23 research outputs found
ΠΠ΄Π½ΠΎΡΠ΅Π°ΠΊΡΠΎΡΠ½ΠΈΠΉ ΡΠΈΠ½ΡΠ΅Π· Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ ΡΠΌΡΠ΄Π°Π·ΠΎΠ»ΡΠ΄ΠΈΠ½-2-ΠΎΠ½ΡΠ² Π·Π° ΡΡΠ°ΡΡΡ ΡΡΠΎΠ±Π°ΡΠ±ΡΡΡΡΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ, Π°ΡΠΈΠ»Π³Π»ΡΠΎΠΊΡΠ°Π»ΡΠ² ΡΠ° ΡΠ΅ΡΠΎΠ²ΠΈΠ½
Derivatives of imidozoline-2-ones containing the pyrimidinthionic moiety in position 4 have been synthesized by three-component one-pot condensation of thiobarbituric acid, arylglyoxal hydrates and ureas. It has been found that these compounds exist in the solution of DMSO-d6 as a mixture of two tautomeric forms: for products obtained from N-substituted ureas the imidazolidin form predominates; and in the case of urea the imidazolidin and imidazolin forms are present in the ratio of 1:1.Π’ΡΠ΅Ρ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΠΎΠΉ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠΈΠ΅ΠΉ ΡΠΈΠΎΠ±Π°ΡΠ±ΠΈΡΡΡΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ, Π³ΠΈΠ΄ΡΠ°ΡΠΎΠ² Π°ΡΠΈΠ»Π³Π»ΠΈΠΎΠΊΡΠ°Π»Π΅ΠΉ ΠΈ ΠΌΠΎΡΠ΅Π²ΠΈΠ½ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΠΈΠΌΠΈΠ΄Π°Π·ΠΎΠ»ΠΈΠ΄ΠΈΠ½-2-ΠΎΠ½ΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΠΎΡΡΠ°ΡΠΎΠΊ ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ° Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ 4. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΡΡΡΠ΅ΡΡΠ²ΡΡΡ Π² ΡΠ°ΡΡΠ²ΠΎΡΠ΅ ΠΠΠ‘Π-d6 Π² Π²ΠΈΠ΄Π΅ ΡΠΌΠ΅ΡΠΈ Π΄Π²ΡΡ
ΡΠ°ΡΡΠΎΠΌΠ΅ΡΠ½ΡΡ
ΡΠΎΡΠΌ: Π΄Π»Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ N-Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
ΠΌΠΎΡΠ΅Π²ΠΈΠ½, ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ ΠΈΠΌΠΈΠ΄Π°Π·ΠΎΠ»ΠΈΠ΄ΠΈΠ½ΠΎΠ²Π°Ρ ΡΠΎΡΠΌΠ°, ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ Π² ΡΠ»ΡΡΠ°Π΅ ΠΌΠΎΡΠ΅Π²ΠΈΠ½Ρ ΠΈΠΌΠΈΠ΄Π°Π·ΠΎΠ»ΠΈΠ΄ΠΈΠ½ΠΎΠ²Π°Ρ ΠΈ ΠΈΠΌΠΈΠ΄Π°Π·ΠΎΠ»ΠΈΠ½ΠΎΠ²Π°Ρ ΡΠΎΡΠΌΡ ΠΏΡΠΈΡΡΡΡΡΠ²ΡΡΡ Π² ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ 1:1.Π’ΡΠΈΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΠΎΡ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΡΡΡ Π³ΡΠ΄ΡΠ°ΡΡΠ² Π°ΡΠΈΠ»Π³Π»ΡΠΎΠΊΡΠ°Π»ΡΠ², ΡΡΠΎΠ±Π°ΡΠ±ΡΡΡΡΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Ρ ΡΠ΅ΡΠΎΠ²ΠΈΠ½ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ ΠΏΠΎΡ
ΡΠ΄Π½Ρ ΡΠΌΡΠ΄Π°Π·ΠΎΠ»ΡΠ΄ΠΈΠ½-2-ΠΎΠ½Ρ ΡΠ· Π·Π°Π»ΠΈΡΠΊΠΎΠΌ ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½ΡΡΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ 4. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ ΠΎΡΡΠΈΠΌΠ°Π½Ρ ΡΠΏΠΎΠ»ΡΠΊΠΈ ΡΡΠ½ΡΡΡΡ Ρ ΡΠΎΠ·ΡΠΈΠ½Ρ ΠΠΠ‘Π-d6 ΡΠΊ ΡΡΠΌΡΡ Π΄Π²ΠΎΡ
ΡΠ°ΡΡΠΎΠΌΠ΅ΡΠ½ΠΈΡ
ΡΠΎΡΠΌ: Π΄Π»Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΡΠ², ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ
Π½Π° ΠΎΡΠ½ΠΎΠ²Ρ N-Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ
ΡΠ΅ΡΠΎΠ²ΠΈΠ½, ΠΏΠ΅ΡΠ΅Π²Π°ΠΆΠ°Ρ ΡΠΌΡΠ΄Π°Π·ΠΎΠ»ΡΠ΄ΠΈΠ½ΠΎΠ²Π° ΡΠΎΡΠΌΠ°, ΡΠΎΠ΄Ρ ΡΠΊ Ρ Π²ΠΈΠΏΠ°Π΄ΠΊΡ ΡΠ΅ΡΠΎΠ²ΠΈΠ½ΠΈ ΡΠΌΡΠ΄Π°Π·ΠΎΠ»ΡΠ΄ΠΈΠ½ΠΎΠ²Π° ΡΠ° ΡΠΌΡΠ΄Π°Π·ΠΎΠ»ΡΠ½ΠΎΠ²Π° ΡΠΎΡΠΌΠΈ ΠΏΡΠΈΡΡΡΠ½Ρ Ρ ΡΠΏΡΠ²Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ 1:1
ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠΌ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ΅
Results of the complex research of apoptosis realization of lymphocytes at acute tick-born encephalitis and during long antigenemia condition has been presented in this article. The acceleration of apoptosis, tumor necrosis factor I presentation and the decrease in mitochondrial transmembrane potential of lymphocytes were determined at tick-born encephalitis. Uncovered changes are more appeared at acute neuroinfection.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠΌ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ΅ Π² ΠΎΡΡΡΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄, Π° ΡΠ°ΠΊΠΆΠ΅ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π°Π½ΡΠΈΠ³Π΅Π½Π΅ΠΌΠΈΠΈ Π²ΠΈΡΡΡΠ° ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ°. ΠΡΠΈ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠΌ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π°ΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½ΡΡ
Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², ΠΊΠ»Π΅ΡΠΎΠΊ, Π½Π΅ΡΡΡΠΈΡ
Π½Π° ΡΠ²ΠΎΠ΅ΠΉ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡ ΠΊ ΡΠ°ΠΊΡΠΎΡΡ Π½Π΅ΠΊΡΠΎΠ·Π° ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΡΠΈΠΏΠ° I, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΡΠΌ ΡΡΠ°Π½ΡΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠΉ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Ρ ΠΏΡΠΈ ΠΎΡΡΡΠΎΠΉ ΡΠΎΡΠΌΠ΅ Π½Π΅ΠΉΡΠΎΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ
ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΎΠΊΠ° 90 ΠΈ 27 Π½Π° Π΄Π΅ΠΊΡΠ°ΠΌΠ΅ΡΠ°Π·ΠΎΠ½ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Π°ΠΏΠΎΠΏΡΠΎΠ· ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
Programmed cell death of tumor cells of line Jurkat in conditions of cultivation with various concentration of dexamethasone, selective inhibitors of Hsp90 (Heat shock protein β Hsp) (17-AAG) and Hsp27 (KRIBB3) was investigated. An estimation of realisation apoptosis spent by method of fluorescent microscopy with use annexin V-FITC and propidium iodide. Inhibition of Hsp90 and Hsp27 leads to activation of tumor cells Jurkat apoptotic program and strengthening of dexamethasone-induced apoptosis. Hsp27 and HsΡ90 play an antiapoptotic role in tumor cells of line Jurkat.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Π»ΠΈΠ½ΠΈΠΈ Jurkat Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΠΌΠΈ Π΄Π΅ΠΊΡΠ°ΠΌΠ΅ΡΠ°Π·ΠΎΠ½Π°, ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ°ΠΌΠΈ Hsp90 (Heat shock protein β Hsp) (17-AAG) ΠΈ Hsp27 (KRIBB3). ΠΡΠ΅Π½ΠΊΡ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ FITCΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π°Π½Π½Π΅ΠΊΡΠΈΠ½Π° V ΠΈ ΠΏΡΠΎΠΏΠΈΠ΄ΠΈΠΉ ΠΉΠΎΠ΄ΠΈΠ΄Π°. ΠΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Hsp90 ΠΈ Hsp27 ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Jurkat ΠΈ ΡΡΠΈΠ»Π΅Π½ΠΈΡ Π΄Π΅ΠΊΡΠ°ΠΌΠ΅ΡΠ°Π·ΠΎΠ½ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π°ΠΏΠΎΠΏΡΠΎΠ·Π°. Π ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΊΠ°Ρ
Hsp27 ΠΈ HsΡ90 ΠΈΠ³ΡΠ°ΡΡ ΡΠΎΠ»Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² Π°ΠΏΠΎΠΏΡΠΎΠ·Π°
Π€ΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½Π°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½ΠΎΠ² ApoE ΠΈ SOD2 Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ HCV-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ
The analysis of gene polymorphism plays an important role in assessment of disposition to infectious diseases at the population and individual level. In this paper, the frequencies of allelic versions of apolipoprotein E and 2nd type superoxide dismutase genes and the corresponding genotypes were determined in healthy persons and chronic viral hepatitis type C patients of the Europeoid population of the Tomsk Region. For the analysis of polymorphism of these genes, we used modern genetic methods: polymerase chain reaction and polymorphism of lengths of restriction fragments. For the studied population, it was revealed that the polymorphism of apolipoprotein E and 2nd type superoxide dismutase genes correlates with the development of chronic viral hepatitis type C and with the fibrogenesis process.ΠΠ½Π°Π»ΠΈΠ· ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½ΠΎΠ² ΠΈΠ³ΡΠ°Π΅Ρ Π²Π°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ Π² ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌ Π½Π° ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΈ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΡΠΎΠ²Π½Π΅. Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ°ΡΡΠΎΡ Π°Π»Π»Π΅Π»ΡΠ½ΡΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² Π³Π΅Π½ΠΎΠ² Π°ΠΏΠΎΠ»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½Π° Π ΠΈ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π΄ΠΈΡΠΌΡΡΠ°Π·Ρ 2-Π³ΠΎ ΡΠΈΠΏΠ° ΠΈ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² Ρ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π²ΠΈΡΡΡΠ½ΡΠΌ Π³Π΅ΠΏΠ°ΡΠΈΡΠΎΠΌ Π‘ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Π΅ΠΉ Π΅Π²ΡΠΎΠΏΠ΅ΠΎΠΈΠ΄Π½ΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ Π’ΠΎΠΌΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ. ΠΠ»Ρ Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π΄Π°Π½Π½ΡΡ
Π³Π΅Π½ΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΡΡ ΡΠ΅ΠΏΠ½ΡΡ ΡΠ΅Π°ΠΊΡΠΈΡ ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ Π΄Π»ΠΈΠ½ ΡΠ΅ΡΡΡΠΈΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ². ΠΠ»Ρ ΠΈΠ·ΡΡΠ΅Π½Π½ΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ Π²ΡΡΠ²Π»Π΅Π½Π° ΡΠ²ΡΠ·Ρ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° Π°ΠΏΠΎΠ»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½Π° Π ΠΈ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π΄ΠΈΡΠΌΡΡΠ°Π·Ρ 2-Π³ΠΎ ΡΠΈΠΏΠ° Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΈΡΡΡΠ½ΠΎΠ³ΠΎ Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘ ΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠΌ ΡΠΈΠ±ΡΠΎΠ³Π΅Π½Π΅Π·Π°
Scaling Reliably: Improving the Scalability of the Erlang Distributed Actor Platform
Distributed actor languages are an effective means of constructing scalable reliable systems, and the Erlang programming language has a well-established and influential model. While the Erlang model conceptually provides reliable scalability, it has some inherent scalability limits and these force developers to depart from the model at scale. This article establishes the scalability limits of Erlang systems and reports the work of the EU RELEASE project to improve the scalability and understandability of the Erlang reliable distributed actor model.
We systematically study the scalability limits of Erlang and then address the issues at the virtual machine, language, and tool levels. More specifically: (1) We have evolved the Erlang virtual machine so that it can work effectively in large-scale single-host multicore and NUMA architectures. We have made important changes and architectural improvements to the widely used Erlang/OTP release. (2) We have designed and implemented Scalable Distributed (SD) Erlang libraries to address language-level scalability issues and provided and validated a set of semantics for the new language constructs. (3) To make large Erlang systems easier to deploy, monitor, and debug, we have developed and made open source releases of five complementary tools, some specific to SD Erlang.
Throughout the article we use two case studies to investigate the capabilities of our new technologies and tools: a distributed hash table based Orbit calculation and Ant Colony Optimisation (ACO). Chaos Monkey experiments show that two versions of ACO survive random process failure and hence that SD Erlang preserves the Erlang reliability model. While we report measurements on a range of NUMA and cluster architectures, the key scalability experiments are conducted on the Athos cluster with 256 hosts (6,144 cores). Even for programs with no global recovery data to maintain, SD Erlang partitions the network to reduce network traffic and hence improves performance of the Orbit and ACO benchmarks above 80 hosts. ACO measurements show that maintaining global recovery data dramatically limits scalability; however, scalability is recovered by partitioning the recovery data. We exceed the established scalability limits of distributed Erlang, and do not reach the limits of SD Erlang for these benchmarks at this scal
Π ΠΎΠ»Ρ Π³Π°Π»Π΅ΠΊΡΠΈΠ½Π°-1 Π² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π·Π° Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ²
Fault in T-lymphocytes homeostasis leads to different diseases with poor or vise versa strong immune response. So it seems to be interesting to research molecules of T-cell cooperation to develop new more effective therapeutic methods. Important factor modulating T-cell activity is galectin-1 which takes part in multiply process of cell biology β regulation of cell maturation, migration, signal transduction, functional ability and apoptosis.ΠΠ°ΡΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π·Π° Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΌΠΎΠΆΠ΅Ρ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡ ΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈΠ»ΠΈ, Π½Π°ΠΏΡΠΎΡΠΈΠ², Π³ΠΈΠΏΠ΅ΡΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ ΠΎΡΠΎΠ±ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ», ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΡ
Π² Π’-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ, Ρ ΡΠ΅Π»ΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ². ΠΠ°ΠΆΠ½ΡΠΌ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΡΠ²Π»ΡΠ΅ΡΡΡ Π³Π°Π»Π΅ΠΊΡΠΈΠ½-1, ΠΊΠΎΡΠΎΡΡΠΉ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ Π² ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ β ΡΠ΅Π³ΡΠ»ΡΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π°, ΠΌΠΈΠ³ΡΠ°ΡΠΈΡ, ΠΏΠ΅ΡΠ΅Π΄Π°ΡΡ ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΡΠΈΠ³Π½Π°Π»ΠΎΠ², Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΎΡΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ ΠΈ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΡ Π°ΠΏΠΎΠΏΡΠΎΠ·Π°
ΠΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ°
In this article results of the clinical-immunological analysis with different forms tick-borne encephalitis of Tomsk Region during the period from 2000 to 2008 are represented. The revealled disbalance of cytokines alongside with breach of the expressions cytokines's receptor by limphocytes's cells, can be one of the main of the reasons to inefficiency answer when introducing the infectious agent in organism and shaping the chronic form to infectious pathology, in particular, with long presence of the antigen of the virus tick-borne encephalitis in blood. The trend to increase the level sick with long presence of the antigen of the virus tick-borne encephalitis in blood, with prevalence of the persons feminine flap, mainly average and senior age for the last years is given.ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ° ΠΏΠΎ Π’ΠΎΠΌΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ Ρ 2000 ΠΏΠΎ 2008 Π³. ΠΡΡΠ²Π»Π΅Π½Π½ΡΠΉ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ²ΡΠΉ Π΄ΠΈΡΠ±Π°Π»Π°Π½Ρ Π½Π°ΡΡΠ΄Ρ Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ²ΡΡ
ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΡΠ½ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ ΠΌΠΎΠΆΠ΅Ρ ΡΠ»ΡΠΆΠΈΡΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· Π³Π»Π°Π²Π½ΡΡ
ΠΏΡΠΈΡΠΈΠ½ Π½Π΅ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΏΡΠΈ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π°Π³Π΅Π½ΡΠ° Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΡΠΌΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ½ΠΎΡΠΈΡΠ΅Π»ΡΡΡΠ²Π° Π²ΠΈΡΡΡΠ° ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ°. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΡΠΎΡΡΡ ΡΠΈΡΠ»Π° Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ½ΠΎΡΠΈΡΠ΅Π»ΡΡΡΠ²ΠΎΠΌ Π²ΠΈΡΡΡΠ° ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ° Ρ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ΠΌ ΡΡΠ΅Π΄ΠΈ Π½ΠΈΡ
Π»ΠΈΡ ΠΆΠ΅Π½ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ»Π° ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ ΠΈ ΡΡΠ°ΡΡΠ΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°