Ce qu’il reste de vivant : mémoire(s) du TNP

Il suffit de pousser les portes du TNP nouvellement rénové et de laisser errer son regard dans les couloirs du bâtiment pour comprendre que ce lieu de théâtre est aussi un lieu chargé d’Histoire. Si les différentes salles vouées à la représentation accueillent le spectacle vivant, les divers espaces qui y mènent (hall, foyer, escaliers...) se font l’écrin des souvenirs, des grands moments qui ont fait ce pour quoi le TNP est aujourd’hui tout à la fois une maison, un esprit, des histoires plut..

Souvenirs d’un lieu, dispersion des fantômes

En juin 2009, Christian Schiaretti faisait ses adieux au plateau du TNP entouré par de nombreux acteurs de l’histoire de ce théâtre. La nostalgie était inévitable, mais les témoins rassemblés se tournaient aussi vers l’avenir : comme le rappelait le directeur des lieux, les bâtiments, achevés en 1930 et rénovés pour la dernière fois en 1972, devaient faire peau neuve pour continuer à abriter des créations vivantes. Une telle mue comportait un risque évident, assumé par l’initiateur du chantie..

« L’ombre cachée derrière l’objet »

C’est à l’occasion de la création des Fenêtres éclairées aux Subsistances du 18 au 29 janvier 2011, que nous rencontrons Michel Laubu, fondateur du TURAK, compagnie dite de « théâtre d’objets » installée à Lyon depuis 1985. Se positionnant à la croisée du théâtre de marionnettes, du théâtre gestuel et de l’exploration plastique, le projet artistique du TURAK repose sur la construction d’un ailleurs imaginaire, où l’objet engendre une dramaturgie singulière tout en proposant un théâtre poétiqu..

« Des amis, des témoins, des possibilités de jeu »

Le Chemin Solitaire d’Arthur Schnitzler joué par le Tg STAN, c’est d’abord la virtuosité incroyable des acteurs du collectif qui incarnent chacun à tour de rôle plusieurs personnages. Mais pour la question qui nous intéresse, c’est aussi, au niveau scénographique, un plateau blanc quadrillé d’objets divers allant du plus quotidien (un grille-pain, une bouilloire électrique, une machine à café), au plus insolite (un bain de pied, un broyeur à bois). C’est autour de cette présence et des foncti..

Volumetric Prefrontal Cortex Alterations in Patients With Alcohol Dependence and the Involvement of Self‐Control

Background: Aspects of self-control such as sensation seeking and impaired impulse control have been implicated in alcohol dependence (ALC). Conversely, sensation seeking has been ascribed a possible protective role in stress-related psychopathologies. We therefore examined gray matter (GM) morphology in individuals with ALC, focusing on differences in prefrontal regions that have been associated with self-control. Additionally, we accounted for differences in lifetime alcohol intake regarding self-control measures and cortical structures in ALC patients. Methods: With voxel-based morphometry (VBM) focusing on prefrontal a priori defined regions of interest, we assessed a group of 62 detoxified ALC patients and 62 healthy controls (HC). ALC patients were subsequently divided into high (n = 9) and low consumers (n = 53). Self-control was assessed by use of the Barratt Impulsiveness Scale and the Sensation Seeking Scale. Results: Compared to HC, ALC had significantly less GM volume in bilateral middle frontal gyrus (MFG) and right medial prefrontal cortex as well as in the right anterior cingulate. High-consuming ALC showed smaller GM in right orbitofrontal cortex as well as lower sensation seeking scores than low consumers. In low-consuming ALC, right MFG-GM was positively associated with magnitude of sensation seeking; particularly, larger MFG-GM correlated with greater thrill and adventure seeking. Conclusion: Thus, our findings (i) indicate deficient GM volume in prefrontal areas related to self-control and (ii) might accentuate the phenotypic divergence of ALC patients and emphasize the importance of the development of individual treatment options

Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation

Growth and regeneration of blood vessels are crucial processes during embryonic development and in adult disease. Members of the bone morphogenetic protein (BMP) family are growth factors known to play a key role in vascular development. The BMP pathway is controlled by extracellular BMP modulators such as BMP endothelial cell precursor derived regulator (BMPER), which we reported previously acts proangiogenically on endothelial cells in a concentration-dependent manner. Here, we explore the function of other BMP modulators, especially Tsg, on endothelial cell behaviour and compare them to BMPER. In Matrigel assays, BMP modulators chordin and noggin had no stimulatory effect; however, gremlin and Tsg enhanced human umbilical vein endothelial cell (HUVEC) sprouting. As the activation dynamics of Tsg were similar to those of BMPER, we further investigated the proangiogenic effect of Tsg on endothelial cells. Tsg enhanced endothelial cell ingrowth in the mouse Matrigel plug assay as well as HUVEC sprouting, migration and proliferatio

Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence.

Evidence suggests that disturbances in neurobiological mechanisms of reward and inhibitory control maintain addiction and provoke relapse during abstinence. Abnormalities within the dopamine system may contribute to these disturbances and pharmacologically targeting the D3 dopamine receptor (DRD3) is therefore of significant clinical interest. We used functional magnetic resonance imaging to investigate the acute effects of the DRD3 antagonist GSK598809 on anticipatory reward processing, using the monetary incentive delay task (MIDT), and response inhibition using the Go/No-Go task (GNGT). A double-blind, placebo-controlled, crossover design approach was used in abstinent alcohol dependent, abstinent poly-drug dependent and healthy control volunteers. For the MIDT, there was evidence of blunted ventral striatal response to reward in the poly-drug-dependent group under placebo. GSK598809 normalized ventral striatal reward response and enhanced response in the DRD3-rich regions of the ventral pallidum and substantia nigra. Exploratory investigations suggested that the effects of GSK598809 were mainly driven by those with primary dependence on alcohol but not on opiates. Taken together, these findings suggest that GSK598809 may remediate reward deficits in substance dependence. For the GNGT, enhanced response in the inferior frontal cortex of the poly-drug group was found. However, there were no effects of GSK598809 on the neural network underlying response inhibition nor were there any behavioral drug effects on response inhibition. GSK598809 modulated the neural network underlying reward anticipation but not response inhibition, suggesting that DRD3 antagonists may restore reward deficits in addiction.The research was carried out at the NIHR/Wellcome Trust Imperial Clinical Research Facility, the NIHR/Wellcome Trust Cambridge Research Facility and Clinical Trials Unit at Salford Royal NHS Foundation Trust, and is supported by the North West London, Eastern and Greater Manchester NIHR Clinical Research Networks

L'enfant autiste (quel travail avec sa famille ?)

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

L'enfant autiste (quel travail avec sa famille ?)

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF