Gauge Theory of Elementary Particle Physics

The aim of this book is to provide student and researcher with a practical introduction to some of the principal ideas in gauge theories and their applications to elementary particle physics. Elementary particle physics has made remarkable progress. We have a comprehensive theory of particle interactions. One can argue that it gives a complete and correct description of all non-gravitational physics. This theory is based on the principle of gauge symmetry. Strong, weak, and electromagnetic interactions are all gauge interactions. A knowledge of gauge theory is essential for anyone interested in modern high energy physics. Regardless of the ultimate correctness of every detail of this theory, it is the framework within which new theoretical and experimental advances will be interpreted in the foreseeable future

Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies

Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and major depressive disorder). Recently, ketamine, an N-methyl-d-aspartate antagonist, has been demonstrated to have promisingly rapid antidepressant efficacy for treatment-resistant depression. Many compounds that target the glutamate system have also become available that possess potential in the treatment of major psychiatric disorders. In this review, we update evidence from recent human studies that directly or indirectly measured glutamatergic neurotransmission and function in major psychiatric disorders using modalities such as magnetic resonance spectroscopy, positron emission tomography/single-photon emission computed tomography, and paired-pulse transcranial magnetic stimulation. The newer generation of antidepressants that target the glutamatergic system developed in human clinical studies is also reviewed

Gauge Theory of Elementary Particle Physics

The aim of this book is to provide student and researcher with a practical introduction to some of the principal ideas in gauge theories and their applications to elementary particle physics. Elementary particle physics has made remarkable progress. We have a comprehensive theory of particle interactions. One can argue that it gives a complete and correct description of all non-gravitational physics. This theory is based on the principle of gauge symmetry. Strong, weak, and electromagnetic interactions are all gauge interactions. A knowledge of gauge theory is essential for anyone interested in modern high energy physics. Regardless of the ultimate correctness of every detail of this theory, it is the framework within which new theoretical and experimental advances will be interpreted in the foreseeable future

Problems of QCD factorization in exclusive decays of B meson to charmonium

We study the exclusive decays of $B$ meson into P-wave charmonium states $\chi_{cJ}(J=0,1)$ in the QCD factorization approach with light-cone distribution functions describing the mesons in the processes. For $B \to \chi_{c1} K$ decay, we find that there are logarithmic divergences arising from nonfactorizable spectator interactions even at twist-2 order and the decay rate is too small to accommodate the experimental data. For $B\to \chi_{c0} K$ decay, we find that aside from the logarithmic divergences arising from spectator interactions at leading-twist order, more importantly, the factorization will break down due to the infrared divergence arising from nonfactorizable vertex corrections, which is independent of the specific form of the light-cone distribution functions. Our results may indicate that QCD factorization in the present form may not be safely applied to $B$-meson exclusive decays to charmonium states.Comment: Latex, 7 pages, 1 eps figure, final version to appear in Phys.Lett.B; a few references are added, the expression of chi_c1 decay constant is give

Secondary Metabolites from the Leaves of Aquilaria agallocha

Twelve compounds, including three flavonoids, 5-hydroxy-4¢,7- dimethoxyflavone (1) [22], luteolin-7,3¢,4¢-trimethyl ether (2) and 5,3¢- dihydroxy-7,4¢-dimethoxyflavone (3), five benzenoids, methylparaben (4), vanillic acid (5), p-hydroxybenzoic acid (6), syringic acid (7), and isovanillic acid (8) and four steroids, b-sitosterol (9), stigmasterol (10), b-sitostenone (11) and stigmasta-4,22-dien-3- one (12) were isolated from the leaves of Aquilaria agallocha (Thymelaeaceae). All of these compounds (1-12) were obtained for the first time from the leaves of this plant

Identifying Ketamine Responses in Treatment-Resistant Depression Using a Wearable Forehead EEG

This study explores the responses to ketamine in patients with treatment-resistant depression (TRD) using a wearable forehead electroencephalography (EEG) device. We recruited fifty-five outpatients with TRD who were randomised into three approximately equal-sized groups (A: 0.5 mg/kg ketamine; B: 0.2 mg/kg ketamine; and C: normal saline) under double-blind conditions. The ketamine responses were measured by EEG signals and Hamilton Depression Rating Scale (HDRS) scores. At baseline, responders showed a significantly weaker EEG theta power than did non- responders (p < 0.05). Responders exhibited a higher EEG alpha power but lower EEG alpha asymmetry and theta cordance at post-treatment than at baseline (p < 0.05). Furthermore, our baseline EEG predictor classified responders and non-responders with 81.3 +- 9.5% accuracy, 82.1 +- 8.6% sensitivity and 91.9 +- 7.4% specificity. In conclusion, the rapid antidepressant effects of mixed doses of ketamine are associated with prefrontal EEG power, asymmetry and cordance at baseline and early post-treatment changes. The prefrontal EEG patterns at baseline may account for recognising ketamine effects in advance. Our randomised, double- blind, placebo-controlled study provides information regarding clinical impacts on the potential targets underlying baseline identification and early changes from the effects of ketamine in patients with TRD.Comment: This revised article is submitting to IEEE TBM

Analyzing 13 Years of Cetacean Strandings: Multiple Stressors to Cetaceans in Taiwanese Waters and Their Implications for Conservation and Future Research

This study summarizes the postmortem investigations of 73 cetaceans stranded on the coast of Taiwan between 2001 and 2013, including 51 Delphinidae, 17 Kogiidae, 3 Ziphiidae, 1 Physeteridae, and 1 Balaenopteridae. Of these, eight (11%) were categorized into direct human-related strandings, including fisheries interaction (bycatch), vessel collision and other anthropogenic-related pathology. Gastrointestinal foreign bodies were found in eight individuals (11%). Most of the bacteria isolated from stranded dolphins were zoonotic pathogens including extended-spectrum β-lactamases Escherichia coli, which indicates waste pollution from land. Severe parasite infestation was found in 36 of the cases (49%), which suggests that the immune function could be compromised. Thirty-eight cases (52%) were diagnosed with myocardial patchy fibrosis or dilated cardiomyopathy. The evidence shown here indicates that cetaceans around Taiwanese waters may suffer from multiple stressors. This study provides baseline data for the health assessment of cetacean populations in Taiwan, which may ultimately provide recommendations for future cetacean conservation and research throughout the western Pacific

Ventricular divergence correlates with epicardial wavebreaks and predicts ventricular arrhythmia in isolated rabbit hearts during therapeutic hypothermia

INTRODUCTION: High beat-to-beat morphological variation (divergence) on the ventricular electrogram during programmed ventricular stimulation (PVS) is associated with increased risk of ventricular fibrillation (VF), with unclear mechanisms. We hypothesized that ventricular divergence is associated with epicardial wavebreaks during PVS, and that it predicts VF occurrence. METHOD AND RESULTS: Langendorff-perfused rabbit hearts (n = 10) underwent 30-min therapeutic hypothermia (TH, 30°C), followed by a 20-min treatment with rotigaptide (300 nM), a gap junction modifier. VF inducibility was tested using burst ventricular pacing at the shortest pacing cycle length achieving 1:1 ventricular capture. Pseudo-ECG (p-ECG) and epicardial activation maps were simultaneously recorded for divergence and wavebreaks analysis, respectively. A total of 112 optical and p-ECG recordings (62 at TH, 50 at TH treated with rotigaptide) were analyzed. Adding rotigaptide reduced ventricular divergence, from 0.13±0.10 at TH to 0.09±0.07 (p = 0.018). Similarly, rotigaptide reduced the number of epicardial wavebreaks, from 0.59±0.73 at TH to 0.30±0.49 (p = 0.036). VF inducibility decreased, from 48±31% at TH to 22±32% after rotigaptide infusion (p = 0.032). Linear regression models showed that ventricular divergence correlated with epicardial wavebreaks during TH (p<0.001). CONCLUSION: Ventricular divergence correlated with, and might be predictive of epicardial wavebreaks during PVS at TH. Rotigaptide decreased both the ventricular divergence and epicardial wavebreaks, and reduced the probability of pacing-induced VF during TH