of human mesenchymal stem cells (hMSCs) in 3D. Finally, we designed a bis-cysteine-bearing linear peptide flanked with SrtA substrates at the peptide’s N- and C-termini (i.e., NH2-GGGCKGGGKCLPRTG-CONH2) to enable cyclic/reversible hydrogel stiffening/softening. We show that matrix stiffening and softening play a crucial role in growth and chemoresistance in pancreatic cancer cells. These results represent the first dynamic hydrogel platform that affords cyclic gel stiffening/softening based on reversible enzymatic reactions. More importantly, the chemical motifs that affords such reversible crosslinking were built-in on the linear peptide crosslinker without any post-synthesis modification
Effect of magnetic field on the spin resonance in FeTe(0.5)Se(0.5) as seen via inelastic neutron scattering
Inelastic neutron scattering and susceptibility measurements have been
performed on the optimally-doped Fe-based superconductor FeTe(0.5)Se(0.5),
which has a critical temperature, Tc of 14 K. The magnetic scattering at the
stripe antiferromagnetic wave-vector Q = (0.5,0.5) exhibits a "resonance" at ~
6 meV, where the scattering intensity increases abruptly when cooled below Tc.
In a 7-T magnetic field parallel to the a-b plane, Tc is slightly reduced to ~
12 K, based on susceptibility measurements. The resonance in the neutron
scattering measurements is also affected by the field. The resonance intensity
under field cooling starts to rise at a lower temperature ~ 12 K, and the low
temperature intensity is also reduced from the zero-field value. Our results
provide clear evidence for the intimate relationship between superconductivity
and the resonance measured in magnetic excitations of Fe-based superconductors.Comment: 4 pages, 3 figure
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