Characteristics Analysis of High Mechanical Strength Gymnastic Leather and Its Producing Process Optimization

Content: With the development of China sports, researches related to sports leather should be paid attention because they usually required higher strength than commonly used leather. In this paper, we focus on the production of gymnastics leather. In gymnastics, the athlete's hand will have high intensity contact with the balance bar, so the gymnastics leather is required to have high intensity performance. At the same time, in order to comply with the ornamental function, gymnastics leather is required to be light color. In this research, glutaraldehyde was used as the main tanning agent, while acrylic polymer and synthetic were used for retanning, in order to obtain high strength, environmentally friendly white gym leather. The shrinkage temperature and mechanical properties of tanned leather were determined and analyzed to determine the suitable tanning agent. Besides, other properties including softness, gas permeability, water permeability, flexing resistance and yellowing-resistance were also measured for selecting proper production process. Therefore, gymnastics leather with ideal performance can be prepared by this method, and the leather conforms to the practical application standard. In addition, the research has guiding significance and application prospect for high strength chrome-free tanned leather. Take-Away: Aldehyde tanning agents and retanning agents, which can be used for gymnastics leather making, were evaluated and selected to achieve ideal effect of finish leather. This research is meaningful to produce not only gymnastics leather but also other sporty leather which require high strength

Characteristics Analysis of High Mechanical Strength Gymnastic Leather and Its Producing Process Optimization

Content: With the development of China sports, researches related to sports leather should be paid attention because they usually required higher strength than commonly used leather. In this paper, we focus on the production of gymnastics leather. In gymnastics, the athlete's hand will have high intensity contact with the balance bar, so the gymnastics leather is required to have high intensity performance. At the same time, in order to comply with the ornamental function, gymnastics leather is required to be light color. In this research, glutaraldehyde was used as the main tanning agent, while acrylic polymer and synthetic were used for retanning, in order to obtain high strength, environmentally friendly white gym leather. The shrinkage temperature and mechanical properties of tanned leather were determined and analyzed to determine the suitable tanning agent. Besides, other properties including softness, gas permeability, water permeability, flexing resistance and yellowing-resistance were also measured for selecting proper production process. Therefore, gymnastics leather with ideal performance can be prepared by this method, and the leather conforms to the practical application standard. In addition, the research has guiding significance and application prospect for high strength chrome-free tanned leather. Take-Away: Aldehyde tanning agents and retanning agents, which can be used for gymnastics leather making, were evaluated and selected to achieve ideal effect of finish leather. This research is meaningful to produce not only gymnastics leather but also other sporty leather which require high strength

Aedes albopictus salivary proteins adenosine deaminase and 34k2 interact with human mast cell specific proteases tryptase and chymase

When mosquitoes probe to feed blood, they inoculate a mixture of salivary molecules into vertebrate hosts' skin causing acute inflammatory reactions where mast cell-derived mediators are involved. Mosquito saliva contains many proteins with largely unknown biological functions. Here, two Aedes albopictus salivary proteins - adenosine deaminase (alADA) and al34k2 - were investigated for their immunological impact on mast cells and two mast cell-specific proteases, the tryptase and the chymase. Mouse bone marrow-derived mast cells were challenged with increased concentrations of recombinant alADA or al34k2 for 1, 3, and 6 h, and to measure mast cell activation, the activity levels of beta-hexosaminidase and tryptase and secretion of IL-6 were evaluated. In addition, a direct interaction between alADA or al34k2 with tryptase or chymase was investigated. Results show that bone marrow-derived mast cells challenged with 10 mu g/ml of alADA secreted significant levels of beta-hexosaminidase, tryptase, and IL-6. Furthermore, both al34k2 and alADA are cut by human tryptase and chymase. Interestingly, al34k2 dose-dependently enhance enzymatic activity of both tryptase and chymase. In contrast, while alADA enhances the enzymatic activity of tryptase, chymase activity was inhibited. Our finding suggests that alADA and al34k2 via interaction with mast cell-specific proteases tryptase and chymase modulate mast cell-driven immune response in the local skin microenvironment. alADA- and al34k2-mediated modulation of tryptase and chymase may also recruit more inflammatory cells and induce vascular leakage, which may contribute to the inflammatory responses at the mosquito bite site

Catalytic oxidation of lignin in solvent systems for production of renewable chemicals: A review

Lignin as the most abundant source of aromatic chemicals in nature has attracted a great deal of attention in both academia and industry. Solvolysis is one of the promising methods to convert lignin to a number of petroleum-based aromatic chemicals. The process involving the depolymerization of the lignin macromolecule and repolymerization of fragments is complicated influenced by heating methods, reaction conditions, presence of a catalyst and solvent systems. Recently, numerous investigations attempted unveiling the inherent mechanism of this process in order to promote the production of valuable aromatics. Oxidative solvolysis of lignin can produce a number of the functionalized monomeric or oligomeric chemicals. A number of research groups should be greatly appreciated with regard to their contributions on the following two concerns: (1) the cracking mechanism of inter-unit linkages during the oxidative solvolysis of lignin; and (2) the development of novel catalysts for oxidative solvolysis of lignin and their performance. Investigations on lignin oxidative solvolysis are extensively overviewed in this work, concerning the above issues and the way-forward for lignin refinery

Development and Application of a Multiple Cross Displacement Amplification Combined With Nanoparticle-Based Lateral Flow Biosensor Assay to Detect Candida tropicalis

Candida tropicalis is an increasingly opportunistic pathogen that causes serious invasive candidiasis threatening a patient’s life. Traditional methods to detect C. tropicalis infection depends on time-consuming, culture-based gold-standard methods. So, we sought to establish a new method that could detect target pathogens quickly, accurately, and straightforwardly. Herein, a combination of multiple cross displacement amplification (MCDA) and lateral flow biosensors (LFB) was employed to detect C. tropicalis. In the MCDA system, 10 primers were designed to identify the specific genes of C. tropicalis and amplify the genes in an isothermal amplification device. Then, MCDA amplification reaction products could be identified visibly by color change, and all the amplification products would be tested by LFB with no special equipment. The results demonstrated that the optimal reaction condition of C. tropicalis-MCDA assay was 64°C within 30 min, and only 10 fg DNA was required in each reaction. No cross-reaction was found between C. tropicalis strains and non-C. tropicalis strains. For 300 sputum samples, the results showed that MCDA-LFB assay could rapidly and successfully detect all of the C. tropicalis-positive (28/300) samples detected by the gold-standard method. The entire procedure, including specimen processing (40 min), isothermal reaction (30 min) and result reporting (within 2 min), could be completed within 75 min. Briefly, the study results demonstrated that the detection ability of C. tropicalis-MCDA-LFB assay was better than culture methods with more simplicity, rapidity, sensitivity and specificity. Hence, MCDA-LFB strategy is an effective tool to rapidly detect C. tropicalis in clinical samples, especially in resource-poor areas

Operational performance of a novel fast-responsive heat storage/exchanging unit (HSEU) for solar heating systems

In order for a solar heating system to provide heat immediately after sunrise, a fast response is needed to the heat demand of a serviced space. The majority of existing solar heating systems have a slow response time due to the large volume of water stored in the heat storage/exchanger unit (HSEU). This leads to a slow heat delivery cycle, which results in discomfort for the occupants and thus creates a huge barrier to the wide deployment of solar heating systems. To overcome this critical issue, a novel interactive heat storage/exchanging unit (HSEU) employing a double-tank configuration was developed. Unlike conventional HSEUs, which have a single tank acting as the heat storage and exchanging unit, the new HSEU is comprised of a small tank for heat exchange combined with a large tank for heat storage. The small tank enables fast transfer of solar heat to the heating loop fluid without having to heat up the large volume of water in the entire HSEU tank, whilst the large tank is used to store and exchange heat between itself and the small tank using a temperature-oriented control mechanism. To test the proposed design, the heat transfer between the first (solar loop) and second (heating loop) fluids, the heat and mass transfer between the small and large tank and the associated operational strategy were investigated experimentally and theoretically for comparison. A conventional single tank HSEU requires around 120 min to deliver heat to a served space, whilst the new interactive double-tank HSEU can provide heat to the served space in around 20 min, thus creating a heating system which can respond significantly faster than traditional systems. The investigation of the heat exchange effect between the solar and heating loop fluids showed that the new HSEU achieved a convective heat transfer coefficient of as high as 391 W/m2·K, which is 551% higher than that of a conventional tank. As a result, the solar thermal efficiency of the solar panel-array in the new HSEU based system was increased by 7.5% compared to conventional HSEU based systems

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.

Immunoglobulin A (IgA) is the major secretory immunoglobulin isotype found at mucosal surfaces, where it regulates microbial commensalism and excludes luminal factors from contacting intestinal epithelial cells (IECs). IgA is induced by both T cell-dependent and -independent (TI) pathways. However, little is known about TI regulation. We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. IEC ER stress causes TI and microbiota-independent expansion and activation of peritoneal B1b cells, which culminates in increased lamina propria and luminal IgA. Increased numbers of IgA-producing plasma cells were observed in healthy humans with defective autophagy, who are known to exhibit IEC ER stress. Upon ER stress, IECs communicate signals to the peritoneum that induce a barrier-protective TI IgA response.Wellcome Trust Senior Investigator Award 106260/Z/14/Z HORIZON2020/European Research Council Consolidator Grant 64888

Alterations in the human lung proteome with lipopolysaccharide

<p>Abstract</p> <p>Background</p> <p>Recombinant human activated protein C (rhAPC) is associated with improved survival in high-risk patients with severe sepsis; however, the effects of both lipopolysaccharide (LPS) and rhAPC on the bronchoalveolar lavage fluid (BALF) proteome are unknown.</p> <p>Methods</p> <p>Using differential in gel electrophoresis (DIGE) we identified changes in the BALF proteome from 10 healthy volunteers given intrapulmonary LPS in one lobe and saline in another lobe. Subjects were randomized to pretreatment with saline or rhAPC.</p> <p>Results</p> <p>An average of 255 protein spots were detected in each proteome. We found 31 spots corresponding to 8 proteins that displayed abundance increased or decreased at least 2-fold after LPS. Proteins that decreased after LPS included surfactant protein A, immunoglobulin J chain, fibrinogen-γ, α₁-antitrypsin, immunoglobulin, and α₂-HS-glycoprotein. Haptoglobin increased after LPS-treatment. Treatment with rhAPC was associated with a larger relative decrease in immunoglobulin J chain, fibrinogen-γ, α₁-antitrypsin, and α₂-HS-glycoprotein.</p> <p>Conclusion</p> <p>Intrapulmonary LPS was associated with specific protein changes suggesting that the lung response to LPS is more than just a loss of integrity in the alveolar epithelial barrier; however, pretreatment with rhAPC resulted in minor changes in relative BALF protein abundance consistent with its lack of affect in ALI and milder forms of sepsis.</p