Geographical distribution and prevalence of mental disorders among healthcare workers in China:A cross-sectional country-wide survey A cross-sectional study to assess mental disorders of healthcare workers in China

Background Reliable and detailed nationwide data on the prevalence and distribution of mental disorders among healthcare workers in China during the coronavirus disease 2019 (COVID-19) outbreak are scarce. Methods We did a cross-sectional online survey from March 2 to 2 April 2020 and a total of 19,379 healthcare workers from 25 provinces participated. Depression, anxiety and post-traumatic stress disorder (PTSD) were assessed by the Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7) and PTSD Checklist for DSM-5 (PCL-5), respectively. Results The age-standardized prevalence of depression, anxiety and PTSD was 15.5%, 12.7% and 5.2%, respectively. Frontline workers had higher prevalence estimates than non-frontline workers (depression: 18.2% vs. 13.9%; anxiety: 14.7% vs. 11.6%; PTSD: 6.1% vs. 4.6%). Subgroups who were nurses, were married or had dependent children reported higher prevalence of depression, anxiety and PTSD. Despite of the large variations, the prevalence of mental disorders was lowest in East China, followed by Middle China, and highest in West China. Conclusion Healthcare workers faced enormous stress not only from the direct risk presented by the COVID-19 outbreak, but also from the profound changes in their professional practice. Prevalence of adverse psychological outcomes has a significant association with geographically distribution of health resources and regional economic level. Sufficient medical resource may be a protective factor to mental health condition of healthcare personnel when such a public health emergency happened

Online synchronous inspection and system optimization of flexible food packaging bags by using machine vision and sensing technique

Flexible food packaging in the market is increasingly favored, and its quality is essential and indispensable for safety and convenience.  However, quality inspection still stays in the manual stage, or partially manual inspection remains, in production, leading low efficiency, lack and even false inspection, hardly meeting the requirements of the modern output.  This paper proposes and optimizes the design of an automatic detection system with intelligence for flexible food packaging bag, which can effectively be adopted to check the quality of packaging trademark patterns, fillers, and sealing quality.  The inspection system runs with two-stage structure, machine vision, pressure sensing and synchronization to improve efficiency and ensure the normal production beat. Simplex Method is adopted to determine the best synchronous speeds online to achieve the best expectation. Comparison has been made between the manual inspection and our automatic operation, the sample of 10000 was statistically analyzed and results have shown that two workers were saved and the correctness rate of inspection raised up to 999.8‰

Breeding progress and preparedness for mass‐scale deployment of perennial lignocellulosic biomass crops switchgrass, miscanthus, willow and poplar

UK: The UK‐led miscanthus research and breeding was mainly supported by the Biotechnology and Biological Sciences Research Council (BBSRC), Department for Environment, Food and Rural Affairs (Defra), the BBSRC CSP strategic funding grant BB/CSP1730/1, Innovate UK/BBSRC “MUST” BB/N016149/1, CERES Inc. and Terravesta Ltd. through the GIANT‐LINK project (LK0863). Genomic selection and genomewide association study activities were supported by BBSRC grant BB/K01711X/1, the BBSRC strategic programme grant on Energy Grasses & Bio‐refining BBS/E/W/10963A01. The UK‐led willow R&D work reported here was supported by BBSRC (BBS/E/C/00005199, BBS/E/C/00005201, BB/G016216/1, BB/E006833/1, BB/G00580X/1 and BBS/E/C/000I0410), Defra (NF0424) and the Department of Trade and Industry (DTI) (B/W6/00599/00/00). IT: The Brain Gain Program (Rientro dei cervelli) of the Italian Ministry of Education, University, and Research supports Antoine Harfouche. US: Contributions by Gerald Tuskan to this manuscript were supported by the Center for Bioenergy Innovation, a US Department of Energy Bioenergy Research Center supported by the Office of Biological and Environmental Research in the DOE Office of Science, under contract number DE‐AC05‐00OR22725. Willow breeding efforts at Cornell University have been supported by grants from the US Department of Agriculture National Institute of Food and Agriculture. Contributions by the University of Illinois were supported primarily by the DOE Office of Science; Office of Biological and Environmental Research (BER); grant nos. DE‐SC0006634, DE‐SC0012379 and DE‐SC0018420 (Center for Advanced Bioenergy and Bioproducts Innovation); and the Energy Biosciences Institute. EU: We would like to further acknowledge contributions from the EU projects “OPTIMISC” FP7‐289159 on miscanthus and “WATBIO” FP7‐311929 on poplar and miscanthus as well as “GRACE” H2020‐EU.3.2.6. Bio‐based Industries Joint Technology Initiative (BBI‐JTI) Project ID 745012 on miscanthus.Peer reviewedPostprintPublisher PD

Early Paleozoic tectonic evolution of the Xing-Meng Orogenic Belt: constraints from detrital zircon geochronology of western Erguna-Xing'an Block, North China

International audienceTo better constrain the Early Paleozoic tectonic evolution of the western part of the Erguna-Xing'an Block, detrital zircon U-Pb dating was applied on the Ordovician to Devonian sedimentary strata along the southeast part of the China-Mongolia border. Most of the zircons from five sedimentary samples display fine-scale oscillatory growth zoning and Th/U ratios higher than 0.1, indicating a magmatic origin. All five Ordovician-Devonian samples display the similar age distribution patterns with age groups at ∼440 Ma, ∼510 Ma, ∼800 Ma, ∼950 Ma, and few Meso- to Paleo-Proterozoic and Neoarchean grains. This age distribution pattern is similar to those from adjacent blocks in the southeastern Central Asian Orogenic Belt. Considering previous tectonic studies, we propose bidirectional provenances from the Erguna-Xing'an Block and Baolidao Arc. Consequently, a new model was proposed to highlight the Early Paleozoic tectonic evolution of the western Erguna-Xing'an Block, which constrains two main Early Paleozoic tectonic events of the Xing-Meng Orogenic Belt: (a) pre-Late Cambrian collision between Erguna-Kerulen Block and Arigin Sum-Xilinhot-Xing'an Block; (b) the Early Paleozoic subduction of Paleo-Asian Ocean and pre-Late Devonian collision between Erguna-Xing'an Block and Songliao-Hunshandake Bloc

Design and Experimental Validation for Direct-Drive Fault-Tolerant Permanent-Magnet Vernier Machines

A fault-tolerant permanent-magnet vernier (FT-PMV) machine is designed for direct-drive applications, incorporating the merits of high torque density and high reliability. Based on the so-called magnetic gearing effect, PMV machines have the ability of high torque density by introducing the flux-modulation poles (FMPs). This paper investigates the fault-tolerant characteristic of PMV machines and provides a design method, which is able to not only meet the fault-tolerant requirements but also keep the ability of high torque density. The operation principle of the proposed machine has been analyzed. The design process and optimization are presented specifically, such as the combination of slots and poles, the winding distribution, and the dimensions of PMs and teeth. By using the time-stepping finite element method (TS-FEM), the machine performances are evaluated. Finally, the FT-PMV machine is manufactured, and the experimental results are presented to validate the theoretical analysis

Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop

Objective: Carbohydrate-response element-binding protein (ChREBP) is the major transcription factor conferring glucose-induced gene expression in pancreatic islets, liver and adipose tissue. Recently, a novel ChREBP isoform, ChREBP-β, was identified in adipose tissue and found to be also expressed in islets and involved in glucose-induced beta cell proliferation. However, the physiological function of this less abundant β-isoform in the islet, and in diabetes, is largely unknown. The aims of the present study, therefore, were to determine how diabetes affects ChREBP-β and elucidate its physiological role in pancreatic beta cells. Methods: Non-obese diabetic and obese, diabetic ob/ob mice were used as models of T1D and T2D and human islets and the rat INS-1 beta cell line were exposed to low/high glucose and used for ChREBP isoform-specific gain-and-loss-of-function experiments. Changes in ChREBP-β and ChREBP-α were assessed by qRT-PCR, immunoblotting, promoter luciferase, and chromatin immunoprecipitation studies. Results: Expression of the ChREBP-β isoform was highly induced in diabetes and by glucose, whereas ChREBP-α was downregulated. Interestingly, ChREBP-β gain-of-function experiments further revealed that it was ChREBP-β that downregulated ChREBP-α through a negative feedback loop. On the other hand, ChREBP-β knockdown led to unabated ChREBP-α activity and glucose-induced expression of target genes, suggesting that one of the physiological roles of this novel β-isoform is to help keep glucose-induced and ChREBP-α-mediated gene expression under control. Conclusions: We have identified a previously unappreciated negative feedback loop by which glucose-induced ChREBP-β downregulates ChREBP-α-signaling providing new insight into the physiological role of islet ChREBP-β and into the regulation of glucose-induced gene expression. Keywords: Carbohydrate response element binding protein, Pancreatic islet, Glucose-induced gene expression, Transcription, Diabete