Study of e+e−→ppˉe^+e^- \rightarrow p\bar{p} in the vicinity of ψ(3770)\psi(3770)

Using 2917 $\rm{pb}^{-1}$ of data accumulated at 3.773~$\rm{GeV}$, 44.5~$\rm{pb}^{-1}$ of data accumulated at 3.65~$\rm{GeV}$ and data accumulated during a $\psi(3770)$ line-shape scan with the BESIII detector, the reaction $e^+e^-\rightarrow p\bar{p}$ is studied considering a possible interference between resonant and continuum amplitudes. The cross section of $e^+e^-\rightarrow\psi(3770)\rightarrow p\bar{p}$, $\sigma(e^+e^-\rightarrow\psi(3770)\rightarrow p\bar{p})$, is found to have two solutions, determined to be ($0.059\pm0.032\pm0.012$) pb with the phase angle $\phi = (255.8\pm37.9\pm4.8)^\circ$ ($<$0.11 pb at the 90% confidence level), or $\sigma(e^+e^-\rightarrow\psi(3770)\rightarrow p\bar{p}) = (2.57\pm0.12\pm0.12$) pb with $\phi = (266.9\pm6.1\pm0.9)^\circ$ both of which agree with a destructive interference. Using the obtained cross section of $\psi(3770)\rightarrow p\bar{p}$, the cross section of $p\bar{p}\rightarrow \psi(3770)$, which is useful information for the future PANDA experiment, is estimated to be either ($9.8\pm5.7$) nb ($<17.2$ nb at 90% C.L.) or $(425.6\pm42.9)$ nb

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notablesuccesses in some cancers; however, significant problems remain with this approach. Many targetedtherapies are highly toxic, costs are extremely high, and most patients experience relapse after a fewdisease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistantimmortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are notreliant upon the same mechanisms as those which have been targeted). To address these limitations, aninternational task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspectsof relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a widerange of high-priority targets (74 in total) that could be modified to improve patient outcomes. For thesetargets, corresponding low-toxicity therapeutic approaches were then suggested, many of which werephytochemicals. Proposed actions on each target and all of the approaches were further reviewed forknown effects on other hallmark areas and the tumor microenvironment. Potential contrary or procar-cinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixedevidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of therelationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. Thisnovel approach has potential to be relatively inexpensive, it should help us address stages and types ofcancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for futureresearch is offered

Neotectonic disruption of silicified palaeovalley systems in an intraplate, cratonic landscape: regolith and landscape evolution of the Mulculca range-front, Broken Hill Domain, New South Wales

The landscape expression of a wide range of ancient and contemporary regolith materials in the vicinity of the Mulculca Fault demonstrates two important points: (i) tectonism can be a significant factor in the evolution of landscapes in some parts of the Australian craton; and (ii) ancient and young regolith-landform features can coexist within a tectonically active landscape. Tectonic activity along the Mulculca Fault has created a range-front near the Broken Hill Domain - Murray Basin margins. This tectonism defeated a now silicified palaeodrainage system that flowed from the area now occupied by the Barrier Ranges towards the present area of the Murray Basin. Stream defeat led to the development of lacustrine-overbank conditions within the area of the fault-angle depression, which was later breached by stream incision across the range-front. The area of lacustrine-overbank deposition is now dominated by alluvial (channel and overbank) deposits with minor colluvial and aeolian deposition. Silicification of palaeovalley sediments and adjacent saprolite has been occurring over a broad range of times during landscape development, including several stages of palaeovalley evolution and as minor red-brown hardpan development in the contemporary landscape. Ferruginised regolith has been developing at many different times during the evolution of the landscape, including: (i) prior to the defeat of the palaeodrainage system; (ii) during the sedimentary infilling of the fault-angle depression; and (iii) within the contemporary landscape. The variable preservation and, therefore, landscape expression of a wide range of regolith materials that formed over a long period of landscape evolution has persisted even though there has been tectonic activity along the Mulculca Fault. For example, topographically inverted, and therefore ancient, silicified alluvial deposits occur alongside contemporary colluvial and alluvial deposits along the tectonically active range-front. This is in contrast to simple models invoking long-term tectonic stability to account for the expression of ancient regolith and landforms in Australian cratonic landscapes.S. M. Hill; R. A. Eggleton; G. Taylo

Measurement of the D--->K^-\pi^+ strong phase difference in \psi(3770)--->D^0\antiD^0

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