Implementation difficulties of tutor support technologies in higher education

The article is devoted to problems of implementation in practice of the University of technology tutor support, which would allow modern students to quickly and painlessly build an individual trajectory of personal and professional development, and University – to implement the requirements of standard of the last generation. The article is based on observations of the included experiment on the implementation of tutor support, which was carried out in the framework of advanced training courses for teachers of PSNIU. During the experiment, conditions that are extremely important for ensuring the effectiveness of the implementation of tutor support technology were identified. Among them: the certainty (firmness) of the tutor's position in the implementation of a specific goal of tutor support; the importance of organizing spatial interaction during the tutorial; the formation of an adequate understanding of the content of the tutor's activity among the participants of the tutorial; recognition of the self-value of the tutor's activity

Investigation of 5’-norcarbocyclic nucleoside analogues as antiprotozoal and antibacterial agents

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein

Implementation difficulties of tutor support technologies in higher education

The article is devoted to problems of implementation in practice of the University of technology tutor support, which would allow modern students to quickly and painlessly build an individual trajectory of personal and professional development, and University – to implement the requirements of standard of the last generation. The article is based on observations of the included experiment on the implementation of tutor support, which was carried out in the framework of advanced training courses for teachers of PSNIU. During the experiment, conditions that are extremely important for ensuring the effectiveness of the implementation of tutor support technology were identified. Among them: the certainty (firmness) of the tutor's position in the implementation of a specific goal of tutor support; the importance of organizing spatial interaction during the tutorial; the formation of an adequate understanding of the content of the tutor's activity among the participants of the tutorial; recognition of the self-value of the tutor's activity.El artículo está dedicado a los problemas de implementación en la práctica del apoyo del tutor de tecnología de la Universidad, lo que permitiría a los estudiantes modernos construir de manera rápida y sin dolor una trayectoria individual de desarrollo personal y profesional, y Universidad - para implementar los requisitos de estándar de la última generación. . El artículo se basa en las observaciones del experimento incluido sobre la implementación del apoyo del tutor, que se llevó a cabo en el marco de los cursos de formación avanzada para docentes del PSNIU. Durante el experimento, se identificaron las condiciones que son de suma importancia para asegurar la efectividad de la implementación de la tecnología de apoyo al tutor. Entre ellos: la certeza (firmeza) de la posición del tutor en la implementación de un objetivo específico de apoyo del tutor; la importancia de organizar la interacción espacial durante el tutorial; la formación de un conocimiento adecuado del contenido de la actividad del tutor entre los participantes de la tutoría; reconocimiento de la autovaloración de la actividad del tutor

Novel 5′-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents

A series of novel 5′-norcarbocyclic derivatives of 5-alkoxymethyl or 5-alkyltriazolyl-methyl uracil were synthesized and the activity of the compounds evaluated against both Gram-positive and Gram-negative bacteria. The growth of Mycobacterium smegmatis was completely inhibited by the most active compounds at a MIC99 of 67 μg/mL (mc2155) and a MIC99 of 6.7⁻67 μg/mL (VKPM Ac 1339). Several compounds also showed the ability to inhibit the growth of attenuated strains of Mycobacterium tuberculosis ATCC 25177 (MIC99 28⁻61 μg/mL) and Mycobacterium bovis ATCC 35737 (MIC99 50⁻60 μg/mL), as well as two virulent strains of M. tuberculosis; a laboratory strain H37Rv (MIC99 20⁻50 μg/mL) and a clinical strain with multiple drug resistance MS-115 (MIC99 20⁻50 μg/mL). Transmission electron microscopy (TEM) evaluation of M. tuberculosis H37Rv bacterial cells treated with one of the compounds demonstrated destruction of the bacterial cell wall, suggesting that the mechanism of action for these compounds may be related to their interactions with bacteria cell walls