Carbohydrate-based peptidomimetics targeting neuropilin-1: synthesis, molecular docking study and in vitro biological activities

International audienceNeuropilin-1 (NRP-1), a transmembrane glycoprotein acting as a co-receptor of VEGF-A, is expressed by cancer and angiogenic endothelial cells and is involved in the angiogenesis process. Taking advantage of functionalities and stereodiversities of sugar derivatives, the design and the synthesis of carbohydrate based peptidomimetics are here described. One of these compounds (56) demonstrated inhibition of VEGF-A165 binding to NRP-1 (IC50 = 39 μM) and specificity for NRP-1 over VEGF-R2. Biological evaluations were performed on human umbilical vein endothelial cells (HUVECs) through activation of downstream proteins (AKT and ERK phosphorylation), viability/proliferation assays and in vitro measurements of anti-angiogenic abilities

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Gertrude Joch Robinson, News Agencies and World News. In Canada, the United States and Yugoslavia : Methods and Data, 1981.

Charron Claude-Yves. Gertrude Joch Robinson, News Agencies and World News. In Canada, the United States and Yugoslavia : Methods and Data, 1981.. In: Communication Information, volume 4 n°3, été 1982. pp. 226-228

Oliver Boyd-Barrett et Michael Palmer. Le trafic des nouvelles. Les agences mondiales de l'information, 1981.

Charron Claude-Yves. Oliver Boyd-Barrett et Michael Palmer. Le trafic des nouvelles. Les agences mondiales de l'information, 1981.. In: Communication Information, volume 4 n°2, hiver 1982. pp. 140-142

Gertrude Joch Robinson, News Agencies and World News. In Canada, the United States and Yugoslavia : Methods and Data, 1981.

Charron Claude-Yves. Gertrude Joch Robinson, News Agencies and World News. In Canada, the United States and Yugoslavia : Methods and Data, 1981.. In: Communication Information, volume 4 n°3, été 1982. pp. 226-228

Emerging knowledge opportunities : monitoring infostates for development ; final technical report

Orbicom’s Digital Divide Index provides a rigorous statistical tool capable of benchmarking the unequal access to the use of ICTs internationally, and monitors the progress made by different countries over time, as well as the relative performance across important components of policy interest, such as network deployment, development of skills and use of ICTs. The index was last published by Orbicom in 2005, coinciding with the Second phase of the World Summit on the Information Society (WSIS). The empirical application and analysis were complemented with several in-depth analytical chapters on topics such as the macro-economic impacts of ICTs, regional perspectives from Africa, Asia and Latin America, as well as women in the information society. The International Telecommunication Union (ITU) adopted the Orbicom framework and, with some changes, updated the index in February 2007 as the ICT Opportunity Index. The 3rd Global Knowledge Conference (Kuala Lumpur, December 2007) offered a strategic opportunity to make use of the new and updated index by the ITU, and use it as the macro backdrop for more detailed national quantitative market analyses in developing regions, as well as further expand the work on Women and the information society. The project was aligned with the themes of the Global Knowledge Conference, “Emerging Markets, Emerging Technologies, Emerging People”..

Digital Review of Asia Pacific - Phase II : final technical report, January 2006 - October 2010

This is an external review of the Digital Review of Asia Pacific (DIRAP). DIRAP is a biennial publication that acts as a comprehensive regional reference on the development of ICTs in Asia and the Pacific. Country case studies constitute an important research component of DIRAP, centering on the collection, interpretation and analysis of secondary data on ICT, its development and its role in the socioeconomic development of the region. DIRAP has become the most-used source on ICT4D in the region while building the capacity of Asian authors. The report recommends development of an online presence for the publication