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Friedrich Jacobi: Only Madman Can Be Follower of Kant!

Friedrich Jacobi (1743-1819) is known mainly as a representative of the “philosophy of feeling and faith” and as one of the first critics of Kant, who drew attention to the fundamental contradiction in his system: without the concept of “thing in itself” (or “thing in oneself”) it is impossible to enter into his “Critique of Pure Reason”, but it is equally impossible to remain in it with this concept. The consistent development of the transcendental philosophy system leads to the elimination of its own initial, fundamental premise. The discovery of this contradiction and the indication of its significance for the evaluation of critical philosophy was often seen as almost the only contribution of Jacobi to world philosophy. In the historical and philosophical literature, the opinion prevails is that Jacobi, by and large, simply did not understand Kant and was in comparison with him, just a “grumpy scoundrel” (Heinrich Heine) and a “lower monad” (Kuno Fischer). This pejorative assessment significantly simplifies and distorts both Jacobi’s philosophy and Jacobi’s actual attitude towards Kant, which was not so unambiguous. It should be considered in a much broader historical and problematic context. The study briefly examines the history of the long and difficult relationship between the “privileged heretic” and the “gray eminence” of the German philosophical classics with the creator of the transcendental philosophy system. The main directions of a deeply thought-out and well-founded serious criticism of Kant’s philosophy (i.e. its inconsistency, idealism, rational intellectualism, subjectivism, “speculative egoism”, etc.) are outlined and analyzed from the positions of radical realism, common sense, Christian faith, metaphysical “sense of the supersensible”, direct knowledge of the most important truths for a person, the absolute values of life, moral intuition, freedom, and dignity of the individual

The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury.

BackgroundMechanical pain hypersensitivity associated with physical trauma to peripheral nerve depends on T-helper (Th) cells expressing the algesic cytokine, interleukin (IL)-17A. Fibronectin (FN) isoform alternatively spliced within the IIICS region encoding the 25-residue-long connecting segment 1 (CS1) regulates T cell recruitment to the sites of inflammation. Herein, we analyzed the role of CS1-containing FN (FN-CS1) in IL-17A expression and pain after peripheral nerve damage.MethodsMass spectrometry, immunoblotting, and FN-CS1-specific immunofluorescence analyses were employed to examine FN expression after chronic constriction injury (CCI) in rat sciatic nerves. The acute intra-sciatic nerve injection of the synthetic CS1 peptide (a competitive inhibitor of the FN-CS1/α4 integrin binding) was used to elucidate the functional significance of FN-CS1 in mechanical and thermal pain hypersensitivity and IL-17A expression (by quantitative Taqman RT-PCR) after CCI. The CS1 peptide effects were analyzed in cultured primary Schwann cells, the major source of FN-CS1 in CCI nerves.ResultsFollowing CCI, FN expression in sciatic nerve increased with the dominant FN-CS1 deposition in endothelial cells, Schwann cells, and macrophages. Acute CS1 therapy attenuated mechanical allodynia (pain from innocuous stimulation) but not thermal hyperalgesia and reduced the levels of IL-17A expression in the injured nerve. CS1 peptide inhibited the LPS- or starvation-stimulated activation of the stress ERK/MAPK pathway in cultured Schwann cells.ConclusionsAfter physical trauma to the peripheral nerve, FN-CS1 contributes to mechanical pain hypersensitivity by increasing the number of IL-17A-expressing (presumably, Th17) cells. CS1 peptide therapy can be developed for pharmacological control of neuropathic pain

Transportation of cuttings by drilling mud in horizontal wells. Part 2. Numerical results of drilling at optimal rheological properties of mud

The relevance. Ensuring technological equipment operation efficiency when drilling wells with an arbitrary orientation of their wellbores. In particular, the search for productive hydrocarbon reservoirs requires drilling deeper wells with extended horizontal sections, for which the removal of the cuttings bed is the key problem of modern drilling. The aim. Study the features and establish the patterns of cuttings movement through the annulus eccentric space formed by a drill string and well walls under various modes (in-situ) and drilling conditions within the framework of modern mathematical models of hydrodynamics, numerical algorithms and approaches implemented in ANSYS CFD. Optimize the parameters that determine drilling, such as an inclination angle, mass-average velocity and morphology of the inlet rheologically complex viscous flow to form the maximum allowable drilling velocity for various combinations of mud effective viscosity and mixture flow rate. Give practical recommendations for engineers to reduce time, costs and material resources for maintenance and optimization of well cleaning. The object.  A well with an eccentric core and an extended horizontal section operating in modes and conditions close to real drilling. The methods. Complex of physical and mathematical analysis and numerical modeling of hydrodynamics and mass transfer in homogeneous and heterogeneous continuous media. The media were widely tested on the class of internal rheological complex flows, the verification of which was carried out under appropriate conditions, performed by other authors when solving problems of drilling and cleaning wells. The results. The paper presents the results of a numerical study of hydrodynamics of a dispersed flow of a rheological complex viscous mixture of a drilling fluid with the properties of a Herschel–Bulkley type fluid and sand particles in wells with an arbitrary generatrix of its wellbore in an eccentric space. The results are required to clarify the features that accompany direct-flow and swirling flow (the moving wall method), identify the patterns in such modes, accounting for which allows for effective cleaning of the annulus. The calculations were performed within the framework of modern mathematical models of the RANS-method and the Euler–Lagrangian approach to describing the motion of heterogeneous media, implemented in the ANSYS CFD software and efficient numerical algorithms for determining intra- and interfacial processes of mass and momentum transfer in mixtures. The authors have determined that when drilling a vertical section, the most effective parameter in terms of cleaning control is the effective viscosity of the mud; the most problematic configurations for cleaning are wells with sloping sections at angles close to the vertical. When drilling a horizontal section, the eccentricity of the drill string creates “the dead” zone of flow and complicates cleaning. This zone should be removed by creating swirling flow conditions through relatively weak rotation of a drill string (30–60 rpm). When drilling inclined sections, it is necessary to reduce a solution viscosity (preferably to the level of fresh water) and increase the flow rate (in this case, to 2 m/s or higher). When drilling a horizontal section, a mud with a viscosity close to fresh water is recommended at flow rates of about 2 m/s (or 640 gpm) at the well inlet and a maximum drilling velocity of 9 m/h

Mobility of edge dislocations in stressed iron crystals during irradiation

The behavior of a/2(111){110} edge dislocations in iron in shear loading and irradiation conditions was studied by means of molecular dynamics simulation. Edge dislocations were exposed to shock waves formed by atomic displacement cascades of different energies. It was shown that starting from a certain threshold amplitude shock waves cause displacement of edge dislocations in the loaded samples. Calculations showed that the larger the shear load and the amplitude of the shock wave, the greater the displacement of dislocations in the crystallite

Dynamics of liquid nanofilms

The van der Waals forces across a very thin liquid layer (nanofilm) in contact with a plane solid wall make the liquid nonhomogeneous. The dynamics of such flat liquid nanofilms is studied in isothermal case. The Navier-Stokes equations are unable to describe fluid motions in very thin films. The notion of surface free energy of a sharp interface separating gas and liquid layer is disqualified. The concept of disjoining pressure replaces the model of surface energy. In the nanofilm a supplementary free energy must be considered as a functional of the density. The equation of fluid motions along the nanofilm is obtained through the Hamilton variational principle by adding, to the conservative forces, the forces of viscosity in lubrication approximation. The evolution equation of the film thickness is deduced and takes into account the variation of the disjoining pressure along the layer.Comment: 13 pages. International Journal of Engineering Science / International Journal of Engineering Sciences 46 (2008) to appea

Инвестиционные модели ведения бизнеса в энергетическом секторе экономики

Investment by companies, which target growth of key labor productivity factors, labor attraction, modernization, and development, as well as reduction of production risks and higher investment attractiveness, is the main growth factor for emerging economies. However, the key drawbacks of the existing models of investment attractiveness assessment of state-sponsored projects are the absence of alternative financing from adjacent sources and the lack of the scenario approach when analyzing cash flows of a project. The authors’ scientific and practical research offers the choice of the best investment project model, ensuring a lower default risk, lesser expected losses for the state (in case of redeeming the loss, occurring in the case of breach of warranty), and a lower possibility of tax receipt shortfalls under the project. The measures imply the use of the scenario and probabilistic approach, ensuring consideration of all possible alternatives for an investment project of companies, engaged in the energy business, and, consequently, higher efficiency of budget spending.El factor principal en el crecimiento de las economías de tipo en desarrollo es la implementación de proyectos de inversión por parte de entidades comerciales centradas en el crecimiento de los principales factores de productividad, atracción de recursos laborales, modernización y desarrollo, reducción de los riesgos de producción y aumento del atractivo de la inversión. Al mismo tiempo, los principales inconvenientes de los modelos utilizados para evaluar los proyectos de inversión implementados con apoyo estatal son la falta de consideración de alternativas para el financiamiento de fuentes relacionadas, la no utilización del enfoque de escenario para analizar los flujos de efectivo del proyecto. Como parte de la investigación, se hizo una selección del modelo de proyecto de inversión más óptimo, que reduce el riesgo de una probabilidad de incumplimiento, reduce las pérdidas esperadas para el estado (en caso de compensación por daños incurridos en el caso de un evento de garantía), y reduce la probabilidad de ingresos fiscales por debajo de lo esperado para el presupuesto. . La implementación de estas medidas implica el uso del escenario y el enfoque probabilístico, que permite considerar todas las alternativas posibles para el proyecto de inversión para las empresas que realizan negocios en los sectores energéticos de la economía y, como consecuencia, la implementación de esta medida permite aumentar la eficiencia del uso de los fondos presupuestarios.Основным фактором роста экономики стран развивающего типа является реализация инвестиционных проектов хозяйствующими субъектами, ориентированными на рост основных факторов производительности, привлечении трудовых ресурсов, модернизации и развития, снижении производственных рисков и увеличении инвестиционной привлекательности. Вместе с тем основными недостатками используемых моделей оценки инвестиционных проектов, реализуемых за счет государственной поддержки, является отсутствие рассмотрение альтернатив финансирования из смежных источников, неиспользование сценарного подхода при анализе денежных потоков проекта. В рамках проведенного научного исследования предложен выбор наиболее оптимальной модели инвестиционного проекта, позволяющей снизить риск вероятности дефолта, уменьшить ожидаемые потери для государства (в случае возмещения ущерба, образовавшегося при наступлении гарантийного случая), снизить вероятность недополучения ожидаемых в рамках проекта налоговых поступлений в бюджет соответствующего уровня. Реализация данных мер подразумевает использование сценарного и вероятностного подхода, что позволяет рассматривать все возможные альтернативы для инвестиционного проекта для компаний, занимающихся ведением бизнеса в энергетических секторах экономики и как следствие реализация данной меры позволяет увеличить эффективность использования бюджетных средств

Development of polyresistance in microorganisms during antibiotic therapy in a multidisciplinary hospital during a pandemic COVID-19

Background. Irrational and excessive use of antimicrobials drugs (AMD) creates conditions for the development of a global crisis of health systems around the world associated with antibiotic resistance. Aim. To conduct a retrospective study of the impact of the use of AMD on the change in the microbiological landscape and the sensitivity of microorganisms in the conditions of pandemic of the new coronavirus infection (COVID-19) in 2020–2021 in intensive care departments (ICD) of a multidisciplinary hospital. Materials and methods. In the course of the work, strains of microorganisms isolated from patients and from the surfaces of the hospital environment and changes in their sensitivity to significant groups of AMD in ICD for somatic and infectious patients with COVID-19 were compared. The sensitivity of the isolates was evaluated in accordance with the criteria of requirements of European Committee on Antimicrobial Susceptibility Testing – EUCAST, version 10.0, 2020. Results. A total of 1,394 isolates were studied, including 1,379 clinical and 15 isolates from the surfaces of the hospital environment. It was found that in all ICD in 2020–2021, gram-negative microorganisms prevailed in infectious loci in 70% of cases or more. In 2021, in the ICD in infectious patients with COVID-19, the persistent dominance of the Acinetobacter baumannii microorganism was revealed with an increase in the number of poly- and pan-resistant strains – 48.7%. While in the ICD for somatic patients Klebsiella Pneumoniae prevailed among gram-negative microorganisms – 37.5% in 2020 and 43.7% in 2021. It has been shown that in one department or in adjacent departments of the same medical institution, various nosocomial microorganisms with an unequal set of resistance genes and sensitivity to AMD may appear over time. Conclusion. The necessity of conducting constant microbiological monitoring and a passport of the medical department with mandatory registration of not only isolated strains of microorganisms, but also resistance genes in order to optimize the appointment of timely adequate empirical antimicrobial therapy is substantiated. The period of the latter should be as short as possible, and confirmed by convincing clinical signs of bacterial infection, and subsequently by the isolation of nosocomial flora from the biomaterial of critical loci from patients