3,155 research outputs found
Have Your Cake and Eat It? Price Discount Programs under the Membership Free Shipping Policy in Online Retailing
Order release in a workload controlled flow-shop with sequence-dependent set-up times
In this paper, we report a simulation study on the role of sequence-dependent
set-up times in decision making at the order release level of a workload controlled
make-to-order flow-shop. The study evaluates the potential for set-ups savings,
dependent on the level of workload in the shop, for two alternative strategies,
namely considering set-up times centrally, within the release decision or locally,
within the dispatching decision. These strategies are compared and assessed on
the basis of two main performance measures namely time in system and standard
deviation of the job lateness. Results indicate that the local strategy, which has
been traditionally adopted in practice and in most of the studies dealing with
sequence-dependent set-up times, does not always give the best results.
The release frequency and the shop workload appear critical to the selection of
the strategy to adopt, strongly influencing system performance.Fundação para a Ciência e a Tecnologia (FCT)Universidade do Minh
Differences in Morphology, Proliferation and Immune Profile among Singe-Cell Cloned Stem Cells from the same Mesenchymal Stem Cell Origin
Vancomycin-resistant Enterococcus faecium sequence type 796 - rapid international dissemination of a new epidemic clone
Background: Vancomycin-resistant Enterococcus faecium (VRE) is a leading cause of hospital-acquired infections. New, presumably better-adapted strains of VRE appear unpredictably; it is uncertain how they spread despite improved infection control. We aimed to investigate the relatedness of a novel sequence type (ST) of vanB E. faecium - ST796 - very near its time of origin from hospitals in three Australian states and New Zealand. Methods: Following near-simultaneous outbreaks of ST796 in multiple institutions, we gathered then tested colonization and bloodstream infection isolates' antimicrobial resistance (AMR) phenotypes, and phylogenomic relationships using whole genome sequencing (WGS). Patient meta-data was explored to trace the spread of ST796. Results: A novel clone of vanB E. faecium (ST796) was first detected at one Australian hospital in late 2011, then in two New Zealand hospitals linked by inter-hospital transfers from separate Melbourne hospitals. ST796 also appeared in hospitals in South Australia and New South Wales and was responsible for at least one major colonization outbreak in a Neonatal Intensive Care Unit without identifiable links between centers. No exceptional AMR was detected in the isolates. While WGS analysis showed very limited diversity at the core genome, consistent with recent emergence of the clone, clustering by institution was observed. Conclusions: Evolution of new E. faecium clones, followed by recognized or unrecognized movement of colonized individuals then rapid intra-institutional cross-transmission best explain the multi-center, multistate and international outbreak we observed
Search for electric dipole moments at storage rings
Permanent electric dipole moments (EDMs) violate parity and time reversal
symmetry. Within the Standard Model (SM) they are many orders of magnitude
below present experimental sensitivity. Many extensions of the SM predict much
larger EDMs, which are therefore an excellent probe for the existence of "new
physics". Until recently it was believed that only electrically neutral systems
could be used for sensitive searches of EDMs. With the introduction of a novel
experimental method, high precision for charged systems will be within reach as
well. The features of this method and its possibilities are discussed.Comment: Proc. EXA2011, 6 pages;
http://www.springerlink.com/content/45l35376832vhrg0
Parafermionic Liouville field theory and instantons on ALE spaces
In this paper we study the correspondence between the
coset conformal field
theories and SU(n) gauge theories on
. Namely we check the correspondence between the
SU(2) Nekrasov partition function on and the
conformal blocks of the parafermion algebra (in and modules).
We find that they are equal up to the U(1)-factor as it was in all cases of
AGT-like relations. Studying the structure of the instanton partition function
on we also find some evidence that this
correspondence with arbitrary takes place up to the U(1)-factor.Comment: 21 pages, 6 figures, misprints corrected, references added, version
to appear in JHE
The Nuts and Bolts of Einstein-Maxwell Solutions
We find new non-supersymmetric solutions of five-dimensional ungauged
supergravity coupled to two vector multiplets. The solutions are regular,
horizonless and have the same asymptotic charges as non-extremal charged black
holes. An essential ingredient in our construction is a four-dimensional
Euclidean base which is a solution to Einstein-Maxwell equations. We construct
stationary solutions based on the Euclidean dyonic Reissner-Nordstrom black
hole as well as a six-parameter family with a dyonic Kerr-Newman-NUT base.
These solutions can be viewed as compactifications of eleven-dimensional
supergravity on a six-torus and we discuss their brane interpretation.Comment: 29 pages, 3 figure
The US stock market leads the Federal funds rate and Treasury bond yields
Using a recently introduced method to quantify the time varying lead-lag
dependencies between pairs of economic time series (the thermal optimal path
method), we test two fundamental tenets of the theory of fixed income: (i) the
stock market variations and the yield changes should be anti-correlated; (ii)
the change in central bank rates, as a proxy of the monetary policy of the
central bank, should be a predictor of the future stock market direction. Using
both monthly and weekly data, we found very similar lead-lag dependence between
the S&P500 stock market index and the yields of bonds inside two groups: bond
yields of short-term maturities (Federal funds rate (FFR), 3M, 6M, 1Y, 2Y, and
3Y) and bond yields of long-term maturities (5Y, 7Y, 10Y, and 20Y). In all
cases, we observe the opposite of (i) and (ii). First, the stock market and
yields move in the same direction. Second, the stock market leads the yields,
including and especially the FFR. Moreover, we find that the short-term yields
in the first group lead the long-term yields in the second group before the
financial crisis that started mid-2007 and the inverse relationship holds
afterwards. These results suggest that the Federal Reserve is increasingly
mindful of the stock market behavior, seen at key to the recovery and health of
the economy. Long-term investors seem also to have been more reactive and
mindful of the signals provided by the financial stock markets than the Federal
Reserve itself after the start of the financial crisis. The lead of the S&P500
stock market index over the bond yields of all maturities is confirmed by the
traditional lagged cross-correlation analysis.Comment: 12 pages, 7 figures, 1 tabl
Lead Increases Lipopolysaccharide-Induced Liver Injury through Tumor Necrosis Factor-α Overexpression by Monocytes/Macrophages: Role of Protein Kinase C and p42/44 Mitogen-Activated Protein Kinase
Although lead and lipopolysaccharide (LPS), both important environmental pollutants, activate cells through different receptors and participate in distinct upstream signaling pathways, Pb increases the amount of LPS-induced tumor necrosis factor-α (TNF-α). We examined the cells responsible for the excess production of Pb-increased LPS-induced TNF-α and liver injury, and the roles of protein kinase C (PKC) and p42/44 mitogen-activated protein kinase (MAPK) in the induction of TNF-α. Peritoneal injection of Pb alone (100 μmol/kg) or a low dose of LPS (5 mg/kg) did not affect serum TNF-α or liver functions in A/J mice. In contrast, coexposure to these noneffective doses of Pb plus LPS (Pb+LPS) strongly induced TNF-α expression and resulted in profound liver injury. Direct inhibition of TNF-α or functional inactivation of monocytes/macrophages significantly decreased the level of Pb+LPS-induced serum TNF-α and concurrently ameliorated liver injury. Pb+LPS coexposure stimulated the phosphorylation of p42/44 MAPK and the expression of TNF-α in CD14(+) cells of cultured mouse whole blood, peritoneal macrophages, and RAW264.7 cells. Moreover, blocking PKC or MAPK effectively reduced Pb+LPS-induced TNF-α expression and liver injury. In summary, monocytes/macrophages were the cells primarily responsible for producing, through the PKC/MAPK pathway, the excess Pb-increased/LPS-induced TNF-α that caused liver injury
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