3,873 research outputs found
Comments on large-N volume independence
We study aspects of the large-N volume independence on R**3 x L**G, where
L**G is a G-site lattice for Yang-Mills theory with adjoint Wilson-fermions. We
find the critical number of lattice sites above which the center-symmetry
analysis on L**G agrees with the one on the continuum S**1. For Wilson
parameter set to one and G>=2, the two analyses agree. One-loop radiative
corrections to Wilson-line masses are finite, reminiscent of the
UV-insensitivity of the Higgs mass in deconstruction/Little-Higgs theories.
Even for theories with G=1, volume independence in QCD(adj) may be guaranteed
to work by tuning one low-energy effective field theory parameter. Within the
parameter space of the theory, at most three operators of the 3d effective
field theory exhibit one-loop UV-sensitivity. This opens the analytical
prospect to study 4d non-perturbative physics by using lower dimensional field
theories (d=3, in our example).Comment: 12 pages; added small clarifications, published versio
CD44+ cancer stem-like cells in EBV-associated nasopharyngeal carcinoma.
published_or_final_versio
Effective Dark Matter Model: Relic density, CDMS II, Fermi LAT and LHC
The Cryogenic Dark Matter Search recently announced the observation of two
signal events with a 77% confidence level. Although statistically inconclusive,
it is nevertheless suggestive. In this work we present a model-independent
analysis on the implication of a positive signal in dark matter scattering off
nuclei. Assuming the interaction between (scalar, fermion or vector) dark
matter and the standard model induced by unknown new physics at the scale
, we examine various dimension-6 tree-level induced operators and
constrain them using the current experimental data, e.g. the WMAP data of the
relic abundance, CDMS II direct detection of the spin-independent scattering,
and indirect detection data (Fermi LAT cosmic gamma-ray), etc. Finally, the LHC
reach is also explored
Goldstone Fermion Dark Matter
We propose that the fermionic superpartner of a weak-scale Goldstone boson
can be a natural WIMP candidate. The p-wave annihilation of this `Goldstone
fermion' into pairs of Goldstone bosons automatically generates the correct
relic abundance, whereas the XENON100 direct detection bounds are evaded due to
suppressed couplings to the Standard Model. Further, it is able to avoid
indirect detection constraints because the relevant s-wave annihilations are
small. The interactions of the Goldstone supermultiplet can induce non-standard
Higgs decays and novel collider phenomenology.Comment: 25 pages, 6 figures. References added, minor typos corrected.
Submitted to JHE
A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists
Background: The discovery, more than ten years ago, of exchange proteins directly activated by cAMP (EPAC) as a new family of intracellular cAMP receptors revolutionized the cAMP signaling research field. Extensive studies have revealed that the cAMP signaling network is much more complex and dynamic as many cAMP-related cellular processes, previously thought to be controlled by protein kinase A, are found to be also mediated by EPAC proteins. Although there have been many important discoveries in the roles of EPACs greater understanding of their physiological function in cAMP-mediated signaling is impeded by the absence of EPAC-specific antagonist. Methodology/Principal Findings: To overcome this deficit, we have developed a fluorescence-based high throughput assay for screening EPAC specific antagonists. Our assay is highly reproducible and simple to perform using the ‘‘mix and measure’ ’ format. A pilot screening using the NCI-DTP diversity set library led to the identification of small chemical compounds capable of specifically inhibiting cAMP-induced EPAC activation while not affecting PKA activity. Conclusions/Significance: Our study establishes a robust high throughput screening assay that can be effectively applied for the discovery of EPAC-specific antagonists, which may provide valuable pharmacological tools for elucidating th
Gamma-rays from millisecond pulsars in Globular Clusters
Globular clusters (GCs) with their ages of the order of several billion years
contain many final products of evolution of stars such as: neutron stars, white
dwarfs and probably also black holes. These compact objects can be at present
responsible for the acceleration of particles to relativistic energies.
Therefore, gamma-ray emission is expected from GCs as a result of radiation
processes occurring either in the inner magnetosperes of millisecond pulsars or
in the vicinity of accreting neutron stars and white dwarfs or as a result of
interaction of particles leaving the compact objects with the strong radiation
field within the GC. Recently, GeV gamma-ray emission has been detected from
several GCs by the new satellite observatory Fermi. Also Cherenkov telescopes
reported interesting upper limits at the TeV energies which start to constrain
the content of GCs. We review the results of these gamma-ray observations in
the context of recent scenarios for their origin.Comment: 20 pages, 9 figures, will be published in Astrophysics and Space
Science Series (Springer), eds. N. Rea and D.F. Torre
Asian-Specific total knee system: 5-14 year follow-up study
<p>Abstract</p> <p>Background</p> <p>Knee size and body size differ in Asians compared with Caucasians. Nevertheless, many total knee arthroplasty (TKA) prostheses used worldwide are made for Western Caucasian subjects. As a result, an Asian's knee might not fit these prostheses. We studied the Flexible Nichidai Knee (FNK) system, a new model of TKA for Asian patients. The purpose of this report is to investigate the outcomes of this prosthesis retrospectively.</p> <p>Methods</p> <p>We investigated 1055 primary TKAs in 595 patients who underwent FNK for osteoarthritis (OA) in Japan and were followed for > 5 years. The knee score and function score were used for clinical evaluation. We examined the range of motion (ROM) preoperatively and at final follow-up and radiographic assessments. In addition, postoperative complications were investigated. A survivorship analysis was also conducted using two endpoints: revision for any reason and aseptic failure.</p> <p>Results</p> <p>890 knees in 502 patients were available for study (follow-up rate of 96.0%). The mean follow-up term was 8.3 years (range, 5.0-14.1 years). The knee and function score significantly improved from 41.3 to 90.3 and from 39.1 to 76.2 points, respectively (p < 0.001). The mean ROM in FNK posterior cruciate retaining (CR) type and FNK posterior-stabilized (PS) type ameliorated significantly from 107.8° and 95.6° to 110.7° and 110.4°, respectively (p < 0.01). Ten knees underwent revision surgery (infection in 3 cases, instability in 2, loosening in 2, and non-union of femoral supracondylar fracture, severe pain, and recurrent hemarthrosis in 1 each). The survivorship rate was 99.4% (95% CI, 99.0-99.8) at 5 years (n = 952 patients at risk) and 96.2% (95% CI, 91.9-100) at 12.5 years (n = 49 patients at risk).</p> <p>Conclusion</p> <p>The FNK prosthesis for Asians achieved excellent mid- to long-term survivorship and clinical results.</p
Minimal Supersymmetric Inverse Seesaw: Neutrino masses, lepton flavour violation and LHC phenomenology
We study neutrino masses in the framework of the supersymmetric inverse
seesaw model. Different from the non-supersymmetric version a minimal
realization with just one pair of singlets is sufficient to explain all
neutrino data. We compute the neutrino mass matrix up to 1-loop order and show
how neutrino data can be described in terms of the model parameters. We then
calculate rates for lepton flavour violating (LFV) processes, such as , and chargino decays to singlet scalar neutrinos. The latter decays
are potentially observable at the LHC and show a characteristic decay pattern
dictated by the same parameters which generate the observed large neutrino
angles.Comment: 26 pages, 4 figures; added explanatory comments, final version for
publicatio
WIMP-nucleus scattering in chiral effective theory
We discuss long-distance QCD corrections to the WIMP-nucleon(s) interactions
in the framework of chiral effective theory. For scalar-mediated WIMP-quark
interactions, we calculate all the next-to-leading-order corrections to the
WIMP-nucleus elastic cross-section, including two-nucleon amplitudes and
recoil-energy dependent shifts to the single-nucleon scalar form factors. As a
consequence, the scalar-mediated WIMP-nucleus cross-section cannot be
parameterized in terms of just two quantities, namely the neutron and proton
scalar form factors at zero momentum transfer, but additional parameters
appear, depending on the short-distance WIMP-quark interaction. Moreover,
multiplicative factorization of the cross-section into particle, nuclear and
astro-particle parts is violated. In practice, while the new effects are of the
natural size expected by chiral power counting, they become very important in
those regions of parameter space where the leading order WIMP-nucleus amplitude
is suppressed, including the so-called "isospin-violating dark matter" regime.
In these regions of parameter space we find order-of-magnitude corrections to
the total scattering rates and qualitative changes to the shape of recoil
spectra.Comment: 23 pages, 6 figures, 1 tabl
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