Overview of the Large Hadron Collider cryo-magnets logistics

More than 1700 superconducting cryo-magnets have to be installed in the Large Hadron Collider tunnel. The long, heavy and fragile LHC cryo-magnets are difficult to handle and transport in particular in the LEP tunnel environment originally designed for smaller, lighter LEP magnets. An installation rate of more than 20 cryo-magnets per week is needed to cope with the foreseen LHC installation end date. The paper gives an overview of the transport and installation sequence complexity, from the storage area at the surface to the cryo-magnet final position in the tunnel. The success of this task depends on a series of independent factors that have to be considered at the same time. The equipment needed for the transport and tunnel installation of the LHC cryo-magnets is briefly described. The manpower and equipment organisation as well as the challenges of logistics are then detailed. The paper includes conclusions and some of the lessons learned during the first phase of the LHC cryo-magnets installation

Positive Study on the Tactics How to Tackle Section 337 Investigation in USA —— From the Answer Examples of Chinese Export Enterprises

当前美国337条款调查已经成为中国出口产品进入美国市场的重要障碍。本文以中国出口企业历年来的应诉实例为切入点，探讨这些案例所反映的调查特征，发现存在的主要问题，结合法律规定和具体案例研究“337调查”程序与实体方面的应对策略，从具体案例中吸取教训，总结经验。取材主要是涉中案例，更具说服力，特别是成功案例，希望借此增强国内企业应诉的信心。 除前言和结论外，本文共分四章，主要内容如下： 第一章介绍了中国出口企业应诉美国“337调查”的现状和存在的问题。详细统计了历年来中国企业的出庭情况，案件的审理结果以及产生这些结果的主要原因。虽然整体来看，中国企业的应对情况并不理想，但出庭案件绝大部分都没有...Currently Section 337 investigation of USA has already become an obstacle to Chinese products to enter into American market. The text takes the answer examples of Chinese enterprises as cut-in point, discusses the character and problems reflecting from these cases, combines rules of law and case study to research the countermeasures about procedure and entity aspects of Section 337 Investigation, ...学位：法学硕士院系专业：法学院法律系_民商法学(含劳动法学、社会保障法学)学号：20040804

A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development

Microscopic examination of Giemsa-stained thin blood smears remains the gold standard method used to quantify and stage malaria parasites. However, this technique is tedious, and requires trained microscopists. We have developed a fast and simple flow cytometry method to quantify and stage, various malaria parasites in red blood cells in whole blood or in vitro cultured Plasmodium falciparum. The parasites were stained with dihydroethidium and Hoechst 33342 or SYBR Green I and leukocytes were identified with an antibody against CD45. Depending on the DNA stains used, samples were analyzed using different models of flow cytometers. This protocol, which does not require any washing steps, allows infected red blood cells to be distinguished from leukocytes, as well as allowing non-infected reticulocytes and normocytes to be identified. It also allows assessing the proportion of parasites at different developmental stages. Lastly, we demonstrate how this technique can be applied to antimalarial drug testing

Improving Care of Patients At-Risk for Osteoporosis: A Randomized Controlled Trial

BACKGROUND: Despite accurate diagnostic tests and effective therapies, the management of osteoporosis has been observed to be suboptimal in many settings. We tested the effectiveness of an intervention to improve care in patients at-risk of osteoporosis. DESIGN: Randomized controlled trial. PARTICIPANTS: Primary care physicians and their patients at-risk of osteoporosis, including women 65 years and over, men and women 45 and over with a prior fracture, and men and women 45 and over who recently used ≥90 days of oral glucocorticoids. INTERVENTION: A multifaceted program of education and reminders delivered to primary care physicians as well as mailings and automated telephone calls to patients. Outcome: Either undergoing a bone mineral density (BMD) testing or filling a prescription for a bone-active medication during the 10 months of follow-up. RESULTS: After the intervention, 144 (14%) patients in the intervention group and 97 (10%) patients in the control group received either a BMD test or filled a prescription for an osteoporosis medication. This represents a 4% absolute increase and a 45% relative increase (95% confidence interval 9–93%, p = 0.01) in osteoporosis management between the intervention and control groups. No differences between groups were observed in the incidence of fracture. CONCLUSION: An intervention targeting primary care physicians and their at-risk patients increased the frequency of BMD testing and/or filling prescriptions for osteoporosis medications. However, the absolute percentage of at-risk patients receiving osteoporosis management remained low

Homogeneous M2 duals

Motivated by the search for new gravity duals to M2 branes with $N>4$ supersymmetry --- equivalently, M-theory backgrounds with Killing superalgebra $\mathfrak{osp}(N|4)$ for $N>4$ --- we classify homogeneous M-theory backgrounds with symmetry Lie algebra $\mathfrak{so}(n) \oplus \mathfrak{so}(3,2)$ for $n=5,6,7$. We find that there are no new backgrounds with $n=6,7$ but we do find a number of new (to us) backgrounds with $n=5$. All backgrounds are metrically products of the form $\operatorname{AdS}_4 \times P^7$, with $P$ riemannian and homogeneous under the action of $\operatorname{SO}(5)$, or $S^4 \times Q^7$ with $Q$ lorentzian and homogeneous under the action of $\operatorname{SO}(3,2)$. At least one of the new backgrounds is supersymmetric (albeit with only $N=2$) and we show that it can be constructed from a supersymmetric Freund--Rubin background via a Wick rotation. Two of the new backgrounds have only been approximated numerically. (The second version of this paper includes an appendix by Alexander~S.~Haupt, closing a gap in our original analysis.)Comment: 56 page

Decision to take osteoporosis medication in patients who have had a fracture and are 'high' risk for future fracture: A qualitative study

Abstract Background Patients' values and preferences are fundamental tenets of evidence-based practice, yet current osteoporosis (OP) clinical guidelines pay little attention to these issues in therapeutic decision making. This may be in part due to the fact that few studies have examined the factors that influence the initial decision to take OP medication. The purpose of our study was to examine patients' experiences with the decision to take OP medication after they sustained a fracture. Methods A phenomenological qualitative study was conducted with outpatients identified in a university teaching hospital fracture clinic OP program. Individuals aged 65+ who had sustained a fragility fracture within 5 years, were 'high risk' for future fracture, and were prescribed OP medication were eligible. Analysis of interview data was guided by Giorgi's methodology. Results 21 patients (6 males, 15 females) aged 65-88 years participated. All participants had low bone mass; 9 had OP. Fourteen patients were taking a bisphosphonate while 7 patients were taking no OP medications. For 12 participants, the decision to take OP medication occurred at the time of prescription and involved minimal contemplation (10/12 were on medication). These patients made their decision because they liked/trusted their health care provider. However, 4/10 participants in this group indicated their OP medication-taking status might change. For the remaining 9 patients, the decision was more difficult (4/9 were on medication). These patients were unconvinced by their health care provider, engaged in risk-benefit analyses using other information sources, and were concerned about side effects; 7/9 patients indicated that their OP medication-taking status might change at a later date. Conclusions Almost half of our older patients who had sustained a fracture found the decision to take OP medication a difficult one. In general, the decision was not considered permanent. Health care providers should be aware of their potential role in patients' decisions and monitor patients' decisions over time

Mind the (treatment) gap: a global perspective on current and future strategies for prevention of fragility fractures

This narrative review considers the key challenges facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health. These challenges broadly fall into four distinct themes: (1) case finding and management of individuals at high risk of fracture, (2) public awareness of osteoporosis and fragility fractures, (3) reimbursement and health system policy and (4) epidemiology of fracture in the developing world. Findings from cohort studies, randomised controlled trials, systematic reviews and meta-analyses, in addition to current clinical guidelines, position papers and national and international audits, are summarised, with the intention of providing a prioritised approach to delivery of optimal bone health for all. Systematic approaches to case-finding individuals who are at high risk of sustaining fragility fractures are described. These include strategies and models of care intended to improve case finding for individuals who have sustained fragility fractures, those undergoing treatment with medicines which have an adverse effect on bone health and people who have diseases, whereby bone loss and, consequently, fragility fractures are a common comorbidity. Approaches to deliver primary fracture prevention in a clinically effective and cost-effective manner are also explored. Public awareness of osteoporosis is low worldwide. If older people are to be more pro-active in the management of their bone health, that needs to change. Effective disease awareness campaigns have been implemented in some countries but need to be undertaken in many more. A major need exists to improve awareness of the risk that osteoporosis poses to individuals who have initiated treatment, with the intention of improving adherence in the long term. A multisector effort is also required to support patients and their clinicians to have meaningful discussions concerning the risk-benefit ratio of osteoporosis treatment. With regard to prioritisation of fragility fracture prevention in national policy, there is much to be done. In the developing world, robust epidemiological estimates of fracture incidence are required to inform policy development. As the aging of the baby boomer generation is upon us, this review provides a comprehensive analysis of how bone health can be improved worldwide for all

Test beam results of a stereo preshower integrated in the liquid argon accordion calorimeter

This paper describes the construction of an integrated preshower within the RD3 liquid argon accordion calorimeter. It has a stereo view which enables the measurement of two transverse coordinates. The prototype was tested at CERN with electrons, photons and muons to validate its capability to work at LHC (Energy resolution, impact point resolution, angular resolution, π o γ rejection). (Elsevier

Revue et bilan de la maintenance des équipements spéciaux pour l'installation des cryo-aimants

Le transport et l'installation des quelques 1800 aimants dans le tunnel LHC ont été réalisés à l'aide d'équipements de transport et de manutention de haute technologie spécialement développés pour le CERN. Ce document présente un bilan du fonctionnement et des problèmes rencontrés par ces prototypes lors de l?installation du LHC de 2005 à 2007, ainsi que les enseignements à en tirer dans l'optique de les garder opérationnels, car uniques et donc indispensables pour tous les futurs remplacements d'aimants dans le LHC. Les besoins et moyens à mettre en place tels que zone de tests, zone de maintenance, zone de stockage à long terme, plan de maintenance préventive, inspections périodiques, formations spécifiques pour les opérateurs et techniciens de maintenance seront présentés ainsi que les contraintes liées à l'infrastructure du tunnel LHC telles que les conditions spécifiques de travail et d'intervention en cas de dépannage dans des espaces restreints et parfois hautement radioactifs et cela en application du principe ALARA