CEDAW and Transformative Judicial Obligations: The Vulnerable Migrant Domestic Worker and Root Causes of Abuse

CEDAW’s transformative provisions, which require states to address root causes of injustice and discrimination, can be made more effective not only through legislation and policy, as commonly argued, but through the judiciary. This article highlights the need to develop the content and implementation of transformative judicial obligations under CEDAW through a comparative study of judicial decisions on the abuse of female MDWs in three key MDW destinations that are party to CEDAW—Hong Kong, Singapore, and Malaysia. By engaging with scholarship on CEDAW’s positive obligations, transformative equality, and theories of adjudication, this article argues that criminal law courts should not only ensure the accountability and punishment of perpetrators of MDW abuse, but should also ascertain and critique the laws, policies, and practices enabling such abuse. Courts in the MDW destination countries studied here have increasingly recognized MDWs’ vulnerabilities by discussing MDWs’ social isolation, financial precariousness, and dependence on employers for their basic needs. However, these judicial discussions generally have not recognized the underlying causes of MDWs’ vulnerabilities. By analyzing positive and negative examples of judicial decisions, this article demonstrates that criminal law courts can and should act as transformative agents by exercising their expressive or statement-making powers to address the causes of MDW vulnerabilities. Importantly, CEDAW requires courts to determine the root causes of MDW abuse, identify the necessary steps forward, target responsible state actors, and counter deep-seated prejudices by representing MDWs as dignified rights-bearing workers

Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy

Radiotherapy is the standard treatment for head and neck squamous cell carcinoma (HNSCC), however, radioresistance remains a major clinical problem despite significant improvements in treatment protocols. Therapeutic outcome could potentially be improved if a patient's tumour response to irradiation could be predicted ex vivo before clinical application. The present study employed a bespoke microfluidic device to maintain HNSCC tissue whilst subjecting it to external beam irradiation and measured the responses using a panel of cell death and proliferation markers. HNSCC biopsies from five newly-presenting patients [2 lymph node (LN); 3 primary tumour (PT)] were divided into parallel microfluidic devices and replicates of each tumour were subjected to single-dose irradiation (0, 5, 10, 15 and 20 Gy). Lactate dehydrogenase (LDH) release was measured and tissue sections were stained for cytokeratin (CK), cleaved-CK18 (cCK18), phosphorylated-H2AX (λH2AX) and Ki.67 by immunohistochemistry. In addition, fragmented DNA was detected using terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL). Compared with non.irradiated controls, higher irradiation doses resulted in elevated CK18-labelling index in two lymph nodes [15 Gy; 34.8% on LN1 and 31.7% on LN2 (p=0.006)] and a single laryngeal primary tumour (20 Gy; 31.5%; p=0.014). Significantly higher levels of DNA fragmentation were also detected in both lymph node samples and one primary tumour but at varying doses of irradiation, i.e., LN1 (20 Gy; 27.6%; p=0.047), LN2 (15 Gy; 15.3%; p=0.038) and PT3 (10 Gy; 35.2%; p=0.01). The λH2AX expression was raised but not significantly in the majority of samples. The percentage of Ki.67 positive nuclei reduced dose-dependently following irradiation. In contrast no significant difference in LDH release was observed between irradiated groups and controls. There is clear interand intra-patient variability in response to irradiation when measuring a variety of parameters, which offers the potential for the approach to provide clinically valuable information

Stress in the Patella Following Autologous Chondrocyte Implantation - A Finite Element Study

Bovine patella cartilage shows signs of damage and cell death when subjected to a compressive cyclic load of 6 MPa, which results in a shear stress of 5.6 MPa. The aim of this research was to investigate the effect of activities of daily living (descending stairs, bicycling and deep flexion) on the contact stresses in the patellofemoral compartment following an articular chondrocyte implantation (ACI). A finite element (FE) model of the patellar femoral joint was created and dynamic non-linear analyses were carried out for this purpose. A shear stress of 5.6 MPa was used as the threshold that cartilage can tolerate without resulting in damage. The FE model was verified numerically. Our results show that, for a 70 kg individual at 50% recovery, (i) contact stress in the patella is 11% higher than that in the femur; (ii) shear stress in the host cartilage reaches 4.75 MPa at 50° of flexion; (iii) shear stress in the patella host cartilage is twice that in a healthy cartilage during deep flexion approaching 70°; (iv) maximum shear stress value was 2.75 MPa during cycling at 60% load; (v) stress shielding still occurs through the host cartilage even when the implanted cartilage reaches 97.5% the Young’s modulus of a healthy cartilage. Based on these results, (i) using an exercise bicycle is recommended for rehabilitation; (ii) deep knee flexion should be avoided; (iii) obese people with a BMI of over 42 kg/m2 should not undertake vigorous weight-bearing exercises involving deep knee flexion

DC Leakage behavior and Conduction Mechanism in (BiFeO3)m(SrTiO3)m Superlattices

Leakage current behavior of (BiFeO3)m(SrTiO3)m superlattice structures was studied and analyzed at different temperatures (303-473K) in the light of various models. While bulk limited Poole-Frenkel emission was observed to dominate the leakage current in the temperature range of 303 - 383 K, the space charge limited conduction was observed up to 473 K. With a Poole-Frenkel emission type of conduction, the activation energy range of 0.06 - 0.2 eV was calculated. The physical parameters, calculated from the analysis correlates with the intrinsic properties. The analysis of leakage current facilitates, interface engineering of heterostructures for device applications.Comment: Submitted to Applied Physics Letter

Mechanism of photodamage of the oxygen evolving Mn Cluster of Photosystem II by excessive light energy

© 2017 The Author(s). Photodamage to Photosystem II (PSII) has been attributed either to excessive excitation of photosynthetic pigments or by direct of light absorption by Mn4CaO5 cluster. Here we investigated the time course of PSII photodamage and release of Mn in PSII-enriched membranes under high light illumination at 460 nm and 660 nm. We found that the loss of PSII activity, assayed by chlorophyll fluorescence, is faster than release of Mn from the Mn4CaO5 cluster, assayed by EPR. Loss of PSII activity and Mn release was slower during illumination in the presence of exogenous electron acceptors. Recovery of PSII activity was observed, after 30 min of addition of electron donor post illumination. The same behavior was observed under 460 and 660 nm illumination, suggesting stronger correlation between excessive excitation and photodamage compared to direct light absorption by the cluster. A unified model of PSII photodamage that takes into account present and previous literature reports is presented

Response of Phytoplankton Photophysiology to Varying Environmental Conditions in the Sub-Antarctic and Polar Frontal Zone

Climate-driven changes are expected to alter the hydrography of the Sub-Antarctic Zone (SAZ) and Polar Frontal Zone (PFZ) south of Australia, in which distinct regional environments are believed to be responsible for the differences in phytoplankton biomass in these regions. Here, we report how the dynamic influences of light, iron and temperature, which are responsible for the photophysiological differences between phytoplankton in the SAZ and PFZ, contribute to the biomass differences in these regions. High effective photochemical efficiency of photosystem II (F 0 q/F 0 mw0.4), maximum photosynthesis rate (PB max), light-saturation intensity (Ek), maximum rate of photosynthetic electron transport (1/tPSII), and low photoprotective pigment concentrations observed in the SAZ correspond to high chlorophyll a and iron concentrations. In contrast, phytoplankton in the PFZ exhibits low F 0 q/F 0 m (* 0.2) and high concentrations of photoprotective pigments under low light environment. Strong negative relationships between iron, temperature, and photoprotective pigments demonstrate that cells were producing more photoprotective pigments under low temperature and iron conditions, and are responsible for the low biomass and low productivity measured in the PFZ. As warming and enhanced iron input is expected in this region, this could probably increase phytoplankton photosynthesis in this region. However, complex interactions between the biogeochemical processes (e.g. stratification caused by warming could prevent mixing of nutrients), which control phytoplankton biomass and productivity, remain uncertain

Mass loss and release of nutrient from empty fruit bunch of oil palm applied as mulch to newly transplanted oil palm

Applying a mulch of oil palm empty fruit bunches (EFBs) from processing mills to newly transplanted oil palm is widely practiced for sustainable management and recycling of solid waste from the oil palm industry. Thus, it is important to understand the decomposition and mass loss of EFBs and its nutrient release pattern for better fertility management. The present study was conducted in a newly transplanted oil palm field to investigate the mass loss of applied EFBs and nutrient release pattern over a 12-month period. The treatments evaluated in the present study were: (1) chemical fertiliser (CF) application only; (2) EFB application only; and (3) EFB and CF application (EFB+CF). The treatments were applied immediately after transplanting 13-month-old palms. EFBs were applied around the base of the oil palm at a rate of 170 kg palm–1. Results showed that 50% dry weight of EFB and EFB+CF was lost within 90 days of application. The C : N ratio decreased from 82 to 20 after 180 and 172 days in EFB and EFB+CF respectively. The breakdown of lignin in EFBs was found to be significantly accelerated by the introduction of CF. Soil properties were improved by EFB application with an increase in pH, total mineral N and exchangeable K of the top soil. After 317 DAP, the soil organic C content subjected to treatment with EFB only and EFB+CF was significantly higher (i.e. 1.7%) when compared with that subjected to the control treatment (i.e., 1.3%). Total N increased significantly from 0.06% to 0.12% for both EFB treatments