Mural Nodules of Clear Cell Carcinoma in a Mucinous Borderline Tumor of the Ovary: A Case Report

Mural nodules of ovarian mucinous borderline tumors are rare. In this study, we report a case of mural nodules of clear cell carcinoma in an intestinal type mucinous borderline tumor of the ovary. The patient was a 54-years-old woman presented with back and pelvic pain for 3 months. A right-sided multiloculated ovarian mass approximately 20 cm was identified on the CT scan. CA-125 was moderately elevated. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and bilateral pelvic and para-aortic lymphadenectomy. Grossly, the right ovarian mass showed a multiloculated cystic mass with mucinous fluid. There were papillations in the internal surface and two mural nodules were seen. Microscopic examination revealed that the cystic mass was an intestinal type borderline mucinous tumor. The mural nodules showed a classic histology of clear cell carcinoma with tubulocystic and papillary growth patterns. This is an extremely rare case of mural nodules of clear cell carcinoma arising in a mucinous borderline tumor

Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve

This paper describes a novel, strategy for fabricating the movable valve on paper-based microfluidic devices to manipulate capillary-driven fluids. The movable valve fabrication is first realized using hollow rivets as the-holding center it, control the paper channel in different layer movement that Jesuits in the :channel's connection or disconnection. The relatively simple Valve fabrication procedure is robust, Versatile, and, compatible with microfluidic paper-based analytical devices (mu PADs) with differing levels of complexity. It is remarkable that the movable valve can be convenient and free to control fluid without the timing setting; advantages that make it user-friendly for untrained users to carry out the complex multistep operations. For the, performance of the Movable valve to be-verified, several different designs of mu PADs were tested and obtained with satisfactory results. In addition; in the proof-of-concept enzyme-linked immunosorbent assay experiments, we demonstrate the use of these valves in mu PADs for the successful analysis of samples of carcino-embryonic antigen, showing good sensitivity and reproducibility. We hope this technique will open new avenues for the fabrication of paper-based valves in an easily adoptable and widely available way on mu PADs and provide potential point-of-Care applications in the future.This paper describes a novel, strategy for fabricating the movable valve on paper-based microfluidic devices to manipulate capillary-driven fluids. The movable valve fabrication is first realized using hollow rivets as the-holding center it, control the paper channel in different layer movement that Jesuits in the :channel's connection or disconnection. The relatively simple Valve fabrication procedure is robust, Versatile, and, compatible with microfluidic paper-based analytical devices (mu PADs) with differing levels of complexity. It is remarkable that the movable valve can be convenient and free to control fluid without the timing setting; advantages that make it user-friendly for untrained users to carry out the complex multistep operations. For the, performance of the Movable valve to be-verified, several different designs of mu PADs were tested and obtained with satisfactory results. In addition; in the proof-of-concept enzyme-linked immunosorbent assay experiments, we demonstrate the use of these valves in mu PADs for the successful analysis of samples of carcino-embryonic antigen, showing good sensitivity and reproducibility. We hope this technique will open new avenues for the fabrication of paper-based valves in an easily adoptable and widely available way on mu PADs and provide potential point-of-Care applications in the future

Report drawn up on behalf of the Committee on Economic and Monetary Affairs on the possible loan from the OPEC countries to the Federal Republic of Germany and to France. EP Working Documents 1982-83, Document 1-284/82, 4 June 1982

Abstract Background Hand, foot, and mouth disease (HFMD) has become an emerging infectious disease in China in the last decade. There has been evidence that meteorological factors can influence the HFMD incidence, and understanding the mechanisms can help prevent and control HFMD. Methods HFMD incidence data and meteorological data in Minhang District, Shanghai were obtained for the period between 2009 and 2015. Distributed lag non-linear models (DLNMs) were utilized to investigate the impact of meteorological factors on HFMD incidence after adjusting for potential confounders of long time trend, weekdays and holidays. Results There was a non-linear relationship between temperature and HFMD incidence, the RR of 5th percentile compared to the median is 0.836 (95% CI: 0.671–1.042) and the RR of 95th percentile is 2.225 (95% CI: 1.774–2.792), and the effect of temperature varied across age groups. HFMD incidence increased with increasing average relative humidity (%) (RR = 1.009, 95% CI: 1.005–1.015) and wind speed (m/s) (RR = 1.197, 95% CI: 1.118–1.282), and with decreasing daily rainfall (mm) (RR = 0.992, 95% CI: 0.987–0.997) and sunshine hours (h) (RR = 0.966, 95% CI: 0.951–0.980). Conclusions There were significant relationships between meteorological factors and childhood HFMD incidence in Minhang District, Shanghai. This information can help local health agencies develop strategies for the control and prevention of HFMD under specific climatic conditions

Unlocking High-Efficiency Methane Oxidation with Bimetallic Pd–Ce Catalysts under Zeolite Confinement

Catalytic complete oxidation is an efficient approach to reducing methane emissions, a significant contributor to global warming. This approach requires active catalysts that are highly resistant to sintering and water vapor. In this work, we demonstrate that Pd nanoparticles confined within silicalite-1 zeolites (Pd@S-1), fabricated using a facile in situ encapsulation strategy, are highly active and stable in catalyzing methane oxidation and are superior to those supported on the S-1 surface due to a confinement effect. The activity of the confined Pd catalysts was further improved by co-confining a suitable amount of Ce within the S-1 zeolite (PdCe0.4@S-1), which is attributed to confinement-reinforced Pd-Ce interactions that promote the formation of oxygen vacancies and highly reactive oxygen species. Furthermore, the introduction of Ce improves the hydrophobicity of the S-1 zeolite and, by forming Pd-Ce mixed oxides, inhibits the transformation of the active PdO phase to inactive Pd(OH)2 species. Overall, the bimetallic PdCe0.4@S-1 catalyst delivers exceptional outstanding activity and durability in complete methane oxidation, even in the presence of water vapor. This study may provide new prospects for the rational design of high-performance and durable Pd catalysts for complete methane oxidation

A Cost-Effective In Situ Zooplankton Monitoring System Based on Novel Illumination Optimization

A cost-effective and low-power-consumption underwater microscopic imaging system was developed to capture high-resolution zooplankton images in real-time. In this work, dark-field imaging was adopted to reduce backscattering and background noise. To produce an accurate illumination, a novel illumination optimization scheme for the light-emitting diode (LED) array was proposed and applied to design a lighting system for the underwater optical imaging of zooplankton. A multiple objective genetic algorithm was utilized to find the best location of the LED array, which resulted in the specific illumination level and most homogeneous irradiance in the target area. The zooplankton imaging system developed with the optimal configuration of LEDs was tested withDaphnia magnaunder laboratory conditions. The maximal field of view was 16 mm x 13 mm and the optical resolution was 15 mu m. The experimental results showed that the imaging system developed could capture high-resolution and high-definition images ofDaphnia. Subsequently,Daphniaindividuals were accurately segmented and their geometrical characters were measured by using a classical image processing algorithm. This work provides a cost-effective zooplankton measuring system based on an optimization illumination configuration of an LED array, which has a great potential for minimizing the investment and operating costs associated with long-term in situ monitoring of the physiological state and population conditions of zooplankton

Challenges and opportunities in atomistic simulations of glasses: a review

Atomistic modeling and simulations have been pivotal in our understanding of the glassy state. Indeed, atomistic modeling offers direct access to the structure and dynamics of atoms in glasses—which is typically hidden from conventional experiments. Simulations also offer a more economical, faster alternative to systematic experiments to decode composition-property relationships and accelerate the discovery of new glasses with desirable properties and functionalities. However, the atomistic modeling of glasses remains plagued by a series of challenges, e.g., high computational cost, limited accessible timescale, lack of accurate interatomic forcefields, etc. These challenges often result in the existence of discrepancies between simulation and experimental data, thereby limiting the predictive power of atomistic modeling. Here, we review recent accomplishments and remaining challenges facing the atomistic modeling of glasses. We discuss future opportunities offered by the seamless integration of simulations, knowledge, experiments, and machine learning in advancing glass modeling to a new era

Challenges and opportunities in atomistic simulations of glasses: a review

Atomistic modeling and simulations have been pivotal in our understanding of the glassy state. Indeed, atomistic modeling offers direct access to the structure and dynamics of atoms in glasses—which is typically hidden from conventional experiments. Simulations also offer a more economical, faster alternative to systematic experiments to decode composition-property relationships and accelerate the discovery of new glasses with desirable properties and functionalities. However, the atomistic modeling of glasses remains plagued by a series of challenges, e.g., high computational cost, limited accessible timescale, lack of accurate interatomic forcefields, etc. These challenges often result in the existence of discrepancies between simulation and experimental data, thereby limiting the predictive power of atomistic modeling. Here, we review recent accomplishments and remaining challenges facing the atomistic modeling of glasses. We discuss future opportunities offered by the seamless integration of simulations, knowledge, experiments, and machine learning in advancing glass modeling to a new era

Potential Role of Stabilized Criegee Radicals in Sulfuric Acid Production in a High Biogenic VOC Environment

We present field observations made in June 2011 downwind of Dallas-Fort Worth, TX, and evaluate the role of stabilized Criegee radicals (sCIs) in gaseous sulfuric acid (H2SO4) production. Zero-dimensional model calculations show that sCI from biogenic volatile organic compounds composed the majority of the sCIs. The main uncertainty associated with an evaluation of H2SO4 production from the sCI reaction channel is the lack of experimentally determined reaction rates for sCIs formed from isoprene ozonolysis with SO2 along with systematic discrepancies in experimentally derived reaction rates between other sCIs and SO2 and water vapor. In general, the maximum of H2SO4 production from the sCI channel is found in the late afternoon as ozone increases toward the late afternoon. The sCI channel, however, contributes minor H2SO4 production compared with the conventional OH channel in the mid-day. Finally, the production and the loss rates of H2SO4 are compared. The application of the recommended mass accommodation coefficient causes significant overestimation of H2SO4 loss rates compared with H2SO4 production rates. However, the application of a lower experimental value for the mass accommodation coefficient provides good agreement between the loss and production rates of H2SO4. The results suggest that the recommended coefficient for the H2O surface may not be suitable for this relatively dry environment

Experimental study of the corona discharge for indoor air treatment : VOC and particles

La qualité de l'air intérieur est devenue une préoccupation de santé publique du fait notamment de l'augmentation du temps passé dans les environnements intérieurs et les espaces clos. L'objectif de ce travail est de développer des procédés mettant en œuvre la décharge couronne afin de traiter les polluants gazeux chimiques et particulaires dans l'air intérieur. Le premier volet du travail concerne la dégradation des polluants gazeux chimiques présents en très faibles concentrations dans l’air intérieur. Le couplage d’une décharge couronne et d’un catalyseur est mis en œuvre pour dégrader du toluène dans des conditions représentatives de l’air intérieur. Cette étude démontre la très bonne efficacité de la décharge couronne vis-à-vis du toluène avec de faibles densités d’énergie. Elle identifie les conditions opératoires optimales et propose des mécanismes réactionnels suite à l’identification des principaux produits de réaction. Cependant, le plasma génère des espèces indésirables comme l'ozone et les oxydes d'azote qui doivent impérativement être détruits. Nous avons choisi d'adjoindre à la décharge couronne un catalyseur à base d'oxydes de métaux de transition (MnOx/Al2O3). Différents catalyseurs sont synthétisés puis modifiés par greffage d’agents modifiants. Leur efficacité vis-à-vis de l’ozone et des NOx est quantifiée en présence de différentes teneurs en vapeur d’eau. Le deuxième volet concerne la collecte des particules par filtration électrostatique. Trois procédés sont étudiés ; ils associent un étage d’ionisation et un étage de collecte. L’ionisation est assurée soit par un électrofiltre fil-plaque soit par des aiguilles portées à un potentiel de quelques kilovolts. L’efficacité de collecte est mesurée dans la gamme de 10 nm à 20 µm en fonction de différents paramètres opératoires (tension, polarité, vitesse, paramètres géométriques, concentration en particules, humidité, etc.). Les aiguilles ont une efficacité légèrement inférieure à celle de l’électrofiltre mais présentent une très faible production de l'ozone et une consommation énergétique moindre. L’étude paramétrique permet de dimensionner, d'optimiser la géométrie du procédé et de définir les meilleures conditions de fonctionnementIndoor air quality has become a public health issue because of the increased time spent in indoor environments and confined spaces. The goal of this work is to develop processes using corona discharge to treat chemical gaseous and particulate pollutants in indoor air. The first part of the work concerns the degradation of chemical gaseous pollutants present in very low concentrations in indoor air. The coupling of a corona discharge and a catalyst is implemented to degrade toluene under conditions representative of the indoor air. Tests were carried out under a range of operating and environmental conditions. This study demonstrates the very good efficiency of the corona discharge for toluene with very low specific density. Optimal operating conditions are identified and reaction mechanisms are proposed following the identification of the main reaction products. However, the generations of by-products, ozone and NOx, which can be hazardous compounds, have to be taken into account. The combination of corona discharge with catalysis seems as a promising way to ensure the suitability and the safety of non-thermal plasma as an indoor air cleaner. Different catalysts based on transition metal oxides (MnOx/Al2O3) are synthesized and then modified by grafting modifying agents. Their efficiency for ozone and NOx elimination is quantified in the presence of different water vapor contents. The second part concerns the particle collection by electrostatic precipitation. Three processes are studied; they combine an ionization stage and a collection stage. The ionization is ensured either by a wire-plate electrostatic precipitator (ESP) or by needles brought to a potential of a few kilovolts. The collection efficiency is measured in the range of 10 nm to 20 μm according to different operating parameters (voltage, polarity, velocity, geometrical parameters, particle concentration, humidity, etc.). The needles have a slightly lower efficiency than the ESP but present a very low production of ozone and a lower energy consumption. The parametric study makes it possible to dimension, to optimize the geometry of the process and to define the best operating condition